By Deena Beasley
(Reuters) - An experimental drug from Gilead Sciences Inc shrank tumors in half of leukemia patients whose cancer had returned, according to an early-stage trial that represents a new foray into oncology by the world's biggest seller of HIV medications.
The pill, idelalisib, is part of a new class of medications designed to selectively block a type of protein known to promote tumor growth in patients with chronic lymphocytic leukemia (CLL) and other types of blood cancer.
The "pretty incredible" results illustrate how a growing understanding of tumor biology is helping researchers develop promising new targeted drugs, said Dr Sandra Swain, president of the American Society of Clinical Oncology, which will feature the research at its conference in Chicago later this month. Swain was not involved in the trial.
Researchers said idelalisib, also known as GS-1101, produced rapid and long-lasting tumor shrinkage in half of the 54 trial patients treated with the drug alone, stalling disease progression for an average of 17 months. Patients in the trial had previously received a median of five other treatments.
CLL, which is typically diagnosed through a routine blood test, is a slow-growing cancer, and many patients do not require treatment until they start having symptoms. The vast majority of patients experience a relapse at some point after initial treatment with chemotherapy or immunotherapy. And about 20 percent of patients have so-called refractory disease, meaning that they either relapse within six months or do not respond to initial treatment at all.
"Drugs like idelalisib are probably going to change the landscape of the disease in the next few years," said lead study author Dr Jennifer Brown, assistant professor of medicine at Dana-Farber Cancer Institute.
Idelalisib works by blocking PI3 kinase delta, a subtype of PI3K proteins known to promote tumor growth.
Researchers said many trial patients experienced fewer disease symptoms, while side effects from the drug, including fatigue, diarrhea and rash, were mostly manageable. Seven percent of patients left the trial due to side effects.
Gilead, which has dominated the market for HIV drugs and is vying for a lead position in therapies for hepatitis C, is testing idelalisib as a treatment for a number of different blood cancers. The drug is currently in late-stage testing as a treatment for both CLL and indolent, or slow-growing, non-Hodgkin's lymphoma (NHL).
Original post:
Experimental Gilead drug effective in early-stage leukemia trial
- CCHR: Psychiatric Drugs Side Effects - March 14th, 2011 [March 14th, 2011]
- Senseless - March 31st, 2011 [March 31st, 2011]
- Acid Reflux Drug Side-Effects - April 3rd, 2011 [April 3rd, 2011]
- Drug Side Effects Up, But Benefits Up More - April 20th, 2011 [April 20th, 2011]
- OCD Drug Commercial Side Effects Spoof - Funny Obsessive-Compulsive Disorder Cartoon - ExoticJess - May 20th, 2011 [May 20th, 2011]
- Bipolar side effects song Dustin Prinz drugs ep - May 22nd, 2011 [May 22nd, 2011]
- Anti-Malaria Drug Side Effects on Military Personnel - Cowardice - May 23rd, 2011 [May 23rd, 2011]
- The A to Z of Drug Side Effects - June 11th, 2011 [June 11th, 2011]
- Neurologic side effects of antipsychotic medication - June 12th, 2011 [June 12th, 2011]
- Side Effects of Drugs - USE a SAFER Alternative - MD / RN - Click link at RIGHT - June 15th, 2011 [June 15th, 2011]
- Yaz | Yasmin Drug Side Effects - June 16th, 2011 [June 16th, 2011]
- Nutrition vs. Conventional Medicine - June 18th, 2011 [June 18th, 2011]
- Side Effects of Cholesterol Drugs (Lipitor) - June 21st, 2011 [June 21st, 2011]
- CCHR: Drugging Our Children—Side Effects - June 25th, 2011 [June 25th, 2011]
- Side effects of Common Arthritis Drugs.wmv - June 30th, 2011 [June 30th, 2011]
- Self Hypnosis Hallucination Video (NO SIDE EFFECTS) - July 11th, 2011 [July 11th, 2011]
- How Medicines Work: Drug Problems 3: Interactions and Substrates - July 25th, 2011 [July 25th, 2011]
- Pharmaceutical Drug Commercial Spoof - July 26th, 2011 [July 26th, 2011]
- Nick Gillespie Talks Ed Schultz, TSA v. Texas on Fox News Red Eye w/ Greg Gutfeld - July 27th, 2011 [July 27th, 2011]
- The Drugging Of Our Children (Full Length) - August 13th, 2011 [August 13th, 2011]
- HIV medicine ATRIPLA/side effects - August 17th, 2011 [August 17th, 2011]
- What are the side-effects of ADHD medications? - August 26th, 2011 [August 26th, 2011]
- Chemotherapy Cancer Treatments - August 31st, 2011 [August 31st, 2011]
- Suzy Cohen Tells You About Side Effects from Drug Muggers - September 11th, 2011 [September 11th, 2011]
- Governor Admits Past Drug Use, Now What? - September 25th, 2011 [September 25th, 2011]
- Adderall - College Student Smart Drug - September 26th, 2011 [September 26th, 2011]
- Children Drugged To Death - Channel 4 - September 26th, 2011 [September 26th, 2011]
- Mom Refuses Ritalin and Heals Her ADHD Autism Kids With Natural Medicine - September 26th, 2011 [September 26th, 2011]
- Taking the Tablets - Side Effects - September 29th, 2011 [September 29th, 2011]
- Side Effects Of HIV Drugs - September 30th, 2011 [September 30th, 2011]
- Narcotics Agent Body Slams Drug Laws - October 4th, 2011 [October 4th, 2011]
- Most Astonishing Health Disaster of the 20th Century - October 4th, 2011 [October 4th, 2011]
- The Drug EFFEXOR will bring you to your knees - October 4th, 2011 [October 4th, 2011]
- Depakote Side Affects Harm Autistic Person - October 4th, 2011 [October 4th, 2011]
- TV Commercial DruG SPOoF ! - October 4th, 2011 [October 4th, 2011]
- Side Effects - Part 2 - October 4th, 2011 [October 4th, 2011]
- Side Effects May Include... : from the Goin' Green album by: Audio Faux Pas - October 5th, 2011 [October 5th, 2011]
- How to Sue Drug Companies for Free - October 5th, 2011 [October 5th, 2011]
- Should You Trust Your Doctor? - October 5th, 2011 [October 5th, 2011]
- Xenical (Orlistat) Side Effects - News Report - October 5th, 2011 [October 5th, 2011]
- Side Effects - Part 1 - October 5th, 2011 [October 5th, 2011]
- Chantix Side Effects: The Carter Albrecht Effect - October 5th, 2011 [October 5th, 2011]
- Can I sue if a pharmaceutical drug I took causes negative side effects? - October 6th, 2011 [October 6th, 2011]
- Powerful Form of Ecstasy Drug Kills Blood Cancer Cells - 8/21/11 - October 6th, 2011 [October 6th, 2011]
- Drug voltaren - October 6th, 2011 [October 6th, 2011]
- The Dark Side Of Psychiatry--Antipsychotic Drugs, Olanzapine, Risperidone, Clozapine - October 6th, 2011 [October 6th, 2011]
- My Review Of Accutane - October 6th, 2011 [October 6th, 2011]
- Evista treatment - October 6th, 2011 [October 6th, 2011]
- Tizanidine medicine - October 6th, 2011 [October 6th, 2011]
- Ponstel 250mg - October 6th, 2011 [October 6th, 2011]
- #14.2 Senior Medication Challenges - October 6th, 2011 [October 6th, 2011]
- Levlen 28 - October 6th, 2011 [October 6th, 2011]
- Diclofenac uses - October 6th, 2011 [October 6th, 2011]
- Happy Juice - Peru - October 6th, 2011 [October 6th, 2011]
- Premarin pill - October 6th, 2011 [October 6th, 2011]
- Revatio cost - October 7th, 2011 [October 7th, 2011]
- Alendronate sodium pills - October 7th, 2011 [October 7th, 2011]
- Provera drug - October 7th, 2011 [October 7th, 2011]
- Tizanidine drug - October 8th, 2011 [October 8th, 2011]
- CCHR Video 8a - Side Effects. Anti-Depressants, Suicidal Thoughts. Psychotropic Drugs. - October 8th, 2011 [October 8th, 2011]
- Drug Duphaston - October 8th, 2011 [October 8th, 2011]
- Dydrogesterone in Usa - October 8th, 2011 [October 8th, 2011]
- Vigora price - October 8th, 2011 [October 8th, 2011]
- Premarin drug - October 8th, 2011 [October 8th, 2011]
- Raloxifene side effects - October 8th, 2011 [October 8th, 2011]
- Tizanidine medication - October 9th, 2011 [October 9th, 2011]
- Zanaflex drug - October 10th, 2011 [October 10th, 2011]
- Zanaflex medicine - October 10th, 2011 [October 10th, 2011]
- Vigora - October 10th, 2011 [October 10th, 2011]
- Side Effects of Alzheimer's Disease Medications - October 10th, 2011 [October 10th, 2011]
- Are You Tired of Your Blood Pressure Medicine? - October 11th, 2011 [October 11th, 2011]
- PCOS- Metformin (Is it worth dealing with the side effects) - October 12th, 2011 [October 12th, 2011]
- 1/5.Prozac, Zoloft, Paxil, Viagra, Lipitor, Cialis, Nexium - October 12th, 2011 [October 12th, 2011]
- Drug Side Effects - Video - October 13th, 2011 [October 13th, 2011]
- Drug Interactions and Side Effects - Video - October 13th, 2011 [October 13th, 2011]
- Do You Understand Your Prescription Blood Pressure Drugs? - Video - October 13th, 2011 [October 13th, 2011]
- What you need to know about statin drugs side effects (animation) - Video - October 14th, 2011 [October 14th, 2011]
- The #1 Most Dangerous Blood Pressure Drug Side Effect - Video - October 14th, 2011 [October 14th, 2011]
- Mental Health Medication Side Effects - October 14th, 2011 [October 14th, 2011]
- Prescription Drug Side Effects - Video - October 15th, 2011 [October 15th, 2011]