Category Archives: BioInformatics

See Inside The torrents of data flowing out of cancer research and treatment are yielding fresh insight into the disease BRENDAN MONROE In 2013, geneticist Stephen Elledge answered a question that had puzzled cancer researchers for nearly 100 years. In 1914, German biologist Theodor Boveri suggested that the abnormal number of chromosomes called aneuploidy seen in cancers might drive the growth of tumours. For most of the next century, researchers made little progress on the matter. They knew that cancers often have extra or missing chromosomes or pieces of chromosomes, but they did not know whether this was important or simply a by-product of tumour growth and they had no way of finding out. People had ignored it for a long time, primarily because it's really hard to understand, says Elledge, of Brigham and Women's Hospital in Boston, Massachusetts. What we didn't know before is that it's actually driving cancer. Elledge found that where aneuploidy had resulted in missing tumour-suppressor genes, or extra copies of the oncogenes that promote cancer, tumours grow more aggressively (T. Davoli et al. Cell 155, 948962; 2013). His insight that aneuploidy is not merely an odd feature of tumours, but an engine of their growth … Continue reading →

Mark Guyer has retired from his post as deputy director of the National Human Genome Research Institute. Guyer joined the Office of Human Genome Research, the institute's precursor, in 1998, and he helped guide NHGRI's research activities from the earliest days of the Human Genome Project. He became director of the NHGRI Division of Extramural Research, now the Extramural Research Program, and he has had a hand in establishing programs such as the 1,000 Genomes Project; the Large-Scale Genome Sequencing and Analysis Centers; the Ethical, Legal and Social Implications research program; and The Cancer Genome Atlas project, among others. Omicia has appointed Heidi Rehm, Geoffrey Ginsberg, Thomas Quertermous, and Mark Yandell to its scientific advisory board. Rehm is director of the Laboratory for Molecular Medicine at Partners Healthcare Personalized Medicine and associate professor of pathology at Harvard Medical School. Ginsberg is director of genomic medicine at the Duke Institute for Genome Sciences & Policy, executive director of Duke's Center for Personalized Medicine and Precision, and a professor of medicine and biomedical engineering. Quertermous is the William G. Irwin professor of medicine and director of research for the division of cardiovascular medicine at Stanford University. Yandell is co-director of the University … Continue reading →

Bioinformatics Core Description This tool recursively align sequenced files to any number of index files in given order. When the sequenceces are aligned to an index file, the r... By: biocore.umassmed.edu … Continue reading →

Released: 5-Jul-2014 9:00 AM EDT Embargo expired: 7-Jul-2014 3:00 PM EDT Source Newsroom: Virginia Tech Contact Information Available for logged-in reporters only Newswise Scientists have long puzzled over the genetic differences between fruit flies that live hardly a puddle jump apart in a natural environment known as Evolution Canyon in Mount Carmel, Israel. Now, an international team of researchers led by scientists with the Virginia Bioinformatics Institute at Virginia Tech has peered into the DNA of these closely related flies to discover how these animals have been able to adapt and survive in such close, but extremely different, ecologies. One reason lies in a startling abundance of repetitive DNA elements that, until recently, were considered little more than unused letters in a word game. The explanation will be published this week in the Proceedings of the National Academy of Sciences. Weve come to understand that not all repeat sequences are junk DNA, said Pawel Michalak, an associate professor at the Virginia Bioinformatics Institute. These repetitive sequences are increasingly being recognized as agents of adaptive change. We discovered a larger than expected amount of genetic variation in these repeating sequences between the fly populations and saw that the variation resulted in … Continue reading →

Bioinformatics Minnesota | MNI Solutions Slow Motion Blue Flare Bioinformatics Minnesota | MNI Solutions. By: Rocky Borchardt … Continue reading →

RubyConfTW2014-TseChing Ho-Ruby on Bioinformatics By: Taiwan RubyConf … Continue reading →

Omicia has appointed Heidi Rehm, Geoffrey Ginsberg, Thomas Quertermous, and Mark Yandell to its scientific advisory board. Rehm is director of the Laboratory for Molecular Medicine at Partners Healthcare Personalized Medicine and associate professor of pathology at Harvard Medical School. Ginsberg is director of genomic medicine at the Duke Institute for Genome Sciences & Policy, executive director of Duke's Center for Personalized Medicine and Precision, and a professor of medicine and biomedical engineering. Quertermous is the William G. Irwin professor of medicine and director of research for the division of cardiovascular medicine at Stanford University. Yandell is co-director of the University of Utah's USTAR Center for Genetic Discovery and a professor of human genetics, and a co-inventor of Omicia's VAAST and Phevor algorithms. Adaptive Biotechnologies has tapped Dean Schorno to be chief financial officer. Schorno held leadership positions at Genomic Health over a 13-year period, including most recently as CFO, where he helped manage the launch and operations of the company's clinical lab. Cepheid said this week that it has appointed Peter Farrell as executive vice president of international commercial operations. He replaces Philippe Jacon, who the company had named head of worldwide commercial operations in January. Jacon is transitioning … Continue reading →

LSM2241, Introductory Bioinformatics at NUS About LSM2241: Introductory Bioinformatics, at the National University of Singapore Table of Contents: 00:00 - Intro 00:31 - About bioinformatics 01:31 - Top... By: Greg Tucker-Kellogg … Continue reading →

Bioinformatics practical 23 motif scan tool to identify known domains in protein sequence This bioinformatics tutorial explains use of motif scan tool to identify known domains in protein sequence. For more information, log on to- http://shomusbio... By: Suman Bhattacharjee … Continue reading →

Bioinformatics How to find sequence 2 Following Video of Video 1 (Bioinformatics How to find sequence 1) By: Atai Rabby … Continue reading →