Targeted exosome coating gene-chem nanocomplex as nanoscavenger for clearing -synuclein and immune activation of Parkinson’s disease – Science…

The most critical problem in the treatment of neurodegenerative diseases is brain neuronal protection, which can be overcome by clearing pathological substances and regulating the immune environment. In the above treatment strategies, the traditional poor drug delivery problem is inevitable. Here, we show an engineering core-shell hybrid system named rabies virus glycoprotein (RVG) peptidemodified exosome (EXO) curcumin/phenylboronic acid-poly(2-(dimethylamino)ethyl acrylate) nanoparticle/small interfering RNA targeting SNCA (REXO-C/ANP/S). It is a nanoscavenger for clearing -synuclein aggregates and reducing their cytotoxicity in Parkinsons disease neurons. The motor behavior of Parkinsons disease mice is substantially improved after REXO-C/ANP/S treatment. In particular, we demonstrate that REXO-C/ANP/S is also a nanoscavenger for clearing immune activation due to its natural immature dendritic cell EXO coating. Our findings show that REXO-C/ANP/S may serve as a platform for neurodegenerative diseases treatment.

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Targeted exosome coating gene-chem nanocomplex as nanoscavenger for clearing -synuclein and immune activation of Parkinson's disease - Science...