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Category Archives: Cardiac Remodeling

Stealth BioTherapeutics Reports Third Quarter 2019 Financial Results And Recent Business Highlights – P&T Community

Posted: November 15, 2019 at 6:46 pm

BOSTON, Nov. 14, 2019 /PRNewswire/ --Stealth BioTherapeuticsCorp(NASDAQ: MITO), a clinical-stage biotechnology company focused on the discovery, development and commercialization of novel therapies for diseases involving mitochondrial dysfunction, today reported financial results for the third quarter ended September 30, 2019 and provided a corporate update. "We're approaching a transformational stage in our company's development, with our recently announced partnership with Alexion and our anticipated pivotal data in primary mitochondrial myopathy in January bringing us even closer toward our goal of delivering transformative therapies to patients with rare, mitochondrial diseases," said Reenie McCarthy, Stealth's Chief Executive Officer. Continue reading

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Angion Presents Data on the Impact and Burden of Delayed Graft Function at the American Society of Nephrology Kidney Week 2019 – GlobeNewswire

Posted: at 6:46 pm

SAN FRANCISCO, Nov. 11, 2019 (GLOBE NEWSWIRE) -- Angion Biomedica Corp. (Angion), a clinical stage biopharmaceutical company developing a first-in-class therapy to treat acute kidney injury, presented five abstracts in addition to a late-breaking abstract at the American Society of Nephrology Kidney Week 2019 Annual Meeting in Washington, D.C. Continue reading

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Effects of genetic transfection on calcium cycling pathways mediated by double-stranded adeno-associated virus in postinfarction remodeling – DocWire…

Posted: November 6, 2019 at 8:46 pm

OBJECTIVE: Restoring calcium sensor protein (S100A1) activity in failing heartsposes a promising therapeutic strategy. We hypothesize that cardiac overexpression of the S100A1 gene mediated by a double-stranded adeno-associated virus (scAAV) results in better functional and molecular improvements compared with the single-stranded virus (ssAAV). Heart failure was induced by coronary artery ligation. Continue reading

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Could Asthma Have Protective Effect in MI? – MedPage Today

Posted: October 26, 2019 at 2:41 am

NEW ORLEANS -- Asthma patients hospitalized for myocardial infarction (MI) had lower mortality risk than patients without asthma a year after the event, analysis of a nationwide hospital inpatient database indicated. Continue reading

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PH Common in Myeloproliferative Neoplasms, Linked to Diastolic Dysfunction – The Cardiology Advisor

Posted: at 2:41 am

Pulmonary hypertension (PH) is common among patients with myeloproliferative neoplasm (MPN) and is linked to left ventricular (LV) hypertrophy and diastolic dysfunction, according to study results published in the Journal of the American Society of Echocardiography. In this retrospective cohort study using consecutive patients with MPN who underwent transthoracic echocardiography between February 2011 and October 2017 (N=301), researchers used established cutoffs for PH (35 mm Hg) and advanced PH (50 mm Hg) and assessed LV and right ventricular (RV) performance via conventional indices. For patients with multiple echocardiographic examinations, they analyzed the initial examination that demonstrated impaired RV function to assess prognostic impact. Continue reading

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AI Pinpoints Genes Associated With Heart Failure – Forbes

Posted: October 3, 2019 at 12:41 am

While AI may increase speed and efficiency of medical care on the front lines, one of its most powerful benefits is the ability to search vast amounts of data to learn about genetic aspects of various diseases. Cardiomegaly Is An Enlargement Of The Heart Due To Dilatation Of The Heart Cavities. Continue reading

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What are the respiratory effects of e-cigarettes? – The BMJ

Posted: at 12:41 am

Electronic cigarettes (e-cigarettes) are alternative, non-combustible tobacco products that generate an inhalable aerosol containing nicotine, flavors, propylene glycol, and vegetable glycerin. Vaping is now a multibillion dollar industry that appeals to current smokers, former smokers, and young people who have never smoked. Continue reading

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Antibody could fine-tune recovery from heart attack – Futurity: Research News

Posted: September 27, 2019 at 4:42 pm

Share this Article You are free to share this article under the Attribution 4.0 International license. An antibody initially developed for rheumatoid arthritis may offer a way to fine-tune recovery after a heart attack and decrease the risk for heart failure, research with mice shows. More than one million Americans per year experience myocardial infarction, commonly known as a heart attack, and the healing and rebuilding phase that begins shortly thereaftera complicated process which involves remodeling and repairing the heart. Continue reading

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Emerging roles of proteoglycans in cardiac remodeling …

Posted: May 23, 2019 at 10:46 am

JavaScript is disabled on your browser. Please enable JavaScript to use all the features on this page.Highlights Proteoglycans are significant modifiers in ischemia and pressure overload-related cardiac remodeling Continue reading

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Cardiac remodelingconcepts and clinical implications: a …

Posted: April 3, 2019 at 5:41 pm

Cardiac remodeling is generally accepted as a determinant of the clinical course of heart failure (HF). Defined as genome expression resulting in molecular, cellular and interstitial changes and manifested clinically as changes in size, shape and function of the heart resulting from cardiac load or injury, cardiac remodeling is influenced by hemodynamic load, neurohormonal activation and other factors still under investigation Continue reading

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