Category Archives: Mesenchymal Stem Cells

Stem cells: What they are and what they do Stem cells and derived products offer great promise for new medical treatments. Learn about stem cell types, current and possible uses, ethical issues, and the state of research and practice. By Mayo Clinic Staff You've heard about stem cells in the news, and perhaps you've wondered if they might help you or a loved one with a serious disease. You may wonder what stem cells are, how they're being used to treat disease and injury, and why they're the subject of such vigorous debate. Here are some answers to frequently asked questions about stem cells. Researchers and doctors hope stem cell studies can help to: Generate healthy cells to replace diseased cells (regenerative medicine). Stem cells can be guided into becoming specific cells that can be used to regenerate and repair diseased or damaged tissues in people. People who might benefit from stem cell therapies include those with spinal cord injuries, type 1 diabetes, Parkinson's disease, Alzheimer's disease, heart disease, stroke, burns, cancer and osteoarthritis. Stem cells may have the potential to be grown to become new tissue for use in transplant and regenerative medicine. Researchers continue to advance the knowledge … Continue reading →

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Journal of Hematology & Oncology20125:19 DOI: 10.1186/1756-8722-5-19 Wang et al.; licensee BioMed Central Ltd.2012 Received: 30January2012 Accepted: 16February2012 Published: 30April2012 Mesenchymal stem cells (MSC) have generated a great amount of enthusiasm over the past decade as a novel therapeutic paradigm for a variety of diseases. Currently, MSC based clinical trials have been conducted for at least 12 kinds of pathological conditions, with many completed trials demonstrating the safety and efficacy. This review provides an overview of the recent clinical findings related to MSC therapeutic effects. Roles of MSCs in clinical trials conducted to treat graft-versus-host-disease (GVHD) and cardiovascular diseases are highlighted. Clinical application of MSC are mainly attributed to their important four biological properties- the ability to home to sites of inflammation following tissue injury when injected intravenously; to differentiate into various cell types; to secrete multiple bioactive molecules capable of stimulating recovery of injured cells and inhibiting inflammation and to perform immunomodulatory functions. Here, we will discuss these four properties. Moreover, the issues surrounding clinical grade MSCs and principles for MSC therapeutic approaches are also addressed on the transition of MSCs therapy from bench side to bedside. The online version of this article (doi:10.1186/1756-8722-5-19) contains supplementary material, which is … Continue reading →

Mesenchymal stem cells are the adult stem cells.Mesenchymal stem cells are of various types such as monocytes, adipocytes, osteocytes and chondrocytes. Mesenchymal stem cells main function is to replace or repair damage tissue. In addition, mesenchymal stem cells have high potential for tissue repair. Mesenchymal stem cells are isolated from other tissues such as fallopian tube, cord blood, fetal liver, peripheral blood and fetal lung. Mesenchymal stem cells are renewable source to substitute tissue and cells to treat disabilities and diseases. North America dominates the global market for mesenchymal stem cell due to large number of aging population and increasing incidence of cancers. Asia is expected to show high growth rates in the next five years in the global mesenchymal stem cell market. China and India are expected to be the fastest growing mesenchymal stem cell markets in Asia-Pacific region. Some of the key driving forces for mesenchymal stem cell market in emerging countries are large pool of patients and rising government funding and support. Interested in report: Please follow the below links to meet your requirements; Request for the Report Brochure:http://www.persistencemarketresearch.com/samples/3309 In recent times there is increased use of mesenchymal stem cell due to increasing aging population. Rising incidence … Continue reading →

March 22, 2016 08:00 ET | Source: Researchmoz Global Pvt Ltd Albany, NY, March 22, 2016 (GLOBE NEWSWIRE) -- The report explores the recent advancements in mesenchymal stem cell research applications and the competitive environment in the market. It further points out the current trends in the global mesenchymal stem cells market and the various factors affecting the market growth. Profiles of some of the key players in the market have been included in the report. Mesenchymal stem cells, better known as MSC, refer to multipotent stem cells that can differentiate into various cell types such as chondrocytes, osteoblasts, adipocytes, myocytes, beta-pancreatic islet cells, and potentially, neuronal cells. MSCs are said to be immune-privileged and hence, are preferred during allogenic transplantation. The report offers an overview of the regenerative medicine and advanced therapies industry and segments the industry on the basis of product type and region. It also includes valuable information about major financial events and, partnerships and acquisitions. The report also points out the major opportunities for large pharmaceutical firms in the regenerative medicine and advanced therapies market. For more info, get a Sample PDF: http://www.researchmoz.us/enquiry.php?type=S&repid=301052 The report provides an overview of various cell therapy products in early-stage and … Continue reading →

Stem Cell Research & Therapy20123:25 DOI: 10.1186/scrt116 BioMed Central Ltd2012 Osteoarthritis (OA) is a degenerative disease of the connective tissue and progresses with age in the older population or develops in young athletes following sports-related injury. The articular cartilage is especially vulnerable to damage and has poor potential for regeneration because of the absence of vasculature within the tissue. Normal load-bearing capacity and biomechanical properties of thinning cartilage are severely compromised during the course of disease progression. Although surgical and pharmaceutical interventions are currently available for treating OA, restoration of normal cartilage function has been difficult to achieve. Since the tissue is composed primarily of chondrocytes distributed in a specialized extracellular matrix bed, bone marrow stromal cells (BMSCs), also known as bone marrow-derived 'mesenchymal stem cells' or 'mesenchymal stromal cells', with inherent chondrogenic differentiation potential appear to be ideally suited for therapeutic use in cartilage regeneration. BMSCs can be easily isolated and massively expanded in culture in an undifferentiated state for therapeutic use. Owing to their potential to modulate local microenvironment via anti-inflammatory and immunosuppressive functions, BMSCs have an additional advantage for allogeneic application. Moreover, by secreting various bioactive soluble factors, BMSCs can protect the cartilage from further tissue destruction … Continue reading →

Arthritis Research & Therapy201315:112 DOI: 10.1186/ar4190 BioMed Central Ltd2013 Published: 20March2013 Although it is generally accepted that osteoarthritis is a degenerative condition of the cartilage, other tissues such as synovium in which immunological and inflammatory reactions occur contribute to the development of joint pathology. This sheds new light on the potential mechanism of action of mesenchymal stem cell therapy in osteoarthritis. Rather than tissue repair due to local transformation of injected mesenchymal stem cells to chondrocytes and filling defects in cartilage, such treatment might suppress synovial activation and indirectly ameliorate cartilage damage. Desando and co-workers report in Arthritis Research & Therapy that intra-articular delivery of adipose-derived stem cells attenuates progression of synovial activation and joint destruction in osteoarthritis in an experimental rabbit model. Clinical studies are warranted to see whether this approach might be a novel way to combat development of joint destruction in inflammatory subtypes of osteoarthritis. Although it is generally accepted that the primary effect of stem cell treatment occurs through tissue-specific differentiation, new data suggest that the therapeutic potential of these cells might also be related to their paracrine effect [1, 2]. Clinically, patients with osteoarthritis (OA) express variable synovitis. Thickening of the lining layer containing predominantly … Continue reading →

Molecular Cancer201312:94 DOI: 10.1186/1476-4598-12-94 Gomez-casal et al.; licensee BioMed Central Ltd.2013 Received: 3April2013 Accepted: 14August2013 Published: 16August2013 Ionizing radiation (IR) is used for patients diagnosed with unresectable non small cell lung cancer (NSCLC), however radiotherapy remains largely palliative due to radioresistance. Cancer stem cells (CSCs), as well as epithelial-mesenchymal transition (EMT), may contribute to drug and radiation resistance mechanisms in solid tumors. Here we investigated the molecular phenotype of A549 and H460 NSCLC cells that survived treatment with IR (5Gy) and are growing as floating tumor spheres and cells that are maintained in a monolayer after irradiation. Non-irradiated and irradiated cells were collected after one week, seeded onto ultra low attachment plates and propagated as tumor spheres. Bulk NSCLC cells which survived radiation and grew in spheres express cancer stem cell surface and embryonic stem cell markers and are able to self-renew, and generate differentiated progeny. These cells also have a mesenchymal phenotype. Particularly, the radiation survived sphere cells express significantly higher levels of CSC markers (CD24 and CD44), nuclear -catenin and EMT markers (Snail1, Vimentin, and N-cadherin) than non-irradiated lung tumor sphere cells. Upregulated levels of Oct-4, Sox2 and beta-catenin were detected in H460 cells maintained in a monolayer … Continue reading →

Arthritis Research & Therapy201517:301 DOI: 10.1186/s13075-015-0819-7 Cras et al.2015 Published: 3November2015 Current systemic therapies are rarely curative for patients with severe life-threatening forms of autoimmune diseases (ADs). During the past 15years, autologous hematopoietic stem cell transplantation has been demonstrated to cure some patients with severe AD refractory to all other available therapies. As a consequence, ADs such as lupus and scleroderma have become an emerging indication for cell therapy. Multipotent mesenchymal stem cells (MSCs), isolated from bone marrow and other sites, display specific immunomodulation and anti-inflammatory properties and appear as ideal tools to treat such diseases. The present update aims at summarizing recent knowledge acquired in the field of MSC-based therapies for lupus and scleroderma. Audrey Cras, Dominique Farge, Dan Dan Wang and Lingyun Sun contributed equally to this work. Autoimmune diseases (ADs) are a group of heterogeneous conditions characterized by aberrant activation of the immune system with failure of the immune regulation to maintain adapted tolerance. They are traditionally classified as organ-specific AD, where the consequences of organ failure can be improved by a replacement opotherapy or an organ transplantation, and as diffuse or systemic AD, notably including systemic lupus erythematosus (SLE) and systemic sclerosis (SSc). However, progressive identification … Continue reading →