Category Archives: Batten Disease Treatment

SHaRe is a multi-center, international repository of clinical and laboratory data on individuals and families with genetic heart disease developed as a collaboration with several world-leading cardiovascular centers. Continue reading →

Sunday2:00 pm - 9:00 pm Arrival and Check-in Dinner Introductory Comments by GRC Site Staff / Welcome from the GRC Chair Discussion Leader: Fred Grinnell (University of Texas Southwestern Medical Center, USA) Paul Martin (University of Bristol, United Kingdom) Discussion Sabine Werner (ETH Zurich, Switzerland) Discussion Breakfast Discussion Leader: Enrique Amaya (University of Manchester, United Kingdom) Introduction by Discussion Leader Philipp Niethammer (Sloan-Kettering Institute, Memorial Sloan Kettering Cancer Center, USA) Discussion Brian Stramer (King's College London, United Kingdom) Discussion Short Talk Selected from Poster Abstracts Discussion Coffee Break Maximina Yun (Center for Regenerative Therapies Dresden, TU Dresden, Germany) Discussion Antonio Jacinto (CEDOC Chronic Diseases Research Centre, NOVA University Lisbon, Portugal) Discussion Short Talk Selected from Poster Abstracts Discussion Short Talk Selected from Poster Abstracts Discussion Lunch Free Time Organizers: Kimberly Mace (University of Manchester, United Kingdom) and Tanya Shaw (King's College London, United Kingdom) Poster Session Dinner Discussion Leader: Paul Martin (University of Bristol, United Kingdom) Michael Brand (Technische Universitt Dresden, Germany) Discussion Robin Franklin (University of Cambridge, United Kingdom) Discussion Short Talk Selected from Poster Abstracts Discussion Michael Galko (University of Texas MD Anderson Cancer Center, USA) Discussion Short Talk Selected from Poster Abstracts Discussion Breakfast Discussion Leader: Sabine Eming (University of Cologne, Germany) Introduction by Discussion Leader Luisa DiPietro (University of Illinois at Chicago, USA) Discussion Paul Kubes (University of Calgary, Canada) Discussion Group Photo / Coffee Break Short Talk Selected from Poster Abstracts Discussion Nadia Rosenthal (The Jackson Laboratory, USA) Discussion Traci Wilgus (Ohio State University, USA) Discussion Short Talk Selected from Poster Abstracts Discussion Short Talk Selected from Poster Abstracts Discussion Lunch Free Time Poster Session Dinner Discussion Leader: Samuel Leibovich (Rutgers New Jersey Medical School, USA) Introduction by Discussion Leader Marjana Tomic-Canic (Miller School of Medicine, University of Miami, USA) Discussion Michael Longaker (Stanford University, USA) Discussion Ellen Roche (Massachusetts Institute of Technology, USA) Discussion Short Talk Selected from Poster Abstracts Discussion Breakfast Discussion Leader: Boris Hinz (University of Toronto, Canada) Introduction by Discussion Leader Stuart Forbes (University of Edinburgh, United Kingdom) Discussion Abigail Tucker (King's College London, United Kingdom) Discussion Short Talk Selected from Poster Abstracts Discussion Coffee Break Paul Riley (University of Oxford, United Kingdom) Discussion Jeremy Duffield (University of Washington / Vertex Pharmaceuticals, USA) Discussion Short Talk Selected from Poster Abstracts Discussion Short Talk Selected from Poster Abstracts Discussion Lunch Free Time Poster Session Dinner Discussion Leader: Kimberly Mace (University of Manchester, United Kingdom) Introduction by Discussion Leader Valerie Horsley (Yale University, USA) Continue reading →

Cancer Conference2018Report: Magnus Group Successfully completed Cancer Conference2018"which was held inRome, Italy, duringSeptember 17-19, 2018. Continue reading →

Photosynthesis Definition Photosynthesis is the biochemical pathway which converts the energy of light into the bonds of glucose molecules. Continue reading →

Description Formula: C99H1529N2630O299S7 Human Growth hormone(HGH), also known assomatotropinorsomatropin, is apeptide hormonethat stimulatesgrowth,cellreproduction and regeneration in humans and other animals. It is a type ofmitogenwhich is specific only to certain kinds of cells. Continue reading →

Surgical procedure Radiofrequency ablation (RFA)[a] is a medical procedure in which part of the electrical conduction system of the heart, tumor or other dysfunctional tissue is ablated using the heat generated from medium frequency alternating current (in the range of 350500kHz).[2] RFA is generally conducted in the outpatient setting, using either local anesthetics or conscious sedation anesthesia. Continue reading →

Abnormalities may affect all aspects of the heart. The heart is a muscle, and as such, abnormalities of heart muscle may occur, including abnormal thickening, weakening of the squeezing strength, as well as stiffening of the muscle. The heart is an electrical organ, so arrhythmias (abnormalities of heart rhythm, and hence abnormality of the electrical system) may affect the top of the heart--relatively commonly--causing atrial fibrillation, for example, while arrhythmias of the bottom chambers of the heart can be more risky, causing ventricular tachycardia or fibrillation Continue reading →

What Are the Risk Factors for Heart Disease? Risk factors are conditions or habits that make a person more likely to develop a disease. They can also increase the chances that an existing disease will get worse Continue reading →

Heart arrhythmiaSynonymsCardiac arrhythmia, cardiac dysrhythmia, irregular heartbeatVentricular fibrillation (VF) showing disorganized electrical activity producing a spiked tracing on an electrocardiogram (ECG).SpecialtyCardiologySymptomsPalpitations, lightheadedness, passing out, shortness of breath, chest pain[1]ComplicationsStroke, heart failure[2][3]Usual onsetOlder age[4]TypesExtra beats, supraventricular tachycardias, ventricular arrhythmias, bradyarrhythmias[3]CausesProblems with the electrical conduction system of the heart[2]Diagnostic methodElectrocardiogram, Holter monitor[5]TreatmentMedications, medical procedures (pacemaker), surgery[6]FrequencyMillions[4] Heart arrhythmia (also known as arrhythmia, dysrhythmia, or irregular heartbeat) is a group of conditions in which the heartbeat is irregular, too fast, or too slow.[2] A heart rate that is too fast above 100 beats per minute in adults is called tachycardia and a heart rate that is too slow below 60 beats per minute is called bradycardia.[2] Many types of arrhythmia have no symptoms.[1] When symptoms are present these may include palpitations or feeling a pause between heartbeats.[1] In more serious cases there may be lightheadedness, passing out, shortness of breath, or chest pain.[1] While most types of arrhythmia are not serious, some predispose a person to complications such as stroke or heart failure.[2][3] Others may result in cardiac arrest.[3] There are four main types of arrhythmia: extra beats, supraventricular tachycardias, ventricular arrhythmias, and bradyarrhythmias.[3] Extra beats include premature atrial contractions, premature ventricular contractions, and premature junctional contractions.[3] Supraventricular tachycardias include atrial fibrillation, atrial flutter, and paroxysmal supraventricular tachycardia.[3] Ventricular arrhythmias include ventricular fibrillation and ventricular tachycardia.[3][7] Arrhythmias are due to problems with the electrical conduction system of the heart.[2] Arrhythmias may occur in children; however, the normal range for the heart rate is different and depends on age.[3] A number of tests can help with diagnosis including an electrocardiogram (ECG) and Holter monitor.[5] Most arrhythmias can be effectively treated.[2] Treatments may include medications, medical procedures such as inserting a pacemaker, and surgery.[6] Medications for a fast heart rate may include beta blockers or agents that attempt to restore a normal heart rhythm such as procainamide.[6] This latter group may have more significant side effects especially if taken for a long period of time.[6] Pacemakers are often used for slow heart rates.[6] Those with an irregular heartbeat are often treated with blood thinners to reduce the risk of complications.[6] Those who have severe symptoms from an arrhythmia may receive urgent treatment with a controlled electric shock in the form of cardioversion or defibrillation.[6] Arrhythmia affects millions of people.[4] In Europe and North America, as of 2014, atrial fibrillation affects about 2% to 3% of the population.[8] Atrial fibrillation and atrial flutter resulted in 112,000 deaths in 2013, up from 29,000 in 1990.[9] Sudden cardiac death is the cause of about half of deaths due to cardiovascular disease or about 15% of all deaths globally.[10] About 80% of sudden cardiac death is the result of ventricular arrhythmias.[10] Arrhythmias may occur at any age but are more common among older people.[4] Arrhythmia may be classified by rate (tachycardia, bradycardia), mechanism (automaticity, re-entry, triggered) or duration (isolated premature beats; couplets; runs, that is 3 or more beats; non-sustained= less than 30 seconds or sustained= over 30 seconds). Continue reading →

Cardiac arrestSynonymsCardiopulmonary arrest, circulatory arrest, sudden cardiac arrest (SCA), sudden cardiac death (SCD)[1]CPR being administered during a simulation of cardiac arrest.SpecialtyCardiologySymptomsLoss of consciousness, abnormal or no breathing[1][2]Usual onsetOlder age[3]CausesCoronary artery disease, major blood loss, lack of oxygen, very low potassium, heart failure[4]Diagnostic methodFinding no pulse[1]PreventionNot smoking, physical activity, maintaining a healthy weight[5]TreatmentCardiopulmonary resuscitation (CPR), defibrillation[6]PrognosisAverage survival 8%[7]Frequency13 per 10,000 people per year (outside hospital in the US)[8] Cardiac arrest is a sudden loss of blood flow resulting from the failure of the heart to effectively pump.[9] Symptoms include loss of consciousness and abnormal or absent breathing.[1][2] Some individuals may experience chest pain, shortness of breath, or nausea before cardiac arrest.[2] If not treated within minutes, it typically leads to death.[9] The most common cause of cardiac arrest is coronary artery disease.[4] Less common causes include major blood loss, lack of oxygen, very low potassium, heart failure, and intense physical exercise.[4] A number of inherited disorders may also increase the risk including long QT syndrome.[4] The initial heart rhythm is most often ventricular fibrillation.[4] The diagnosis is confirmed by finding no pulse.[1] While a cardiac arrest may be caused by heart attack or heart failure, these are not the same.[9] Prevention includes not smoking, physical activity, and maintaining a healthy weight.[5] Treatment for cardiac arrest includes immediate cardiopulmonary resuscitation (CPR) and, if a shockable rhythm is present, defibrillation.[6] Among those who survive, targeted temperature management may improve outcomes.[10][11] An implantable cardiac defibrillator may be placed to reduce the chance of death from recurrence.[5] In the United States, cardiac arrest outside hospital occurs in about 13 per 10,000 people per year (326,000 cases).[8] In hospital cardiac arrest occurs in an additional 209,000.[8] Cardiac arrest becomes more common with age.[3] It affects males more often than females.[3] The percentage of people who survive with treatment is about 8%.[7] Many who survive have significant disability.[7] However, many American television programs have portrayed unrealistically high survival rates of 67%.[7] Cardiac arrest is preceded by no warning symptoms in approximately 50 percent of people.[12] For those who do experience symptoms, they will be non-specific, such as new or worsening chest pain, fatigue, blackouts, dizziness, shortness of breath, weakness and vomiting.[13] When cardiac arrest occurs, the most obvious sign of its occurrence will be the lack of a palpable pulse in the victim. Continue reading →