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Category Archives: Femtomedicine

In Vitro and In Vivo Studies of a New Class of Anticancer …

Posted: Published on July 12th, 2016

There is a compelling need to develop anticancer therapies that target cancer cells and tissues. Arising from innovative femtomedicine studies, a new class of nonplatinum-based halogenated molecules (called FMD molecules) that selectively kill cancer cells and protect normal cells in treatments of multiple cancers has been discovered. This article reports the first observation of the radiosensitizing effects of such compounds in combination with ionizing radiation for targeted radiotherapy of a variety of cancers. We present in vitro and in vivo studies focused on combination with radiotherapy of cervical, ovarian, head and neck, and lung cancers. Our results demonstrate that treatments of various cancer cells in vitro and in vivo mouse xenograft models with such compounds led to enhanced efficiencies in radiotherapy, while the compounds themselves induced no or little radiotoxicity toward normal cells or tissues. These compounds are therefore effective radiosensitizers that can be translated into clinical trials for targeted radiotherapy of multiple types of cancer. This study also shows the potential of femtomedicine to bring breakthroughs in understanding fundamental biologic processes and to accelerate the discovery of novel drugs for effective treatment or prevention of a variety of cancers. Mol Cancer Ther; 15(4); 64050. 2016 AACR. See original here: … Continue reading

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Electron transfer-based combination therapy of cisplatin …

Posted: Published on July 12th, 2016

Electron-transfer reactions play key roles in diverse processes in chemistry, physics, and biology, ranging from photo-induced reactions (1, 2), electron tunneling in proteins (3), and electron transport in DNA (4) to the ozone hole formation (5) and reductive DNA damage (6, 7). Electron-transfer reactions in molecular systems have therefore been the subject of intense experimental and theoretical studies. Following the pioneering contribution of Zewail (8), the advent of femtosecond time-resolved laser spectroscopy (fs-TRLS; 1fs=10-15s) provided an unprecedented capacity in techniques of observing molecular reactions, including electron transfer. Its application to the study of chemical and biological systems led to the birth of new scientific subfields: femtochemistry and femtobiology (8). Recently, Lu (9) further proposed that integrating ultrafast laser techniques with biomedical methods to advance fundamental understandings and treatments of major human diseases might lead to the opening of a new frontier called femtomedicine. Regarding the latter, we have recently unraveled unique dissociative electron-transfer (DET) mechanisms of reductive DNA damage (6, 7) and several anticancer agents for radiotherapy and chemotherapy (1014). In this paper, we present results of experimental studies on a unique combination therapy based on the DET mechanism of cisplatin to enhance the efficacy of human ovarian-, cervical-, and … Continue reading

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Scientists discover new molecules that kill cancer cells …

Posted: Published on July 12th, 2016

Research in mice suggests molecules could treat cervical, breast, ovarian, and lung cancers A new family of molecules that kill cancer cells and protect healthy cells could be used to treat a number of different cancers, including cervical, breast, ovarian and lung cancers. Research published in EBioMedicine shows that as well as targeting and killing cancer cells, the molecules generate a protective effect against toxic chemicals in healthy cells. Cells can become cancerous when their DNA is damaged. Many different things can cause DNA damage, including smoking, chemicals and radiation; understanding exactly what happens at the point of DNA damage can help scientists develop new cancer treatments. By studying this mechanism, researchers from the University of Waterloo in Canada could identify new molecules that selectively target cancer cells. The researchers studied the process of DNA damage using a sort of molecular filming technique called femtosecond time-resolved laser spectroscopy. The technique is like a high-speed camera, which uses two pulses of light: one to start a reaction, and the other to monitor the way the molecules react. This technique let researchers watch how molecules interact in real-time, revealing how cells become cancerous. Researchers have been using femtosecond laser spectroscopy to study … Continue reading

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Femto Medicine | Mayo Clinic In The News

Posted: Published on September 9th, 2015

January 8th, 2015 Mayo Clinic in the News Weekly Highlights By Karl W Oestreich Mayo Clinic in the Newsis a weekly highlights summary of major media coverage. If you would like to be added to the weekly distribution list, send a note toLaura Wuotilawith this subject line: SUBSCRIBE toMayo Clinic in the News. Thank you. Karl Oestreich, manager enterprise media relations Wall Street JournalWhat CEOs Expect for Business in 2015by John Bussey We asked the 153 members of the Wall Street Journals CEO Council to tell uswhether theyre positive or negativeabout business prospects in 2015, and why. Heres what several had to say:John Noseworthy, Mayo Clinic, Disruptive technologies ranging from regenerative and genomic medicine to remote monitoring devices have already begun to alter health care delivery. Were excited to work with diverse business partners to quickly commercialize these and other novel scientific discoveries so they benefit patients everywhere. Reach:The Wall Street Journal, a US-based newspaper published by Dow Jones & Company, is second in newspaper circulation in America with an average circulation of 223 million copies on week days. Its website has more than 4.3 million unique visitors each month. Previous Coverage in December 12, 2014 Mayo Clinic in the … Continue reading

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Scientists discover new molecules that kill … – EurekAlert!

Posted: Published on July 10th, 2015

Research in mice suggests molecules could treat cervical, breast, ovarian, and lung cancers Amsterdam, May 13, 2015 - A new family of molecules that kill cancer cells and protect healthy cells could be used to treat a number of different cancers, including cervical, breast, ovarian and lung cancers. Research published in EBioMedicine shows that as well as targeting and killing cancer cells, the molecules generate a protective effect against toxic chemicals in healthy cells. Cells can become cancerous when their DNA is damaged. Many different things can cause DNA damage, including smoking, chemicals and radiation; understanding exactly what happens at the point of DNA damage can help scientists develop new cancer treatments. By studying this mechanism, researchers from the University of Waterloo in Canada could identify new molecules that selectively target cancer cells. The researchers studied the process of DNA damage using a sort of molecular filming technique called femtosecond time-resolved laser spectroscopy. The technique is like a high-speed camera, which uses two pulses of light: one to start a reaction, and the other to monitor the way the molecules react. This technique let researchers watch how molecules interact in real-time, revealing how cells become cancerous. Researchers have been using … Continue reading

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MTB Europe biotechnology news

Posted: Published on July 3rd, 2015

Plasticell wins 1.3m funding for cord blood stem cell manufacturing project Innovate UK has awarded a grant of 1.3m to a research consortium led by Plasticell for a project to expand cord blood stem cell production using the company's technology. 10 Feb 2015 Biomedical engineer Dr Robert Langer wins Queen Elizabeth Prize for Engineering Dr Robert Langer, a David H. Koch Institute Professor in the Department of Chemical Engineering at MIT, has been awarded the Queen Elizabeth Prize for Engineering. 3 Feb 2015 Inflammatory bowel disease associated with viruses in gut Inflammatory bowel diseases are associated with greater variety of viruses in the gut, according to a study led by Washington University School of Medicine in St Louis, USA. 3 Feb 2015 First map of all known proteins in human body is goldmine for drug discovery The Human Protein Atlas is an open source interactive map showing all the known proteins in the human body and how they are distributed in tissues and organs. 28 Jan 2015 Bone repair technology reconstructs Irish racehorse jaw An Irish racehorse successfully returned to racing after jaw reconstruction using a new bone repair material made from collagen and hydroxyapatite developed by the Advanced Materials … Continue reading

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Femto Medicine | Femto Medicine News

Posted: Published on July 1st, 2015

Charles A. Goldthwaite, Jr., PhD. Data from 2007 suggest that approximately 1.4 million men and women in the U.S. population are likely to be diagnosed with cancer, and approximately 566,000 American adults are likely to die from cancer in 2008.1 Data collected between 1996 and 2004 indicate that the overall 5-year survival rate for cancers from all sites, relative to the expected survival from a comparable set of people without cancer, is 65.3%.1 However, survival and recurrence rates following diagnosis vary greatly as a function of cancer type and the stage of development at diagnosis. For example, in 2000, the relative survival rate five years following diagnosis of melanoma (skin cancer) was greater than 90%; that of cancers of the brain and nervous system was 35%. Once a cancer has metastasized (or spread to secondary sites via the blood or lymph system), however, the survival rate usually declines dramatically. For example, when melanoma is diagnosed at the localized stage, 99% of people will survive more than five years, compared to 65% of those diagnosed with melanoma that has metastasized regionally and 15% of those whose melanoma has spread to distant sites.2 The term cancer describes a group of diseases that … Continue reading

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In Vitro and In Vivo Studies of Non-Platinum-Based …

Posted: Published on June 18th, 2015

Highlights Femtomedicine may accelerate drug discovery for effective treatment of cancer. A previously undiscovered class of non-platinum-based halogenated compounds is found to have potent antitumor effects. FMD agents can be used for natural targeted chemotherapy of multiple types of cancer while inducing minimal toxicity. Based on a molecular-mechanism-based anticancer drug discovery program enabled by an innovative femtomedicine approach, we have found a previously unknown class of non-platinum-based halogenated molecules (called FMD compounds) as potent antitumor agents for effective treatment of cancers. Here, we present in vitro and in vivo studies of the compounds for targeted chemotherapy of cervical, breast, ovarian, and lung cancers. Our results show that these FMD agents led to DNA damage, cell cycle arrest in the S phase, and apoptosis in cancer cells. We also observed that such a FMD compound caused an increase of reduced glutathione (GSH, an endogenous antioxidant) levels in human normal cells, while it largely depleted GSH in cancer cells. We correspondingly found that these FMD agents exhibited no or little toxicity toward normal cells/tissues, while causing significant cytotoxicity against cancer cells, as well as suppression and delay in tumor growth in mouse xenograft models of cervical, ovarian, breast and lung cancers. These … Continue reading

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Think Twice Before Eating That Ham Sandwich Or Triple Meat …

Posted: Published on June 15th, 2015

(Before It's News) Unless you eat organic foods and prepare them at home, youve probably purchased packaged, processed meats at some time. Non-organic versions contain added preservatives, chemicals and GMOs; and, many harbor bacterial toxins that harm the body. Even their organic counterparts may be similarly contaminated during processing. Most processed meats are treated to stop the growth of molds and to prevent spoilage. Those that have not been chemically treated, such as organic meats, are still potential breeding grounds for unwelcome micro-organisms. Processed meat Fresh meat contains one ingredient, meat. Processed meats contain numerous ingredients, and not all are meat. Additives prolong shelf life, enhance flavors, stabilize colors, and inhibit bacterial growth.Processed meats include sliced deli meats, sausage, jerky, pepperoni, bacon, lunch meats, hot dogs, and meats used on pizzas, in canned foods, and in packaged products. Bacterial toxins Salmonella bacteriais common in processed meats. Organic meats are no exception. Consuming salmonella-contaminated foods can produce illness in the form of fever, vomiting, chills and severe diarrhea leading to dehydration and death in sensitive individuals. The primary form of transmission is through contaminated hands spreading bacteria during packaging. Washing hands thoroughly and sterilizing cooking surfaces and utensils help prevent contamination. … Continue reading

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Visualizing Light at Trillion FPS, Camera Culture, MIT …

Posted: Published on June 10th, 2015

Home|News|Join Us|People|Projects|Publications|Talks|Courses The device has been developed by the MIT Media Labs Camera Culture group in collaboration with Bawendi Lab in the Department of Chemistry at MIT. A laser pulse that lasts less than one trillionth of a second is used as a flash and the light returning from the scene is collected by a camera at a rate equivalent to roughly half a trillion frames per second. However, due to very short exposure times (roughly two trillionth of a second) and a narrow field of view of the camera, the video is captured over several minutes by repeated and periodic sampling. The new technique, which we call Femto Photography, consists of femtosecond laser illumination, picosecond-accurate detectors and mathematical reconstruction techniques. Our light source is a Titanium Sapphire laser that emits pulses at regular intervals every ~13 nanoseconds. These pulses illuminate the scene, and also trigger our picosecond accurate streak tube which captures the light returned from the scene. The streak camera has a reasonable field of view in horizontal direction but very narrow (roughly equivalent to one scan line) in vertical dimension. At every recording, we can only record a '1D movie' of this narrow field of view. In … Continue reading

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