Category Archives: BioInformatics

Contact Information Available for logged-in reporters only Newswise BOSTON -- Developing and testing a new anti-cancer drug can cost billions of dollars and take many years of research. Finding an effective anti-cancer medication from the pool of drugs already approved for the treatment of other medical conditions could cut a considerable amount of time and money from the process. Now, using a novel bioinformatics approach, a team led by investigators at Beth Israel Deaconess Medical Center (BIDMC) has found that the approved antimicrobial drug pentamidine may help in the treatment of patients with advanced kidney cancer. Described online in the journal Molecular Cancer Therapeutics, the discovery reveals how linking cancer gene expression patterns with drug activity might help advance cancer care. The strategy of repurposing drugs that are currently being used for other indications is of significant interest to the medical community as well as the pharmaceutical and biotech industries, says senior author Towia Libermann, PhD, Director of the Genomics, Proteomics, Bioinformatics and Systems Biology Center at BIDMC and Associate Professor of Medicine at Harvard Medical School. Our results demonstrate that bioinformatics approaches involving the analysis and matching of cancer and drug gene signatures can indeed help us identify new … Continue reading →

PUBLIC RELEASE DATE: 5-May-2014 Contact: Bonnie Prescott bprescot@bidmc.harvard.edu 617-667-7306 Beth Israel Deaconess Medical Center BOSTON -- Developing and testing a new anti-cancer drug can cost billions of dollars and take many years of research. Finding an effective anti-cancer medication from the pool of drugs already approved for the treatment of other medical conditions could cut a considerable amount of time and money from the process. Now, using a novel bioinformatics approach, a team led by investigators at Beth Israel Deaconess Medical Center (BIDMC) has found that the approved antimicrobial drug pentamidine may help in the treatment of patients with advanced kidney cancer. Described online in the journal Molecular Cancer Therapeutics, the discovery reveals how linking cancer gene expression patterns with drug activity might help advance cancer care. "The strategy of repurposing drugs that are currently being used for other indications is of significant interest to the medical community as well as the pharmaceutical and biotech industries," says senior author Towia Libermann, PhD, Director of the Genomics, Proteomics, Bioinformatics and Systems Biology Center at BIDMC and Associate Professor of Medicine at Harvard Medical School. "Our results demonstrate that bioinformatics approaches involving the analysis and matching of cancer and drug gene signatures … Continue reading →

Metal Slug 3 Soundtrack - Bioinformatics Extendido Descarga MP3 256 Kbps: Download MP3 256 Kbps: http://www.mediafire.com/listen/typxa7cj3pfmakz/Bioinformatics.mp3. By: elsenocida11 … Continue reading →

bioinformatics-phamerator By: Hansol Kim … Continue reading →

Two Cambridge UK genomics scientists have been honoured with Fellowships by the Royal Society.Professor Julian Parkhill of the Wellcome Trust Sanger Centre and Dr Ewan Birney at the EMBL European Bioinformatics Institute have been named Fellows for their contributions to genomics research, which has led to innovation in medical technology. They are among eleven scientists and engineers from Cambridge named in the 50-strong roll call of new Fellows named today by the Royal Society. They include Autonomy founder Dr Mike Lynch who now heads up the Cambridge and London venture capital vehicle, Invoke Capital. Lynch is a distinguished leader in the application of non-linear adaptive signal processing and pattern recognition to unstructured information. Creator of the Bayesian framework and platform at the heart of Autonomy's products and CEO of the company for 15 years, Lynch is an inspiration and role model for entrepreneurs particularly in the engineering and technology sectors. Professor Parkhill has been recognised for his work on infectious disease; he is a leading researcher in microbiology, using genomics to develop better understanding of bacterial evolution and improving healthcare as a direct result. Thomson Reuters, which measures publication records of researchers, has placed Professor Parkhill in its most highly … Continue reading →

Bioinformatics Erasing the line between biology and hacking Krystal Thomas White and Patrick Thomas Recorded for Bsides Chicago http://www.securitybsides.com/w/page/70187476/BSidesChicago-2014 https://securechicago.org/ All videos will be at: http://www.iro... By: Adrian Crenshaw … Continue reading →

Visual Genome Analysis Suite Bioinformatics Software Demonstration Demonstration of Visual Genome Analysis Suite Software http://iiid.murdoch.edu.au. By: IIIDVideos … Continue reading →

BIT001 Bioinformatics assignments 5 and 6 By: John Yoder … Continue reading →

Mission and Central activities: The GBG's mission is to manage and assess molecular interaction data obtained through multiple platforms, increase the understanding of the effect of those interactions on the chemosensitivity of cancer, and create tools that will facilitate that process. Translation of that information will be directed towards the recognition of diagnostic and therapeutic cancer biomarkers, and directed cancer therapy. Freely available for public use are our professional grade Miner Suite bioinformatics software package, as well as our characterization and annalysis of the NCI-60 cancer cell lines, the DNA, RNA, protein, epigenetic and pharmacological levels (accessible through CellMiner). The Miner Suite of bioinformatic software packages. CellMiner: A database and query tool designed for the cancer research community to facilitate integration of the molecular datasets generated by the GBG and its collaborators on the NCI-60. SpliceCenter: A suite of very user-friendly tools designed for use by every bench biologist who needs to check for the impact of gene splice variation on common molecular biology technologies including RT-PCR, RNAi, expression microarrays, and peptide-based assays. SpliceMiner: A web application for mapping microarrray probes to transcripts in an exon-specific manner. CIMminer: A tool that produces Clustered Image Maps (CIMs) (i.e., clustered heat maps). … Continue reading →

By Estel Grace Masangkay Using a bioinformatics approach, Ohio State University researchers found that isolation of the endothelial progenitor cell might not be necessary to understand and possibly improve cardiovascular health. Instead, stem cells in circulating blood might be used to study cardiovascular health. Nicanor Moldovan, senior author of the study and a research associate professor of cardiovascular medicine at The Ohio State University, said, There are people who still dream that the prototypical progenitors for several components of the cardiovascular tree will be found and isolated. I decided to focus the analysis on the whole nonpurified cell population the blood as it is. The research group decided to skip the traditional method of isolation and keep the entire blood sample for analysis. The team analyzed gene activity at the messenger RNA level, then narrowed the search to detect mRNA for 45 genes in the blood cells. The sorting produced gene clusters which were aggregated into two modules. A total of 15 primitive and cardiovascular genes showed a clear connection in a module. Blood samples from healthy volunteers helped define the cardiovascular-relevant module, which suggested that higher expression of the identified genes were associated with younger age, more flexible vessels, … Continue reading →