Xconomy San Francisco
Skin treatments developer Dermira is adding another experimental drug to its pipeline that it plans to test as a potential treatment for eczema, through a deal announced this morning with healthcare giant Roche.
But in picking up the global rights to lebrikizumab, Menlo Park, CA-based Dermira (NASDAQ: DERM) is entering a suddenly crowded field of new treatments for the skin condition, which is characterized by inflamed, itchy, and scaly rashes on the skin. Dermira has agreed to pay Roche $80 million now, plus $55 million next year for global rights to the drug. If Dermira can hit development and regulatory goals for the lebrikizumab, the company could be on the hook to pay Roche up to $250 million more.
Should Dermira commercialize the injectable drug in other diseases, the company would have to pay more than $1 billion as the drug hits undisclosed sales marks. Dermira would also need to pay Roche royalties on the drugs sales. Roche is keeping the rights to the drug in interstitial lung diseases, a group of disorders that lead to progressive scarring of the lungs.
Eczema, also known as atopic dermatitis, is an autoimmune disorder that produces an inflammatory response thats visible on the skin. The condition affects at least 28 million people in the United States, according to the American Academy of Dermatology. Lebrikizumab is a monoclonal antibody drug that targets interleukin 13, a protein associated with inflammation.
Other pharmas are aiming to address the eczema market with new drugs. Last December, the FDA approved Pfizers (NYSE: PFE) topical ointment crisaborole (Eucrisa) as a treatment for mild-to-moderate eczema. That drug, which blocks the inflammatory enzyme PDE4, came to Pfizer through its $5.2 billion acquisition of Anacor Pharmaceuticals last year. Meanwhile, Tarrytown, NY-based Regeneron Pharmaceuticals (NASDAQ: REGN) received FDA approval in March for its moderate-to-severe eczema drug dupilumab (Dupixent). Like the Roche drug, dupilumab targets interleukin 13.
Dermira and Roche expect to close the licensing deal later this quarter. In early 2018, Dermira plans to start a Phase 2b dose-ranging study, enrolling patients who have moderate-to-severe eczema. The goal of the trial is to find the best dose for a larger Phase 3 clinical trial. Dermira said it expects that it will spend approximately $200 million to get the early results for the Phase 2b study.
Photo by Flicker user Oregon State Universityvia a Creative Commons license.
Frank Vinluan is editor of Xconomy Raleigh-Durham, based in Research Triangle Park. You can reach him at fvinluan [at] xconomy.com
Visit link:
Dermira Commits $135M for Global Rights to Roche Eczema Drug - Xconomy
- Eczema: Read About Symptoms and Medications - October 15th, 2014 [October 15th, 2014]
- Dermatitis - Wikipedia, the free encyclopedia - October 15th, 2014 [October 15th, 2014]
- Eczema and Your Skin | Eczema Types, Symptoms, Causes, and ... - October 15th, 2014 [October 15th, 2014]
- Kangen Water Testimony - Eczema, Weight Loss, Headaches - Video - October 15th, 2014 [October 15th, 2014]
- Controlling eczema - Video - October 17th, 2014 [October 17th, 2014]
- Eczema update! - When To Seek Medical Attention - Video - October 18th, 2014 [October 18th, 2014]
- My Makeup Routine For Eczema & Psoriasis - Video - October 18th, 2014 [October 18th, 2014]
- Dyson launches humidifier to combat eczema and psoriasis - October 20th, 2014 [October 20th, 2014]
- Sanofi, Regeneron Begin Phase 3 Study For Eczema Drug Dupilumab - October 20th, 2014 [October 20th, 2014]
- Ayurvedic treatment for Atopic Eczema - Video - October 20th, 2014 [October 20th, 2014]
- How To Treating Eczema at Home? EASY! Find it On This Video - Video - October 20th, 2014 [October 20th, 2014]
- Topical BioMedics Announces "Soothe the Skin They're in," a New Program for Children Who Suffer with Eczema - October 21st, 2014 [October 21st, 2014]
- Vitamin D Might Help Kids With Eczema - October 21st, 2014 [October 21st, 2014]
- Edguard tube cream for acne, eczema, scars and pregnancy blemishes - Video - October 21st, 2014 [October 21st, 2014]
- Cara Veldman #1848200 Eczema Cream - Video - October 21st, 2014 [October 21st, 2014]
- Tampa dermatologists clinical trial for sufferers of eczema ongoing - October 23rd, 2014 [October 23rd, 2014]
- Eczema - A recurrent rash everyone complains about - October 23rd, 2014 [October 23rd, 2014]
- My Essentials for Dry Skin & Eczema - Video - October 23rd, 2014 [October 23rd, 2014]
- Taking a 'Selfie' May Help With Dermatology Care, Study Shows - October 24th, 2014 [October 24th, 2014]
- EP.2 Cures Thermales : Business ou Sant ? - EczemaHelp - Video - October 24th, 2014 [October 24th, 2014]
- EP.1 Cures Thermales : Business ou Sant ? - EczemaHelp - Video - October 24th, 2014 [October 24th, 2014]
- Home remedy for eczema - Beat eczema - Video - October 24th, 2014 [October 24th, 2014]
- Trailer - EczemaHelp - Video - October 24th, 2014 [October 24th, 2014]
- Family First: Calming the symptoms of severe eczema - October 25th, 2014 [October 25th, 2014]
- what causes eczema - Eczema Free Providing ... - October 27th, 2014 [October 27th, 2014]
- Atopic eczema - Treatment - NHS Choices - Your health ... - October 27th, 2014 [October 27th, 2014]
- Atopic dermatitis - Wikipedia, the free encyclopedia - October 27th, 2014 [October 27th, 2014]
- Atopic eczema - NHS Choices - October 27th, 2014 [October 27th, 2014]
- Eczema Treatment Options : How To Cure Eczema & Home Remedies For Eczema - Video - October 27th, 2014 [October 27th, 2014]
- Chamomile: A herbal medicine of the past with bright future - October 29th, 2014 [October 29th, 2014]
- How SELFIES can help cure skin conditions - October 30th, 2014 [October 30th, 2014]
- Eczema linked to bone fractures, injuries in new Northwestern study - October 30th, 2014 [October 30th, 2014]
- Adult eczema may be unrecognized risk factor for fracture, other injuries - October 30th, 2014 [October 30th, 2014]
- Mom Tips: Relief for Baby Eczema - Video - October 30th, 2014 [October 30th, 2014]
- BEST BABY ECZEMA PRODUCTS - Video - October 30th, 2014 [October 30th, 2014]
- Eczema Tied to Bone Fracture Risk in Study - October 30th, 2014 [October 30th, 2014]
- Accident prone eczema patients - October 30th, 2014 [October 30th, 2014]
- Eczema girl's agony is over thanks to allergen-busting extra washing machine rinse cycles - November 1st, 2014 [November 1st, 2014]
- Helping Healing Eva's Eczema with Applied Kinesiology - Video - November 1st, 2014 [November 1st, 2014]
- Eczema May Increase Risk of Injury - Video - November 1st, 2014 [November 1st, 2014]
- treatmyeczema - November 2nd, 2014 [November 2nd, 2014]
- My Eczema Care Routine March 2014 | ... ... - November 2nd, 2014 [November 2nd, 2014]
- The Psoriasis Eczema Skin Puzzle #42 - Video - November 3rd, 2014 [November 3rd, 2014]
- Can some patients' bodies become 'addicted' to topical steroids? - November 5th, 2014 [November 5th, 2014]
- How To Treat Eczema Naturally Review DO NATURAL REMEDIES REALLY WORK - Video - November 5th, 2014 [November 5th, 2014]
- I Will Beat Anyone I Find Eczema On His/Her Body - Video - November 5th, 2014 [November 5th, 2014]
- Proper amount of bathing and moisturizing your baby may help prevent skin disease - November 8th, 2014 [November 8th, 2014]
- How to get rid of super dry skin psoriasis, eczema and more! - Video - November 12th, 2014 [November 12th, 2014]
- Easy Homemade Remedy For Eczema - Pulse Daily - Video - November 13th, 2014 [November 13th, 2014]
- Aveeno Eczema Therapy Moisturizing Cream - Video - November 15th, 2014 [November 15th, 2014]
- aveeno eczema moisturizing cream | Sample Promo - Video - November 16th, 2014 [November 16th, 2014]
- Psoriasis & Eczema : Rain soul by Johnny - Video - November 16th, 2014 [November 16th, 2014]
- aveeno baby eczema therapy moisturising cream | Sample Promo - Video - November 17th, 2014 [November 17th, 2014]
- aveeno baby eczema therapy reviews | Sample Promo - Video - November 18th, 2014 [November 18th, 2014]
- Peanut in household dust linked to peanut allergies, especially for children with eczema - November 19th, 2014 [November 19th, 2014]
- Peanut in household dust linked to peanut allergy in children with eczema during infancy - November 19th, 2014 [November 19th, 2014]
- 10 Tips to Manage Psoriasis and Eczema this Winter - November 19th, 2014 [November 19th, 2014]
- Tampa dermatologist excited over eczema clinical trial results - November 20th, 2014 [November 20th, 2014]
- aveeno baby eczema moisturizing cream | Sample Promo - Video - November 20th, 2014 [November 20th, 2014]
- Why I am sharing my eczema journey and what I deal with everyday living with eczema - Video - November 20th, 2014 [November 20th, 2014]
- Cetaphil Restoraderm Restoring Formulated Eczema - Video - November 20th, 2014 [November 20th, 2014]
- Cetaphil Restoraderm Restoring Moisturizer 10 Fluid - Video - November 20th, 2014 [November 20th, 2014]
- Childhood Eczema Cure With Kangen Water - Testimonial - Video - November 22nd, 2014 [November 22nd, 2014]
- Natural Remedies for Eczema - The Best Eczema Treatment - Video - November 23rd, 2014 [November 23rd, 2014]
- Eczema in Kids - Read More About It - Video - November 23rd, 2014 [November 23rd, 2014]
- Hypoallergenic labels may not be accurate - November 23rd, 2014 [November 23rd, 2014]
- Danielle Sheehan's life transformed after Botox eradicates her eczema - November 25th, 2014 [November 25th, 2014]
- Eczema's effects can be bone-deep - November 25th, 2014 [November 25th, 2014]
- New recommendations for treating kids with eczema - November 25th, 2014 [November 25th, 2014]
- Eczema cases rising among U.S. children - November 25th, 2014 [November 25th, 2014]
- Eczema Cases Rising Among U.S. Children: Report - November 25th, 2014 [November 25th, 2014]
- New guidelines released for treating kids with eczema - Video - November 25th, 2014 [November 25th, 2014]
- TCM Recipe Natural Herbal Eczema Cream Review - Video - November 25th, 2014 [November 25th, 2014]
- New product to heal eczema to use topically and progress pictures - Video - November 25th, 2014 [November 25th, 2014]
- 15 Proven Natural Cures for Eczema - Baby dermatitis: how ... - November 26th, 2014 [November 26th, 2014]
- Aveeno Moisturizing Bar - Aveeno Eczema Therapy Moisturizing Cream - Video - November 26th, 2014 [November 26th, 2014]
- How to psychologically & physically confront eczema in you. - Video - November 26th, 2014 [November 26th, 2014]
- Woman, 21, left looking sunburnt by severe eczema finally has the perfect complexion - thanks to a 'magical' cream - November 27th, 2014 [November 27th, 2014]
- Aveeno Baby Sunscreen - Aveeno Baby Coupons - Aveeno Baby Eczema - Video - November 27th, 2014 [November 27th, 2014]
- How I cured my eczema in just over 10 days and you can to. My personal review - Video - November 28th, 2014 [November 28th, 2014]