Cardiovascular In vivo Models for Drug Discovery

Cardiovascular disease (CVD) is one of the leading causes of death for both men and women worldwide. CVDs affect the heart and blood vessels, leading to a variety of conditions including ischemia, stroke, heart attack, angina, and cardiomyopathy. Pharmacology Discovery Services has conducted in vivo testing for cardiovascular disease using in vivomodels for both side-effect profiling and efficacy for over 30 years.

We can meet a variety of study endpoints to generate the high-quality, reproducible data your projects require. All experimental models are tested in a dose-dependent manner with approved benchmark positive controls. We also have experience running combination studies with standard of care control regimes. Whether you are trying to evaluate potential cardiovascular liabilities during lead optimization or trying to verify in vivo efficacy, we can provide high quality and reproducible results to progress your drug discovery program. To meet the needs of your specific Cardiovascular drug discovery project we also have the flexibility and expertise to develop custom in vivo models.

Each of our Technical Directors specializes in selected therapeutic areas so they may provide expert scientific support to our clients. This involves consulting with clients to identify an appropriate model to meet their scientific objectives, designing studies and writing the custom protocols and statements of work (SOWs) to meet quality assurance guidelines. They also work closely with our Study Directors to assure that SOWs are clear and that all methods and timelines are feasible. Our laboratory staff also averages 15 years of experience conducting in vivo pharmacology studies.

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Cardiovascular In vivo Models for Drug Discovery