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Monthly Archives: February 2012
Catalyst Pharma's Infantile Spasms Therapy CPP-115 Gets EC Orphan Drug Status
Posted: Published on February 13th, 2012
(RTTNews.com) - Catalyst Pharmaceuticals Partners Inc. (CPRX) Monday reported that its West Syndrome, or infantile spasms, therapy CPP-115 was given orphan medicinal product designation by the European Commission upon the recommendation of the European Medicines Agency, or EMA, Committee on Orphan Medicinal Products, or COMP. The decision was based on preclinical data which showed CPP-115 as being active for a longer time, and resulting in fewer retinal side effects. Patrick McEnany, Catalyst's chief executive officer, said "We have hit another major milestone in our efforts to advance this clinically important treatment for patients around the world. Obtaining an orphan designation for CPP-115 in the European Union (EU) is an important step that builds upon our recent progress with CPP-115, including the grant of Fast Track development program designation by the U.S. Food and Drug Administration (FDA) for cocaine dependency and commencement of a first-in-man Phase I(a) safety study." For comments and feedback: contact editorial@rttnews.com http://www.rttnews.com More here: Catalyst Pharma's Infantile Spasms Therapy CPP-115 Gets EC Orphan Drug Status … Continue reading
Posted in Drug Dependency
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Catalyst Pharmaceutical Partners Granted Orphan Medicinal Product Designation in European Union for CPP-115 for the …
Posted: Published on February 13th, 2012
CORAL GABLES, Fla., Feb. 13, 2012 (GLOBE NEWSWIRE) -- Catalyst Pharmaceutical Partners, Inc. (Nasdaq:CPRX - News) today announced that the European Commission (EC) has granted orphan medicinal product designation for the company's investigational drug, CPP-115, a novel GABA aminotransferase inhibitor, for the treatment of West Syndrome (infantile spasms). The EC designation is based on the recommendation by the European Medicines Agency (EMA) Committee on Orphan Medicinal Products (COMP) after their review of all relevant preclinical data for CPP-115, which showed that it may have a longer duration of action, improved benefits and fewer retinal side effects than the existing first-line treatment. "We have hit another major milestone in our efforts to advance this clinically important treatment for patients around the world," said Patrick J. McEnany, Chief Executive Officer of Catalyst. "Obtaining an orphan designation for CPP-115 in the European Union (EU) is an important step that builds upon our recent progress with CPP-115, including the grant of Fast Track development program designation by the U.S. Food and Drug Administration (FDA) for cocaine dependency and commencement of a first-in-man Phase I(a) safety study." "Our orphan designations in the EU and U.S. support our global development strategy for CPP-115 and our goal … Continue reading
Posted in Drug Dependency
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Celine Dion: "Drugs" and "Show Business" Killed Whitney Houston
Posted: Published on February 13th, 2012
The cause of Whitney Houston's death remains under investigation -- but according to Celine Dion, this case is already closed. Speaking via phone on Monday's Good Morning America (she called the late icon "an amazing inspiration") the "My Heart Will Go On" singer didn't mince words looking back on Houston's legendary career and troubled later life. PHOTOS: Whitney's life remembered "It's just really unfortunate that drugs, bad people, bad influences took over her dreams, her motherhood," the French-Canadian star, 43, said of Houston, who famously fessed up in a 2002 interview with Diane Sawyer about using cocaine, marijuana and pills. "When you think about Elvis Presley, Marilyn Monroe, Amy Winehouse, Michael Jackson . . . To get into drugs like that for whatever reason--because of stress, bad influence, whatever." PHOTOS: Tragic celeb deaths of 2011 Dion lamented that her immensely talented idol, who left behind daughter Bobbi Kristina, apparently succumbed like other superstars before her. "What happens when you have everything? Love, support, motherhood…Something happens that I don't understand. That's why I'm scared of show business, of drugs and hanging out. That's why I don't go to parties!" PHOTOS: The troubled life of Amy Winehouse Tell Us: Did Dion speak … Continue reading
Posted in Drugs
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Proteins hope for cancer drugs
Posted: Published on February 13th, 2012
13 February 2012 Last updated at 09:55 ET New insights into how cells multiply could help scientists develop drugs to treat cancer, it has been claimed. Edinburgh University researchers have been studying two key proteins which control cell division. They have found a link between the proteins' activity and formation of new healthy cells, which could be vital to the development of anti-cancer drugs. The team from Edinburgh is working in collaboration with researchers at Montreal University in Canada. They have identified a key process in the way the proteins called "polo" and "aurora" work to divide cells correctly. Their discovery will contribute to the development of new drugs which stop cancerous cells multiplying and so prevent the spread of the disease. Dr Mar Carmena, of Edinburgh University's school of biological sciences, said: "Cell division is a complex and tightly regulated process, and when it goes out of control this can lead to cancer. "The greater our understanding of the proteins that control cell division, the better equipped scientists will be to design more effective treatments against cancer." More: Proteins hope for cancer drugs … Continue reading
Posted in Drugs
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Legalizing drugs gains ground in Latin America
Posted: Published on February 13th, 2012
Guatemalan President Otto Perez Molina has suggested decriminalizing drugs in order to reduce violence in the Americas. • A version of this post ran on the author's blog, centralamericanpolitics.blogspot.com. The views expressed are the author's own. Skip to next paragraph Guatemalan President Otto Perez Molina has repeated his suggestion that Guatemala and the other nations of Central America should consider decriminalizing drugs in order to help reduce violence. The Guatemalan president said he will propose legalizing drugs in Central America in an upcoming meeting with the region's leaders. President Perez Molina said in a radio interview that legalization would include decriminalizing the transportation of drugs through the area. The Guatemalan president said the war on drugs, and all the money and technology received from the US, has not diminished drug trafficking in the area. While the details would have to be worked out, he would also consider setting up legal mechanisms to sell drugs (link in Spanish). Some effort at decriminalization would be beneficial both to the people of Central America and the United States. On the other hand, I'm not convinced that the US government and regional governments could design some sort of effective policy. They would include too … Continue reading
Posted in Drugs
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Online Clinical Education Platform Pedagogy Gains in Popularity
Posted: Published on February 13th, 2012
Husband and Wife Team Up to Develop Successful Formula for Delivering Valuable Courses to Health Care Professionals Tyler, TX (PRWEB) February 13, 2012 Realizing the need for an efficient and effective means to provide educational and training courses for nurses, nurse practitioners, physicians, pharmacists, nurse aids and medical assistants, Patrick and Capra Dalton decided to apply their respective skills to create Pedagogy, Inc. As a consultant for a national pharmacy company serving long term care facilities, Capra Dalton, RN and Pedagogy CEO, previously traveled throughout the state of Texas teaching infusion therapy to nurses within a traditional classroom setting. “I began to notice that nurses were having difficulty travelling to locations for these two-day courses due to conflicts with their typical work schedules, child care issues, travel expenses, and of course, ensuring proper coverage at the nursing homes where they worked,” observed Capra. Relaying her experiences to her husband, Patrick Dalton, Capra was at first skeptical about Patrick’s suggestion that the courses could be delivered online. However the more Capra thought about Patrick’s idea, the more the it took hold, “I realized that these classes could be presented in an online format and resolve so many barriers that traditional classroom … Continue reading
Posted in Online Pharmacy
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Comprehensive Care Corporation, Tampa, Florida, Offers New Pharmacy Management Initiative Designed to Reduce …
Posted: Published on February 13th, 2012
TAMPA, Fla., Feb. 13, 2012 /PRNewswire/ -- Comprehensive Care Corporation ("CompCare" or the "Company") (OTCBB: CHCR.OB - News) today announced that it has launched its innovative new pharmacy management program designed to substantially lower prescription drug costs in California. "This is an innovative initiative, which has provided us with the ability, in almost every case, to materially lower the costs of prescription drugs for our clients. An example, outside of California, is noteworthy. One of our HMO clients is at risk for its member's prescription drugs and spends approximately $300 million annually. After analyzing the drug spend, CompCare offered to go at full risk for the identical drugs for only $270 million. If the client accepts this proposal, it would totally eliminate the client's drug cost risk, providing the client an immediate $30 million savings to its bottom line over its previous year drug spend," said Clark A. Marcus, Chairman and CEO. "We are able to provide savings because of our affiliation with a major retailer, affording us significantly lower prices," Mr. Marcus explained. "In California, at CompCare's sole cost and expense, we will conduct a detailed analysis of any potential client's pharmacy costs over any selected 90-day period. Based on … Continue reading
Posted in Pharmacy
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ACT Announces Third Patient with Stargardt’s Disease Treated in U.S. Clinical Trial with RPE Cells Derived from …
Posted: Published on February 13th, 2012
MARLBOROUGH, Mass.--(BUSINESS WIRE)-- Advanced Cell Technology, Inc. (“ACT”; OTCBB: ACTC), a leader in the field of regenerative medicine, announced today the dosing of third patient in its Phase 1/2 trial for Stargardt’s macular dystrophy (SMD) using retinal pigment epithelial (RPE) cells derived from human embryonic stem cells (hESCs). The patient was treated on Monday (Feb. 6) by Steven Schwartz, M.D., Ahmanson Professor of Ophthalmology at the David Geffen School of Medicine at the University of California, Los Angeles (UCLA) and retina division chief at UCLA’s Jules Stein Eye Institute. The outpatient transplantation surgery was performed successfully and the patient is recovering uneventfully. “With the treatment of this third Stargardt’s patient at Jules Stein Eye Institute, we have now completed the treatment of the first cohort of patients under our clinical protocol for phase I/II of our U.S. SMD trial,” said Gary Rabin, chairman and chief executive officer of ACT. “We will continue to regularly monitor the three SMD patients in this trial, and by early spring anticipate review of their progress and safety-related data by the Data and Safety Monitoring Board (DSMB). With approval of the DSMB, we would then advance to the next cohort of patients and administer a … Continue reading
Posted in Stem Cell Human Trials
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The Gamida Cell-Teva Joint Venture Concludes Enrollment for the Phase III Study of StemEx®, a Cord Blood Stem Cell …
Posted: Published on February 13th, 2012
JERUSALEM--(BUSINESS WIRE)-- Gamida Cell announced today that the Gamida Cell-Teva Joint Venture (JV), equally held by Gamida Cell and Teva Pharmaceutical Industries, has enrolled the last of 100 patients in the international, multi-center, pivotal registration, Phase III clinical trial of StemEx, a cell therapy product in development as an alternative therapeutic treatment for adolescents and adults, with blood cancers such as leukemia and lymphoma, who cannot find a family related, matched bone marrow donor. StemEx is a graft of an expanded population of stem/progenitor cells, derived from part of a single unit of umbilical cord blood and transplanted by IV administration along with the remaining, non-manipulated cells from the same unit. Dr. Yael Margolin, president and chief executive officer of Gamida Cell, said, "The JV is planning to announce the safety and efficacy results of the Phase III StemEx trial in 2012 and to launch the product into the market in 2013. It is our hope that StemEx will provide the answer for the thousands of leukemia and lymphoma patients unable to find a matched, related bone marrow donor.” Dr. Margolin continued, “StemEx may be the first allogeneic cell therapy to be brought to market. This is a source of … Continue reading
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Discovery of how infection triggers blood stem cell growth
Posted: Published on February 13th, 2012
Friday, 10 February 2012, 11:06 am Press Release: University of Auckland New Zealand scientists discover how infection triggers blood stem cell growth Research at The University of Auckland has shed light on an area of medicine which has intrigued the international scientific community for decades. Scientists at the Faculty of Medical and Health Sciences have identified a molecular mechanism which links infection to an increase in rare blood stem cells in an animal. Their paper was published today in the prestigious Boston-based journal Cell Stem Cell. This high impact journal publishes novel results of unusual significance in the field of stem cell research. The findings show blood stem and progenitor cells can directly react to inflammatory stress by proliferating and differentiating into the required mature blood cells. The discovery opens up a field of study into stem cells and how the blood system is “fine-tuned” in response to stressors. This new understanding of exactly how microbes signal to the stem cells has important implications for the treatment of infections and many diseases that have an inflammatory component, including cancer. “The longer term impact could be significant in terms of how stem cell growth and development can be manipulated therapeutically. There … Continue reading
Posted in Cell Medicine
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