Monthly Archives: February 2012

Bad breath being used in Stem Cell research

Posted: Published on February 28th, 2012

SALT LAKE CITY — Researchers may have found a use for the chemical that causes the stench in bad breath, stink bombs, and flatulence. This smelly substance known as Hydrogen Sulphide has been used in helping to convert stem cells from human teeth into liver cells. The scientists conducting the investigation and research in the Journal of Breath Research claim that the gas increased the purity of the stem cells. The goal is that the liver cells produced from the stem cells could be used for repair if the organ was damaged. Hydrogen Sulphide is produced by bacteria, and is toxic in large amounts. A group in China has reportedly tested the gas on rats to enhance the survival of mesenchymal stem cells taken from the bone marrow. Researchers from the Nippon Dental University were investigating stem cells from dental pulp — the material in the middle of the tooth. The dental pulp was taken from patients undergoing a routine tooth extraction. Dr. Ken Yaegaki, the lead author of the study, told the BBC why the dental pulp was so effective. "High purity means there are less 'wrong cells' that are being differentiated to other tissues, or remaining as stem … Continue reading

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Researchers Use Noxious Gas To Convert Stem Cells To Liver Cells

Posted: Published on February 28th, 2012

February 27, 2012 Japanese scientists have recently discovered that hydrogen sulfide (H2S) – the chemical responsible for such malodorous phenomena as human flatulence, bad breath and rotten eggs – can be used to efficiently convert stem cells from human teeth into liver cells. While the fetid chemical compound is produced in small quantities by the human body for use in a variety of biological signaling mechanisms, at high concentrations it is highly poisonous and extremely flammable. A team of researchers at the Nippon Dental University in Tokyo collected stem cells from the teeth of patients undergoing extractions. The cells were harvested from the central part of the tooth known as the pulp which is made up predominantly of connective tissue and cells. Stem cells recovered from the pulp were then divided into two groups and incubated in sealed chambers, one filled with hydrogen sulfide and the other a control group. The cells from each chamber were then examined at three-day intervals to look for signs of transformation into liver cells. One such indicator is the ability to store glycogen, a compound that can be converted to glucose when the body needs energy. According to a report of their findings that … Continue reading

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Stem cell fertility treatments could be risky for older women

Posted: Published on February 28th, 2012

Harvard scientists are challenging traditional medical logic that dictates that women are born with a finite amount of eggs.  The scientists said they have discovered the ovaries of young women harbor rare stem cells that are in fact capable of producing new eggs. If properly harnessed, those stem cells may someday lead to new treatments for women suffering from infertility due to cancer or other diseases – or for those who are simply getting older, according to the researchers.  Lead researcher Jonathan Tilly of Harvard's Massachusetts General Hospital has co-founded a company, OvaScience Inc., to try to develop the findings into fertility treatments. The idea that women are born with all the egg cells – called oocytes – they’ll ever have has been called into question by past research, which found egg-producing stem cells in adult mice. In this latest study, Harvard researchers, in collaboration with Japanese scientists, used donated frozen ovaries from 20 year olds and ‘fished out’ the purported stem cells.   The researchers inserted a gene into the stem cells, which caused them to glow green.  If the cells produced eggs, those would glow green, too. The researchers first watched through a microscope as new eggs grew … Continue reading

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‘Scope for innovation in genetic medicine’

Posted: Published on February 28th, 2012

There is a tremendous opportunity in genetic medicine for innovation and for new players to make significant contributions, because it is still experimental, noted biologist and Nobel Laureate Dr David Baltimore said yesterday. “Today, it is mainly the province of biotechnology companies and universities, not big pharmaceutical companies,” he observed in a keynote presentation at the Qatar International Conference on Stem Cell Science and Policy 2012. There are new genetic tools available – though they are still experimental - to treat diseases which involve adding, subtracting or modifying genes in the cells of the body. “However, they are powerful tools and I am confident they will be an important part of the medicine of the future,” he said. Speaking on ‘The hematopoietic stem cell (HSC) as a target for therapy against cancer and Aids,’ Dr Baltimore explained that HSCs are one of the few cell types routinely used for bone marrow transplant. The HSCs are easily accessible, retroviruses can be used to carry genes into these stem cells, the genes are then expressed in all of cells that derive from the HSC and can correct inherited defects and bring genes that perform therapy under a programme called engineering immunity. “Though … Continue reading

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MissionIR News – Seeking Alpha Publishes Article Featuring VistaGen Therapeutics

Posted: Published on February 28th, 2012

Atlanta, GA (PRWEB) February 27, 2012 MissionIR would like to highlight VistaGen Therapeutics, Inc. (OTCBB: VSTA). VistaGen Therapeutics is a biotechnology company applying stem cell technology for drug rescue and cell therapy. Drug rescue combines human stem cell technology with modern medicinal chemistry to generate new chemical variants ("drug rescue variants") of promising drug candidates that have been discontinued during preclinical development ("put on the shelf") due to safety concerns. Today, Seeking Alpha published the following article featuring VistaGen Therapeutics: http://seekingalpha.com/article/394361 The article titled “VistaGen Therapeutics: A Hidden Stem Cell Opportunity” reviews the largely overlooked application of stem cells in the early stage testing of drug candidates. Using advanced stem cell technology, VistaGen has produced functional human cardiac cells that can be used early on in the drug development process to test for cardiotoxicity. Cardiotoxicity has been a factor in over 30% of drug withdrawals, and addressing it is seen as a major market. The use of real human heart cells in pre-clinical testing offers important advantages over traditional testing methods, such as animal testing. First of all, it can be performed at the earliest stages of development, reducing the risks of developing the wrong drug. It's also more accurate, … Continue reading

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The Lancet Publishes Results from Gentium's Phase III Defibrotide Trial for the Prevention of VOD in Paediatric Patients

Posted: Published on February 27th, 2012

VILLA GUARDIA, Italy, Feb. 27, 2012 (GLOBE NEWSWIRE) -- Gentium S.p.A. (Nasdaq:GENT - News) (the "Company") announced today that results from a Phase III randomised controlled trial which evaluated Defibrotide for use in preventing hepatic veno-occlusive disease (VOD) in paediatric patients undergoing haemopoietic stem-cell transplantation (HSCT) were published in the medical journal, The Lancet (Vol 379). The results of Corbacioglu et al. show that Defibrotide leads to a 40% a reduction in the incidence of VOD thirty days after HSCT in patients receiving Defibrotide, compared with those who did not receive Defibrotide. Additionally, in allogeneic HSCT recipients (70% of study population), the incidence and severity of acute graft-versus-host disease (GvHD) were significantly lower in the Defibrotide arm. These finding supports the prophylactic use of Defibrotide in the HSCT transplant setting. In a commentary article to the study, Drs. Uwe Platzbecker and Martin Bornhauser from Medizinische Klinik und Poliklinik I, Universitatsklinikum "Carl Gustav Carus" Dresden, Germany, conclude "Most importantly, defibrotide prophylaxis was well tolerated and did not lead to an increased risk of bleeding. Restriction by the legislative authorities means that there are few randomised trials in children, and thus Corbacioglu and colleagues' investigation is a pivotal European study, one that … Continue reading

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Stem cells give Barbaro's half-brother a chance to run again

Posted: Published on February 27th, 2012

by WHAS editors WHAS11.com Posted on February 27, 2012 at 1:22 PM TUSCON, Ariz. (WHAS11) -- A famous horse has a new lease on life thanks to a cutting-edge stem cell treatment. He's the half-brother to Kentucky Derby winner Barbaro and he’s known around the world as Dynaking, but the people who rescued him in Tucson, Ariz. call him "Gifted." He was born to run, but now he can barely walk. "Gifted" suffers from a condition that affects horses feet, an inflammation of the hoof that kills if left untreated. Veterinarian Dr. Vernon Dryden flew to Arizona from Kentucky to help. “What he has is a very difficult thing to overcome and really truly we're not going to cure him but we're going to try to prolong his life,” Dryden said. Now the recovery is up to "Gifted." “He's got the will to live like no horse I’ve ever seen before. He is a fighter,” Judy Glore, Heart of Tucson president, said.     Follow this link: Stem cells give Barbaro's half-brother a chance to run again … Continue reading

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Nature: BrainStorm's NurOwn™ Stem Cell Technology Offers Hope for Treating Huntington Disease

Posted: Published on February 27th, 2012

NEW YORK & PETACH TIKVAH--(BUSINESS WIRE)-- BrainStorm Cell Therapeutics Inc. (OTCBB: BCLI.OB - News), a leading developer of adult stem cell technologies and therapeutics, announced today that the prestigious Nature Reviews Neurology, a Nature Publishing Group Journal, highlighted recently published preclinical research results indicating that stem cells, generated with Brainstorm’s NurOwn™ technology, provide hope for Huntington disease's patients. In the preclinical studies conducted by leading scientists including Professors Melamed and Offen of Tel Aviv University and originally reported in Experimental Neurology, patients' bone marrow derived mesenchymal stem cells secreting neurotrophic factors (MSC-NTF) that were transplanted into an animal model of Huntington disease showed therapeutic benefits. Addressing the role of these MSC-NTF cells in Huntington disease, Professor Daniel Offen explains, "the premise is that such cells can be transplanted safely into affected areas of the brain, and thereby serve as vehicles for delivering neurotrophic factors." Offen expressed his hope that this cell-based therapy may eventually progress to the clinic. BrainStorm is currently conducting a Phase I/II Human Clinical Trial for Amyotrophic Lateral Sclerosis (ALS) also known as Lou Gehrig’s disease at the Hadassah Medical center. Initial results have shown that Brainstorm’s NurOwn™ therapy is safe, does not show any significant treatment-related … Continue reading

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StemCells, Inc. to Participate in Qatar International Conference on Stem Cell Science and Policy 2012

Posted: Published on February 27th, 2012

NEWARK, Calif., Feb. 27, 2012 (GLOBE NEWSWIRE) -- StemCells, Inc. (Nasdaq:STEM - News) today announced that it will participate in the Qatar International Conference on Stem Cell Science and Policy, which is being held in Qatar from February 27 to March 1, 2012. The Company, which is the leader in development of cell-based therapeutics for central nervous system disorders, was specifically invited by the conference's sponsors, the State of Qatar and Amir of Qatar His Highness Sheikh Hamad bin Khalifa Al-Thani, as well as the James A. Baker III Institute for Public Policy of Rice University, and is the only company to be invited. Ann Tsukamoto, Ph.D., StemCells' Executive Vice President, Research and Development, will make a presentation on the clinical translation of human neural stem cells. StemCells was the first company to receive authorization from the US Food and Drug Administration to conduct a clinical trial of purified human neural stem cells, and the Company is currently conducting two clinical trials with a third anticipated to start later this year. Dr. Tsukamoto will also be the moderator of the panel session on neurological disorders, which is scheduled to be held on March 1 from 9:30 a.m. to 11:00 a.m. … Continue reading

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Canadians with epilepsy face serious health and social impacts: new survey

Posted: Published on February 27th, 2012

Stigma, independence, social and work barriers among top challenges to be addressed TORONTO, Feb. 27, 2012 /CNW/ - Results released today from The Impact of Epilepsy on Canadians survey reveal that Canadian adults struggling to control the common seizure disorder face serious health obstacles, including access to specialized care and treatment options, as well as numerous social impacts. They list stigma, independence, and social and work barriers among the top challenges that need to be addressed. Conducted by Leger Marketing in late 2011, The Impact of Epilepsy on Canadians survey is the first of its kind in Canada to explore the impact on life and health among adults living with the disorder. "We are grateful to the many Canadians from St. John's to Victoria who shared their experiences living with epilepsy through this important survey," says Gail Dempsey, President of the Canadian Epilepsy Alliance (CEA). "Their insights confirm that many are still struggling to live well with epilepsy, and importantly, they point to where changes are needed most across the country to improve lives." Restricted independence and discrimination Every day, many Canadians living with epilepsy experience social isolation, work barriers and relationship issues, according to The Impact of Epilepsy on … Continue reading

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