Clinical Success Rates for New Cancer Drugs Doubled From the Mid-1990s to Early-2000s, According to the Tufts Center …

BOSTON, MA--(Marketwired - May 7, 2013) - Clinical success rates for new cancer drugs doubled between the mid-1990s to the early 2000s, while the number of new cancer drugs entering clinical testing increased 50 percent during the same time, according to an analysis recently completed by the Tufts Center for the Study of Drug Development.

Clinical success rates -- which reflect the share of investigational new compounds entering clinical testing that eventually obtain marketing approval from the U.S. Food and Drug Administration -- rose from 9.9 percent in the mid-1990s to 19.8 percent in the early-2000s, the study found.

The clinical success rate for new cancer drugs entering clinical testing over the entire study period was 13 percent.

"That success rates increased during the 12 years we examined suggests, while drug development remains highly complex, drug companies are making headway in improving the development process," said Joseph A. DiMasi, Tufts CSDD director of economic analysis, who served as principal investigator on the study.

He added, "Lower transition rates between Phase I and Phase II studies, and between Phase II and Phase III studies, suggest that early termination of less promising candidates early on helps improve later transition rates."

DiMasi said a similar study he previously conducted found that, for the top 50 drug companies, clinical approval success rates for self-originated compounds across all therapeutic areas that entered clinical study during the same period ranged from 14 percent to 18 percent.

Study results, reported in the May/June Tufts CSDD Impact Report released today, also found that:

ABOUT THE TUFTS CENTER FOR THE STUDY OF DRUG DEVELOPMENT

The Tufts Center for the Study of Drug Development (http://csdd.tufts.edu) at Tufts University provides strategic information to help drug developers, regulators, and policy makers improve the quality and efficiency of pharmaceutical development, review, and utilization. Tufts CSDD, based in Boston, conducts a wide range of in-depth analyses on pharmaceutical issues and hosts symposia, workshops, and public forums, and publishes Tufts CSDD Impact Reports, a bi-monthly newsletter providing analysis and insight into critical drug development issues.

Visit link:
Clinical Success Rates for New Cancer Drugs Doubled From the Mid-1990s to Early-2000s, According to the Tufts Center ...