Monthly Archives: January 2021

Mounting behavior, that awkward thrusting motion dogs sometimes do against your leg, is usually associated with sexual arousal in animals, but this is not always the case. New research by Caltech neuroscientists that explores the motivations behind mounting behavior in mice finds that sometimes there is a thin line between love and hate (or anger) in the mouse brain. Continue reading →

The Chandigarh-based premier tertiary care hospital, the Postgraduate Institute of Medical Education and Research (PGIMER), has said that its team of endoscopic skull-base surgeons have successfully removed a large brain tumour (craniopharyngioma) through the nose on the youngest-ever patient for such a surgery in the world. An official statement from PGIMER said the operation was conducted by team of surgeons, including Dr. Continue reading →

Representative Image Doctors at the Postgraduate Institute of Medical Education and Research (PGIMER) here have created history by operating on the world's youngest large brain tumour patient that was removed through the nose, it was announced on Thursday. The youngest child reported till date to have undergone endoscopic surgery through the nose for removal of such a tumour was two years old, operated on in 2019 in Stanford in the US, said a hospital press release. Continue reading →

Far too many people willingly accept whatever drivel is meted out to them as irrefutable facts. Sadly, its now become fairly common for charlatans, demented, misguided, or attention-seeking nuts to don farcical faades virtually and splash rubbish all across the Internet. Continue reading →

Tribune News Service Chandigarh, January 21 The PGI today successfully removed a large brain tumour through the nose of a one year and four months old girl child, who is said to be the youngest patient in the world to have such an endoscopic surgery. According to a press release, the girl from Uttarakhand was referred to the premier institute with complaints of loss of vision. Continue reading →

This article was originally published onWeedWeek, and appears here with permission. The cannabis plant offers so much to humanity high highs, good times, relief from pain, inflammation, and other ailments. Continue reading →

Introduction Reprogramming of the metabolic landscape is a hallmark of cancer cells.1 Transformed cells modulate metabolic pathways and nutrient uptake using various adaptation mechanisms to support tumor progression.2 In this regard, the polyamine metabolism is a central pathway hijacked by cancer cells.3,4 Polyamines are small aliphatic polycations biosynthesized from amino acids such as methionine and ornithine and are tightly regulated by de novo synthesis and diet.5 Polyamines play a crucial role in key cellular processes such as cell growth, cell proliferation, apoptosis, and gene regulation.6,7 Notably, polyamine levels are frequently dysregulated in multiple cancer types.3,4 Besides malignant transformation, elevated polyamines are essential for the developmental and compensatory growth of cancer cells in response to systemic stimuli like hormones.8 Elevated polyamine levels contribute to cancer progression by binding to nucleic acids, thereby controlling DNA replication, transcription, translation, and cell cycle progression.912 Dysregulation of polyamine metabolism is directly controlled by oncogenic signaling pathways, including RAS, PI3K, mTORC, and MYC genes.13 Specifically, MYC oncogenes upregulate the expression of ornithine decarboxylase (ODC), a pyridoxal phosphate-dependent enzyme. Continue reading →