Monthly Archives: February 2012

Stem cells – ISWA project – Video

Posted: Published on February 14th, 2012

14-02-2012 08:13 STEM CELLS The dance of life Recent developments in regenerative medicine and modern biology are going to have an enormous impact on our lives. Also the way itself we face the problem of sickness, aging and death changes as the hope (or the illusion?) grows that we always can fight and delay them. Stem cell research is in fact changing our knowledge of the fundamental mechanisms of life and feeding the idea that we can increasingly contrast the cruel natural selection rules which make us fall ill, grow old and die. A new frontier opens and unpredictable changes in our culture are taking place. People's hopes and fears grow at the same time. The general properties of the stem cells is presented, namely the ability to proliferate and, under certain conditions, to differentiate in other types of cells. In this way they can generate a new tissue replacing a damaged one, and also a new organ (like blood, thrachea, liver, heart, skin, cornea and very recently retina). A stamp is shown, which was emitted by the Japanese government to celebrate the discovery of a university team, which was able to regenerate a cornea and giving the opportunity to … Continue reading

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U-M Human Embryonic Stem Cell Line Placed On National Registry for Researchers

Posted: Published on February 14th, 2012

To: EDUCATION, MEDICAL AND NATIONAL EDITORS Line is first from U-M accepted to the U.S. National Institutes of Health registry, now available for federally-funded research ANN ARBOR, Mich., Feb. 14, 2012 /PRNewswire-USNewswire/ -- The University of Michigan's first human embryonic stem cell line will be placed on the U.S. National Institutes of Health's registry, making the cells available for federally-funded research. It is the first of the stem cell lines derived at the University of Michigan to be placed on the registry. The line, known as UM4-6, is a genetically normal line, derived in October 2010 from a cluster of about 30 cells removed from a donated five-day-old embryo roughly the size of the period at the end of this sentence. That embryo was created for reproduction but was no longer needed for that purpose and was therefore about to be discarded. "This is significant, because acceptance of these cells on the registry demonstrates our attention to details of proper oversight, consenting, and following of NIH guidelines established in 2009," says Gary Smith, Ph.D., who derived the line and also is co-director of the U-M Consortium for Stem Cell Therapies, part of the A. Alfred Taubman Medical Research Institute. "It … Continue reading

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U-M human embryonic stem cell line placed on national registry

Posted: Published on February 14th, 2012

Public release date: 14-Feb-2012 [ | E-mail | Share ] Contact: Mary F. Masson mfmasson@umich.edu 734-764-2220 University of Michigan Health System ANN ARBOR, Mich. ? The University of Michigan's first human embryonic stem cell line will be placed on the U.S. National Institutes of Health's registry, making the cells available for federally-funded research. It is the first of the stem cell lines derived at the University of Michigan to be placed on the registry. The line, known as UM4-6, is a genetically normal line, derived in October 2010 from a cluster of about 30 cells removed from a donated five-day-old embryo roughly the size of the period at the end of this sentence. That embryo was created for reproduction but was no longer needed for that purpose and was therefore about to be discarded. "This is significant, because acceptance of these cells on the registry demonstrates our attention to details of proper oversight, consenting, and following of NIH guidelines established in 2009," says Gary Smith, Ph.D., who derived the line and also is co-director of the U-M Consortium for Stem Cell Therapies, part of the A. Alfred Taubman Medical Research Institute. "It now makes the line available to researchers who … Continue reading

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Bioheart Acquires Exclusive Rights to Ageless Regenerative Institute’s Adipose Cell Technology

Posted: Published on February 14th, 2012

SUNRISE, Fla., Feb. 14, 2012 (GLOBE NEWSWIRE) -- Bioheart, Inc. (BHRT.OB) announced today that it has acquired the worldwide exclusive rights to Ageless Regenerative Institute's adipose (fat) derived therapeutic cell technology for use in the cardiac field. "The Ageless adipose stem cell technology will allow us to broaden our portfolio of product candidates for cardiac patients," said Mike Tomas, President and CEO of Bioheart. "We have successfully treated patients in Mexico and now we are ready to expand into the US." Adipose tissue is readily available and has been shown to be rich in microvascular, myogenic and angiogenic cells. Bioheart has recently applied to the FDA to begin trials using adipose derived stem cells or LipiCell(TM) in patients with chronic ischemic cardiomyopathy. Transplantation of LipiCell(TM) will be accomplished through endocardial implantations with the MyoStar(TM) Injection Catheter under the guidance of the NOGA(R) cardiac navigation system by Biosense Webster, Inc. -- A Johnson & Johnson Company. Under the terms of the agreement, Bioheart will have a worldwide exclusive license to all of Ageless technology for use in the heart attack and heart failure markets. The agreement provides for upfront and milestone equity payments to Ageless. Ageless' President and Chief Executive Officer, … Continue reading

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Bioheart Acquires Exclusive Rights to Ageless Regenerative Institute's Adipose Cell Technology

Posted: Published on February 14th, 2012

SUNRISE, Fla., Feb. 14, 2012 (GLOBE NEWSWIRE) -- Bioheart, Inc. (BHRT.OB) announced today that it has acquired the worldwide exclusive rights to Ageless Regenerative Institute's adipose (fat) derived therapeutic cell technology for use in the cardiac field. "The Ageless adipose stem cell technology will allow us to broaden our portfolio of product candidates for cardiac patients," said Mike Tomas, President and CEO of Bioheart. "We have successfully treated patients in Mexico and now we are ready to expand into the US." Adipose tissue is readily available and has been shown to be rich in microvascular, myogenic and angiogenic cells. Bioheart has recently applied to the FDA to begin trials using adipose derived stem cells or LipiCell(TM) in patients with chronic ischemic cardiomyopathy. Transplantation of LipiCell(TM) will be accomplished through endocardial implantations with the MyoStar(TM) Injection Catheter under the guidance of the NOGA(R) cardiac navigation system by Biosense Webster, Inc. -- A Johnson & Johnson Company. Under the terms of the agreement, Bioheart will have a worldwide exclusive license to all of Ageless technology for use in the heart attack and heart failure markets. The agreement provides for upfront and milestone equity payments to Ageless. Ageless' President and Chief Executive Officer, … Continue reading

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Teva-Gamida Cell complete enrollment for blood cancer trial

Posted: Published on February 14th, 2012

Teva Pharmaceutical Industries Ltd. (Nasdaq: TEVA; TASE: TEVA) and Gamida Cell Ltd. have completed enrollment of 100 patients for their Phase III clinical trial of StemEx, a cell therapy for the treatment of blood cancers, such as leukemia and lymphoma. StemEx is intended for adolescents and adults who cannot find a family related, matched bone marrow donor. Teva and Gamida Cell are conducting the multi-center international clinical trial through their joint venture, which they own in equal shares. StemEx is a graft of an expanded population of stem/progenitor cells, derived from part of a single unit of umbilical cord blood and transplanted together with the remaining, non-manipulated cells from the same unit. Gamida Cell president and CEO Dr. Yael Margolin said, "The joint venture is planning to announce the safety and efficacy results of the Phase III StemEx trial in 2012 and to launch the product into the market in 2013. It is our hope that StemEx will provide the answer for the thousands of leukemia and lymphoma patients unable to find a matched, related bone marrow donor." Margolin added, ?StemEx may be the first allogeneic cell therapy to be brought to market. This is a source of pride for … Continue reading

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Stem Cells May Help Regenerate Heart Muscle

Posted: Published on February 14th, 2012

A promising stem cell therapy approach could soon provide a way to regenerate heart muscle damaged by heart attacks. Researchers at Cedars-Sinai Heart Institute and The Johns Hopkins University harvested stem cells from the hearts of 17 heart attack patients and after prepping the cells, infused them back into the patients' hearts. Their study is published in the current issue of The Lancet. The patients received the stem cell infusions about three months after their heart attacks. Researchers found that six months after treatment, patients had significantly less scarring of the heart muscle and also showed a considerable increase the amount of healthy heart muscle, compared to eight post-heart attack patients studied who did not receive the stem cell infusions. One year after, scar size was reduced by about 50 percent. "The damaged tissue of the heart was replaced by what looks like healthy myocardium," said Dr. Peter Johnston, a study co-author and an assistant professor of medicine at The Johns Hopkins University School of Medicine. "It's functioning better than the damaged myocardium in the control subjects, and there's evidence it's starting to contract and generate electrical signals the way healthy heart tissue does." While this research is an early … Continue reading

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VistaGen Updates Pipeline of Stem Cell Technology-Based Drug Rescue Candidates

Posted: Published on February 14th, 2012

SOUTH SAN FRANCISCO, CA--(Marketwire -02/14/12)- VistaGen Therapeutics, Inc. (OTC.BB: VSTA.OB - News) (OTCQB: VSTA.OB - News), a biotechnology company applying stem cell technology for drug rescue and cell therapy, has identified its initial Top 10 drug rescue candidates and plans to launch two formal drug rescue programs by the end of next quarter. VistaGen's goal for each of its stem cell technology-based drug rescue programs is to generate and license a new, safer variant of a once-promising large market drug candidate previously discontinued by a pharmaceutical company no earlier than late-preclinical development. "We are now at an advanced stage in our business model," said Shawn Singh, VistaGen's Chief Executive Officer. "After more than a decade of focused investment in pluripotent stem cell research and development, we are now at the threshold where game-changing science becomes therapeutically relevant to patients and commercially relevant to our shareholders. We have positioned our company and our stem cell technology platform to pursue multiple large market opportunities. We plan to launch two drug rescue programs by the end of the next quarter." Over the past year, VistaGen, working with its network of strategic partners, identified over 525 once-promising new drug candidates that meet the Company's … Continue reading

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WJZ Investigates Why Critical Prescriptions Are In Short Supply

Posted: Published on February 14th, 2012

BALTIMORE (WJZ) — What if you need a certain medicine, maybe one that would save your life, and you can’t get it? WJZ investigates prescription drug shortages. Denise Koch talks with University of Maryland women’s basketball coach Brenda Frese about her very personal fight to find a solution. You’d never know it now, but not too long ago one of these twins nearly died. “They told me he had only a matter of weeks to live,” said Mark Thomas, Tyler’s father. University of Maryland women’s basketball coach Brenda Frese and her husband Mark remember the moment doctors told them their son Tyler had leukemia. “Obviously you feel helpless,” said Frese. “You’re thinking the worst.  My initial thought that whole night without being educated was ‘How much time do I have left with my son?’” Doctors at Johns Hopkins Hospital immediately started pumping chemotherapy drugs into Tyler to stop the fast moving disease. “These chemicals are doing these things to your child, yet they’re also saving his life,” said Thomas. It was only after his chemotherapy that Thomas and Frese discovered the miracle drug that saved their son might not be there for others. In short supply, its cost had skyrocketed from $12 … Continue reading

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Investigators look into Whitney Houston's prescriptions as family prepares funeral

Posted: Published on February 14th, 2012

As preparations continue for Whitney Houston's funeral in her hometown of Newark, NJ, so does the investigation into her death. After an autopsy Sunday, authorities said there were no indications of foul play and no obvious signs of trauma. It could be weeks, however, before the coroner's office completes toxicology tests to establish the cause of death. Reports say some of the prescription bottles found in her room may have come from the same pharmacy that provided drugs to the late Michael Jackson. Six prescription pill bottles were reportedly found, for Xanax, Lorazepam, Ibuprofen, Midol, Amoxicillin and Valium. If anyone was criminally negligent in prescribing the drugs to Houston, and they caused her death, they could be charged, a source told The Sun newspaper.  "[Authorities] need to determine that no one is criminally negligent. There still could be charges in this case," the source said. Houston's death recalled the end of Michael Jackson's life, as he tried to turn his career around with an ambitious series of concerts. The 50-year-old struck many as youthfully energetic and upbeat, while others said he was bedeviled by insomnia that led him to a fatal dosage of prescription drugs in June 2009. Houston too … Continue reading

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