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Archives
Monthly Archives: May 2012
Stem Cell Operation Attempts To Heal Corneal Blindness
Posted: Published on May 24th, 2012
May 22, 2012 Connie K. Ho for RedOrbit.com Scottish specialists were recently able to transplant stem cells into the eyes of two corneal blindness patients in an attempt to restore their sight. Doctors will be able to know the effects of the procedure within a few months. It is thought to be the first treatment of its kind in the United Kingdom. The operation, corneal epithelial stem cell transplantation, is part of a new group of regenerative therapies. Stem cells are grown from deceased donors and transplanted to the patients cornea. Before the transplant occurs, scarred and damaged parts of the cornea are taken out. If proves to be successful, we could see many more people benefit as a result, stated Scotlands Health Secretary Nicola in a BBC article. The first person to receive the surgery was Sylvia Paton, a 50-year-old short-sighted female from Edinburgh. My vision is deteriorating as I get older, much the same as other peoples. However, I already only have around 10% of the vision of sighted people. Until now theres really nothing that could be done to combat the effects of this type of blindness, stated Paton in an article by the Independent. Paton suffers … Continue reading
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Stem-cell-growing surface enables bone repair
Posted: Published on May 24th, 2012
ScienceDaily (May 23, 2012) University of Michigan researchers have proven that a special surface, free of biological contaminants, allows adult-derived stem cells to thrive and transform into multiple cell types. Their success brings stem cell therapies another step closer. To prove the cells' regenerative powers, bone cells grown on this surface were then transplanted into holes in the skulls of mice, producing four times as much new bone growth as in the mice without the extra bone cells. An embryo's cells really can be anything they want to be when they grow up: organs, nerves, skin, bone, any type of human cell. Adult-derived "induced" stem cells can do this and better. Because the source cells can come from the patient, they are perfectly compatible for medical treatments. In order to make them, Paul Krebsbach, a professor of biological and materials sciences in the School of Dentistry, said, "We turn back the clock, in a way. We're taking a specialized adult cell and genetically reprogramming it, so it behaves like a more primitive cell." Specifically, they turn human skin cells into stem cells. Less than five years after the discovery of this method, researchers still don't know precisely how it works, … Continue reading
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Prochymal – First Stem Cell Drug Approved
Posted: Published on May 24th, 2012
Editor's Choice Main Category: Bones / Orthopedics Also Included In: Stem Cell Research Article Date: 22 May 2012 - 12:00 PDT Current ratings for: 'Prochymal - First Stem Cell Drug Approved' 4.5 (2 votes) Prochymal (remestemcel-L) is also the first drug to be approved for the treatment of acute graft-vs-host disease (GvHD) in children, a devastating complication of bone marrow transplantation that kills almost 80% of all affected children, many of which just weeks after they have been diagnosed. GvHD is the leading cause of transplant-related mortality, caused by an immunologic attack. Severe GvHD can cause blistering of the skin, intestinal hemorrhage and liver failure and is extremely painful with a death rate of up to 80%. At present, the first-line standard therapies for GvHD are steroids. Given that the success rate of steroids is only 30 to 50%, the only other therapy if steroids fail is limited to immunosuppressive agents that are used off-label with little benefit and significant toxicities. Until the approval of Prochymal, there has not been any other therapy for GvHD. Osiris Therapeutics Inc. was awarded authorization for Prochymal under Health Canada's Notice of Compliance with conditions (NOC/c). A NOC/c is an authorization to market a … Continue reading
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Stem cell treatment for heart failure takes small step forward
Posted: Published on May 24th, 2012
Researchers at the Technion-Israel Institute of Technology in Haifa, Israel, reported Tuesday that they had removed skin cells from two patents with heart failure, returned those cells to an embryonic state, and then transformed them into beating heart cells that could communicate with the patients existing heart tissue. We have shown that it is possible to take skin cells from an elderly patient with advanced heart failure and end up with his own beating cells in a laboratory dish that are healthy and young the equivalent to this stage of his heart cells when he was just born, study leader Dr. Lior Gepstein said in a statement. The discovery marks a small step toward a long-sought goal: using stem cells to regrow the cardiac tissue that is damaged in heart attacks. (The Times reported on the quest in February, 2011.) But it doesnt mean that patients with heart failure are likely to get shiny new hearts through stem cell treatments anytime soon. Several hurdles stand in the way of using induced pluripotent stem cells, as the skin-derived cells are called, to reverse heart attack damage. The Israeli researchers acknowledged several. Such cells are known to spin out of control and … Continue reading
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Bentsen Stroke Center Awards Grants for Regenerative Medicine Research
Posted: Published on May 21st, 2012
Newswise Every year, approximately 795,000 people in the United States suffer a stroke and the late U.S. Senator and Democratic Party vice presidential candidate Lloyd Bentsen was one of them. As the senator and his wife, B. A., dealt with the challenges of stroke, they developed the idea for a stroke research center. The couples efforts led to the 2009 opening of the Senator Lloyd and B.A. Bentsen Center for Stroke Research at The Brown Foundation Institute of Molecular Medicine for the Prevention of Human Diseases (IMM), a part of The University of Texas Health Science Center at Houston (UTHealth). Sen. Bentsen died prior to the centers opening. In April at the IMM, B.A. Bentsen and one of the couples sons, Lan, got updates on six projects funded by the stroke center. The center was launched with a generous gift from the Bentsen family and the center distributes up to $1 million annually for research. The primary focus of the Bentsen Stroke Center is to develop cell-based therapeutics, including the use of certain populations of stem cells, to reduce secondary brain injury and enhance recovery, said Brian R. Davis, Ph.D., interim director of Center for Stem Cell and Regenerative Medicine … Continue reading
Posted in Mesenchymal Stem Cells
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Frozen cord could save a life
Posted: Published on May 21st, 2012
Tim and Padma Vellaichamy of Parramatta have had their new born child's umbilical cord stored cryogenically for future treatment. Pictured with their as yet unnamed three week old daughter. Picture: Adam Ward Source: The Daily Telegraph IT'S current preservation for future regeneration - and now umbilical cord tissue is going on ice in Australia for the first time. Usually discarded after birth, umbilical tissue from newborn babies is being collected and cryogenically frozen to be used one day for regenerative and stem cell medicine. And it doesn't just have potential for the babies involved, either. Experts say stem cells could also be used for family members who are genetically compatible. It is hoped the cells will eventually be able to be used to repair damaged tissues and organs, with researchers investigating its uses for treating diseases like multiple sclerosis, cerebral palsy and diabetes, as well as for bone and cartilage repair. Although cord blood storage has been available for many years, Cell Care Australia has added cord tissue storage in anticipation of new discoveries in the regenerative medicine field. Cell Care Australia medical director associate professor Mark Kirkland said the storage process - already popular in the US, Europe and … Continue reading
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Biostem U.S., Corporation Adds Jeanne Ann Lumadue, MD, PhD, MBA to Its Scientific and Medical Board of Advisors
Posted: Published on May 21st, 2012
CLEARWATER, FL--(Marketwire -05/21/12)- Biostem U.S., Corporation, (HAIR.PK) (HAIR.PK) (Biostem, the Company), a fully reporting public company in the stem cell regenerative medicine sciences sector, today announced that Jeanne Ann Lumadue, MD, PhD, MBA, has been appointed to its Scientific and Medical Board of Advisors (SAMBA). Dr. Lumadue currently is Medical Director at the Mount Nittany Physician Group Laboratory in State College, PA. She also serves as Medical Director of the Central Pennsylvania Blood Bank and is a member of the medical staff of the Mount Nittany Medical Center, all in State College. Dr. Lumadue stated, "Biostem's international technology development and licensing approach is well planned. Stem cell regenerative medicine is a rapidly expanding field that has the potential to affect every human being in a positive way. I am delighted to be part of this highly promising company." Biostem CEO Dwight Brunoehler said, "I am thrilled for the opportunity to work with Jeanne again. She is an innovative thinker, a tireless contributor, and a great team player." Dr. Lumadue received her undergraduate degree magna cum laude from the Pennsylvania State University and her PhD in Genetics from Yale University. She received an MD degree from the Johns Hopkins University in … Continue reading
Posted in Mesenchymal Stem Cells
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Stem cell medicine thrown umbilical rope
Posted: Published on May 21st, 2012
Tim and Padma Vellaichamy of Parramatta have had their new born child's umbilical cord stored cryogenically for future treatment. Pictured with their as yet unnamed three week old daughter. Picture: Adam Ward Source: The Daily Telegraph IT'S current preservation for the future regeneration - and now umbilical cord tissue is going on ice in Australia for the first time. Usually discarded after birth, umbilical tissue from newborn babies is being collected and cryogenically frozen to be used one day for regenerative and stem cell medicine. And it doesn't just have potential for the babies involved, either. Experts say stem cells could also be used for family members who are genetically compatible. It is hoped the cells will eventually be able to be used to repair damaged tissues and organs, with researchers investigating its uses for treating diseases like multiple sclerosis, cerebral palsy and diabetes, as well as for bone and cartilage repair. Although cord blood storage has been available for many years, Cell Care Australia has added cord tissue storage in anticipation of new discoveries in the regenerative medicine field. Cell Care Australia medical director associate professor Mark Kirkland said the storage process - already popular in the US, Europe … Continue reading
Posted in Mesenchymal Stem Cells
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Family hangs hope on stem cells
Posted: Published on May 21st, 2012
Indian clinic's stem cell therapy real? STORY HIGHLIGHTS For more of CNN correspondent Drew Griffin's investigation of India's experimental embryonic stem cell therapy, watch "CNN Presents: Selling a Miracle," at 8 and 11 p.m. ET Sunday on CNN. New Delhi (CNN) -- Cash Burnaman, a 6-year-old South Carolina boy, has traveled with his parents to India seeking treatment for a rare genetic condition that has left him developmentally disabled. You might think this was a hopeful mission until you learn that an overwhelming number of medical experts insist the treatment will have zero effect. Cash is mute. He walks with the aid of braces. To battle his incurable condition, which is so rare it doesn't have a name, Cash has had to take an artificial growth hormone for most of his life. His divorced parents, Josh Burnaman and Stephanie Krolick, are so driven by their hope and desperation to help Cash they've journeyed to the other side of the globe and paid tens of thousands of dollars to have Cash undergo experimental injections of human embryonic stem cells. The family is among a growing number of Americans seeking the treatment in India -- some at a clinic in the heart … Continue reading
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UTHealth Pediatric Surgery Expands Regenerative Medicine Program
Posted: Published on May 21st, 2012
Newswise About 3 percent of the babies born in the United States have a birth defect. Children without a birth defect are also susceptible to injury or disease. At The University of Texas Health Science Center at Houston (UTHealth), regenerative medicine researchers are exploring innovative ways to treat these conditions. The Department of Pediatric Surgery at the UTHealth Medical School operates a research program devoted to childhood conditions that is seeking to harness the bodys regenerative powers to repair malformed organs and to mitigate injury from illness or trauma. It is called the Childrens Regenerative Medicine Program. Kevin Lally, M.D., chairman of the Department of Pediatric Surgery at the UTHealth Medical School and surgeon-in-chief at Children's Memorial Hermann Hospital, announced the recruitment of four stem cell scientists to the program. The researchers are associate professor Yong Li, M.D., Ph.D., and assistant professors Scott Olson, Ph.D., Fabio Triolo, M.Phil., D.d.R., Ph.D., and Pamela Wenzel, Ph.D. We were able to recruit outstanding investigators thanks in part to the generous support of Mrs. Clare Glassell and Mrs. Evelyn Griffin, said Lally, who is the A.G. McNeese Chair in Pediatric Surgery and the Richard Andrassy, M.D., Endowed Distinguished Professor at UTHealth. Our program in … Continue reading
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