Category Archives: Cardiac Regeneration

Cell Biosci 2018 23;8:32. Epub 2018 Apr 23. Continue reading →

Cardiac muscle (also called heart muscle or myocardium) is one of three types of vertebrate muscles, with the other two being skeletal and smooth muscles. Continue reading →

Rapid cell regeneration (also referred to as "rapid cellular regeneration", "spontaneous regeneration", "tissue regeneration", "epithelial cell regeneration", or simply "regeneration" or "healing") is the ability to regenerate cells at an increased rate, resulting in physical injuries healing in a matter of seconds or minutes. Continue reading →

More About Zebrafish Heart Regeneration When the zebrafish heart is damaged, the wound site is rapidly sealed with a fibrin clot that stems bleeding within seconds. Continue reading →

Reparative stem cells have the capability to restore function to damaged tissue by renewing cell growth (shown in green) in cardiac cells destroyed by heart disease. Approximately 28 million Americans have been diagnosed with heart disease. Traditional medical therapies are not able to fully address the burden of disease, and the shortage of organs for transplantation remains a key barrier more than 117,000 people are on the national transplant list Continue reading →

Cardiac Regeneration and Repair, Volume One reviews the pathology of cardiac injury and the latest advances in cell therapy. Chapters in part one explore the pathogenesis of congestive heart failure, the mechanisms responsible for adverse cardiac matrix remodeling, and potential interventions to restore ventricular function. Part two highlights new approaches to cell therapy for cardiac regeneration, and includes chapters covering alternative routes of cell delivery, monitoring cell engraftment, and the feasibility of using allogeneic stem cells to restore cardiac function. Continue reading →

Achievements The achievement of Heart Regeneration Technologies is to refine low-energy regenerative shockwave therapy. Continue reading →

When I started my working life in a pediatric intensive care unit, I could not possibly have imagined that, 30 years later, I would be living through a phenomenal scientific revolution in which we are using mRNA to give the instructions a cell uses to make proteins. Even as recently as 2003, when the human genome was cloned and we were all brimming with curiosity about what it meant for DNA-based therapies, I do not think we realized that mRNA therapeutics would prove so attractive. The beauty of mRNA therapy is that it acts locally and transiently. Continue reading →

1.Sugimoto K, Hui SP, Sheng DZ, Kikuchi K. Dissection of zebrafish shha function using site-specific targeting with a Cre-dependent genetic switch.eLIFE DOI: 10.7554/eLife.24635 Continue reading →

Theme Leaders James Martin, M.D. Ph.D.Professor, Molecular PhysiologyResearch Interest - Hippo, Wnt, Bmp signaling in development, regeneration, heart disease Todd Rosengart, M.D., F.A.C.S.Chair/Professor, SurgeryResearch Interest - Cardiac regeneration, cardiac gene therapy, angiogenesis Members of Theme Six are developing stem cell and cellular reprogramming strategies to treat cardiovascular diseases such as infarction in situ. Continue reading →