Category Archives: BioInformatics

Biology, Computers Collide in High-Demand Field of Bioinformatics Dr. Shivas Amin calls bioinformatics a "collision of biology and computers." Students learn how to use computers and skills in math and biology to analyze ge... By: StThomasHouston … Continue reading →

Biology is no longer restricted to its qualitative quests. The huge amount of data being generated from the Genomics and proteomics research and other associated techniques has transformed biology into an increasingly quantitative science. There is a growing need for Bioinformatics skill to deal with this explosion of data. For many, especially those who are very little acquainted with the subject, Bioinformatics deals with research, development, or application of computational tools and approaches for expanding the use of biological, medical, behavioral or health data, including those to acquire, store, organize, archive, analyze, or visualize such data. It involves the creation and advancement of algorithms, computational and statistical techniques, and theory to solve formal and practical problems posed by or inspired from the management and analysis of biological data. To put it in simpler terms, Bioinformatics is where the domain of fundamental biolog y meets with those of mathematics, statistics and computational sciences to analyze the data generated by large number of individual experimental data. The Bioinformatics domain is expanding fast and wide and this has already been stimulated to a significant extent by the completion of the human DNA sequence in the spring of 2003. The world bioinformatics market value … Continue reading →

Ryan Taft has joined Illumina as director of scientific research. Taft is laboratory head and senior research fellow at the University of Queensland's Institute for Molecular Bioscience. He holds a BSc in biochemistry and molecular biology from the University of California, Davis. Taft will maintain a joint appointment with UQ while working for Illumina. Vermillion has tapped its James LaFrance, chairman of the firms' board of directors, to succeed Thomas McLain as president and CEO. LaFrance, who will continue to serve as Vermillion's board chairman, formerly was CEO of Omnyx, and he held executive leadership posts at Ventana Medical Systems and Bayer Diagnostics. CollabRx has appointed Paul Billings to its board of directors. Billings is a board certified internist and clinical geneticist and most recently served as chief medical officer for Life Technologies. He is executive chairman of Melanoma Diagnostics, a director of Trovagene, and a co-founder and past medical director of the Cordblood Registry. He was also a senior vice president for corporate development at Laboratory Corporation of America and a co-founder of Omicia. Billings also currently serves on the Scientific Advisory Board of the US Food and Drug Administration, the Genomic Medicine Advisory Committee at the Department of … Continue reading →

Pronounce Medical Words Bioinformatics This video shows you how to say Bioinformatics. How would you pronounce Bioinformatics? By: Medical 101 … Continue reading →

April 24, 2014 Swiss Institute of Bioinformatics This news release is available in French and German. Man or woman? Male or female? In humans and other mammals, the difference between sexes depends on one single element of the genome: the Y chromosome. It is present only in males, where the two sexual chromosomes are X and Y, whereas women have two X chromosomes. Thus, the Y is ultimately responsible for all the morphological and physiological differences between males and females. But this has not always been the case. A very long time ago, the X and Y were identical, until the Y started to differentiate from the X in males. It then progressively shrank to such an extent that, nowadays, it only contains about 20 genes (the X carries more than one thousand genes). When did the Y originate and which genes have been kept? The answer has just been brought to light by the team of Henrik Kaessmann, Associate Professor at the CIG (UNIL) and group leader at the SIB Swiss Institute of Bioinformatics, and their collaborators in Australia. They have established that the first sex genes appeared concomitantly in mammals around 180 million years ago. 4,3 billion genetic … Continue reading →

UST Bioinformatics 2014 Project YOUTUBE What do you get when science collides with computers? Bioinformatics! It is a field program offered at University of St. Thomas. By: cdeschamps1 … Continue reading →

PUBLIC RELEASE DATE: 22-Apr-2014 Contact: Karen Kreeger karen.kreeger@uphs.upenn.edu 215-349-5658 University of Pennsylvania School of Medicine PHILADELPHIA - Over the last few decades researchers have characterized a set of clock genes that drive daily rhythms of physiology and behavior in all types of species, from flies to humans. Over 15 mammalian clock proteins have been identified, but researchers surmise there are more. A team from the Perelman School of Medicine at the University of Pennsylvania wondered if big-data approaches could find them. To accelerate clock-gene discovery, the investigators, led by John Hogenesch, PhD, professor of Pharmacology and first author Ron Anafi, MD, PhD, an instructor in the department of Medicine, used a computer-assisted approach to identify and rank candidate clock components. This approach found a new core clock gene, which the team named CHRONO. Their findings appear this week in PLOS Biology. Hogenesch likens their approach to online profiling of movie suggestions for customers: "Think of Netflix. Based on your personalized movie profile, it predicts what movies you may want to watch in the future based on what you watched in the past." He thought the team could use this approach to identify new clock genes, given criteria already established from … Continue reading →

PHILADELPHIA Over the last few decades researchers have characterized a set of clock genes that drive daily rhythms of physiology and behavior in all types of species, from flies to humans. Over 15 mammalian clock proteins have been identified, but researchers surmise there are more. A team from the Perelman School of Medicine at the University of Pennsylvania wondered if big-data approaches could find them. To accelerate clock-gene discovery, the investigators, led by John Hogenesch, PhD, professor of Pharmacology and first author Ron Anafi, MD, PhD, an instructor in the department of Medicine, used a computer-assisted approach to identify and rank candidate clock components. This approach found a new core clock gene, which the team named CHRONO. Their findings appear this week in PLOS Biology. Hogenesch likens their approach to online profiling of movie suggestions for customers: Think of Netflix. Based on your personalized movie profile, it predicts what movies you may want to watch in the future based on what you watched in the past. He thought the team could use this approach to identify new clock genes, given criteria already established from the behavior of known clock genes identified in the past two decades: We used a simple … Continue reading →

What is Bioinformatics? Bioinformatics has evolved into a full-fledged multidisciplinary subject that integrates developments in information and computer technology as applied to Biotechnology and Biological Sciences. Bioinformatics uses computer software tools for database creation, data management, data warehousing, data mining and global communication networking. Bioinformatics is the recording, annotation, storage, analysis, and searching/retrieval of nucleic acid sequence (genes and RNAs), protein sequence and structural information. This includes databases of the sequences and structural information as well methods to access, search, visualize and retrieve the information. Bioinformatics concern the creation and maintenance of databases of biological information whereby researchers can both access existing information and submit new entries. Function genomics, biomolecular structure, proteome analysis, cell metabolism, biodiversity, downstream processing in chemical engineering, drug and vaccine design are some of the areas in which Bioinformatics is an integral component. Sub-disciplines within bioinformatics There are three important sub-disciplines within bioinformatics involving computational biology: Activities in bioinformatics We can split the activities in bioinformatics in two areas (1) the organization and (2) the analysis of biological data Organization activity in Bioinformatics Analysis activity in Bioinformatics Aims of Bioinformatics: The aims of bioinformatics are basically three-fold. They are Three levels of bioinformatics Bioinformatics and its … Continue reading →

Section Editors Adam Godzik, Sanford-Burnham Medical Research Institute and UCSD Lawrence Hunter, University of Colorado Denver Igor Jurisica, Ontario Cancer Institute Alexey Nesvizhskii, University of Michigan Adam Olshen, University of California, San Francisco Hanchuan Peng, Allen Institute for Brain Science Graziano Pesole, University of Bari Mihai Pop, University of Maryland Executive Editor Irene Pala, BioMed Central Editorial Board | Editorial Team | Instructions for authors | FAQ There has been an error retrieving the data. Please try again. Viral metagenome analysis web server Metavir 2 provides a user-friendly comprehensive analysis environment for viral metagenomes, including tools for multiple comparison and analysis, both from raw reads and from contig-assembled viromes. Fetal gene expression project database DFLAT, designed for curating human fetal gene functions by combining the existing Gene Ontology framework with 13,344 new annotations, is available for use in novel developmental genomics analyses. HTS-based method to identify rare species HTS barcode checker pipelineis software for identifying illegally traded species in DNA mixtures, using DNA barcodes compared against the NCBI database for CITES-protected species, though not intended for Whole Genome Shotgun data. SInC for SNPs, Indels and CNVs The rest is here: BMC Bioinformatics - BioMed Central | The Open Access ... … Continue reading →