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Research in biochemistry and molecular biology | Institute …

Posted: August 27, 2016 at 12:45 pm

Marc Aucoin Process dynamics of virus-based systems for the production of complex biologics such as viral vectors and vaccines, and the development of strategies using multiple viruses to obtain recombinant products in cell culture. Michael Beazely How growth factor receptors and G protein-coupled receptors modulate ion channels involved in excitatory neurotransmission, neuroprotective mechanisms, and neuronal development; intracellular signaling pathways downstream of GPCRs such as the 5-HT7 receptor and growth factor receptors such as the PDGF receptor. Niels C. Bols Animal cell culture, in vitro toxicology, and biotechnology. Differentiated fish cell lines and culture systems. Hormones and polypeptide growth factors. Toxicology of dioxin-like compounds and polycyclic aromatic to cultured cells. Barb Butler Undergraduate teaching in microbiology, the way microorganisms function and interact with surrounding habitat; microbial ecology; biodegradation of organic contaminants, particularly in groundwater and soil environments. Trevor C. Charles Molecular genetic studies of plant-associated bacteria. Rhizobium carbon metabolism. Genetics of polyhydroxyalkanoate metabolism. General environmental microbiology. Jeff Z.Y. Chen Computer simulations of protein folding and protein-protein interaction. Specialization in molecular dynamics and Monte-Carlo simulations. C. Perry Chou Recombinant protein production, biofuel production, and bioprocessing technology. Applied biological sciences and engineering theories to develop novel and effective bioprocesses for the production of recombinant proteins (including industrial enzymes and therapeutic proteins) and metabolites (including biohydrogen, biodiesel, and biobutanol). Such bioprocess development includes upstream technology for biological strain construction, midstream technology for bioreaction (i.e. cultivation), and downstream processing for bioproduct recovery and purification. Thorsten Dieckmann NMR-spectroscopy, RNA and protein structure, RNA-protein interactions, RNA catalysis, viral infections, cellular defense mechanisms. Brian Dixon Characterization of fish immune system at the molecular level. Cytokines and receptors in fish immune systems. Defining fish populations using polymorphism of immune system genes. Cold-blooded vertebrate immunotoxicology. D. George Dixon Effects of toxic chemicals on aquatic organisms. Biotic modifying factors of toxicity. Development of methods for environmental effects monitoring. Physiologically based pharmacokinetic modelling of contaminant levels in fish. Gary I. Dmitrienko Enzyme structure and function. Bernard P. Duncker Genetics and DNA replication. Use of the budding yeast Saccharomyces cerevisiae to investigate protein factors that control the initiation of DNA replication. Heidi Engelhardt The dialogue between the developing fetus and the mother during mammalian pregnancy, and the role of the placenta as the mediator; the ability of the placenta to protect the developing organism from sub-optimal maternal environments through adaptive changes in structure, vasculature or functional exchange capacity. Moira Glerum Mitochondrial myopathies, mitochondrial biogenesis, assembly of cytochrome oxidase in yeast and humans, mitochondrial copper transport, mitochondrial peroxide metabolism, heme A biosynthesis. Bernard R. Glick Isolation and manipulation of microbial genes involved in microbial stimulation of plant growth. Use of bacteria as biocontrol agents. Biochemical consequences of the genetic transformation of plant growth-promoting bacteria. Bruce M. Greenberg Environmental Chemistry and Biology: Photochemistry and photobiology of xenobiotic contamination and ultraviolet radiation. Frank Gu Nanotechnology, Nanomedicine, Cancer Therapy, Drug Delivery, Biomaterials, Bioconjugated Chemisry and Bioinformatics. Guy Guillemette Nitric Oxide Synthase: Function, structure, catalysis, and regulation. Analysis of enzyme activity, mechanism and inhibition. Cytochrome c: Function, structure, stability, redox potential, and protein folding. John J. Heikkila

The use of recombinant DNA methodology to examine the molecular response of amphibian embryos and tissue culture cells to environmental stress. Isolation and expression of heat shock genes.

My laboratorys research interests lie in the areas of enzyme structure, mechanism, inhibition and allostery. In light of these general interests our research currently focuses on the role that conformational plasticity plays in these areas of enzymology and how these dynamic aspects of enzyme structure can be exploited in the regulation of enzyme function.

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Research in biochemistry and molecular biology | Institute …

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Parkinson’s disease Lifestyle and home remedies – Mayo Clinic

Posted: August 18, 2016 at 4:44 am

If you’ve received a diagnosis of Parkinson’s disease, you’ll need to work closely with your doctor to find a treatment plan that offers you the greatest relief from symptoms with the fewest side effects. Certain lifestyle changes may also help make living with Parkinson’s disease easier.

While there’s no food or combination of foods proven to help in Parkinson’s disease, some foods may help ease some of the symptoms. For example, eating foods high in fiber and drinking an adequate amount of fluids can help prevent constipation that is common in Parkinson’s disease.

A balanced diet also provides nutrients, such as omega-3 fatty acids, that may be beneficial for people with Parkinson’s disease.

Exercising may increase your muscle strength, flexibility and balance. Exercise can also improve your well-being and reduce depression or anxiety.

Your doctor may suggest you work with a physical therapist to learn an exercise program that works for you. You may also try exercises such as walking, swimming, gardening, dancing, water aerobics or stretching.

Parkinson’s disease can disturb your sense of balance, making it difficult to walk with a normal gait. Exercise may improve your balance. These suggestions may also help:

In the later stages of the disease, you may fall more easily. In fact, you may be thrown off balance by just a small push or bump. The following suggestions may help:

Daily living activities such as dressing, eating, bathing and writing can be difficult for people with Parkinson’s disease. An occupational therapist can show you techniques that make daily life easier.


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Parkinson’s disease Lifestyle and home remedies – Mayo Clinic

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Facts About Menopausal Hormone Therapy – NHLBI, NIH

Posted: at 4:43 am

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Facts About Menopausal Hormone Therapy – NHLBI, NIH

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Stem Cell 100 – Powerful Rejuvenation and Anti-Aging …

Posted: at 4:43 am

Stem Cell 100 is formulated to rejuvenate your body and slow the aging process to help you feel and function more like a young person. This can help you feel better, look younger and improve your health. Most of the cells in your body lose function with age. Everyone has special cells called adult stem cells which are needed to rejuvenate damaged and old tissues, but adult stem cells themselves are also aging. Until now there was not much you could do about it. Stem Cell 100 rejuvenates adult stem cells and their micro-environments. Stem Cell 100+ is a more advanced and faster acting version of Stem Cell 100.

Developed by experts in the anti-aging field, patent-pending Stem Cell 100 is the only supplement proven to double maximum lifespan of an animal model. No other product or therapy including caloric restriction even comes close.

SK of Santa Fe, NM

I have been using Stem Cell 100 for about one year. Initially I noticed a boost in energy level, which now remains steady-hence not noticed I have experienced no adverse effects from taking this product. I heartily recommend Stem Cell 100 and plan to continue on it.


Stem Cell 100 has made a noticeable difference in me, including turning my gray hair back to its original color, which supposedly is impossible. The reversal of the gray hair to original color began a couple of months after starting the pill. After about 10 months, the gray hair is mostly gone. At the current rate of improvement, I expect my hair to completely be back to its original color within 1 to 2 months. I think my beard will take longer, but it was the first to gray. Also, my skin became smoother and younger looking. The skin and hair rely heavily on stem cells, and they seem to benefit strongly from this product. I’m so excited about telling people my results because there is nothing that can reverse the graying of hair. It will give me evidence that this supplement thing is really powerful. Unfortunately, I don’t have before and after pictures because I didn’t read any claims that the product would affect hair color. I would just say that I’m a person who totally believes that it does me no good to imagine things or interpret tings in a way favorable to what I want to believe. When I’m convinced enough to make a statement, you can count on it.

Joey of San Diego, CA

I am a 48 year old working woman. A friend of mine introduced me to Stem Cell 100. After taking Stem Cell 100 for about 4 months my anxiety level has really been diminished. Its a great supplement and I would recommend it to everyone!

Paul of San Diego, CA

I am an active 61 year old man in excellent health, but had experienced a serious drop in my energy level at the time I enrolled in a 4-month trial of Stem Cell 100. Within a month, my energy increased noticeably and I began to take to my physical activities (running, cycling) with a renewed enthusiasm and intensity level. My mood began to elevate steadily, and soon I had even lost those few stubborn pounds that had eluded me for years. I am very enthusiastic about Stem Cell 100. I look forward to continuing with the new, improved formulation, and would not hesitate to recommend it.

Mike, Texas

After taking the Stem Cell 100 for the last month my sinuses have also cleared, unplugging my ears for the first time since mid September.

Willie, California

As I was sprinting this morning around 6:00am I noticed that I was not hurting anymore! I have been having sore knees, ankles, hamstrings and back for the last couple of years. I usually just ran through it, but I noticed since I have been taking the Stem Cell 100 capsules for about 45 days now, those nagging pains are gone away!

Tom, Australia

Only after about 2-3 weeks of taking Stem Cell 100 my eye sight returned back to a level where I did not need glasses to work on my computer monitors. My eyes had always been good but had started to deteriorate about a year ago where 50% of the time I had to wear my glasses. I was shocked to find the improvement so quick. I found I was less stressed. No other changes to lifestyle yet a measureable difference. My fingers would sometimes get stiff in the mornings after long days on the keyboard. This stiffness disappeared. Some of my hair is getting darker. I have a full body of hair that had virtually all turned grey but I noticed that some of my hair was starting regrow brown – my original colour. I had some age spots in my left leg that are disappearing. Generally, I feel great.

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Harness the Power of Your Own Stem Cells

Millions of people suffer from chronic conditions of aging and disease. Based on international scientific studies in many academic and industry laboratories, there is new hope that many of the conditions afflicting mankind can some day be cured or greatly improved using stem cell regenerative medicine. Stem Cell 100 offers a way to receive some of the benefits of stem cell therapy today by improving the activity and effectiveness of your own adult stem cells.

Stem Cell 100 Helps to Support:

The statements above have not been reviewed by the FDA. Stem Cell 100 is not a preventive or treatment for any disease.

Help Rejuvenate Your Body by Boosting Your Own Stem Cells

As a child, we are protected from the ravages of aging and can rapidly recover from injury or illness because of the ability of the young regenerative stem cells of children have a superior ability to repair and regenerate most damaged tissues. As we age, our stem cell populations become depleted and/or slowly lose their capacity to repair. Moreover, the micro-environment (i.e. niches) around stem cells becomes less nurturing with age, so cell turnover and repair are further reduced. This natural progression occurs so slowly that we are barely aware of it, but we start to notice the body changes in our 20s, 30s, 40s, and especially after 50 years of age. Stem Cell 100 helps adults regain their youthful regenerative potential by stabilizing stem cell function.

Stem Cell 100 works differently than other stem cell products on the market

You may have seen a number of products that are advertised as stimulating or enhancing the number of stem cells. Each person only has a limited number of stem cells so using them up faster may not be a good strategy. Stem Cell 100 is about improving the effectiveness and longevity of your stem cells as well as preserving the stem cell micro-environment. That should be the goal of any effective stem cell therapy and is what Stem Cell 100 is designed to do and what other stem cell products cannot do.

Stem Cell 100 Extends Drosophila (Fruit Fly) Lifespan

In extensive laboratory testing Stem Cell 100 greatly extended both the average and maximum lifespan of Drosophila fruit flies. The study (see Charts below) included three cages of Drosophila fruit flies that were treated with Stem Cell 100 (Cages T1 to T3) and three cages which were untreated controls (Cages C1 to C3). Each cage started with 500 fruit flies including 250 males and 250 females. The experiment showed that median lifespan more than doubled with a 123% increase. While fruit flies are not people they are more like us than you might think. Drosophila have a heart and circulatory system, and the most common cause of death is heart failure. Like humans and other mammals (e.g. mice), it is difficult to increase their lifespan significantly. These observed results outperform every lifespan enhancing treatment ever tested – including experiments using genetic modification and dietary restriction.

The longest living fruit fly receiving Stem Cell 100 lived 89 days compared to the longest living untreated control which lived 48 days. It is possible that the single longest living fruit fly lived longer for other reasons such as genetic mutation, however, there were many others that lived almost as long so it was not just an aberation. The oldest 5% of the treated fruit flies lived 77% longer than the oldest 5% of the control group. It is also important that the study showed an improved ability of the fruit flies to survive stress and illness at all ages not just during old age. Even after the first few days of the study there were already more of the Stem Cell 100 treated fruit flies alive that survived youth than the control group of untreated fruit flies. For additional information about the study please go to our Longevity page.

Supplement Facts

Stem Cell 100 is a Patent-Pending Life Code Nutraceutical. All Life Code products are nutraceutical grade and provide the best of science along with the balance of nature.

All Life Code products are nutraceutical grade and provide the best of science along with the balance of nature.

Click label to enlarge

Stem Cell 100 Plus+ is a more powerful and faster acting version of Stem Cell 100.

Click label to enlarge

Serving Size: One type O capsule

Servings Per Container: 60 Capsules

Recommended Use: Typical usage of Stem Cell 100 is two capsules per day, preferably at meal times. While both capsules can be taken at the same time, it is preferable to separate the two capsules by at least 4 hours. Since Stem Cell 100 is a potent formulation, do not take more than three capsules per day. One capsule per day may be sufficient for those below 110 pounds.

Recommended Users: Anyone from ages 22 and up could benefit from Stem Cell 100. Those in their 20s and 30s will like the boost in endurance during sports or exercise, while older users will notice better energy and general health with the potential for some weight loss.

Active Ingredients in Stem Cell 100: There are ten herbal components that make up the patent-pending combination in Stem Cell 100. The herbal components are highly extracted natural herbs that are standardized for active components that promote adult stem cells and lower inflammation:

1) Polysaccharides, flavonoids, and astragalosides extracted from Astragalus membranaceus, which has many positive effects on stem cells and the cardiovascular and immune systems.

2) Proprietary natural bilberry flavonoids and other compounds from a stabilized nutraceutical grade medicinal Vaccinium extract. Activate metabolic PPARS and helps produce healthy levels of cholesterol and silent inflammation. Also has anti-fungal and anti-viral activity.

3) Flavonoids and oligo-proanthocyanidins (OPCs) extracted from Pine Bark, which greatly reduce oxidative stress, DNA damage, and inflammation.

4) L-Theanine, which is a natural amino acid from Camellia sinesis that reduces mental stress and inflammation while improving cognition and protecting brain cells from ischemic or toxic injury.

5) Pterocarpus Marsupium, which contains two stable resveratrol analogs which promote stem cells, lower inflammation, and stabilized metabolism.

6) Polygonum Multiflorium stem stem is a popular Chinese herbal tonic that fights premature aging and promotes youthfulness. Polygonum is reported to enhance fertility by improving sperm count in men and egg vitality in women. Polygonum is also widely used in Asia to strengthen muscle and is thus used by many athletes as an essential tonic for providing strength and stamina to the body. Modern research has supported Polygonum multiflorium stem in that animal studies have proven that it can extend lifespan and improve the quality of life. Polygonum appears to protect the liver and brain against damage, perhaps by improving immune and cardiovascular health. The stem sections of Polygonum multiflorium are also calming to the nervous system and promote sounder sleep. Life Code uses a proprietary Polygonum multiflorium stem extract.

7) Schisandra Berry is used by many Chinese women to preserve their youthful beauty. For thousands of years, Schisandra has been prized as an antiaging tonic that increases stamina and mental clarity, while fighting stress and fatigue. In Chinese traditional medicine, Schisandra berry has been used for liver disorders and to enhance resistance to infection and promote skin health and better sleep. Schisandra berry is classified as an adaptogen, which can stimulate the central nervous system, increase brain efficiency, improve reflexes, and enhance endurance. Modern research indicates that Schisandra berry extracts have a protective effect on the liver and promote immunity. A double-blind human trial suggested that Schisandra berry may help patients with viral hepatitis, which is very prevalent in China. Recent work indicates that the liver is protected by the enhanced production of glutathione peroxidase, which helps detoxify the liver. Life Code uses a proprietary Schisandra berry extract.

8) Fo-Ti Root (aka He-Shou-Wu) is one of the most widely used Chinese herbal medicines to restore blood, kidney, liver, and cardiovascular health. Fo-Ti is claimed to have powerful rejuvenating effects on the brain, endocrine glands, the immune system, and sexual vigor. Legend has it that Professor Li Chung Yun took daily doses of Fo-Ti to live to be 256 and is said to have outlived 23 wives and spawned 11 generations of descendents before his death in 1933. While it is unlikely that he really lived to such an old age there is scientific support for Fo-Ti as beneficial for health and longevity. Like the Indian Keno bark, Fo-ti contains resveratrol analogs and likely acts by various mechanism, which includes liver detoxification and protection of skin from UVB radiation. Life CodeTM uses a proprietary Fo-Ti root extract.

9 ) Camellia sinensis has many bioactive polyphenols including the potent epigallocatechin-3-gallate (EGCG). A 2006 Japanese study published in the Journal of the American Medical Association reports that adults aged 40 to 79 years of age who drank an average of 5 or more cups of tea per day had a significantly lower risk of dying from all causes (23% lower for females and 12% lower for males). The study tracked more than 40,000 adults for up to 11 years and found dramatically lower rates of cardiovascular disease and strokes in those drinking 5 or more cups of tea. Many studies have found that adults drinking 3 or more cups of tea per day have significantly less cancer. Other studies have found that green tea helps protect against age-related cognitive decline, kidney disease, periodontal disease, and type 2 diabetes. Green tea also promotes visceral fat loss and higher endurance levels. Summarizing all of the thousands of studies on tea and tea polyphenols that have been published, it can be concluded that tea polyphenols preserve health and youth. This conclusion is backed up by gene studies showing that tea polyphenols decrease insulin-like growth factor-1 (IGF-1), which is a highly conserved genetic pathway that has been strongly linked to aging in yeast, worms, mice, and humans. If everyone could drink 4 to 5 cups of green tea each day, they could enjoy these important health benefits, but for most people drinking that much green tea can disturb their sleep patterns. Life Code uses a nutraceutical grade green tea extract that has 98% polyphenols and 50% ESCG that provides the polyphenol and ESCG equivalent of 4 to 5 cups of green tea with only 2% of the caffeine. Thus, most or all of the benefits of green tea are provided without concerns about disturbing sleep.

10) Drynaria Rhizome is used extensively in traditional Chinese medicine as an effective herb for healing bones, ligaments, tendons, and lower back problems. Eastern martial art practitioners have used Drynaria for thousands of years to help in recovering from sprains, bruises, and stress fractures. Drynaria has also helped in many cases of bleeding gums and tinnitus (ringing in the ears). The active components of Drynaria protect bone forming cells by enhancing calcium absorption and other mechanisms. Drynaria is also reported to act as a kidney tonic and to promote hair growth and wound healing. Life Code uses a proprietary Drynaria rhizome extract.

Active Ingredients in Stem Cell 100+ There are 11 herbal extracts in Stem Cell 100+ along with two nutraceutical grade vitamins Methyl Folate (5-MTHF) and Methyl B12 that are bioavailable vitamin supplements that are highly potent but rarely found. The highly extracted natural herbs are standardized for active components that promote adult stem cells and lower inflammation and have been tested as a synergistic herbal formulation with the proper dosage of each component:

1) Polysaccharides, flavonoids, and astragalosides extracted from Astragalus membranaceus, which has many positive effects on stem cells and the cardiovascular and immune systems. Astragalus has been used for thousands of years in Traditional Chinese Medicine (TCM) to promote cardiovascular and immune health. Astragalus is also known as a primary stimulator of Qi (Life Force). Life Code uses a high quality proprietary TCM extract that tested highest in our longevity experiments.

2) Proprietary natural bilberry flavonoids and other compounds from a stabilized nutraceutical grade medicinal Vaccinium extract. Activate metabolic PPARS and helps produce healthy levels of cholesterol and silent inflammation. Also has anti-fungal and anti-viral activity.

3) Flavonoids and oligo-proanthocyanidins (OPCs) extracted from Pine Bark, which promote the vascular system and reduce oxidative stress, DNA damage, and inflammation.

4) L-Theanine, which is a natural amino acid from Camellia sinesis that reduces mental stress and inflammation while improving cognition and protecting brain cells from ischemic or toxic injury. Life Code tested supplement with Mass Spec to verify high purity.

5) Genistein, which is an isoflavone phytoestrogen, activates telomerase, metabolic PPARs, autophagy (cell waste disposal), and smooth muscles. It also inhibits DNA methylation and the carbohydrate transporter GLUT1. Life Code tested supplement with Mass Spec to verify high purity.

6) Harataki Extract (aka Terminalia chebula) contains rejuvenating tannin flavonoids that have doubled human cell longevity in culture while maintaining telomere length. In Traditional Indian Medicine, Harataki has been used to treat skin disorders and heart disease, among many other uses.

7) Two stable resveratrol analogs from extracts of Pterocarpus Marsupium, which promote stem cells, less silent inflammation, and better metabolism. Life Code uses a highly purified proprietary source that is only available to Indian doctors. Life Code does not recommend taking resveratrol supplements or synthetic analogs, as these supplements are inherently unstable.

8) He-Shou-Wu is one of the most widely used Chinese herbal medicines to restore blood, kidney, liver, and cardiovascular health. He-Shou-Wu is claimed to have powerful rejuvenating effects on the brain, endocrine glands, the immune system, and sexual vigor. Legend has it that Professor Li Chung Yun took daily doses to live to 256 years and is said to have outlived 23 wives and spawned 11 generations of descendants before his death in 1933. While it is unlikely that he really lived to such an old age, there is scientific support for He-Shou-Wu as beneficial for health and longevity. Life Code uses a proprietary TCM He-Shou-Wu root extract.

9) Schisandra Berry is used by many Chinese women to preserve their youthful beauty. For thousands of years, Schisandra has been prized as an antiaging tonic that increases stamina and mental clarity, while fighting stress and fatigue. In TCM, Schisandra berry has been used for liver disorders and to enhance resistance to infection and promote skin health and better sleep. Schisandra berry is classified as an adaptogen, which can stimulate the central nervous system, increase brain efficiency, improve reflexes, and enhance endurance. Life Code uses a proprietary TCM extract.

10) Drynaria Rhizome is used extensively in TCM as an effective herb for healing bones, ligaments, tendons, and lower back problems. Eastern martial art practitioners have used Drynaria for thousands of years to help in recovering from sprains, bruises, and stress fractures. The active components of Drynaria protect bone forming cells by enhancing calcium absorption and other mechanisms. Drynaria is also reported to act as a kidney tonic and to promote hair growth and wound healing. Life Code uses a proprietary TCM Drynaria rhizome extract.

11) BioPerine is a proprietary brand of peperine extracted from black pepper. BioPerine has been shown to enhance bioavailability of herbal extracts. Piperine has been shown in rats to have cognitive enhancing effects and to help control silent inflammation.

Safety: The extracts in Stem Cell 100 and Stem Cell 100+ are nutraceutical grade and have been individually tested in both animals and humans without significant safety issues. Those with pre-existing conditions of diabetes or hypertension should coordinate this product with your doctor, as lower blood glucose or reduced blood pressure can result from taking the recommended dose of this product.

Warnings: may lower glucose and/or blood pressure in some individuals. The supplement is not recommended for pregnant, lactating, or hypoglycemic individuals.


1. Yu, Q., Y.S. Bai, and J. Lin, [Effect of astragalus injection combined with mesenchymal stem cells transplantation for repairing the Spinal cord injury in rats]. Zhongguo Zhong Xi Yi Jie He Za Zhi, 2010. 30(4): p. 393-7.

2. Xu, C.J., et al., [Effect of astragalus polysaccharides on the proliferation and ultrastructure of dog bone marrow stem cells induced into osteoblasts in vitro]. Hua Xi Kou Qiang Yi Xue Za Zhi, 2007. 25(5): p. 432-6.

3. Xu, C.J., et al., [Effects of astragalus polysaccharides-chitosan/polylactic acid scaffolds and bone marrow stem cells on repairing supra-alveolar periodontal defects in dogs]. Zhong Nan Da Xue Xue Bao Yi Xue Ban, 2006. 31(4): p. 512-7.

4. Zhu, X. and B. Zhu, [Effect of Astragalus membranaceus injection on megakaryocyte hematopoiesis in anemic mice]. Hua Xi Yi Ke Da Xue Xue Bao, 2001. 32(4): p. 590-2.

5. Qiu, L.H., X.J. Xie, and B.Q. Zhang, Astragaloside IV improves homocysteine-induced acute phase endothelial dysfunction via antioxidation. Biol Pharm Bull, 2010. 33(4): p. 641-6.

6. Araghi-Niknam, M., et al., Pine bark extract reduces platelet aggregation. Integr Med, 2000. 2(2): p. 73-77.

7. Rohdewald, P., A review of the French maritime pine bark extract (Pycnogenol), a herbal medication with a diverse clinical pharmacology. Int J Clin Pharmacol Ther, 2002. 40(4): p. 158-68.

8. Koch, R., Comparative study of Venostasin and Pycnogenol in chronic venous insufficiency. Phytother Res, 2002. 16 Suppl 1: p. S1-5.

9. Rimando, A.M., et al., Pterostilbene, a new agonist for the peroxisome proliferator-activated receptor alpha-isoform, lowers plasma lipoproteins and cholesterol in hypercholesterolemic hamsters. J Agric Food Chem, 2005. 53(9): p. 3403-7.

10. Manickam, M., et al., Antihyperglycemic activity of phenolics from Pterocarpus marsupium. J Nat Prod, 1997. 60(6): p. 609-10.

11. Grover, J.K., V. Vats, and S.S. Yadav, Pterocarpus marsupium extract (Vijayasar) prevented the alteration in metabolic patterns induced in the normal rat by feeding an adequate diet containing fructose as sole carbohydrate. Diabetes Obes Metab, 2005. 7(4): p. 414-20.

12. Mao, X.Q., et al., Astragalus polysaccharide reduces hepatic endoplasmic reticulum stress and restores glucose homeostasis in a diabetic KKAy mouse model. Acta Pharmacol Sin, 2007. 28(12): p. 1947-56.

13. Schafer, A. and P. Hogger, Oligomeric procyanidins of French maritime pine bark extract (Pycnogenol) effectively inhibit alpha-glucosidase. Diabetes Res Clin Pract, 2007. 77(1): p. 41-6.

14. Kwak, C.J., et al., Antihypertensive effect of French maritime pine bark extract (Flavangenol): possible involvement of endothelial nitric oxide-dependent vasorelaxation. J Hypertens, 2009. 27(1): p. 92-101.

15. Xue, B., et al., Effect of total flavonoid fraction of Astragalus complanatus R.Brown on angiotensin II-induced portal-vein contraction in hypertensive rats. Phytomedicine, 2008.

16. Mizuno, C.S., et al., Design, synthesis, biological evaluation and docking studies of pterostilbene analogs inside PPARalpha. Bioorg Med Chem, 2008. 16(7): p. 3800-8.

17. Sato, M., et al., Dietary pine bark extract reduces atherosclerotic lesion development in male ApoE-deficient mice by lowering the serum cholesterol level. Biosci Biotechnol Biochem, 2009. 73(6): p. 1314-7.

18. Kimura, Y. and M. Sumiyoshi, French Maritime Pine Bark (Pinus maritima Lam.) Extract (Flavangenol) Prevents Chronic UVB Radiation-induced Skin Damage and Carcinogenesis in Melanin-possessing Hairless Mice. Photochem Photobiol, 2010.

19. Pavlou, P., et al., In-vivo data on the influence of tobacco smoke and UV light on murine skin. Toxicol Ind Health, 2009. 25(4-5): p. 231-9.

20. Ni, Z., Y. Mu, and O. Gulati, Treatment of melasma with Pycnogenol. Phytother Res, 2002. 16(6): p. 567-71.

21. Bito, T., et al., Pine bark extract pycnogenol downregulates IFN-gamma-induced adhesion of T cells to human keratinocytes by inhibiting inducible ICAM-1 expression. Free Radic Biol Med, 2000. 28(2): p. 219-27.

22. Rihn, B., et al., From ancient remedies to modern therapeutics: pine bark uses in skin disorders revisited. Phytother Res, 2001. 15(1): p. 76-8.

23. Saliou, C., et al., Solar ultraviolet-induced erythema in human skin and nuclear factor-kappa-B-dependent gene expression in keratinocytes are modulated by a French maritime pine bark extract. Free Radic Biol Med, 2001. 30(2): p. 154-60.

24. Van Wijk, E.P., R. Van Wijk, and S. Bosman, Using ultra-weak photon emission to determine the effect of oligomeric proanthocyanidins on oxidative stress of human skin. J Photochem Photobiol B, 2010. 98(3): p. 199-206.

25. Haskell, C.F., et al., The effects of L-theanine, caffeine and their combination on cognition and mood. Biol Psychol, 2008. 77(2): p. 113-22.

26. Owen, G.N., et al., The combined effects of L-theanine and caffeine on cognitive performance and mood. Nutr Neurosci, 2008. 11(4): p. 193-8.

27. Yamada, T., et al., Effects of theanine, a unique amino acid in tea leaves, on memory in a rat behavioral test. Biosci Biotechnol Biochem, 2008. 72(5): p. 1356-9.

28. Jia, R.Z., et al., [Neuroprotective effects of Astragulus membranaceus on hypoxia-ischemia brain damage in neonatal rat hippocampus]. Zhongguo Zhong Yao Za Zhi, 2003. 28(12): p. 1174-7.

29. Nathan, P.J., et al., The neuropharmacology of L-theanine(N-ethyl-L-glutamine): a possible neuroprotective and cognitive enhancing agent. J Herb Pharmacother, 2006. 6(2): p. 21-30.

30. Nobre, A.C., A. Rao, and G.N. Owen, L-theanine, a natural constituent in tea, and its effect on mental state. Asia Pac J Clin Nutr, 2008. 17 Suppl 1: p. 167-8.

31. Murakami, S., et al., Effects of oral supplementation with cystine and theanine on the immune function of athletes in endurance exercise: randomized, double-blind, placebo-controlled trial. Biosci Biotechnol Biochem, 2009. 73(4): p. 817-21.

32. Kawada, S., et al., Cystine and theanine supplementation restores high-intensity resistance exercise-induced attenuation of natural killer cell activity in well-trained men. J Strength Cond Res, 2010. 24(3): p. 846-51.

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Stem Cell 100 – Powerful Rejuvenation and Anti-Aging …

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Cerebral Palsy Treatment & Management: Approach …

Posted: August 16, 2016 at 7:46 am

Numerous medications, although often used off label for age and indication, may relieve the movement difficulties associated with cerebral palsy. These drugs target spasticity, dystonia, myoclonus, chorea, and athetosis. For example, baclofen, administered either orally or intrathecally, is often used for treating spasticity in these patients.

AbobotulinumtoxinA (Dysport) is the first botulinum toxin to gain FDA approval for the treatment of lower limb spasticity in children aged 2-17 years. Approval was based on a randomized, multicenter, double-blind, placebo-controlled, international Phase III study in 235 pediatric patients (158 received abobotulinumtoxinA and 77 received placebo) aged 2 to 17 years with lower limb spasticity due to cerebral palsy causing dynamic equinus foot deformity. Patients treated with abobotulinumtoxinA showed statistically significant improvement in efficacy assessments (ie, mean change from baseline in Modified Ashworth scale [MAS] in ankle plantar flexor muscle tone and mean Physicians Global Assessment [PGA]) response to treatment score at Week 4 and Week 12.[38]

OnabotulinuimtoxinA (Botox)may reduce spasticity for 3-6 months and may be considered for off-label use in children with cerebral palsy with spasticity in the lower extremities (gastrocnemius, in particular).[1, 2, 3, 4, 5, 39] This therapy can allow for improved range of motion, reduced deformity, improved response to occupational and physical therapy, and delay in the need for surgical management of spasticity. Casting, with or without botulinum toxin type A, may be an additional option for children with an equinus deformity, although the evidence is still somewhat conflicting.[40]

The established total body dose of onabotulinumtoxinA is limited to 12 U/kg, to a maximum of 400 U per visit. (Many practices, however, have been safely using 20 U/kg, to a maximum of 600 U). Each small muscle receives 1-2 U/kg, and large muscles, 4-6 U/kg. The interval between doses should be at least 4 months in order to help prevent antibody formation, which could make subsequent botulinum toxin procedures less effective. Note that large muscles may not respond to this limiting dose, or quite often, patients need several muscles done at each visit.

Historically, phenol intramuscular neurolysis has been considered another medication option. This agent can be used for some large muscles or when several muscles are treated, but phenol therapy is more difficult to administer than other agents. Because phenol is administered using a nerve stimulator, this treatment is more painful, and anesthesia is often used when the therapy is performed. In addition, phenol can, in certain nerves, cause unpleasant sensory dysesthesias, therefore, its use is often limited to nerves with only motor innervation, such as the musculocutaneous (for decreasing arm flexion) and the obturator (for decreasing hip adduction). Phenol treatment is also used for hamstring motor point blocks (for knee flexion).

Although antiparkinsonian drugs (eg, anticholinergic and dopaminergic drugs) and antispasticity agents (eg, baclofen) have primarily been used in the management of dystonia, anticonvulsants, antidopaminergic drugs, and antidepressants have also been tried.

Anticonvulsants (including benzodiazepines such as diazepam, valproic acid, and barbiturates) have been useful in the management of myoclonus. Chorea and athetosis are often difficult to manage, although benzodiazepines, neuroleptics, and antiparkinsonian drugs (eg, levodopa) have been tried. Benzodiazepines and baclofen are commonly used to manage spasticity.

A multidisciplinary panel conducted a systematic evaluation of published evidence of efficacy and safety of pharmacologic treatments for childhood spasticity due to cerebral palsy.[41] The panel members consisted of the Quality Standards Subcommittee of the American Academy of Neurology (AAN), and the Practice Committee of the Child Neurology Society.[41]

Localized or segmental spasticity

For localized or segmental spasticity, results of the panel found botulinum toxin type A is effective treatment in the upper and lower extremities; however, conflicting evidence exists regarding functional improvement.[41] Botulinum toxin type A was found to be generally safe in children with cerebral palsy; however, the US Food and Drug Administration (FDA) investigated isolated cases of generalized weakness resulting in poor outcomes and issued a black box warning, as follows:

“Effects of all botulinum toxin products may spread from the area of injection to produce symptoms consistent with botulinum toxin effects. These symptoms may include asthenia, generalized muscle weakness, diplopia, blurred vision, ptosis, dysphagia, dysphonia, dysarthria, urinary incontinence, and breathing difficulties. These symptoms have been reported hours to weeks after injection. Swallowing and breathing difficulties can be life threatening, and death have been reported. The risk of symptoms is probably greatest in children treated for spasticity, but symptoms can also occur in adults treated for spasticity and other conditions, particularly in those patients who have underlying conditions that would predispose them to these symptoms. In unapproved uses, including spasticity in children and adults, and in approved indications, cases of spread of effect have been reported at doses comparable to those used to treat cervical dystonia and at lower doses.”

Generalized spasticity

For generalized spasticity, the panel listed diazepam as probably effective and tizanidine as possibly effective, although insufficient data exist regarding motor function and side-effect profile.[41] The panel recommends diazepam for short-term use, and tizanidine may also be considered as a treatment option. Data were insufficient for use of dantrolene, oral baclofen, and intrathecal baclofen, and toxicity was frequently reported.[41]

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Periodontics Bloomington IL | Urbana IL | Periodontist …

Posted: August 15, 2016 at 8:44 am

Kirk W. Noraian, DDS, MS, PC

Periodontist Dr. Kirk W. Noraian, with offices in Bloomington & Urbana Illinois, practices a full scope of periodontics with expertise ranging from dental implants to cosmetic periodontal surgery gum grafting, and Laser Assisted New Attachment Procedure (LANAP). Kirk W. Noraian can now correct a wide variety of periodontal (gum) disease. Even a subtle change in your smile helps you to project an image of self-confidence and high personal esteem. When you feel good about yourself, it shows in your appearance.

We have two convenient locations:

If you are missing one tooth or multiple teeth, dental implants may change your life because they feel and look natural and function like real teeth. The design of dental implants provides a solid base for replacement teeth while not changing the shape of your facial features. You can eat, talk, and smile with confidence. If you want more information about dental implants or you would like to schedule a consultation appointment, call Dr. Noraians office. His caring staff will help you.

Cosmetic periodontal procedures are a predictable way to cover unsightly, sensitive, or exposed root surfaces and to prevent future gum recession. If you are unhappy with the appearance of short unsightly teeth, Kirk W. Noraian can improve the way you look with a combination of periodontal procedures and cosmetic dentistry by your dentist. For more information about cosmetic periodontal surgery or to schedule a consultation appointment, call one of our offices: Bloomington 309-663-4577 or Urbana 217-367-6149.

With bone grafting, Dr. Noraian now has the opportunity to replace missing bone. This procedure gives him the opportunity to place implants of proper length and width, provide a good base to support a denture, or provide more anatomically correct shapes for bridgework; all of which give you a chance to restore functionality and esthetic appearance.

To provide you with a better understanding of dental implants, we have provided the following multimedia presentation. Many common questions pertaining to dental implants are discussed.

Having trouble? Please make sure you have the Adobe Flash Player plugin installed in order to correctly view this presentation. This software is available as a free download.

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Periodontics Bloomington IL | Urbana IL | Periodontist …

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BodyLogicMD – Hormone Replacement Therapy for Men

Posted: at 8:44 am

Hormone therapy programs aren’t only for women. Men experience a more gradual loss of hormones, mainly testosterone. The result is andropause, known as the “male menopause.” Andropause can make daily life feel like an uphill battle, and because men are living longer, more active lives they are seeking and finding relief from the serious symptoms of hormone imbalance with bioidentical hormone replacement therapy for men.

The signs of andropause and related hormonal issues include:

This personalized, medically supervised program includes natural HRT for men, as well as customized fitness and nutrition programs for millions of men suffering from hormonal imbalance. These expert bioidentical hormone doctors provide a natural treatment for the symptoms of andropause, helping men regain their health and confidence.

Hormonal imbalances in men are at the root of many chronic health problems and can increase the risk of serious disease. BodyLogicMD affiliated physicians have developed customized hormone replacement therapy for men that has proven successful in supporting men’s health and a healthy hormonal balance.

Individual male hormone replacement treatment programs includes:

To determine your hormonal needs, BodyLogicMD affiliated physicians thoroughly evaluate your symptoms using state-of-the-art diagnostic tests, such as, saliva, urine and/or blood tests to determine your hormone levels and your unique bioidentical hormonal needs. After starting bioidentical hormone therapy, your physician will monitor and re-evaluate your hormone levels, meeting with you, to insure that they are maintained at their optimum balance.

Read about Bioidentical Hormones For Women




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BodyLogicMD – Hormone Replacement Therapy for Men

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multiple sclerosis –

Posted: August 13, 2016 at 7:47 pm

An Italian doctor has been getting dramatic results with a new type of treatment for Multiple Sclerosis, or MS, which affects up to 2.5 million people worldwide. In an initial study, Dr. Paolo Zamboni took 65 patients with relapsing-remitting MS, performed a simple operation to unblock restricted bloodflow out of the brain – and two years after the surgery, 73% of the patients had no symptoms. Dr. Zamboni’s thinking could turn the current understanding of MS on its head, and offer many sufferers a complete cure.

Multiple sclerosis, or MS, has long been regarded as a life sentence of debilitating nerve degeneration. More common in females, the disease affects an estimated 2.5 million people around the world, causing physical and mental disabilities that can gradually destroy a patient’s quality of life.

It’s generally accepted that there’s no cure for MS, only treatments that mitigate the symptoms – but a new way of looking at the disease has opened the door to a simple treatment that is causing radical improvements in a small sample of sufferers.

Italian Dr. Paolo Zamboni has put forward the idea that many types of MS are actually caused by a blockage of the pathways that remove excess iron from the brain – and by simply clearing out a couple of major veins to reopen the blood flow, the root cause of the disease can be eliminated.

Dr. Zamboni’s revelations came as part of a very personal mission – to cure his wife as she began a downward spiral after diagnosis. Reading everything he could on the subject, Dr. Zamboni found a number of century-old sources citing excess iron as a possible cause of MS. It happened to dovetail with some research he had been doing previously on how a buildup of iron can damage blood vessels in the legs – could it be that a buildup of iron was somehow damaging blood vessels in the brain?

He immediately took to the ultrasound machine to see if the idea had any merit – and made a staggering discovery. More than 90% of people with MS have some sort of malformation or blockage in the veins that drain blood from the brain. Including, as it turned out, his wife.

He formed a hypothesis on how this could lead to MS: iron builds up in the brain, blocking and damaging these crucial blood vessels. As the vessels rupture, they allow both the iron itself, and immune cells from the bloodstream, to cross the blood-brain barrier into the cerebro-spinal fluid. Once the immune cells have direct access to the immune system, they begin to attack the myelin sheathing of the cerebral nerves – Multiple Sclerosis develops.

He named the problem Chronic Cerebro-Spinal Venous Insufficiency, or CCSVI.

Zamboni immediately scheduled his wife for a simple operation to unblock the veins – a catheter was threaded up through blood vessels in the groin area, all the way up to the effected area, and then a small balloon was inflated to clear out the blockage. It’s a standard and relatively risk-free operation – and the results were immediate. In the three years since the surgery, Dr. Zamboni’s wife has not had an attack.

Widening out his study, Dr. Zamboni then tried the same operation on a group of 65 MS-sufferers, identifying blood drainage blockages in the brain and unblocking them – and more than 73% of the patients are completely free of the symptoms of MS, two years after the operation.

In some cases, a balloon is not enough to fully open the vein channel, which collapses either as soon as the balloon is removed, or sometime later. In these cases, a metal stent can easily be used, which remains in place holding the vein open permanently.

Dr. Zamboni’s lucky find is yet to be accepted by the medical community, which is traditionally slow to accept revolutionary ideas. Still, most agree that while further study needs to be undertaken before this is looked upon as a cure for MS, the results thus far have been very positive.

Naturally, support groups for MS sufferers are buzzing with the news that a simple operation could free patients from what they have always been told would be a lifelong affliction, and further studies are being undertaken by researchers around the world hoping to confirm the link between CCSVI and MS, and open the door for the treatment to become available for sufferers worldwide.

It’s certainly a very exciting find for MS sufferers, as it represents a possible complete cure, as opposed to an ongoing treatment of symptoms. We wish Dr. Zamboni and the various teams looking further into this issue the best of luck.

Via The Globe and Mail.

Update (Feb. 10,2014): A study conducted by researchers at the University of Buffalo has cast doubt the validity of this approach.

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Itchy bumps on elbows psoriasis or eczema? – Dermatology …

Posted: August 11, 2016 at 6:46 am

Since my last posts, I’ve had improvement with my foot.I’ve made several changes to my diet which have changed my overall feeling of well being as well.There’s still some other things with the lower GI, but we’ll figure them out soon enough.One step at a time, and a little trial and error.

Things I have done that have given me some health improvement.

I significantly cut back on junk food such as snack cakes, candy (especially chocolate it’s a double whammy food allergy nut & made with dairy), chips.

I cut out as much food made with/from nuts as possible.No more peanut butter, almond milk, walnut chips, etc.

I’ve known I was lactose intolerant for a long time, but pizza is pretty hard to resist, as is chocolate.

I reduced my caffeine intake by at least 50%, and increased my water intake.

I avoid foods that contain hydrogenated, and exotic oils such as palm kernel (again a kinda a nut), and seed oils such as cottonseed, sesame, and sunflower.

I also increased my fiber intake to help push out some of the rotting food that was stagnating in my body.

I’ve attempted to take a more positive outlook, and removed as many stressors from my life as possible.I talk to people more, and I try to smile even when I don’t feel like it.Stress will exasperate any condition.

Visualization of my body’s own healing powers helps me cope with the pain too.When it gets tough, I picture my white blood cells riding around in police cars, or driving tanks, or other such silly ‘non-sense’ to arrest/ward off the bad cells.I also visualize damaged parts being repaired, and my personal mantra of healing is the keep telling my body “poisons out”.

Breathing exercise helps with stress, and releases my own body’s chemicals that make me feel better.

I stopped working with/touching the compounds listed in the above posts, and my foot improved, but it wasn’t going away.

With a lot of trial and error, label reading, and persistence I feel like a new person.

My psoriasis on my elbows has all but disappeared too.

Try it if you want, I still feel that the eczema is an allergic reaction.

Remember, natural food is medicine.Processed food is often poison in disguise.Conventional medicine is great for trauma, and stabilizing serious disease, but concentrated medicine can also kill you too.Organic foods, and natural plants & minerals can contain some of the same compounds, in safer doses.

Do your homework on what you put in your body, you may be aghast at what you find out too.

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Itchy bumps on elbows psoriasis or eczema? – Dermatology …

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Stories | I Have Ulcerative Colitis

Posted: August 10, 2016 at 2:44 am

One of the most common questions we all ask ourselves is with regards to the healing of colon. Some of us might refer to it as mucosal healing. Especially when we are in the middle of a nasty flare up and maybe even more when we have just gotten out of a nasty period of []

5.0 from 1 reviews SCD Chicken Curry Print Prep time 15 mins Cook time 1 hour Total time 1 hour 15 mins Tasty chicken dish that is gonna warm you up especially if you miss and enjoy curry spices. Author: Adam Recipe type: Entree Cuisine: Indian Serves: 2 Ingredients medium onion 2 chicken []

The two eBooks Ive written are specifically for people living with UC and/or family members who are watching someone go through active colitis symptoms. If you click on the books image above, you will be able to purchase them with either a credit card or with your PayPal account. After your order is complete, the []

SCD (Specific Carbohydrate Diet) and UC Success Stories One of the most important things for people who are considering trying the SCD for treating their ulcerative colitis is to know that other people before them have had success. This is by far the most important thing to know with many things in life, but especially []

Adam Scheuer is the founder of and colitis patient since October 2008. He has met and communicated with thousands of UC’ers since his diagnosis in search of solutions to managing symptoms and living a fun, fulfilling, and healthy lifestyle with this disease.

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Stories | I Have Ulcerative Colitis

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