Brain injuries from blasts similar to football impacts

ScienceDaily (May 20, 2012) In an advance that may someday provide health benefits for soldiers and athletes, a team of researchers has discovered a mechanism that could be the cause of traumatic brain injuries (TBI) in blast-exposed soldiers.

The breakthrough study, published recently in the journal Science Translational Medicine, finds that the brain injuries suffered by soldiers from improvised explosive devices (IEDs) are due to the head rotation or motion from the blast wind.

The research team created a blast neurotrauma mouse model that controlled head motion during blast exposure. The study showed that the brain injuries observed in mice exposed to blasts -- equivalent to battlefield exposures -- are identical to the brain injuries suffered by soldiers from military blasts, such as IEDs, when the heads were allowed to move.

However, when the head motions were restrained, there were no brain injuries or other neurological effects in the mice.

The researchers also compared brain tissue samples from four soldiers with known blast exposure and/or concussive injury with brain tissue samples from three amateur American football players and a professional wrestler with histories of repetitive concussive injuries. In addition, they compared the brain tissue samples to those from a control group of four young men without a history of blast exposure, concussive injury or neurological disease.

The results showed that the brain damage in blast-exposed veterans is similar to the brain injuries observed in football players who have sustained repetitive concussive head injuries. This result is a significant finding because it demonstrates a common link between what has previously been believed to be two disparate injury mechanisms.

The three-year-long study, believed to be the first and only research effort that has clearly identified an injury mechanism from the direct effects of blasts, involved 35 researchers from 14 university research centers, medical schools, hospitals or other centers.

The research team was led by Lee Goldstein, a medical doctor and associate professor at Boston University School of Medicine (BUSM) and Boston University College of Engineering, and Ann McKee, a medical doctor, professor at BUSM and director of the Neuropathology Service for the Veterans Affairs New England Healthcare System. It included William Moss, a physicist in B Division at Lawrence Livermore National Laboratory.

In addition to Boston University, the Veterans Affairs Boston Healthcare System and LLNL, among the other institutions participating in the study were New York Medical College, Harvard Medical School, Massachusetts General Hospital, Emerson Hospital (Concord, Mass.), the Veteran Affairs Medical Center (White River Junction, Vt.), and the University of Massachusetts, Lowell.

As a co-author of the paper, Moss contributed to the sections describing the blast characteristics and the discussion leading to the conclusion that blast-induced head motion was the predominant brain injury mechanism. He also showed that the experimentally produced blast waves were similar -- in amplitude and duration -- to military exposures.

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Brain injuries from blasts similar to football impacts