Monthly Archives: February 2012

February 14, 2012, 11:24 AM EST By Ryan Flinn Feb. 14 (Bloomberg) -- Stem cells grown from patients’ own cardiac tissue can heal damage once thought to be permanent after a heart attack, according to a study that suggests the experimental approach may one day help stave off heart failure. In a trial of 25 heart-attack patients, 17 who got the stem cell treatment showed a 50 percent reduction in cardiac scar tissue compared with no improvement for the eight who received standard care. The results, from the first of three sets of clinical trials generally needed for regulatory approval, were published today in the medical journal Lancet. “The findings in this paper are encouraging,” Deepak Srivastava, director of the San Francisco-based Gladstone Institute of Cardiovascular Disease, said in an interview. “There’s a dire need for new therapies for people with heart failure, it’s still the No. 1 cause of death in men and women.” The study, by researchers from Cedars-Sinai Heart Institute in Los Angeles and Johns Hopkins University in Baltimore, tested the approach in patients who recently suffered a heart attack, with the goal that repairing the damage might help stave off failure. While patients getting the stem … Continue reading →

SOUTH SAN FRANCISCO, CA--(Marketwire -02/14/12)- VistaGen Therapeutics, Inc. (OTC.BB: VSTA.OB - News) (OTCQB: VSTA.OB - News), a biotechnology company applying stem cell technology for drug rescue and cell therapy, has identified its initial Top 10 drug rescue candidates and plans to launch two formal drug rescue programs by the end of next quarter. VistaGen's goal for each of its stem cell technology-based drug rescue programs is to generate and license a new, safer variant of a once-promising large market drug candidate previously discontinued by a pharmaceutical company no earlier than late-preclinical development. "We are now at an advanced stage in our business model," said Shawn Singh, VistaGen's Chief Executive Officer. "After more than a decade of focused investment in pluripotent stem cell research and development, we are now at the threshold where game-changing science becomes therapeutically relevant to patients and commercially relevant to our shareholders. We have positioned our company and our stem cell technology platform to pursue multiple large market opportunities. We plan to launch two drug rescue programs by the end of the next quarter." Over the past year, VistaGen, working with its network of strategic partners, identified over 525 once-promising new drug candidates that meet the Company's … Continue reading →

Stem cells grown from patients’ own cardiac tissue can heal damage once thought to be permanent after a heart attack, according to a study that suggests the experimental approach may one day help stave off heart failure. In a trial of 25 heart-attack patients, 17 who got the stem cell treatment showed a 50 percent reduction in cardiac scar tissue compared with no improvement for the eight who received standard care. The results, from the first of three sets of clinical trials generally needed for regulatory approval, were published today in the medical journal Lancet. “The findings in this paper are encouraging,” Deepak Srivastava, director of the San Francisco-based Gladstone Institute of Cardiovascular Disease, said in an interview. “There’s a dire need for new therapies for people with heart failure, it’s still the No. 1 cause of death in men and women.” The study, by researchers from Cedars-Sinai Heart Institute in Los Angeles and Johns Hopkins University (43935MF) in Baltimore, tested the approach in patients who recently suffered a heart attack, with the goal that repairing the damage might help stave off failure. While patients getting the stem cells showed no more improvement in heart function than those who didn’t … Continue reading →

ScienceDaily (Feb. 13, 2012) — Results from a Cedars-Sinai Heart Institute clinical trial show that treating heart attack patients with an infusion of their own heart-derived cells helps damaged hearts re-grow healthy muscle. Patients who underwent the stem cell procedure demonstrated a significant reduction in the size of the scar left on the heart muscle by a heart attack. Patients also experienced a sizable increase in healthy heart muscle following the experimental stem cell treatments. One year after receiving the stem cell treatment, scar size was reduced from 24 percent to 12 percent of the heart in patients treated with cells (an average drop of about 50 percent). Patients in the control group, who did not receive stem cells, did not experience a reduction in their heart attack scars. "While the primary goal of our study was to verify safety, we also looked for evidence that the treatment might dissolve scar and regrow lost heart muscle," said Eduardo Marbán, MD, PhD, the director of the Cedars-Sinai Heart Institute who invented the procedures and technology involved in the study. "This has never been accomplished before, despite a decade of cell therapy trials for patients with heart attacks. Now we have done … Continue reading →

PIEDMONT, Okla. -- Stem cell research is one of the newest and most exciting areas of study. Experts believe these tiny unwritten cells hold the keys to curing a number of diseases and debilitating injuries. But here in the U.S., stem cell research isn't moving fast enough for a growing number of families. This is the story of an Oklahoma family that traveled to China for cutting-edge stem cell treatment not offered in the US. Cora Beth Taylor walks a different road than most will ever travel. Her journey is filled with obstacles, heartbreak and triumph. Cora, William and Tate Taylor are triplets born premature. The brothers have never shown any signs of prematurity. But Cora, at about a year old, started falling behind developmentally. By 18 months she had been diagnosed with Cerebral Palsy. Cora has never had any cognitive delays. She's a super-smart little gal but her muscles haven't developed properly. It's devastating; they just won't cooperate. Cora's parents, Kevin and Beth Taylor, have tried everything for their little girl; that is, everything available in the U.S. Last year, Piedmont Schools raised the money to help the Taylors take Cora to China for treatment, close to $50,000. Research … Continue reading →

By Jenny Hope Last updated at 1:03 PM on 14th February 2012 Breakthrough: The heart's own stem cells can be used to heal it, according to a new study The heart’s own stem cells can be used to repair damage caused to it, scientists say. They help the organ re-grow healthy muscle after a heart attack, a clinical trial shows. The procedure was found to halve the size of scar left on a patient’s heart muscle and led to a ‘sizeable increase’ in healthy muscle. Scientists said this discovery challenges a belief that scarring is permanent and that, once lost, healthy heart muscle cannot be restored. One year after receiving the experimental treatment, scar size was reduced on average from 24 per cent to 12 per cent of the heart. Patients who did not receive the heart stem cells had no reduction. Results from the U.S. study, published online in The Lancet medical journal, offer hope for patients with heart failure, where the pumping action is diminished. Researcher Eduardo Marb?n, director of the Cedars-Sinai Heart Institute, said: ‘While the primary goal of our study was to verify safety, we also looked for evidence that the treatment might dissolve scar and … Continue reading →

MONDAY, Feb. 13 (HealthDay News) -- Stem cell therapy's promise for healing damaged tissues may have gotten a bit closer to reality. In a small, early study, heart damage was reversed in heart-attack patients treated with their own cardiac stem cells, researchers report. The cells, called cardiosphere-derived stem cells, regrew damaged heart muscle and reversed scarring one year later, the authors say. Up until now, heart specialists' best tool to help minimize damage following a heart attack has been to surgically clear blocked arteries. "In our treatment, we dissolved scar and replaced it with living heart muscle. Such 'therapeutic regeneration' has long been the holy grail of cell therapy, but had never been accomplished before; we now seem to have done it," said study author Dr. Eduardo Marban, director of the Cedars-Sinai Heart Institute in Los Angeles. However, outside experts cautioned that the findings are preliminary and the treatment is far from ready for widespread use among heart-attack survivors. The study, published online Feb. 14 in The Lancet, involved 25 middle-aged patients (average age 53) who had suffered a heart attack. Seventeen underwent stem cell infusions while eight received standard post-heart attack care, including medication and exercise therapy. The stem … Continue reading →