Search Results for: glioma genetic

Researchers discover brain cancer treatment using genetic material from bone marrow cells

Posted: Published on April 2nd, 2013

Public release date: 1-Apr-2013 [ | E-mail | Share ] Contact: Dwight Angell dwight.angell@hfhs.org 313-876-8709 Henry Ford Health System DETROIT In a first-of-its-kind experiment using microvesicles generated from mesenchymal bone marrow cells (MSCs) to treat cancer, neurological researchers at Henry Ford Hospital have discovered a novel approach for treatment of tumor. Specifically, the research team found that introducing genetic material produced by MSCs, significantly reduced a particularly resistant form of malignant brain tumor in living lab rats. "This is the first foray of its type in experimental cancer therapy, and it represents a highly novel and potentially effective treatment," says Michael Chopp, Ph.D., scientific director of the Henry Ford Neuroscience Institute and vice chairman of the Department of Neurology at Henry Ford Hospital. The research is published in the current issue Cancer Letters. "I think this is an important and very novel approach for the treatment of cancers, and in this particular case the treatment of glioma," says Dr. Chopp. "We have been at the forefront of developing microRNAs as a means to treat disease, such as cancer and neurological injury. "This study shows it is effective in the living brain, and may even lend itself to specific cancer therapy, … Continue reading →

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‘Novel, effective’ brain cancer treatment using genetic material from bone marrow cells

Posted: Published on April 2nd, 2013

Apr. 1, 2013 In a first-of-its-kind experiment using microvesicles generated from mesenchymal bone marrow cells (MSCs) to treat cancer, neurological researchers at Henry Ford Hospital have discovered a novel approach for treatment of tumors. Specifically, the research team found that introducing genetic material produced by MSCs significantly reduced a particularly resistant form of malignant brain tumor in living lab rats. "This is the first foray of its type in experimental cancer therapy, and it represents a highly novel and potentially effective treatment," says Michael Chopp, Ph.D., scientific director of the Henry Ford Neuroscience Institute and vice chairman of the Department of Neurology at Henry Ford Hospital. The research is published in the current issue Cancer Letters. "I think this is an important and very novel approach for the treatment of cancers, and in this particular case the treatment of glioma," says Dr. Chopp. "We have been at the forefront of developing microRNAs as a means to treat disease, such as cancer and neurological injury. "This study shows it is effective in the living brain, and may even lend itself to specific cancer therapy, customized for the individual patient," Chopp adds. Chopp and his colleagues focused their efforts on glioma, by … Continue reading →

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[Full text] A Comprehensive Review on Factors Influences Biogenesis, Functions, Th | IJN – Dove Medical Press

Posted: Published on February 18th, 2021

Introduction Extracellular vesicles (EVs) including exosomes, microvesicles, and apoptotic bodies are produced and released by almost all types of cell. EVs vary in size, properties, and secretion pathway depending on the originating cell.1,2 Exosomes are small EVs (sEVs) which are formed by a process of inward budding in early endosomes to form multivesicular bodies (MVBs) with an average size of 100 nm, and released into the extracellular microenvironment to transfer their components.3,4 Microvesicles are composed of lipid components of the plasma membrane and their sizes range from 1001000 nm, whereas apoptotic bodies result from programmed cell death.5 Initially, EVs were considered to maintain cellular waste through release of unwanted proteins and biomolecules; later, these organelles were considered important for intercellular communications through various cargo molecules such as lipids, proteins, DNA, RNA, and microRNAs (miRNAs).6 Previously, it was suggested that EVs play a critical role in normal cells to maintain homeostasis and prevent cancer initiation. Inhibition of EVs secretion causes accumulation of nuclear DNA in the cytoplasm, leading to apoptosis.1 The induction of apoptosis is the principal event of the reactive oxygen species (ROS) dependent DNA damage response.7,8 Several studies reported that exosomes are synthesized by means of two major pathways, the endosomal sorting complexes required for transport (ESCRT)-dependent and ESCRT-independent, and the processes are highly regulated by multiple signal transduction cascades.18 Exosomes released from the cell through normal exocytosis mechanisms are characterized by vesicular docking and fusion with the aid of SNARE complexes. Continue reading →

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Researchers discover novel regulators of myelin repair and regeneration – Baylor College of Medicine News

Posted: Published on September 22nd, 2020

Rapid and accurate transmission of nerve signals highly depends on the integrity of myelin, an insulating sheath that surrounds the nerves of the brain and the spinal cord. Damage or loss of the myelin sheath is a hallmark of several neurological diseases in adults (such as multiple sclerosis, MS, in the image below), as well as in infants (cerebral palsy, for instance), and is common after injury. Continue reading →

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Annexin A1dependent tethering promotes extracellular vesicle aggregation revealed with singleextracellular vesicle analysis – Science Advances

Posted: Published on September 16th, 2020

INTRODUCTION Considerable molecular understanding of membrane vesicle trafficking within and between cells related to cell growth and maintenance, neurotransmission, and regulated insulin secretion has been achieved (14). Yet, pathophysiological roles of vesicles outside of cells, termed extracellular vesicles (EVs), are less defined. Intracellularly, vesicles serve as transporters with vesicle and cell membrane proteins mediating tethering at membrane contact sites by serving as a bridge between membranes (5), a process often followed by SNARE (soluble N-ethylmaleimidesensitive factor attachment protein receptor)driven membrane fusion. Continue reading →

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EED-mediated histone methylation is critical for CNS myelination and remyelination by inhibiting WNT, BMP, and senescence pathways – Science Advances

Posted: Published on August 12th, 2020

INTRODUCTION Chromatin reorganization, regulated by such features as histone modifications, is a major epigenetic event essential for vertebrate development (1, 2). The polycomb repressive complex PRC2 (polycomb repressive complex 2), the sole complex that catalyzes trimethylation of histone H3 lysine K27 (H3K27me3) in mammals (3), has two functional modules, the catalytic EZH1/2 and the methyl groupbinding EED, which function as a writer and a reader of methylated H3K27, respectively (4). Continue reading →

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Edited Transcript of NLNK earnings conference call or presentation 6-Nov-19 1:30pm GMT – Yahoo Finance

Posted: Published on November 10th, 2019

Q3 2019 NewLink Genetics Corp Earnings Call AMES Nov 10, 2019 (Thomson StreetEvents) -- Edited Transcript of NewLink Genetics Corp earnings conference call or presentation Wednesday, November 6, 2019 at 1:30:00pm GMT TEXT version of Transcript ================================================================================ Corporate Participants ================================================================================ * Carl W. Continue reading →

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Institute of Bioinformatics

Posted: Published on June 1st, 2017

Trainees at IOB Delna Mathew obtained her B.Tech. degree in Biotechnology from Sahrdaya College of Engineering and Technology, Calicut University, Kerala. Currently she is pursuing M.Tech. in Bioinformatics from Karunya University, Coimbatore, Tamil Nadu. At IOB, she is working towards the integration and interpretation of phosphoproteomic data through visualization tools and curation of pathways. C. Lakshmipriya is currently pursuing her B.Tech. degree in Bioinformatics from Tamil Nadu Agricultural University, Coimbatore. At IOB, she is being trained in analysis of human signaling pathways as a part of her internship program. Rehmataj Javeed is currently pursuing her B.Tech. degree in Bioinformatics from Tamil Nadu Agricultural University, Coimbatore. At IOB, she is being trained in analysis of human signaling pathways as a part of her internship program. Mathumitha Raju is currently pursuing her B.Tech. degree in Bioinformatics from Tamil Nadu Agricultural University, Coimbatore. At IOB, she is being trained in analysis of human signaling pathways as a part of her internship program. Sphoorti Sood obtained her B.Tech. degree in Computer Science and Engineering from Dr. A.P.J. Abdul Kalam Technical University, Lucknow, Uttar Pradesh. Currently she is pursuing M.Tech. in Computational Biology from Indraprastha Institute of Information Technology (IIIT) Delhi. At IOB, she will … Continue reading →

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SURGICAL TREATMENT OF EPILEPSY – Neurosurgery

Posted: Published on July 12th, 2016

SURGICAL TREATMENT OF EPILEPSY by: G. Rees Cosgrove, M.D., F.R.C.S.(C) and Andrew J. Cole M.D., FRCP(C) Departments of Neurology and Neurosurgery, Massachusetts General Hospital Epilepsy Center, Harvard Medical School, Boston, Massachusetts Address correspondence to: Emad N. Eskandar, M.D. E-mail: eeskandar@partners.org Patient Appointments: 617.724.6590 FAX: 617.724.0339 Referrals | Stereotactic Surgery | Parkinson's Disease | Intractable Epilepsy | Movement Disorder Surgery Guestbook | Selected Publications | Links INTRODUCTION In the majority of patients with epilepsy, seizures can be well controlled with appropriate medication. However, current estimates indicate that 20 - 30% of patients with epilepsy are refractory to all forms of medical therapy.(1) These medically intractable patients are candidates for surgical treatment in an attempt to achieve better seizure control. Another group of patients who might benefit are those whose seizures may be relatively well controlled but who have certain characteristic presentations or lesions that strongly suggest surgical intervention might be curative. Overall, the single most important determinant of a successful surgical outcome is patient selection. This requires detailed presurgical evaluation to characterize seizure type, frequency, site of onset, psychosocial functioning and degree of disability in order to select the most appropriate treatment from a variety of surgical options. This type of … Continue reading →

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Mesenchymal Stromal Cells

Posted: Published on July 3rd, 2016

Curr Opin Hematol. Author manuscript; available in PMC 2012 Jun 1. Published in final edited form as: PMCID: PMC3365862 NIHMSID: NIHMS16948 Mesenchymal stromal cells (MSCs) are the spindle shaped plastic-adherent cells isolated from bone marrow, adipose, and other tissue sources, with multipotent differentiation capacity in vitro. However, whether MSCs truly qualify as stem cells is an area of some debate[1]. MSCs were first described by Friendenstein as hematopoietic supportive cells of bone marrow. He showed that MSCs could differentiate to bone in vitro and a subset of the cells had a high proliferative potential (CFU-F) when plated at low density in tissue culture[2,3]. Based largely on Friendensteins work, Maureen Owen proposed the existence of a stromal stem cell to maintain the marrow microenvironment as the hematopoietic stem cell maintains hematopoiesis[4]. The notion of a mesenchymal stem cell was popularized by Arnold Caplan proposing that MSCs gave rise to bone, cartilage, tendon, ligament, marrow stroma, adipocytes, dermis, muscle and connective tissue[5]. However, convincing data to support the stemness of these cells were not forthcoming, and now most investigators recognize that in vitro isolated MSCs are not a homogenous population of stem cells, although a bona fide mesenchymal stem cell may reside … Continue reading →

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