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Monthly Archives: February 2012
The app that could save life after a stroke
Posted: Published on February 21st, 2012
MEDICAL experts from the North East are piloting a new tool to ensure stroke patients get the best treatment. Having developed the FAST acronym – face, arms, speech and time – which has been seen on national TV adverts, the Newcastle University and NHS team are now trying out an app for use on smartphones or tablets. The iPad app, called DASH II, aims to help people who have had a stroke and their medical team work out which course of treatment is most suitable for them. The app is being trialled in Newcastle and North Tyneside hospitals to help weigh up the risks and benefits of different treatments for people who have had an ischaemic stroke, which is caused by a blood clot on the brain. Its potential benefits have caught the attention of the national NHS after the researchers were nominated by a public vote as one of the top 50 uses of technology. The app will be demonstrated to the Health Secretary Andrew Lansley at the Maps and Apps Showcase in London tomorrow. From the moment people suffer a stroke, medics only have a four and a half-hour window to treat them with clot-busting drugs. This means … Continue reading
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High Doses of Load Slows Bone Loss in Spinal Cord Injury
Posted: Published on February 21st, 2012
Newswise — Loss of bone density leads to brittle bones that fracture easily. It is a major complication of spinal cord injury (SCI), which affects about 250,000 Americans every year. A new clinical trial conducted by University of Iowa researchers shows that delivering high doses of "load," or stress, to bone through programmed electrical stimulation of the muscle significantly slows the loss of bone density in patients with SCI. The focus on quantifying the effective dose of load is one of the study's most important aspects, says Richard Shields, P.T., Ph.D., a professor and director of the UI Physical Therapy and Rehabilitation Science Graduate Programs. The study also is the first to carefully test the impact of different doses of load in humans with paralysis. Previous research had suggested that stressing or loading bone through muscle contractions could slow the loss of bone density, but results from clinical trials have been mixed. "Thirty years ago a clinical trial concluded that putting patients with SCI in an upright weight-bearing position with braces or standing frames did nothing to prevent loss of bone density," Shields says. "The novelty of our study is we have designed a method for individuals with paralysis to … Continue reading
Posted in Spinal Cord Injury Treatment
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Parkinson's Disease – How Much Exercise Improves Symptoms?
Posted: Published on February 21st, 2012
Editor's Choice Main Category: Parkinson's Disease Article Date: 20 Feb 2012 - 9:00 PST email to a friend printer friendly opinions Current Article Ratings: Patient / Public: 5 (5 votes) Healthcare Prof: For over two decades, Daniel Corcos has researched Parkinson's disease. During his studies he spent the majority of the past decade focusing on the effects of exercise. Corcos, a professor of kinesiology and nutrition at the University of Illinois at Chicago, explained: "It became obvious several years ago that exercise really was good for people with Parkinson's disease. Not only is it good for the heart, the brain, and muscles in the same way it is for healthy people, it also modifies signs and symptoms of Parkinson's disease." At present, Corcos is co-leading a study funded by a four-year, $3 million grant from the National Institute of Neurological Disorders. The aim of the study is to assess the benefits of aerobic exercise in controlling symptoms in individuals recently diagnosed with Parkinson's disease. At the annual meeting of the American Academy of Neurology in April, 2012, Corcos will present findings from the study. Results from the study show that 2 years of weight training can considerably … Continue reading
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Purdue researchers reveal role of protein mutation in Parkinson's disease
Posted: Published on February 21st, 2012
Public release date: 21-Feb-2012 [ | E-mail | Share ] Contact: Elizabeth K. Gardner ekgardner@purdue.edu 765-494-2081 Purdue University WEST LAFAYETTE, Ind. - Purdue University researchers revealed how a mutation in a protein shuts down a protective function needed to prevent the death of neurons in Parkinson's disease, possibly opening the door to new drug strategies to treat the disorder. Fred Regnier, the J.H. Law Distinguished Professor of Chemistry, and Jean-Christophe Rochet, an associate professor of medicinal chemistry and molecular pharmacology, led the team that discovered how the protein DJ-1, which plays a significant role in protecting neurons from damage, is shut down by a subtle mutation. A substitution in one link of the chain of amino acids that makes up the protein renders it unable to be activated to protect neurons from the build up of protein "aggregates," or "clumps," that lead to cell death in those with Parkinson's disease. "The saying that you are only as strong as your weakest link appears to hold true in the case of the chain of amino acids that make up a protein," Regnier said. "The magnitude of the effect of this subtle change is surprising. It can make the difference between having … Continue reading
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National Parkinson Foundation, Its Leading Medical Centers of Excellence and Chapters Nationwide Launch Aware in Care
Posted: Published on February 21st, 2012
To: HEALTH AND NATIONAL EDITORS New campaign to improve hospital care for over 1 million people with Parkinson's disease; Emerging data shows hospitalization puts Parkinson's patients at great risk MIAMI, Feb. 21, 2012 /PRNewswire-USNewswire/ -- The National Parkinson Foundation (NPF) announced the launch of the Aware in Care campaign today, the first-ever, nationwide initiative to address the growing problem of poor hospital care for over one million people with Parkinson's disease (PD). Aware in Care features a free kit for PD patients and caregivers to help make hospital stays safer. NPF, its Centers of Excellence at leading medical institutions, and local chapters urge patients and caregivers to know the steps to take to ensure that people with PD get the best possible care during hospital stays. "Our research scientists have unearthed important factors which can lower the risk of illness, serious complications and even death of hospitalized Parkinson's patients," said Michael S. Okun, MD, NPF's National Medical Director. "For my patients, and for the up to one million people suffering from Parkinson's in the U.S., Aware in Care will improve the type of attention and treatment they get in hospitals." Emerging data shows that 75% of hospitalized patients with PD … Continue reading
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Earnings Beat for Acorda
Posted: Published on February 21st, 2012
Acorda Therapeutics Inc.’s (NasdaqGS:ACOR - News) fourth quarter earnings (including share-based compensation charges) of 32 cents per share were way above the Zacks Consensus Estimate of 17 cents and the year-ago earnings of 9 cents per share. Fiscal year 2011 earnings (including share-based compensation charges) of 64 cents per share were also higher than the Zacks Consensus Estimate of 62 cents per share and the year-ago loss of 31 cents per share. The company reported earnings (excluding share-based compensation charges) of 45 cents and $1.13 per share for the fourth quarter of 2011 and fiscal year 2011, respectively. Quarterly revenues increased 8.7% to $72.6 million, beating the Zacks Consensus Estimate of $69 million. In fiscal year 2011, revenues increased a whopping 53.0% to $292.2 million. Revenues came in above the Zacks Consensus Estimate of $285 million. Quarter in Detail Product sales consisted mainly of Ampyra, which has patent protection till 2027. Ampyra sales came in at $57.2 million, reflecting a year-over-year increase of 9.4%. Acorda has a licensing agreement with Biogen Idec (NasdaqGS:BIIB - News) for the development and commercialization of Ampyra outside the US. Further, Acorda has a supply agreement with Elan Corporation (NYSE:ELN - News) for manufacturing Ampyra. … Continue reading
Posted in Cerebral Palsy Treatment
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Promising Treatment for Traumatic Brain Injury
Posted: Published on February 21st, 2012
(Ivanhoe Newswire) -- A new study performed on rats shows promise in helping fight against the harmful effects of traumatic brain injury. Traumatic brain injury causes a decrease in blood flow in the cerebrum of the brain. If blood flow is prolonged, it could lead to death or permanent cell dysfunction. The endothelin receptor A (ETrA), a receptor in the brain, contributes to the decrease of blood flow as early as four hours after the injury on the brain occurs. A new drug, called clazosentan, is thought to specifically block these receptors. "There are currently no primary treatments for TBI, so this research provides hope that effective treatments can be developed," study author Michael Kaufman, a medical student at Wayne State University School of Medicine in Detroit and a member of the American Academy of Neurology, was quoted as saying. First, researchers gave rats that had brain injuries the clazosentan drug through an IV line at various points after injuries. Then they measured the rat's blood flow in the sensory motor cortex and hippocampus with an MRI brain scan and tested their behavior in learning a maze. The study found that the drug decreased the effects of brain injury on … Continue reading
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Cleveland Clinic Neurologist Awarded Dystel Prize for MS Research
Posted: Published on February 21st, 2012
FOR IMMEDIATE RELEASE Newswise — NEW ORLEANS – The American Academy of Neurology and the National Multiple Sclerosis Society are awarding the 2012 John Dystel Prize for MS Research to Richard M. Ransohoff, MD, with the Cleveland Clinic. Ransohoff, a member of the American Academy of Neurology and Associate Editor of Neurology®, the Academy’s medical journal, will receive the award at the Academy’s 64th Annual Meeting in New Orleans, April 21-28, 2012. The Annual Meeting is the world’s largest gathering of neurologists with more than 10,000 attendees and more than 2,300 scientific presentations on the latest research advance in brain disease. The John Dystel Prize recognizes a significant contribution to research in the understanding, treatment or prevention of multiple sclerosis (MS). Ransohoff’s research has focused on the central nervous system, which includes the brain, optic nerves and spinal cord. “This award recognizes the superb research done by my colleagues in my laboratory, and I'm proud to receive it on their behalf. Support by the National Institutes of Health, the National MS Society and generous individual donors showed confidence in our research and inspired our work,” said Ransohoff. “During the past 15 years, we’ve identified several new molecules as potential targets … Continue reading
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Cannabis-based treatment could be cleared for MS patients
Posted: Published on February 21st, 2012
Cannabis-based treatment could be cleared for MS patients By Gordon Deegan Tuesday, February 21, 2012 Cannabis-based medicinal products, such as Sativex, could soon be available to people with multiple sclerosis and other medical conditions on prescription. Róisín Shortall, minister for state at the Department of Health, said the department was "examining the issues associated with applying controls, similar to those that apply to other controlled drugs that can be misused, such as morphine and methadone, to cannabis-based medicinal products to permit them to be prescribed and dispensed in Ireland". In a written response to a Dáil question tabled by Luke "Ming" Flanagan (Ind), Ms Shorthall said: "As the law currently stands, it is not possible for cannabis-based medicinal products such as Sativex to be prescribed by a medical practitioner in Ireland. "I am aware that claims have been made in respect of the possible health benefits of cannabis-based medicinal products for patients suffering from certain conditions, such as MS. I am also aware that Sativex is authorised in the UK for the relief of spasm in patients with multiple sclerosis." Mr Flanagan described the policy of prohibiting the supply of cannabis-based medicinal products as "heartless and cruel". Sativex has been … Continue reading
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Vitamin D could be weapon against MS
Posted: Published on February 21st, 2012
A CLINICAL trial will test whether Vitamin D can help fight multiple sclerosis (MS). If successful, researchers say the trial could open the door to a treatment which is 100 times cheaper than other drugs available. The $2 million trial, announced today by MS Research Australia, will begin recruiting in Victoria, NSW, Tasmania and New Zealand from April. Researchers hope to find 150 people with early or suspected symptoms of MS and put them on varying doses of Vitamin D. "If we can ... watch to see if that actually slows the progress or stops the progress, and they don't actually get MS, then we know Vitamin D is having an effect," MS Research Australia CEO Jeremy Wright said. The vitamin, which can be sourced from sunlight and some foods, is gaining credence as an effective treatment in preventing MS. But all the evidence so far has been circumstantial, Mr Wright said. "If we can prove the efficacy we are going to come up with a treatment which, would you believe, is about 100 times cheaper than the current treatments," Mr Wright said. "But it won't be a solo treatment. It will join the other treatments and add impacts, is … Continue reading
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