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About Cerebral Palsy | What is CP? | CerebralPalsy.org

Posted: August 16, 2017 at 9:47 pm

What is Cerebral Palsy?

While Cerebral Palsy (pronounced seh-ree-brel pawl-zee) is a blanket term commonly described by loss or impairment of motor function, Cerebral Palsy is actually caused by brain damage.

The brain damage is caused by brain injury or abnormal development of the brain that occurs while a childs brain is still developing before birth, during birth, or immediately after.

Cerebral Palsy affects body movement, muscle control, muscle coordination, muscle tone, reflex, posture and balance. It can also impact fine motor skills, gross motor skills and oral motor functioning.

Signs and symptoms of Cerebral Palsy may not always be apparent at birth. The child will likely experience a delay in development and growth milestones.

About two to three children out of every 1,000 have Cerebral Palsy studies in the United States studies have yielded rates as low as 2.3 per 1,000 children to as high as 3.6 per 1,000 children.

Today, although there is no cure for Cerebral Palsy, but the condition can be managed and individuals with Cerebral Palsy can live a long, healthy and quality life. To learn about the various aspects of Cerebral Palsy, click on the links below.

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Outsourcing proposed to trim Lodi budget – Lodi News-Sentinel

Posted: at 9:47 pm

With the City of Lodi already struggling to balance budgets, local leaders are exploring ways to make sure the city stays solvent with soaring pension costs expected to eat up bigger chunks of the general budget in the coming years.

Back in June, when the City Council approved the 2017-18 budget, Councilman Bob Johnson suggested that the city consider outsourcing some of its services to save money, and he reiterated the idea at a recent council meeting.

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Outsourcing proposed to trim Lodi budget – Lodi News-Sentinel

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Stem Cells From Young Hearts Could Rejuvenate Old Hearts – Technology Networks

Posted: at 9:47 pm

Cardiac stem cell infusions could someday help reverse the aging process in the human heart, making older ones behave younger, according to a new study from the Cedars-Sinai Heart Institute.

“Our previous lab studies and human clinical trials have shown promise in treating heart failure using cardiac stem cell infusions,” said Eduardo Marbn, MD, PhD, director of the Cedars-Sinai Heart Institute and the primary investigator of the study. “Now we find that these specialized stem cells could turn out to reverse problems associated with aging of the heart.”

In the study, investigators injected cardiosphere-derived cells, a specific type of stem cell known as CDCs, from newborn laboratory rats into the hearts of rats with an average age of 22 months, which is considered aged. Other laboratory rats from the same age group were assigned to receive placebo treatment, saline injections instead of stem cells. Both groups of aged rats were compared to a group of young rats with an average age of 4 months.

Baseline heart function was measured in all rats, using echocardiograms, treadmill stress tests and blood analysis. The older rats underwent an additional round of testing one month after receiving cardiosphere-derived cells that came from young rats.

“The way the cells work to reverse aging is fascinating,” Marbn said. “They secrete tiny vesicles that are chock-full of signaling molecules such as RNA and proteins. The vesicles from young cells appear to contain all the needed instructions to turn back the clock.”

Results of those tests show lab rats that received the cardiosphere-derived cells:

– Experienced improved heart function

– Demonstrated longer heart cell telomeres, compound structures located at the ends of chromosomes that shrink with age

– Improved their exercise capacity by an average of approximately 20 percent

– Regrew hair faster than rats that didn’t receive the cells

“This study didn’t measure whether receiving the cardiosphere-derived cells extended lifespans, so we have a lot more work to do,” said Lilian Grigorian-Shamagian, MD, PhD, co-primary investigator and the first author of the study. “We have much to study, including whether CDCs need to come from a young donor to have the same rejuvenating effects and whether the extracellular vesicles are able to reproduce all the rejuvenating effects we detect with CDCs.”

Since Marbn’s team completed the world’s first cardiac stem cell infusion in 2009, the Cedars-Sinai Heart Institute has made significant contributions to decoding and understanding how cardiac stem cells regenerate damaged heart muscle. The team is studying the use of stem cells to treat patients with Duchenne muscular dystrophy as well as patients with heart failure with preserved ejection fraction, a condition that affects more than 50 percent of all heart failure patients.

General support for Marbn’s laboratory is provided by the National Institutes of Health. The CDCs, manufactured by Capricor Inc. (NASDAQ: CAPR) as its product CAP-1002, have been used in other human clinical trials.

The process to grow cardiac-derived stem cells was developed by Marbn when he was on the faculty of Johns Hopkins University and further developed at Cedars-Sinai. Capricor has licensed the process from Johns Hopkins and from Cedars-Sinai for clinical and commercial development. Capricor has licensed additional intellectual property from Cedars-Sinai and the University of Rome. Cedars-Sinai and Marbn have financial interests in Capricor.

This article has been republished frommaterialsprovided byCedars-Sinai Heart Institute. Note: material may have been edited for length and content. For further information, please contact the cited source.

Reference:

Grigorian-Shamagian, L., Liu, W., Fereydooni, S., Middleton, R. C., Valle, J., Cho, J. H., & Marbn, E. (2017). Cardiac and systemic rejuvenation after cardiosphere-derived cell therapy in senescent rats. European Heart Journal. doi:10.1093/eurheartj/ehx454

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Stem Cells From Young Hearts Could Rejuvenate Old Hearts – Technology Networks

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Miracle chemical ‘cocktail’ could cure spinal cord damage – New York Post

Posted: at 9:46 pm

A chemical cocktail could restore movement for people crippled after suffering spinal cord injuries, suggests new research.

Scientists say the mixture of three molecules could potentially be given therapeutically to patients to aid in their recovery after serious injury.

After spinal cord injury or stroke, axons originating in the brains cortex and along the spinal cord become damaged, disrupting motor skills.

Now, according to findings published in the journal Neuron, a team of scientists at Boston Childrens Hospital in the United States has developed a method to promote axon regrowth after injury.

They administered the therapeutic cocktail of molecules to mice with either a spinal cord injury or stroke and observed that the mice were able to recover fine motor skills.

Study senior author Doctor Zhigang He, of Boston Childrens Hospital and Harvard Medical School, said: In our lab, for the first time we have a treatment that allowed the spinal cord injury and the stroke model to regain functional recovery.

His team designed the mixture by building on earlier work from Dr. Joshua Sanes group at Harvard who focused on optical nerve injuries. Sanes observed that the combination of insulin-like growth factor 1 (IGF1) and a protein called osteopontin (OPN) promoted nerve regrowth and vision improvement in optically-injured mice.

To investigate whether the combination would influence functional recovery, the team studied a mouse model of spinal cord injury to one side of the body.

Without intervention after injury, the mice were gradually able to recover some major motor function through natural resprouting of their axons.

But big shortfalls remained in their fine motor skills, making it difficult for them to walk on ladders with irregularly spaced rungs or retrieve food pellets.

In contrast, when the mice were injected with IGF1 and OPN one day after spinal cord injury, their fine motor skills greatly improved.

By week 12, the researchers observed that the mices error rates on the irregular ladder dropped to 46 percent, performing strikingly better than the untreated control group, which still continued to make errors 70 percent of the time.

He said the improvement was caused by a boost in axon sprouting and regeneration that resulted from the therapeutic mixture.

The team wondered if adding 4- aminopyridine-3-methanol, known to improve axon conduction, into their therapeutic cocktail would further enhance the mices functional recovery.

When they gave the cocktail of three molecules, they saw that the mices error rates in the irregular ladder task fell to 30 percent only 10 per cent higher than the healthy side.

Studying a mouse model of stroke, Hes team made a surprising observation.

He said: We saw what we expected, axon sprouting in the spinal cord.

But we also found something unexpected, increased axon sprouting in the subcortical area.

By genetic manipulation Hes team ablated the sprouted axons of the CST and found that the improvement diminished. That means the functional recovery was not particularly dependent on sprouting in subcortical regions but on those in the spinal cord.

He added: The functional outcomes of such subcortical sprouting remain to be tested.

He said that his team are now in talks with rehab centres to determine the prerequisites of ultimately taking their work forward to clinical trials.

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Poet With Cerebral Palsy Speaks To Early Eugenics Movement – NPR – NPR

Posted: August 15, 2017 at 1:44 pm

In her book The Virginia State Colony For Epileptics And Feebleminded, poet Molly McCully Brown explores themes of disability, eugenics and faith. Kristin Teston/Persea hide caption

In her book The Virginia State Colony For Epileptics And Feebleminded, poet Molly McCully Brown explores themes of disability, eugenics and faith.

Growing up in southwestern Virginia in recent decades, poet Molly McCully Brown often passed by a state institution in Amherst County that was once known as the “Virginia State Colony for Epileptics and Feebleminded.”

Since 1983 the facility, which was founded in 1910, has been called the Central Virginia Training Center, and it is now a residential home for people with various intellectual disabilities. But in the early 20th century, the place Brown now refers to as “the colony” was part of the eugenics movement taking hold in the U.S., and a variety of treatments now considered inhumane were practiced there including forced sterilization. Brown, who has cerebral palsy, notes that had she been born in an earlier era, she might have been sent to live at the institution herself.

“It is impossible to know that for sure,” she says. “I can look at my life and look at my family and look at my parents and think, No, never. That never would have happened. But I also understand that if I had been born 50 years earlier, the climate was very different.”

She hopes to give voice to those early generations of residents, in her book of poetry, The Virginia State Colony For Epileptics And Feebleminded.

For Brown, the themes of disability and poetry have been constant throughout her life: “In my life, there has always been my body in some state of falling apart or disrepair or attempting to be fixed, and there has always been poetry. And I couldn’t untwine those things if I tried.”

Interview Highlights

On seeing the buildings and grounds of the old facility

It was incredibly moving and incredibly powerful. The place is interesting because it is still an operational facility for adults with really serious disabilities, although it is in the process of closing. But like a lot of things in Virginia, it was initially built on an enormous amount of land. And, so, a really interesting thing happened, which is that as the buildings that were originally part of the colony fell into disrepair, they were largely just moved out of and new buildings were built on accompanying land, but those original buildings were not necessarily torn down. So the place itself is this really strange combination of functioning facility and ghost town of everything that it has been. I’ve never been in a place that felt more acutely haunted in my life.

On how some people assume her physical disability means she also has an intellectual disability

We do have a strange tendency in this country to equate any kind of disability with less intellectual capability and with even a less complete humanity. Certainly as a child and as a teenager and even now as an adult [I] encountered people who assumed that just because I used a wheelchair, maybe I couldn’t even speak to them. I often get questions directed at people I’m with, as opposed to me, and that’s a really interesting phenomenon.

On the connection between poetry and theology

Both poetry and theology for me are about paying attention to the world in a very intentional way, and about admitting a mystery that is bigger than anything that I rationally understand. … I think poetry has always been for me a kind of prayer. So those things feel very linked for me. And, again, poetry does feel like the first and in some ways best language I ever had for mystery and for my sense of what exists beyond the world we’re currently living in.

On how Catholicism has helped her accept her body

One of the things that I find so moving about Catholicism is that it never forgets that to be a person is inherently and inescapably and necessarily to be in a body a body that brings you pain, a body that brings you pleasure, a body that can be a barrier to thinking more completely about your life and your soul but [that it] can also be a vehicle to delivering you into better communion with the world, with other people and to whatever divinity it is that you believe in.

What Catholicism did for me, in part, is give me a framework in which to understand my body as not an accident or a punishment or a mistake, but as the body that I am meant to have and that is constitutive of so much of who I am and what I’ve done and what I hope I will do in the world.

More and more … I’ve come to see my body as a place of pride and potential, and as something that gives me a unique outlook onto the world. And I’d rather that, I guess, than be infuriated by it.

On her twin sister, who died shortly after birth

She lived about 36 hours after we were born. … It’s a phenomenon in my life that I have not a lot of rational explanation for, … but it is true that I miss my sister with a kind of intense specificity that has no rational explanation, and that I feel aware of her presence in this way that I can’t exactly explain or articulate, but which feels undeniable to me. …

I do think that that sort of gave me no other option than to believe in some kind of something beyond this current mortal life that we’re living. Because what is the explanation otherwise for the fact that I feel like I miss and I know this person who only lived a matter of hours? And for the fact as much as I know that she is dead and is gone in a real way, she doesn’t feel “disappeared” to me.

On how her physical disability and her poetry are intertwined

I think the easiest way I have of describing it is I have two [early] memories. … One of them is of sitting on a table in a hospital room in the children’s hospital in St. Louis, choosing the flavor of the anesthetic gas I was going to breathe when they put me under to do my first major surgery. I was picking between cherry and butterscotch and grape. And the second memory that I have is of my father reading a Robert Hayden poem called “Those Winter Sundays.”

Roberta Shorrock and Therese Madden produced and edited this interview for broadcast. Bridget Bentz, Molly Seavy-Nesper and Deborah Franklin adapted it for the Web.

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Poet With Cerebral Palsy Speaks To Early Eugenics Movement – NPR – NPR

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Young girl with cerebral palsy has mode of transportation stolen … – BarrieToday

Posted: at 1:44 pm

NEWS RELEASE

BARRIE POLICE SERVICE

*************************UpdateTuesday, August 15, 2017

The Barrie Police Service has received numerous e-mails, direct messages and telephone calls from the residents of Barrie and the Greater Toronto Area, all wishing to purchase the victim a new ride-on toy car.

With the assistance of social media and our media partners Toys R Us has offered to purchase a new ride-on toy for the little girl. The family is overwhelmed by the generosity and would like to thank everyone.

The investigation is ongoing.

Original release

The Barrie Police Service is seeking the publics assistance to find and return a ride-on toy car that belongs to a 10-year-old girl with cerebral palsy.

The toy car was stolen from outside a home on Bourbon Circle, Sunday night at 11:30 p.m. A witness reported seeing a male and a young boy drag the toy car away from the side of the home and onto the sidewalk. The child was then observed getting into the toy car and driving it away as the male followed.

Any theft is unacceptable, and in this particular incident this theft leaves a 10-year-old girl with limited mobility. The car is not just a toy, it has become a mode of transportation for the 10-year-old girl when outside playing with her family and friends.

The suspect is described as;

Anyone with information is asked to contact Constable Graber of the Barrie Police Serviceat 705-725-7025, ext. 2753,cgraber@barriepolice.caor call Crime Stoppers at 1-800-222-TIPS, leave an anonymous tip online atwww.tipsubmit.com.

*************************

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Tim Tebow joins fan with cerebral palsy as she sings ‘God Bless America’ – Fox News

Posted: at 1:44 pm

Tim Tebow had another heartwarming moment Saturday, joining a fan with cerebral palsy as she sang “God Bless America.”

Tebow, who plays for the St. Lucie Mets, a minor league baseball team affiliated with the New York Mets, joined the fan during a game against the Tampa Yankees.

“Moment of the night: fan w/ cerebral palsy sings God Bless America and asked Tebow to join her. This is what it’s all about,” Jason Woodell tweeted.

While Tebow didn’t join her in her rendition, his presence beside her was apparently all she needed.

Tebow’s latest act of kindness comesafter a video went viralshowing the ex-NFL quarterback forsaking practice swings prior to an at-bat to shake an autistic boys hand — and followed it up with a monster three-run home run.

Tebows three-run homer on July 29 lifted the St. Lucie Mets to a 10-3 victory over the Charlotte Stone Crabs.

Tebow is hitting .238 with a .305 on-base percentage and five home runs for St. Lucie. He’s hit eight home runs with two teams this season.

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Tim Tebow joins fan with cerebral palsy as she sings ‘God Bless America’ – Fox News

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Tips for Being an Excellent Teacher to Students With Disabilities – Cerebral Palsy News Today

Posted: at 1:44 pm

As the summer closes, our attention turns toward school. School bags, pencils, crayons and other school supplies are at the forefront of parents and students minds. When the student has a disability, however, there are many other aspects to think through and be prepared to handle. If you are a teacher with a student who has a disability, there are many suggestions that you can use not only to make you a successful teacher, but also help your student be more comfortable and ready to learn.

The first step on your to-do list is to research the disability of the student. I sat through an entire individualized education plan (IEP) meeting once, and the mainstream teacher continued to say that the student had multiple sclerosis instead of cerebral palsy. Please avoid this embarrassment and do research. As you research, keep in mind that each student is an individual. So, you might know the facts about the disability, but each disability affects the person in unique ways.

If your student uses a wheelchair or mobility device, it might be tempting to have him or her sit in the very front of class. Now its your time to be creative. Students who have disabilities do not want to stand out anymore than they already feel they do. If you seat students by alphabetical order, then think about how you can do that for disabled students as well. If you cant put them in the middle of the classroom, at least put them on the end of the row in the middle or back. Consider various desk layouts, such as a horseshoe placement.

Try to set your mind not to place any limits on the student. If you have in your mind that students cant succeed, then you arent going to teach them in the way they deserve. Set no limits on your students and they will soar. Be realistic without setting any limitations that will hurt or hinder them. If students think a teacher believes in them, all kinds of terrific things will happen.

If your student has a speech impediment, you might feel the need to ignore him or her because its easier on both of you. But for all students there will be a time when they will not be in the safety of the school and they will need to communicate with others. Practicing communication is a benefit, as is discovering the best methods for them to communicate. Do not allow other students to make fun of how someone talks. We all communicate differently, and that needs to be respected.

Be prepared to adapt to the student. I was a very good algebra student, even though I had to dictate everything to my aide. My teacher knew I knew the material, so for the final exam, he gave me five different problems that covered everything he was looking for instead of insisting I do the full 30-question test that would take me hours to dictate.

Wonderful teachers have similar qualities. They care, learn, seek solutions and want children to succeed. Try putting yourself in the shoes of the student. What kind of teacher would you want to have?

***

Note:Cerebral Palsy News Todayis strictly a news and information website about the disease. It does not provide medical advice, diagnosis, or treatment. This content is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician orother qualified health providerwith any questions you may have regarding a medical condition. Never disregard professional medical advice or delay in seeking it because of something you have read on this website. The opinions expressed in this column are not those ofCerebral Palsy News Today, or its parent company, BioNews Services, and are intended to spark discussion about issues pertaining to cerebral palsy.

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Tips for Being an Excellent Teacher to Students With Disabilities – Cerebral Palsy News Today

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Eight-year-old Elvis Presley fan with cerebral palsy enjoys ‘absolutely fantastic’ holiday to home of his hero – Lancashire Telegraph

Posted: at 1:44 pm

AN eight-year-old avid Elvis Presley fan with cerebral palsy was ‘all shook up’ after having a holiday at the home of his hero.

Blackburn’s Samuel Hosker has been on an ‘absolutely fantastic’ weeklong trip to Graceland, the former home of Elvis Presley in Memphis, Tennessee.

An anonymous businessman paid for the child and his parents to enjoy the trip, who heard about Samuel’s love of Elvis after his parents set up a now completed campaign to raise 30,000 for surgery not available on the NHS.

The family even got to enjoy an extra day in America after a flight mix up meant they had an extra days stay paid for.

Mother Michelle Hosker, 39, said their stay at the Guest House Hotel, which was located on the Graceland Estate, was ‘amazing’ for all of them.

She said: “It was absolutely fantastic.

“Samuel absolutely loved every minute of it.

“He was singing along to all the songs.

“Memphis is just Elvis mad, there is Elvis everywhere.

“It was just perfect for Samuel, it was a dream come true.”

More than 60,000 has been raised in total for Samuel, who will now undergo an operation in September which will prevent him being wheelchair bound.

That fund also included a donation from the mystery benefactor who paid for Samuel’s trip of a life time.

Highlights of the holiday included taking a the Elvis Presley Tour, walking round his old mansion, signing his name on the at the site and visiting where he was buried.

They also got to see his old ‘Lisa Marie Plane’ and ‘Hound Dog’ jet on the trip.

The family also went on a tour of Memphis, which included trips to Elvis’ home, the zoo, the famous BB King Blue Club and the site where Martin Luther King was shot.

Samuel also got the chance to visit Marlowe’s Restaurant, which was adorned with a variety of music memorabilia, and he arrived in style in a pink Cadillac.

Another highlight of the trip for both parents and child was a trip to Beale Street, which featured venues full of soul and blues music.

The family said Samuel is already planning to go again.

Mrs Hosker said: “We keep thinking about how great it was, it is a bit of a comedown after.

“Samuel wants to go again in a few years and is asking if we can save up.

“We just can’t thank the person enough for ending us there, words just aren’t enough.”

Samuel will be having his spinal dorsal rhizotomy surgery on September 21 at Alder Hey Childrens Hospital in Liverpool.

Following surgery, Samuel, a pupil at St Peters RC Primary School, will have to undergo two years of intensive physiotherapy.

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Researchers Develop Newborn Screening Tool for Duchenne – Muscular Dystrophy News

Posted: at 1:43 pm

Cardiff Universityscientists, partneringwith the biotech company PerkinElmer, have developed a diagnostic kit to screen for Duchenne muscular dystrophy (DMD) in newborns using dried blood spots, according to researchers.

The study, Characterization of a Blood Spot Creatine Kinase Skeletal Muscle Isoform Immunoassay for High-Throughput Newborn Screening of Duchenne Muscular Dystrophy, was published in the journal Clinical Chemistry.

This new diagnostic method works by detecting the presence of the enzyme CK-MM, which is elevated in patients with DMD due to muscle damage. The test was created by Dr. Ian Weeks, a professor at Cardiff Universitys School of Medicinein Wales and the lead author of the study. The test was then adapted into an existing assay developed by PerkinElmer.

The successful outcome of this study is an example of the impact that can be achieved through collaboration between academic, clinical and industry colleagues in developing improvements in human healthcare, Weeks said in a press release.

Previous attempts at developing a diagnostic kit using blood spot CK (creatinine kinase) enzyme assays were met with little success because the tests were nonspecific and the results were unreliable. This is due to the fact that prior tests could not distinguish between the three different forms of CK that are present in muscle tissue, which include CK-MM, CK-MB, and CK-BB.

CK-MB and CK-BB are also increased when there is non-DMD muscle-related injury, which can lead to inaccurate results. This has been the main reason why screening for DMD has not been incorporated into newborn screening tests.

Due to recent advances in therapies for treating DMD that have the potential to be disease-modifying, scientists have become interested in diagnosing DMD as soon as possible to treat the disease at an earlier stage.

Therefore, researchers decided to create a CK-MM assay that could be used as a potential screening tool for DMD by collaborating with PerkinElmer. They used the PerkinElmer GSP analyzer, which is a high-throughput screening tool, to test dried blood spots of newborns.

After conducting the study, researchers concluded that CK-MM could be accurately quantified in dried blood spots and that its quantification on a commercial enzyme analyzer could allow newborn screening of DMD.

This new test moves us closer to a definitive newborn screening test for Duchenne, which will give families more time to plan for the future. We are hopeful that the rapid improvements in testing will allow the rollout of a national newborn screening program in the coming years, which will allow for treatments to be delivered to the very young at the earliest possible stage, said Nic Bungay, director of campaigns, care and information at Muscular Dystrophy UK.

Pilot programs for this screening method have currently been set up by PerkinElmer in China and in the state of Wisconsin for potential widespread applicability.

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