By Amy Norton HealthDay Reporter
WEDNESDAY, Aug. 20, 2014 (HealthDay News) -- Monthly blood transfusions may lower the chances of "silent" strokes in some children with sickle cell anemia, a new clinical trial indicates.
The study, reported in the Aug. 21 issue of the New England Journal of Medicine, found that in children with a previous silent stroke, monthly blood transfusions cut the rate of future strokes by more than half.
The researchers said their findings support screening children with sickle cell for evidence of silent stroke -- something that is not routinely done now.
"Prior to this, there was no treatment, so the argument was, 'Why screen?'" explained Dr. James Casella, vice chair of the clinical trial and director of pediatric hematology at Johns Hopkins Children's Center in Baltimore. "Now we have a treatment to offer."
However, Casella also stressed that "this study is a first step, not the last one."
Many questions remain, he said. A big one is, do the blood transfusions have to be continued for life?
"It's possible the treatment could be indefinite," Casella said.
Sickle cell anemia is an inherited disease that mainly affects people of African, South or Central American or Mediterranean descent. In the United States, about one in 500 black children are born with the condition, according to the U.S. National Institutes of Health.
The central problem in sickle cell is that the body produces red blood cells that are crescent-shaped, rather than disc-shaped. Those abnormal cells tend to be sticky and can block blood flow.
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Blood Transfusions May Cut Risk of 'Silent' Stroke in Kids With Sickle Cell