Category Archives: Hypertension

Introduction Hypertension intracerebral hemorrhage (ICH) is associated with high mortality and disability.14 Few effective treatments are available in the several prospective, randomized, controlled, multicenter trials, except for rapid blood-pressure lowering.58 Primary brain injury is mainly caused by mechanical damage to the surrounding tissues inducing by dissection and compression of the hematoma formation within the first few hours after ICH onset.9 Secondary brain injury caused by the physiologic response to the primary brain injury could lead more serious and fatal injury, which plays a key role in the overall prognosis of ICH.9 The preclinical studies have suggested that inhibition of neuroinflammation holds beneficial effect on ICH animals after central nervous system (CNS) injury.2,913 The renin-angiotensin-aldosterone system (RAAS), existing in the cardiovascular system, kidneys and CNS, can influence the outcome of ischemic stroke.1416 Angiotensin (Ang) is a product of the proteolytic cleavage of Ang I by Angiotensin-converting enzyme (ACE) and is the pivotal protein of the RAAS for the regulation of blood pressure.14 Ang can also produce an inflammatory response by binding to type-1 Ang receptors.17 Angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin II receptor blockers (ARBs) are two critical suppressors of the RAAS and widely used as the first-line anti-hypertensive drugs.18 Previous researches have shown that ACEIs/ARBs have multiple neuroprotective effects, such as slowing inflammatory processes, inhibition of fibrinoid necrosis, anti-apoptotic and anti-oxidant effects by the reduction of Ang in the animal models after CNS injury.2,17,1924 However, the role of ACEIs and ARBs in ICH patients with hypertension remains elusive in clinic.25 Herein, the aim of the present study is to evaluate the effect of ACEIs/ARBs on ICH patients with hypertension using a retrospective, single-center data analysis. This retrospective study was approved by the Ethics Committee of the Southwest Hospital, Third Military Medical University (approval no. Continue reading →

SOUTH SAN FRANCISCO, Feb. 3, 2021 /PRNewswire/ --The Janssen Pharmaceutical Companies of Johnson & Johnson today announced results from an analysis determining the validity of the Registry to Evaluate Early and Long-Term PAH Disease Management (REVEAL) Lite 2 risk calculator, an abridged version of the REVEAL 2.0 risk calculator, in patients with pulmonary arterial hypertension (PAH), a rapidly progressive disease with no known cure.1,2,3 The analysis showed that REVEAL Lite 2 offers a simplified method of risk assessment using six non-invasive and modifiable variables that may be implemented routinely in daily clinical practiceand can be used in conjunction with REVEAL 2.0, and differentiates patients among low, intermediate and high risk of one-year mortality Continue reading →

INDIANAPOLIS (WISH) Dr. Ashwin Ravichandran at Ascension St. Vincent Hospital in Indianapolis wasnt predicting the future when he first joined a clinical trial for a new way to treat pulmonary hypertension, a type of blood pressure in the lungs now associated with COVID-19 Continue reading →

For more information, visitSMFM.org A prospective study has found that even though vitamin D prophylaxis fails to prevent hypertensive disorders of pregnancy, it does increase maternal and cord blood vitamin D levels. Study results were presented virtually at the 41st Annual Pregnancy meeting of the Society for Maternal Fetal Medicine (SMFM). Continue reading →

TheOcular Hypertension Treatment Marketresearch report thoroughly explains each and every aspect related to the Global Ocular Hypertension Treatment Market, which facilitates the reports reader to study and evaluate the upcoming market trend and execute the analytical data to promote the business. Ocular Hypertension Treatment Market Insight: Ocular hypertension treatment market is expected to gain market growth in the forecast period of 2020 to 2027. Data Bridge Market Research analyses the market is growing at a healthy CAGR in the above-mentioned research forecast period Continue reading →

Findings from a new study reported that hepatitis B virus (HBV) and hepatitis C virus (HCV) infection in pregnant women was associated with higher incidences of premature births. HCV infection was further linked to edemas, hypertension, and pruritus. Investigators from the Department of Infectious Disease and Hepatology, Medical University of Bialystok, Poland, evaluated the course of pregnancy among women infected with either viruses Continue reading →

They call it the silent killer. Hypertension, also known as high blood pressure, is a condition that has few noticeable symptoms but which can lead to all sorts of unpleasantness in the long run Continue reading →

This article was originally published here Cell Discov. Continue reading →

In fact, blood pressure should be measured in both arms during a proper cardiovascular disease risk assessment. Blood pressure measurement. Image courtesy Wikimedia Commons While most people know of the harm both high blood pressure (hypertension) and low blood pressure (hypotension) can do to the body, many wouldnt know that the smallest factors could alter blood pressure measurements Continue reading →

Treatment with Keytruda (pembrolizumab), Avastin (bevacizumab) and cyclophosphamide in patients with recurrent ovarian cancer was well tolerated and demonstrated clinical benefit in most patients, according to results from a trial published in JAMA Oncology. The quality of life of our patients who took part in this clinical trial was excellent, said Dr Continue reading →