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Monthly Archives: July 2012
Modeling of new enzymes helps develop therapies for cocaine abuse
Posted: Published on July 27th, 2012
ScienceDaily (July 26, 2012) Researchers from the University of Kentucky have designed and discovered a series of highly efficient enzymes that effectively metabolize cocaine. These high-activity cocaine-metabolizing enzymes could potentially prevent cocaine from producing physiological effects, and could aid in the treatment of drug dependency. The results of this study by Chang-Guo Zhan et al are published in the journal PLOS Computational Biology. The effectiveness of the enzymes' work was evaluated through modeling cocaine pharmacokinetics, the study of the body's action on administered external substances, such as cocaine, when the enzyme exists in the body. As there is no FDA-approved anti-cocaine medication, the medical and social consequences of cocaine abuse have made the development of anti-cocaine medication a high priority. Administration of an enzyme to enhance cocaine metabolism has been recognized as a promising treatment strategy for overdose and abuse. A remarkable feature of the enzyme-based therapeutic approach is that one enzyme molecule can degrade many thousands of drug molecules per minute. This pharmacokinetic modelling is a crucial step of enzyme-based therapy development for cocaine abuse. Furthermore, the general insights of the research should also be valuable for future development of an enzyme therapy for any addictive drug, as the … Continue reading
Posted in Drug Dependency
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The modeling of new enzymes helps develop therapies for cocaine abuse
Posted: Published on July 27th, 2012
Researchers from the University of Kentucky have designed and discovered a series of highly efficient enzymes that effectively metabolize cocaine. These high-activity cocaine-metabolizing enzymes could potentially prevent cocaine from producing physiological effects, and could aid in the treatment of drug dependency. The results of this study by Chang-Guo Zhan et al are published in the journal PLOS Computational Biology. The effectiveness of the enzymes' work was evaluated through modeling cocaine pharmacokinetics, the study of the body's action on administered external substances, such as cocaine, when the enzyme exists in the body. As there is no FDA-approved anti-cocaine medication, the medical and social consequences of cocaine abuse have made the development of anti-cocaine medication a high priority. Administration of an enzyme to enhance cocaine metabolism has been recognized as a promising treatment strategy for overdose and abuse. A remarkable feature of the enzyme-based therapeutic approach is that one enzyme molecule can degrade many thousands of drug molecules per minute. This pharmacokinetic modelling is a crucial step of enzyme-based therapy development for cocaine abuse. Furthermore, the general insights of the research should also be valuable for future development of an enzyme therapy for any addictive drug, as the general methodology of the … Continue reading
Posted in Drug Dependency
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90 Arrests in War on Synthetic Drugs
Posted: Published on July 27th, 2012
Jul 26, 2012 6:41pm Credit: The US Drug Enforcement Agency Less than a month after President Obama banned the sale, production, and possession of synthetic drugs known as bath salts, the Drug Enforcement Agency announced today that it has made 90 arrests in a nationwide synthetic drug takedown. Law enforcement agents also seized $36 million in cash and 19 million packets of synthetic drugs, including bath salts (a powder hallucinogen) and spice (also known as fake marijuana), the agency said. The DEA collaborated with Immigration and Customs Enforcement and several other federal, state, and local law enforcement agencies in a project called Operation Log Jam. This enforcement action has disrupted the entire illegal industry, from manufacturers to retailers, said DEA administrator Michele Leonhart. The largest number of arrests were in Albuquerque, but the most significant synthetic drug activity was in Tampa, DEA spokeswoman Barbara Cerrano told ABCNews.com. Part of Operation Log Jam included serving search warrants to gather evidence in addition to the arrests, she said. The criminal organizations behind the importation, distribution and selling of these synthetic drugs have scant regard for human life in their reckless pursuit of illicit profits, said James Chaparro, the Acting Director of ICEs … Continue reading
Posted in Drugs
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Propecia Online Pharmacy Canada
Posted: Published on July 27th, 2012
Viernes 16 de Abril de 2010 10:01 CAROLINA (CyberNews) - La primera dama, Luc Vela de Fortuo, sobrina nieta de Jess T. Piero, inaugur el jueves las nuevas facilidades de lo que ser la Sala Jess T. Piero en la Universidad del Este en Carolina donde el estudiantado y el pblico en general podrn estudiar y disfrutar sobre la vida y obra del ilustre gobernador. A la actividad, donde se conmemor el 113 Aniversario del Natalicio de Jess T. Piero asisti su hijo Jos Emilio Piero, miembros de la familia Piero y de la familia Vela, allegados de la familia, lderes polticos, el presidente de Sistema Ana G. Mndez, Jos Mndez, el licenciado Alberto Maldonado, Rector de la UNE, entre otros representantes y profesores de la mencionada Institucin Universitaria. Actualmente la mencionada institucin educativa posee por designacin de la familia Piero los recuerdos y escritos personales del ex gobernador con el propsito de mantener vivo su legado es que se construye la sala que lleva su nombre. Adicional a la ceremonia de inauguracin se presentaron cortometrajes y fotografas recopiladas por el propio ex gobernador en los tiempos en que estuvo inmerso en la poltica de la isla. El material, el … Continue reading
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Pharmacy owner grabs gun, chases down robbery suspect in Southwest Portland
Posted: Published on July 27th, 2012
The owner of a pharmacy in downtown Portland chased a robber down the street with a gun, apprehending him with the help of an employee until police arrived. The suspect, who was not identified, was arrested by Portland police. Hell be questioned by detectives and then booked into Multnomah County Jail, said Sgt. Pete Simpson, spokesman for Portland police. The man walked into Central Drug Pharmacy at 538 S.W. Fourth Ave. just after 1 p.m., said he had a gun and would use it if the staff didn't give him drugs and cash. The stores owner, longtime pharmacist Gary Lundgren, gave the man a few bottle of pills and the suspect fled. Lundgren did not give the man what he wanted, Simpson said. "He wanted opiates. The owner gave him something else to get rid of him." As soon as the man left, Lundgren grabbed his own gun and with a pharmacy technician chased the man down. They held him at Southwest Fourth Avenue and Yamhill Street until police arrived and took him into custody. Lundgren keeps a gun in his store for protection, said his lawyer Steven Ungar. "He does need to protect himself and his business, and the … Continue reading
Posted in Pharmacy
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WV Man with Muscular Dystrophy Struggles Due to State Laws
Posted: Published on July 27th, 2012
WESTOVER - Josh Hancock and his mother moved to West Virginia to be closer to family. What they never expected is that living here would prevent Josh from getting the very specific care he needs. Recently, his mother suffered a back injury leaving Josh without his main caregiver and the Hancock's wondering, what now? "She's taken care of me since I was born basically and I just was thinking, what's going to happen to me?" questioned Hancock. Hancock, 38, has Duchenne muscular dystrophy. He uses a ventilator with a tracheotomy to breathe 24 hours a day. His mother's back injury a few weeks ago has forced the Hancock's to find alternative ways Josh can be taken care of. "There were no nursing homes in West Virginia that provide care for someone with a ventilator," he explained. While his mother was in the hospital, Josh's sister and three children helped care for him. Continue reading here: WV Man with Muscular Dystrophy Struggles Due to State Laws … Continue reading
Posted in Muscular Dystrophy Treatment
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CareZone announces freebie for epilepsy care cases
Posted: Published on July 27th, 2012
Jonathan Schwartz's startup announces a third partnership, part of an effort to promote his company, gain insight into patient needs, and of course attract subscribers. Jonathan Schwartz CareZone, a startup for organizing and sharing personal information, announced a promotion that grants free access to those with a family member with epilepsy. Chief Executive Jonathan Schwartz, who previously led Sun Microsystems, said a partnership with the Epilepsy Foundation will match what CareZone has done with groups dealing with autism and Parkinson's disease. (For a look at the executive and his views on Oracle, Apple, Amazon, and Intel, check CNET's accompanying Q&A with Schwartz.) Schwartz hopes CareZone will catch on as a way to let people privately share information such as instructions for babysitters, emergency lists of online banking passwords for family members, medication schedules, and treatment records from doctors and pharmacies. It'll cost $5 per month or $48 per year per person being monitored, but for now the service is free during an introductory period and for cases where a person has a particular affliction. Schwartz clearly enjoys the idea of a startup that helps people. What he's concerned about, he says, is "how do I help you connect with your … Continue reading
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Winthrop Designated A Level 4 Epilepsy Center
Posted: Published on July 27th, 2012
Members of Winthrops Comprehensive Epilepsy Center Team celebrate their designation as a Level 4 Epilepsy Center with members of Winthrops Administration Patients living with epilepsy, a complex seizure disorder, face many challenges. Characterized by disabling seizures triggered by abnormal electrical activity in the brain cells, the disease can manifest itself through a range of symptoms from minor physical signs and thought disturbances to traumatic physical convulsions. Several types of seizures are easy to control, and many patients are well enough between episodes to lead normal lives. However, about 30% of the estimated 3 million Americans with epilepsy suffer with persistent seizures. In an outstanding validation of its commitment to improving the lives of patients with epilepsy, The Winthrop Comprehensive Epilepsy Center was recently recognized by the National Association of Epilepsy Centers (NAEC) as a Level 4 Epilepsy Center. Level 4 Epilepsy Centers have the professional expertise and facilities to provide the highest level medical and surgical evaluation and treatment for patients with complex epilepsy. This outstanding achievement is a testament to Winthrops dedicated team of epilepsy physicians - Dr. Alan Ettinger, Dr. David Friedman, Dr. Brian Snyder, Dr. Shicong Ye, Dr. Neil Schaul, Dr. Dmitriy Kolesnik, Dr. Vijaya Alturu and … Continue reading
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Autism program expands to meet growing need in West Metro
Posted: Published on July 27th, 2012
MINNETONKA, Minn. -St. David's Center in Minnetonka celebrated a grand opening on a new campus project on Thursday. The effort will renovate its Children's Mental Health Clinic and Autism Day Treatment Center. Staff unveiled autism treatment suites designed to accommodate more kids and their specific struggles. The project also relieves a year long waiting list for the autism day treatment program, where some children age out of the program before they ever have the chance to enroll. The renovation allows parents, like Krista Mullin, a closer look into her little boy's world. Through an observation window in a new autism treatment suite, she sees how her 5-year-old, Evan, has embraced his new environment. "He is your typical little boy, just with some challenges most kids don't have," said Mullin. "Things like paint color and calming colors are huge. We don't think about that, but the calming colors, lower lighting really helps the kids with their sensory sensitivities." Program Director Sarah Rehman said her students need area to both soothe and stimulate the senses. Before the construction, her students would have to travel throughout the building for occupational therapy and speech therapy. Now, their services are in one place, eliminating difficult … Continue reading
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FDA approves BrainsGate stroke treatment study
Posted: Published on July 27th, 2012
BrainsGate Ltd. has obtained US Food and Drug Administration (FDA) approval for the clinical trial protocols for a study that the company began in June 2011 on its ischemic stroke treatment. The clinical trial includes 176 patients at 57 medical centers around the world. The FDA approval means that the company can recruit patients for the trial in the US. BrainsGate's technology uses electrical neurostimulation of the Spheno-Palatine Ganglion (SPG), a nervous center known to increase cerebral blood flow. It is designed to treat ischemic strokes with 24 hours of an event. Current pharmaceutical treatments, which include tPA proteins, are permitted only within 3-4.5 hours of a stroke. BrainsGate expects to complete the trial on 450 patients in the fourth quarter of 2013. BrainsGate has raised $70 million to date. Investors include IDB Holding Corp. Ltd. (TASE:IDBH) unit Elron Electronic Industries Ltd. (TASE: ELRN), which owns 30% of the company, Johnson & Johnson (NYSE: JNJ) investment arm J&J Development Corporation, Boston Scientific Inc. (NYSE: BSX), Pitango Venture Capital, Infinity Private Equity, Agate Medical Investments LP, and Cipio Partners. The World Health Organization estimates the direct cost of ischemic strokes at $73.7 billion, and that 15 million worldwide suffer strokes every … Continue reading
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