PUBLIC RELEASE DATE:
21-Oct-2014
Contact: Quinn Eastman qeastma@emory.edu 404-727-7829 Emory Health Sciences @emoryhealthsci
Researchers at Emory University School of Medicine have identified a protein released by neurons while the brain is recovering from a stroke.
The results are scheduled for publication Oct. 21 in Journal of Neuroscience.
The protein, called urokinase-type plasminogen activator or uPA, has been approved by the FDA to dissolve blood clots in the lungs. It has been tested in clinical trials in some countries as a treatment for acute stroke.
The Emory team's findings suggest that in stroke, uPA's benefits may extend beyond the time when doctors' principal goal is dissolving the blood clot that is depriving the brain of blood.
Instead, uPA appears to help brain cells recover from the injuries induced by loss of blood flow. Treating mice with uPA after an experimental stroke can improve their recovery of motor function, the researchers found.
uPA (urokinase-type plasminogen activator) and tPA (tissue-type plasminogen activator), the drug that is the only approved treatment for acute stroke, have similar names, because they both act biochemically to activate plasmin, which directly dissolves blood clots.
"We are finding that uPA and tPA do very different things in the brain. We see that uPA is released during the recovery phase of a stroke over several hours," says lead author Manuel Yepes, MD, associate professor of neurology at Emory University School of Medicine. "This is in sharp contrast with tPA, which is released from neurons within milliseconds of hypoxia or ischemia [loss of blood flow]."
Read more here:
Clot dissolver tPA's tardy twin could aid in stroke recovery