FASEB Science Research Conference: Histone Deacetylases and Sirtuins in Biology, Disease and Aging

Bethesda, MD - The FASEB Science Research Conference titled "Histone Deacetylases and Sirtuns in Biology, Disease and Aging" will be held in August 16-21, 2015 in Hamburg, Germany. Recent progress in this area of research has truly been explosive, from ground-breaking discoveries in basic research to rapid advancements in the clinic. The impressive roster of speakers who are at the forefront of this rapid advancing field will be presenting their latest studies at the meeting.

Histone deacetylases (HDACs) and acetyl transferases (HATs) are vital regulators of fundamental cellular events, including cell cycle progression, stem cell functions, cell fate determination, cell differentiation, many diseases and even aging. New technologies are being rapidly developed to identify and quantify these post-translational modifications. Importantly, small molecule HDAC inhibitors and activators are currently in clinical trials for the treatment of leukemia and lymphoma, solid tumors, neuromuscular disorders, and metabolic disorders. One exciting group of deacetylases covered by the conference is the Sirtuins, which delay more than a dozen different diseases, to reverse aspects of aging, and extend lifespan in rodents. For example resveratrol, a sirtuin activator and one of the components in red wine that has been linked to increased health and lifespan in humans. Synthetic sirtuin activators that are 1000 times more potent than resveratrol have extended lifespan in mice and are now in clinical trials. New ways to activate Sirtuins (e.g. NAD precursors, CD38 inhibitors) are emerging as exciting new approaches to treating diseases. Thus, a thorough understanding of HDACs and HATs is required, not merely for understanding the regulation of chromatin structure, gene regulation and protein function, but also because HDACs are intimately involved in normal and abnormal cellular processes that greatly impact human health. This meeting will foster rapid exchange of the most recent findings and concepts on HDACs, HATs and lysine modification. A session on drug development and clinical results will disseminate information about the latest advances in human research and in industry.

FASEB has announced a total of 34 Science Research Conferences (SRC) in 2015. Registration opens January 17, 2015. For more information about an SRC, view preliminary programs, or find a listing of all our 2015 SRCs, please visit http://www.faseb.org/SRC.

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Since 1982, FASEB SRC has offered a continuing series of inter-disciplinary exchanges that are recognized as a valuable complement to the highly successful society meetings. Divided into small groups, scientists from around the world meet intimately and without distractions to explore new approaches to those research areas undergoing rapid scientific changes. In efforts to expand the SRC series, potential organizers are encouraged to contact SRC staff at SRC@faseb.org. Proposal guidelines can be found at http://www.faseb.org/SRC.

FASEB is composed of 27 societies with more than 120,000 members, making it the largest coalition of biomedical research associations in the United States. Our mission is to advance health and welfare by promoting progress and education in biological and biomedical sciences through service to our member societies and collaborative advocacy.

Federation of American Societies for Experimental Biology 9650 Rockville Pike, Bethesda, MD 20814-3998 http://www.faseb.org/SRC-HDAC

HISTONE DEACETYLASES AND SIRTUINS IN BIOLOGY, DISEASE AND AGING Date: August 16-21, 2015, Timmendorfer Strand, Germany Organizers: David Sinclair, Ming-Ming Zhou

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FASEB Science Research Conference: Histone Deacetylases and Sirtuins in Biology, Disease and Aging