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Monthly Archives: February 2012
Rearranging the cell's skeleton: Small molecules at the cell’s membrane enable cell movement
Posted: Published on February 3rd, 2012
ScienceDaily (Feb. 2, 2012) — Cell biologists at Johns Hopkins have identified key steps in how certain molecules alter a cell's skeletal shape and drive the cell's movement. Results of their research, published in the December 13 issue of Science Signaling, have implications for figuring out what triggers the metastatic spread of cancer cells and wound-healing. "Essentially we are figuring out how cells crawl," says Takanari Inoue, Ph.D., an assistant professor of cell biology and member of the Center for Cell Dynamics in the Johns Hopkins University School of Medicine's Institute for Basic Biomedical Sciences. "With work like ours, scientists can reveal what happens when cells move when they aren't supposed to." Their new discovery highlights the role of the cell's skeleton, or cytoskeleton, in situations where "shape shifting" can rapidly change a cell's motion and function in response to differing environmental conditions. When cell's such as fibroblasts, which gather to heal wounds, move from one place to another, its cytoskeleton forms ripple-like waves or ruffles across its surface that move towards the front of the cell and down, helping pull the cell across a surface. Researchers have shown that these ruffles form when a small molecule, PIP2, appears on … Continue reading
Posted in Cell Medicine
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New study building framework to bring personalized medicine to the clinic
Posted: Published on February 3rd, 2012
TORONTO, Feb. 2, 2012 /CNW/ - Dr. Tom Hudson, President and Scientific Director of The Ontario Institute for Cancer Research (OICR), today announced a new study to develop a framework for the implementation of personalized medicine in cancer care. The framework aims to integrate genomics research into everyday clinical practice, with a goal to provide improved and more targeted care for patients. Published in the journal Cell, the framework supports improved diagnostics for cancer patients based on DNA analyses of tumours. The results of these analyses could be used to predict a patient's response to novel therapies. More immediately, it could be used to predict how drugs currently approved and in use today could help to treat other types of cancer. "As the cost of genome sequencing decreases, we are presented with the reality that soon genome analysis will be no more or less expensive than most diagnostic tests in use today," said Dr. Hudson. "This presents a huge opportunity to improve diagnosis for patients and ultimately improve patient outcomes. But in order to implement these tools, we must first understand their impact in a clinical setting." "This framework is not about simply doing a new test but creating evidence … Continue reading
Posted in Cell Medicine
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stem cell therapy mexico, Successfully Results – Video
Posted: Published on February 3rd, 2012
23-11-2011 02:11 For instance, neural cells in the brain and spinal cord that have been damaged can be replaced by stem cells. In the treatment of cancer, cells partially damaged by radiation or chemotherapy can be replaced with new healthy stem cells that adapt to the affected area, whether it be part of the brain, heart, liver, lungs, or wherever. Dead cells of almost any kind, no matter the type of injury or disease, can be replaced with new healthy cells thanks to the amazing flexibility of stem cells. More here: stem cell therapy mexico, Successfully Results - Video … Continue reading
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Prescriptions Blog: Drug Makers Dial Down TV Advertising
Posted: Published on February 3rd, 2012
Spending on the advertising of brand-name prescription drugs on television — which not long ago was a fast-growing marketing venue for the pharmaceutical industry in the United States — has dropped more than 20 percent in the last five years. According to new figures from Nielsen, spending on television advertising fell 23 percent to $2.4 billion from the beginning of 2007 to the end of last year. Spending in 2011 dropped 2 percent from 2010, and last year was the fourth consecutive year that such spending fell. Drug companies in the United States spent more than $3.1 billion on advertising pharmaceuticals on television in 2007, Nielsen said. The decline is in sharp contrast to the decade-long drug-industry advertising spree that began in 1997, when the Food and Drug Administration loosened its regulations and allowed direct-to-consumer advertising of prescription drugs on TV. Some industry analysts attribute part of the decline to controversy over such ads. Employers and health insurance companies have long complained that TV ads drive consumers to the latest, often most expensive, pills. And doctors complain that their patients often pressure them into prescribing these heavily advertised drugs. Perhaps the most well-known criticism of TV advertising of pharmaceuticals arose in … Continue reading
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The US Drug Watchdog Expands Its Vital Yaz Yasmin Birth Control Pill Initiative Focused on Identifying Women Heart …
Posted: Published on February 3rd, 2012
The US Drug Watchdog is expanding its national investigation of the birth control drugs called Yaz and Yasmin given increasing evidence these drugs may be responsible for serious pulmonary embolism's, deep vein thrombosis, heart attacks, strokes and other serious side affects with users. According to the New York Times, "In September of 2009, the Food and Drug Administration (FDA) cited Bayer for running misleading television commercials, and for not following proper quality-control procedures at a plant that makes hormone ingredients. In addition, the US FDA was very critical of Bayer for failing to warn about serious possible side effects associated with Yaz, or Yasmin, such as heart attacks, blood clotting, and strokes, in the same September 2009 report." According to the US Drug Watchdog, "Our initiative effects millions of US women, and we want to hear from any Yaz, or Yasmin user, or loved ones, if the user had a heart attack, stroke, blood clotting, or any other serious medical issue." Yaz, or Yasmin users can call the US Drug Watchdog anytime at 866-714-6466, or they can contact the group via its web site at http://USDrugWatchdog.Com (PRWEB) February 03, 2012 According to the US Drug Watchdog, "We are expanding our … Continue reading
Posted in Drug Side Effects
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Silver as effective as popular chemotherapy drug to treat cancer
Posted: Published on February 3rd, 2012
Washington, Feb 3 (ANI): Silver is as efficient as a leading chemotherapy drug in treating cancer and may even have fewer side effects, a new study has revealed. Results from the study at the University of Leeds, show that particular silver compounds are as toxic to cancer cells as the platinum-based drug Cisplatin, which is widely used to treat a range of cancers. But the crucial difference is that silver is thought to be much less toxic to healthy human cells, and in some cases, can be beneficial. Silver is currently used for its antiseptic and antibiotic properties, in bandages, wound dressings and water purification filters in the third world. Nausea and vomiting, kidney damage and an increased risk of infection are common side effects of Cisplatin, which is used to treat cancer of the lungs, breast, bladder, testicles, head and neck, ovaries and lymph nodes. "As many are unfortunately aware, chemotherapy can be a very gruelling experience for the patient. Finding effective, yet non-toxic drugs is an ongoing problem, but these preliminary results are an important step in solving it," Dr Charlotte Willans who is leading the study said. "Our research has looked at the structure which surrounds a … Continue reading
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Balancing oxaliplatin dose with neurological side effects in metastatic colon cancer
Posted: Published on February 3rd, 2012
However, "Many patients don't receive the necessary dose to try to keep their cancer in check, because their symptoms become too debilitating and their quality of life is reduced," says Andrew Weickhardt, MD, clinical fellow at the University of Colorado Cancer Center. Weickhardt, along with Keith Wells, MD, and Wells Messersmith, MD, CU Cancer Center investigator and developmental therapeutics program co-leader, recently published a review in the Journal of Oncology that describes how to maximize the positives of this tricky balance between oxaliplatin's effects and side effects. "Before, when patients died in a few months, these symptoms were overlooked. Now they're living two to three years and the symptoms deserve closer attention," Weickhardt says. The review recommends two approaches, used alone or simultaneously – what Weickhardt calls a "stop and go" approach, along with supplements that may mitigate the drug's neurological damage. In the stop and go approach, a patient starts oxaliplatin along with another drug and takes both for two months. Then, the patient takes a hiatus from oxaliplatin (while continuing the first drug), and reintroduces oxaliplatin two months later or at the point of disease progression, whichever is sooner. "After about six to nine months of total treatment, … Continue reading
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Duloxetine dosage – Video
Posted: Published on February 3rd, 2012
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Rimonabant deutschland – Video
Posted: Published on February 3rd, 2012
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Nuvigil ADHD – Video
Posted: Published on February 3rd, 2012
30-12-2011 09:36 Nuvigil ADHD - link to online store GenuineTabs.com Modalert (Modafinil) 200 mg / 100 mg Modalert is an analeptic drug manufactured by Cephalon, for the treatment of narcolepsy, shift work sleep disorder, and excessive daytime sleepiness associated with obstructive sleep apnea. The first... See the original post: Nuvigil ADHD - Video … Continue reading
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