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Category Archives: Cardiomyopathies

Ahmad Masri, MD, MS: 2024 Update on Development and Future of Cardiac Myosin Inhibitor Class – MD Magazine

Posted: Published on February 20th, 2024

Although it does not receive the same level of fanfare as other classes of pharmacotherapies in the cardiometabolic health space, the development of the cardiac myosin inhibitor class represents a significant advancement in the management of hypertrophic cardiomyopathy and, potentially, cardiovascular medicine as a whole in recent years. In April 2022, the FDA made history with the approval of mavacamten (Camzyos) for treatment of adults with symptomatic New York Heart Association class II-III obstructive HCM to improve functional capacity and symptoms based on data from the phase 3 EXPLORER-HCM trial Continue reading

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VIDEO: Using genetics in cardiology to enable earlier interventions – Cardiovascular Business

Posted: Published on January 10th, 2023

"My work for many years has been to understand genetic basis for heart muscle diseases, in particular cardiomyopathy," Seidman said. Continue reading

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Inherited Cardiac Disease Genetic Diagnoses Linked to Ancestry … – GenomeWeb

Posted: Published on January 10th, 2023

A Garvan Institute of Medical Research- and University of New South Wales Sydney-led team reporting in Genome Medicine explores genomic contributions to inherited cardiac disease diagnoses and management at a multidisciplinary clinic at Sydney's Royal Prince Alfred Hospital that specializes in dealing with inherited cardiomyopathies and other heart conditions. Across almost 1,700 cases considered consecutively from 2002 to 2020, the researchers focused on 888 individuals who met the study's inclusion criteria, including the availability of genetic testing and clinical profiles. Of those cases, genetic testing uncovered pathogenic or likely pathogenic variants in 37 percent of cases and variants of uncertain significance (VUS) in another 8 percent, they report, with genetic results impacting diagnoses or care for 51 individuals. Continue reading

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Fixing Heart Failure Workforce Issues: Baby Steps Start This Year – Medpage Today

Posted: Published on January 10th, 2023

This spring, discussions on how to build a workforce that better meets the needs of the heart failure population will begin in earnest. The alarming number of unfilled fellowship spots for advanced heart failure and transplant cardiology (AHFTC) each year shows that the field is not enticing new trainees, despite the growing clinical need and advances in therapeutics. As recently as the 2023-2024 cycle, just 71 of the 127 AHFTC positions were filled, according to data from the National Resident Matching Program Continue reading

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What is cardiac transplantation? An overview – Emergency Live International

Posted: Published on October 6th, 2022

The surgical technique used in almost all cases is what is known as orthotopic, indicating that the transplanted organ is placed in the same position as the native one. Today, cardiac transplantation is the decisive therapy for a number of extremely serious heart diseases in which alternative pharmacological and non-pharmacological therapies are no longer able to ensure adequate survival and/or quality of life. The heart diseases that lead to cardiac transplantation in the most severe cases are ischaemic heart disease, in patients with very extensive or multiple infarcts, cardiomyopathies (primary diseases of the heart muscle, with no known identifiable cause), some heart valve diseases and some congenital heart diseases. Continue reading

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Cytokinetics to Participate in the Piper Sandler 33rd Annual Virtual Healthcare Conference – GuruFocus.com

Posted: Published on November 18th, 2021

SOUTH SAN FRANCISCO, Calif., Nov. Continue reading

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Stealth BioTherapeutics Reports Third Quarter 2021 Financial Results and Recent Business Highlights – PRNewswire

Posted: Published on November 18th, 2021

BOSTON, Nov. Continue reading

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Hypertrophic Cardiomyopathy Market to be Driven by the Emergence of Novel Pharmacotherapies & Gene-directed Approaches at a 22.24% CAGR During the…

Posted: Published on August 14th, 2021

LAS VEGAS, Aug. Continue reading

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Delta has set back herd immunity estimates. Heres how that affects the course of the pandemic – The Dallas Morning News

Posted: Published on August 14th, 2021

A bag containing COVID-19 vaccines rests on a table during the last day of vaccinations at the drive-thru Fair Park site on Saturday, July 17, 2021, in Dallas. When health officials announced in early July that 80% of Dallas County residents were immune to the coronavirus, it was cause for celebration. Cautious celebration. Continue reading

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Suspicion of Frasier’s syndrome in the nephrology unit | IMCRJ – Dove Medical Press

Posted: Published on August 14th, 2021

Background Frasier syndrome is a rare genetic nephropathy caused by a point mutation in the WT 1 gene located on chromosome 11.14 First described in 1964 by Professor Frasier,5 it is characterized by the presence of progressive glomerulopathy with proteinuria associated with male pseudo hermaphroditism (presence of female external genitalia in a male phenotype).2,3,68 Initial manifestations of patients with Frasier syndrome include morning edema (facial puffiness), elevated blood pressure, proteinuria, with hypospadias and/or ambiguity of the external genitalia accompanied by cryptorchidism at birth.2,3,9 The symptomatology evolves into a treatment-resistant nephrotic syndrome that progressively leads to end-stage renal failure during the first two decades of the childs life.2,3,6,911 We present a case of Frasier syndrome that was seen at the nephrology/dialysis unit of HUEH. This is a young phenotypically male (presence of secondary male characteristics) who is 19 years old and born with a genital malformation in a family without history of consanguinity. They were seen on referral at the nephrology/dialysis unit of the internal medicine department of HUEH for evaluation and follow-up. Continue reading

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