Search Results for: glioma genetic

Moffitt Cancer Center Study Validates Activity of Rare Genetic Variant in Glioma

Posted: Published on July 3rd, 2012

Newswise Researchers at Moffitt Cancer Center working with colleagues at three other institutions have validated a link between a rare genetic variant and the risk of glioma, the most common and lethal type of brain tumor. The validation study also uncovered an association between the same rare genetic variant and improved rates of survival for patients with glioma. The study, the first to confirm a rare susceptibility variant in glioma, appeared in a recent issue of the Journal of Medical Genetics, a journal published by the British Medical Association. "Glioma is a poorly understood cancer with high morbidity and devastating outcomes," said study lead author Kathleen M. Egan, Sc.D., interim program leader of Cancer Epidemiology and vice chair of the Department of Cancer Epidemiology. "However, the discovery of the association of the TP53 genetic variant rs78378222 with glioma provides new insights into these tumors and offers better prospects for identifying people at risk." According to the authors, their study "genotyped' the single nucleotide polymorphism (SNP, or "snip") rs78378222 in TP53, an important tumor suppressor gene. The researchers said the SNP disrupts the TP53 signal and, because of its activity, has been linked to a variety of cancers. This study linked … Continue reading

Comments Off on Moffitt Cancer Center Study Validates Activity of Rare Genetic Variant in Glioma

Activity of rare genetic variant in glioma validated

Posted: Published on July 3rd, 2012

ScienceDaily (July 2, 2012) Researchers at Moffitt Cancer Center working with colleagues at three other institutions have validated a link between a rare genetic variant and the risk of glioma, the most common and lethal type of brain tumor. The validation study also uncovered an association between the same rare genetic variant and improved rates of survival for patients with glioma. The study, the first to confirm a rare susceptibility variant in glioma, appeared in a recent issue of the Journal of Medical Genetics, a journal published by the British Medical Association. "Glioma is a poorly understood cancer with high morbidity and devastating outcomes," said study lead author Kathleen M. Egan, Sc.D., interim program leader of Cancer Epidemiology and vice chair of the Department of Cancer Epidemiology. "However, the discovery of the association of the TP53 genetic variant rs78378222 with glioma provides new insights into these tumors and offers better prospects for identifying people at risk." According to the authors, their study "genotyped' the single nucleotide polymorphism (SNP, or "snip") rs78378222 in TP53, an important tumor suppressor gene. The researchers said the SNP disrupts the TP53 signal and, because of its activity, has been linked to a variety of cancers. … Continue reading

Comments Off on Activity of rare genetic variant in glioma validated

Hypertension – Genetics Home Reference – NIH

Posted: Published on January 20th, 2019

Hypertension is abnormally high blood pressure in the arteries, which are the blood vessels that carry blood from the to the rest of the body. As the heart beats, it forces blood through the arteries to deliver nutrients and oxygen to the rest of the body. The strength of the blood pushing against the artery walls is blood pressure, which is measured in units called millimeters of mercury (mmHg). Continue reading

Posted in Hypertension | Comments Off on Hypertension – Genetics Home Reference – NIH

Molecular Genetics – Cell and Gene Therapy Conferences

Posted: Published on June 11th, 2017

Sessions/Tracks Track 1:Molecular Biology Molecular biologyis the study of molecular underpinnings of the processes ofreplication,transcription,translation, and cell function. Molecular biology concerns themolecularbasis ofbiologicalactivity between thebiomoleculesin various systems of acell,gene sequencingand this includes the interactions between theDNA,RNAand proteinsand theirbiosynthesis. Inmolecular biologythe researchers use specific techniques native to molecular biology, increasingly combine these techniques and ideas from thegeneticsandbiochemistry. RelatedMolecular Biology Conferences| Genetics Conferences|Gene Therapy Conferences|Biotechnology Conferences| Immune Cell Therapy Conferences 2nd World Congress onHuman Genetics&Genetic Disorders, November 02-03, 2017 Toronto, Canada; 9th International Conference onGenomicsandPharmacogenomics, June 15-16, 2017 London, Uk; 6th International Conference and Exhibition onCellandGene Therapy, Mar 27-28, 2017 Madrid, Spain; Gordon Research Conference,Viruses&Cells, 14 - 19 May 2017, Lucca, Italy;Human Genome Meeting(HGM 2017), February 5-7 2017, Barcelona, Spain; Embl Conference:Mammalian GeneticsAndGenomics:From Molecular Mechanisms To Translational Applications, Heidelberg, Germany, October 24, 2017;GeneticandPhysiological Impacts of Transposable Elements, October 10, 2017, Heidelberg, Germany. American Society for Cell Biology;The Society for Molecular Biology & Evolution;American Society for Biochemistry and Molecular Biology;The Nigerian Society of Biochemistry and Molecular Biology;Molecular Biology Association Search Form - CGAP. Track 2:Gene Therapy and Genetic Engineering Thegenetic engineeringis also called asgenetic modification. It is the direct manipulation of an organism'sofgenomeby usingbiotechnology. It is a set of technologies used to change … Continue reading

Posted in Cell Therapy | Comments Off on Molecular Genetics – Cell and Gene Therapy Conferences

Gerson: Novel Gene Therapy for Glioma – Video

Posted: Published on December 10th, 2014

Gerson: Novel Gene Therapy for Glioma Stanton Gerson, MD, discusses study findings that looked into a novel genetic therapy for patients with glioma. He presented his study at the American Society of Hematology 2014 meeting in... By: Cancer Therapy Advisor … Continue reading

Posted in Gene Therapy | Comments Off on Gerson: Novel Gene Therapy for Glioma – Video

New study identifies first gene associated with familial glioma

Posted: Published on December 8th, 2014

PUBLIC RELEASE DATE: 7-Dec-2014 Contact: Glenna Picton picton@bcm.edu 713-798-7973 Baylor College of Medicine @bcmhouston HOUSTON - (Dec. 7, 2014) - An international consortium of researchers led by Baylor College of Medicine has identified for the first time a gene associated with familial glioma (brain tumors that appear in two or more members of the same family) providing new support that certain people may be genetically predisposed to the disease. "It is widely thought amongst the clinical community that there is no association between family history and development of glioma. Because we know very little about the contributing genetic factors, when cases occur in two or more family members, it is viewed as coincidental," said Dr. Melissa Bondy, associate director of cancer prevention and population sciences at the NCI-designated Dan L. Duncan Cancer Center at Baylor College of Medicine and lead author of the report that appears in the Journal of the National Cancer Institute today. "By understanding more about the genetic link, we hope that one day we can improve treatments and preventive strategies for those with a family history of glioma." Bondy estimates that approximately five percent of brain tumors run in families. The study was conducted through the … Continue reading

Comments Off on New study identifies first gene associated with familial glioma

New study sheds light on genetic drivers of fatal pediatric cancer

Posted: Published on April 6th, 2014

New insights on the genetic drivers behind a rare type of fatal pediatric brain cancer may lead to the development of new patient-targeted treatments, a new study suggests. Each year about 30 children in Canada are diagnosed with diffuse intrinsic pontine glioma (DIPG), a pediatric cancer for which there is no effective treatment. Because DIPG tumours occur in the middle of the brainstem specifically in the "pons" region that controls vital functions such as breathing, heart regulation and movement doctors are not able to surgically remove them. As well, biopsies are rarely performed on the tumours, meaning researchers have faced challenges investigating the genetic landscape of DIPG. But in a new study from Toronto's Hospital for Sick Children, researchers have uncovered the genetic drivers of DIPG. The study, published online Sunday in the journal Nature Genetics, found that DIPG is comprised of three molecularly distinct subgroups: "MYCN," "silent" and "H3-K27M." "Although previously considered to be one disease, DIPG represents three distinct subgroups with different methylation, expression, copy number alteration (CAN) and mutational profiles," the authors write. The results from the study show that DIPG tumours are distinct from adult brain cancer, the study says. Dr. Cynthia Hawkins, a neuropathologist and … Continue reading

Comments Off on New study sheds light on genetic drivers of fatal pediatric cancer

Gender influences symptoms of genetic disorder

Posted: Published on February 8th, 2014

PUBLIC RELEASE DATE: 6-Feb-2014 Contact: Michael C. Purdy 314-286-0122 Washington University School of Medicine A genetic disorder that affects about 1 in every 2,500 births can cause a bewildering array of clinical problems, including brain tumors, impaired vision, learning disabilities, behavioral problems, heart defects and bone deformities. The symptoms and their severity vary among patients affected by this condition, known as neurofibromatosis type 1 (NF1). Now, researchers at Washington University School of Medicine in St. Louis have identified a patient's gender as a clear and simple guidepost to help health-care providers anticipate some of the effects of NF1. The scientists report that girls with NF1 are at greater risk of vision loss from brain tumors. They also identified gender-linked differences in male mice that may help explain why boys with NF1 are more vulnerable to learning disabilities. "This information will help us adjust our strategies for predicting the potential outcomes in patients with NF1 and recommending appropriate treatments," said David H. Gutmann, MD, PhD, the Donald O. Schnuck Family Professor of Neurology, who treats NF1 patients at St. Louis Children's Hospital. The findings appear online in the Annals of Neurology. Kelly Diggs-Andrews, PhD, a postdoctoral research associate in Gutmann's laboratory, … Continue reading

Comments Off on Gender influences symptoms of genetic disorder

Genetic signature of deadly brain cancer identified

Posted: Published on June 4th, 2013

June 3, 2013 A multi-institutional team of researchers have pinpointed the genetic traits of the cells that give rise to gliomas -- the most common form of malignant brain cancer. The findings, which appear in the journal Cell Reports, provide scientists with rich new potential set of targets to treat the disease. "This study identifies a core set of genes and pathways that are dysregulated during both the early and late stages of tumor progression," said University of Rochester Medical Center (URMC) neurologist Steven Goldman, M.D., Ph.D., the senior author of the study and co-director of the Center for Translational Neuromedicine. "By virtue of their marked difference from normal cells, these genes appear to comprise a promising set of targets for therapeutic intervention." As its name implies, gliomas arise from a cell type found in the central nervous system called the glial cell. Gliomas progress in severity over time and ultimately become highly invasive tumors known as glioblastomas, which are difficult to treat and almost invariably fatal. Current treatments, which include surgery, radiation therapy, and chemotherapy, can delay disease progression, but ultimately prove ineffective. Cancer research has been transformed over the past several years by new concepts arising from stem … Continue reading

Comments Off on Genetic signature of deadly brain cancer identified

Researchers identify genetic signature of deadly brain cancer

Posted: Published on June 3rd, 2013

Public release date: 3-Jun-2013 [ | E-mail | Share ] Contact: Mark Michaud mark_michaud@urmc.rochester.edu 585-273-4790 University of Rochester Medical Center A multi-institutional team of researchers have pinpointed the genetic traits of the cells that give rise to gliomas the most common form of malignant brain cancer. The findings, which appear in the journal Cell Reports, provide scientists with rich new potential set of targets to treat the disease. "This study identifies a core set of genes and pathways that are dysregulated during both the early and late stages of tumor progression," said University of Rochester Medical Center (URMC) neurologist Steven Goldman, M.D., Ph.D., the senior author of the study and co-director of the Center for Translational Neuromedicine. "By virtue of their marked difference from normal cells, these genes appear to comprise a promising set of targets for therapeutic intervention." As its name implies, gliomas arise from a cell type found in the central nervous system called the glial cell. Gliomas progress in severity over time and ultimately become highly invasive tumors known as glioblastomas, which are difficult to treat and almost invariably fatal. Current treatments, which include surgery, radiation therapy, and chemotherapy, can delay disease progression, but ultimately prove ineffective. … Continue reading

Comments Off on Researchers identify genetic signature of deadly brain cancer