Search Results for: six human multiple embryo

Plug-and-Play Human Organ-on-a-Chip Can Be Customized to the Patient – SciTechDaily

Posted: Published on May 7th, 2022

The new multi-organ chip has the size of a glass microscope slide and allows the culture of up to four human engineered tissues, whose location and number can be tailored to the question being asked. These tissues are connected by vascular flow, but the presence of a selectively permeable endothelial barrier maintains their tissue-specific niche. Credit: Kacey Ronaldson-Bouchard/Columbia Engineering Major advance from Columbia Engineering team demonstrates the first multi-organ chip made of engineered human tissues linked by vascular flow for improved modeling of systemic diseases like cancer Continue reading →

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Genetics expert discusses creating ground rules for human germline … – Medical Xpress

Posted: Published on August 9th, 2017

A Stanford professor of genetics discusses the thinking behind a formal policy statement endorsing the idea that researchers continue editing genes in human germ cells. A team of genetics experts has issued a policy statement recommending that research on editing human genes in eggs, sperm and early embryos continue, provided the work does not result in a human pregnancy. Kelly Ormond, MS, professor of genetics at the Stanford School of Medicine, is one of three lead authors of the statement, which provides a framework for regulating the editing of human germ cells. Germ cells, a tiny subset of all the cells in the body, give rise to eggs and sperm. Edits to the genes of germ cells are passed on to offspring. The statement, published today in the American Journal of Human Genetics, was jointly prepared by the American Society for Human Genetics and four other human genetics organizations, including the National Society of Genetic Counselors, and endorsed by another six, including societies in the United Kingdom, Canada, Australia, Africa and Asia. Germline gene editing raises a host of technical and ethical questions that, for now, remain largely unanswered. The ASHG policy statement proposes that federal funding for germline genome … Continue reading →

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Multiple Sclerosis Stem Cell Treatment – StemGenex

Posted: Published on January 23rd, 2017

Can Stem Cell Therapy help patients with Multiple Sclerosis? Today, new treatments and advances in research are giving new hope to people affected by Multiple Sclerosis. StemGenex Medical Group provides stem cell therapy for Multiple Sclerosis to help those with unmet clinical needs achieve optimum health and better quality of life. A clinical study registered through the National Institutes of Health (NIH) atwww.clinicaltrials.gov/stemgenexhas been established to evaluate the quality of life changes in individuals with Multiple Sclerosis following stem cell therapy. Multiple sclerosis stem cell treatment is being studied for efficacy in improving the complications in patients with MS, through the use of their own stem cells. These procedures may help patients who dont respond to typical drug treatment, want to reduce their reliance on medication, or are looking to try stem cell therapy before starting drug treatment. To learn more about becoming a patient and receiving stem cell therapy through StemGenex Medical Group, please contact one of our Patient Advocates at (800) 609-7795. Below are some frequently asked questions aboutstem cell therapy for Multiple Sclerosis. Multiple sclerosis (MS) is widely believed to be an autoimmune condition the bodys immune system mistakenly attacks, and subsequently damages, the myelin sheath protecting … Continue reading →

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Stem Cells in MS : National Multiple Sclerosis Society

Posted: Published on October 21st, 2015

There are many types of stem cells that are undergoing research and which are producing knowledge about their potential use in treating MS. Many of these studies involve adult mesenchymal (pronounced messENkimmul) stem cells, which are present in many tissues of the body, including bone marrow and fat (adipose tissue). These cells are being tested for their ability both to treat immune disorders and promote tissue repair. Further study is necessary to determine what kind of cells might prove optimal for treating some or all people with MS. Stem cell therapy, even in the controlled setting of a clinical trial, carries the possibility for substantial risks. Anyone who is considering enrolling in a clinical trial should evaluate carefully the potential adverse events that will be outlined in the informed consent form that trial participants must sign. HSCT to Reboot the Immune System: One type of procedure that has been explored for several years in MS is called autologous hematopoietic (blood cell-producing) stem cell transplantation -- or HSCT. This procedure has been used in attempts to reboot the immune system, which is believed to launch attacks on the brain and spinal cord in people with MS. In HSCT, these stem cells … Continue reading →

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BioTime Receives Authorization to Begin Pivotal Human Clinical Trial of Renevia in Europe

Posted: Published on November 4th, 2014

Renevia has the potential to be the first approved product that allows cells to be easily transplanted through a syringe and then safely polymerized into three-dimensional tissue constructs within the human body, said William Tew, Ph.D., BioTimes Chief Commercial Officer. We are excited to enter this last phase of clinical trials for Renevia as well as by the promise of this technology for the transplantation of other types of cells to address unmet medical needs. BioTime considers Renevia a key strategic asset for its future regenerative medicine programs which are focused on the development of human embryonic stem cell-derived brown adipocytes, vascular, and osteochondral cells to treat tissues afflicted with degenerative disease. If the pivotal trial meets its primary end points, then we would expect to submit Renevia for CE Mark approval in 2016. About the Renevia Clinical Trial The Spanish Agency of Medicines and Medical Devices (AEMPS) authorized BioTime to conduct a randomized, evaluator-blinded, delayed-treatment-controlled study of the effectiveness and safety of Renevia as a resorbable matrix for the delivery of autologous adipose-derived cells to treat subcutaneous facial lipoatrophy defects arising from HIV infection. The study will include a minimum of 56 and up to 92 HIV positive males … Continue reading →

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New stem cells may help in battling multiple sclerosis

Posted: Published on June 5th, 2014

The great promise of stem cells may finally be getting close for multiple sclerosis patients. Stem cells, which have the power to transform into other types of cells, have been much anticipated for more than a decade as a way to treat or even cure diseases like MS, Parkinson's, blindness and spinal cord injuries. But it's taken time to turn that promise into a workable reality. Two new studies, both published in the journal Stem Cell Reports, suggest that researchers are getting close. "We haven't landed on the moon yet, but we've tested the rockets," said Jeanne Loring, author of one of the studies and a professor and director of the Center for Regenerative Medicine at The Scripps Research Institute in La Jolla, Calif. Her study found that a certain type of stem cell, injected once into the spinal cords of mice with an MS-like condition, could dramatically improve the animals for at least six months. The mice's immune systems almost immediately rejected and destroyed the cells, known as human embryonic stem cell-derived neural precursor cells. But the cells seemed to trigger a long-lasting benefit, dampening inflammation to slow the disease's progression, and repairing the damaged sheathing around nerve cells … Continue reading →

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The First Embryonic Stem Cell Trial

Posted: Published on November 29th, 2013

Six weeks before the hoopla over President Barack Obama's executive order lifting restrictions on embryonic-stem-cell research, Hans Keirstead, a scientist at the University of California, Irvine, was already sipping champagne. In 2005 Keirstead had published a study showing that a therapy derived from human embryonic stem cells could make partially paralyzed rats walk. Now he'd gotten word that the FDA had cleared the way for Geron, a small biotech company in California, to launch the first clinical trial of the treatment in human beings with spinal-cord injuries. It was incredible news,not just for Keirstead, who'd been wanting to invent a therapy for brain and spinal-cord disorders since he was 11 years old, but for scientists who believe human embryonic stem cells can teach them about complex diseases and potentially lead to cures. Keirstead, 41, and his team of scientists hailed the news over a case of chilled Veuve Clicquot. "We put the last bottle down about six hours later," Keirstead says. "It was just a really fun time." Opinions about the moral status of an embryo won't change with presidential decrees or FDA decisions, so you can bet that the debate over embryonic-stem-cell research is far from over. But no … Continue reading →

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How bioelectricity could regrow limbs and organs, with Michael … – UChicago News

Posted: Published on April 28th, 2023

In the near future, birth defects, traumatic injuries, limb loss and perhaps even cancer could be cured through bioelectricityelectrical signals that communicate to our cells how to rebuild themselves. This innovative idea has been tested on flatworms and frogs by biologist Michael Levin, whose research investigates how bioelectricity provides the blueprint for how our bodies are builtand how it could be the future of regenerative medicine Continue reading →

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US Food and Drug Administration Accepts for Priority Review Applications for OPDIVO (nivolumab) in Combination with CABOMETYX (cabozantinib) in…

Posted: Published on October 21st, 2020

Oct. Continue reading →

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Microengineered 3D pulmonary interstitial mimetics highlight a critical role for matrix degradation in myofibroblast differentiation – Science…

Posted: Published on September 15th, 2020

INTRODUCTION Fibrosis is implicated in nearly 45% of all deaths in the developed world and plays a role in numerous pathologies, including pulmonary fibrosis, cardiac disease, atherosclerosis, and cancer (1). In particular, interstitial lung diseases, such as idiopathic pulmonary fibrosis (IPF), are fatal and incurable with a median survival of only 2 to 5 years (2) Continue reading →

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