Introduction
[Note: Many of the medical and scientific terms used in this summary are found in the NCI Dictionary of Genetics Terms. When a linked term is clicked, the definition will appear in a separate window.]
[Note: Many of the genes described in this summary are found in the Online Mendelian Inheritance in Man (OMIM) database. When OMIM appears after a gene name or the name of a condition, click on OMIM for a link to more information.]
Colorectal cancer (CRC) is the third most commonly diagnosed cancer in both men and women.
Estimated new cases and deaths from CRC in 2015:[1]
About 75% of patients with CRC have sporadic disease with no apparent evidence of having inherited the disorder. The remaining 25% of patients have a family history of CRC that suggests a hereditary contribution, common exposures among family members, or a combination of both. Genetic mutations have been identified as the cause of inherited cancer risk in some colon cancerprone families; these mutations are estimated to account for only 5% to 6% of CRC cases overall. It is likely that other undiscovered genes and background genetic factors contribute to the development of familial CRC in conjunction with nongenetic risk factors.
(Refer to the PDQ summaries on Colorectal Cancer Screening; Colorectal Cancer Prevention; Colon Cancer Treatment; and Rectal Cancer Treatment for more information about sporadic CRC.)
Colorectal tumors present with a broad spectrum of neoplasms, ranging from benign growths to invasive cancer and are predominantly epithelial-derived tumors (i.e., adenomas or adenocarcinomas).
Pathologists have classified the lesions into the following three groups:
Research, however, suggests increased CRC risk in some families who have multiple members affected with juvenile polyposis, Peutz-Jeghers syndrome, and hyperplastic polyposis.[2-4]
Go here to read the rest:
Genetics of Colorectal Cancer - National Cancer Institute
- Atossa Genetics: a focused pure play breast health testing company with huge potential to grow - January 3rd, 2013 [January 3rd, 2013]
- Genetics Introduction(with commentary)! - Video - January 19th, 2013 [January 19th, 2013]
- Genetics of Sickle Cell Disease - Video - January 15th, 2014 [January 15th, 2014]
- Atossa Genetics (ATOS) Multiple Bottom Pattern - Video - January 19th, 2014 [January 19th, 2014]
- How to plan an effective and efficient population genetics sampling strategy - Video - January 21st, 2014 [January 21st, 2014]
- Attack of the B-Team Advanced Genetics Mod Tutorial Ep.1 - Video - February 9th, 2014 [February 9th, 2014]
- Scientific Evidence for Creation CSE BIBLE FORUM Origins 1110 Creation Genetics - Video - February 9th, 2014 [February 9th, 2014]
- Genetics - Wikipedia, the free encyclopedia - April 10th, 2014 [April 10th, 2014]
- Is It Genetics Or Are You A Loser? - Video - April 10th, 2014 [April 10th, 2014]
- Abbas Ravji - Keyword Genetics Review - Video - April 10th, 2014 [April 10th, 2014]
- Minecraft: Attack of Mojo Jojo Episode 3 - Thermal Advanced Genetics! - Video - April 10th, 2014 [April 10th, 2014]
- Q&A with Dr. Rudy Tanzi: Alzheimer's & Genetics - Video - April 10th, 2014 [April 10th, 2014]
- Dr Shane McKee, Regional Medical Genetics Unit: Joining Information Together for Better Care - Video - April 10th, 2014 [April 10th, 2014]
- Neil deGrasse Tyson on Genetics - Video - April 10th, 2014 [April 10th, 2014]
- Timothytrespas-Genetics, chromaphores=nanoelectronics! Targeted Individual science. - Video - April 15th, 2014 [April 15th, 2014]
- Advanced Genetics mod review have any mob's ability in minecraft - Video - April 15th, 2014 [April 15th, 2014]
- VaderOG Genetics Week 5 HD1080p - Video - April 15th, 2014 [April 15th, 2014]
- Human Mutation Lora Bean, Madhuri Hegde, and Stuart Tinker - Video - April 15th, 2014 [April 15th, 2014]
- Keyword Genetics - Video - April 15th, 2014 [April 15th, 2014]
- Keyword Genetics | Use My Free System To Buy Keyword Genetics - Video - April 15th, 2014 [April 15th, 2014]
- Keyword Genetics | Keyword Genetics Review - Video - April 15th, 2014 [April 15th, 2014]
- Let's play Mace Griffin: Bounty Hunter - 14 - Genetics Lab - Video - April 15th, 2014 [April 15th, 2014]
- Genetics: The Roots of Life - Video - April 15th, 2014 [April 15th, 2014]
- Keyword Genetics Review - Should You Buy Keyword Genetics? - Video - April 15th, 2014 [April 15th, 2014]
- Jurassic Genetics | Prototype Tech Demo ... Thing. - Video - April 15th, 2014 [April 15th, 2014]
- RR Let's Play - S02E33 - Advanced Genetics - Video - April 15th, 2014 [April 15th, 2014]
- Genetics and law of probability when order specified and not specified - Video - April 15th, 2014 [April 15th, 2014]
- Let's Play The Sims 3 - Perfect Genetics - Episode 37 - Video - April 15th, 2014 [April 15th, 2014]
- Long overdue skunkhouse genetics update - Video - April 15th, 2014 [April 15th, 2014]
- Let's Play The Sims 3 - Perfect Genetics - Episode 38 - Video - April 16th, 2014 [April 16th, 2014]
- Hybrid Turkeys / Hendrix Genetics - Animal Aubsers - Office Invasion - Apr 11th, 2014 - Video - April 16th, 2014 [April 16th, 2014]
- Attack of the Bteam Mod Tutorials - Advanced Genetics - Video - April 16th, 2014 [April 16th, 2014]
- Keyword Genetics Review | Watch Video Keyword Genetics Demo - Video - April 16th, 2014 [April 16th, 2014]
- Genetics and Inheritance - Video - April 17th, 2014 [April 17th, 2014]
- Introduction to Population Genetics - Lynn Jorde (2014) - Video - April 17th, 2014 [April 17th, 2014]
- Laser Genetics ND1 SubZero Tactical Laser Sight - Video - April 17th, 2014 [April 17th, 2014]
- How to solve genetics problems using factorials - Video - April 17th, 2014 [April 17th, 2014]
- Keyword Genetics Review - How to use it? - Video - April 17th, 2014 [April 17th, 2014]
- Theo's Strain Reviews Lemon Skunk from DNA Genetics - Video - April 17th, 2014 [April 17th, 2014]
- Gerbil Colors And Genetics - Video - April 17th, 2014 [April 17th, 2014]
- Simons Institute Open Lecture: Evolutionary Genetics in the Crush of Genomics - Video - April 17th, 2014 [April 17th, 2014]
- NewLink Genetics Presents Data at the AACR 2014 Annual Meeting - Video - April 17th, 2014 [April 17th, 2014]
- The Future of Genetics in Our Everyday Lives - SXSW Interactive 2014 (Full Session) - Video - April 18th, 2014 [April 18th, 2014]
- Laser Genetics ND5 Mini Subzero Long-distance Laser Illuminator - Video - April 18th, 2014 [April 18th, 2014]
- Shaman Genetics @ Spannabis 2014 (Espaol) - Video - April 18th, 2014 [April 18th, 2014]
- Attack of the Silverswords! Episode 11- Advanced Genetics - Video - April 18th, 2014 [April 18th, 2014]
- Mischa Janiec - Polska Genetics vs Kenzo Karagz - Turkesteron (Natural Bodybuilding) GNBF 2013 - Video - April 19th, 2014 [April 19th, 2014]
- Class 30- 4/14/2014 - Video - April 19th, 2014 [April 19th, 2014]
- Silvia Paracchini, PhD: Recent Advances in the Genetics of Dyslexia - Video - April 19th, 2014 [April 19th, 2014]
- Holistic Alzheimer's Video Series: Genetics NOT the prime factor - Video - April 21st, 2014 [April 21st, 2014]
- The Role of Genetics in My Cancer - Video - April 21st, 2014 [April 21st, 2014]
- My Bad Genetics - Week 4 of Powerlifting - Video - April 21st, 2014 [April 21st, 2014]
- Minecraft: Feed The Beast Monster: Advanced Genetics! (Part 18) (Dutch Commentary) - Video - April 21st, 2014 [April 21st, 2014]
- Genetics Practice Problems - University of Cincinnati - April 22nd, 2014 [April 22nd, 2014]
- Introduction to genetics - Wikipedia, the free encyclopedia - April 22nd, 2014 [April 22nd, 2014]
- How Genetics Help Understand Aging: Martin Denzel at TEDxJacobsUniversity - Video - April 22nd, 2014 [April 22nd, 2014]
- European Population Genetics: Haplogroup R-M343 Part 2 - Video - April 22nd, 2014 [April 22nd, 2014]
- Attack Of The B Team Advanced Genetics Tutorial - Video - April 22nd, 2014 [April 22nd, 2014]
- Skunk House Genetics - Video - April 22nd, 2014 [April 22nd, 2014]
- Let's Play The Sims 3 - Perfect Genetics Challenge - Episode 15 - Video - April 24th, 2014 [April 24th, 2014]
- Brandon Lilly - Genetics - Video - April 24th, 2014 [April 24th, 2014]
- Can You Overcome Genetics? - Video - April 24th, 2014 [April 24th, 2014]
- My Parkinson's Story: Genetics - Video - April 24th, 2014 [April 24th, 2014]
- How Genetics Determine Your Baby's Gender - Video - April 24th, 2014 [April 24th, 2014]
- Station genetics manager sad to leave, happy with progress - April 25th, 2014 [April 25th, 2014]
- Station genetics manager sad to leave - April 25th, 2014 [April 25th, 2014]
- Genetics | The Biology Corner - April 25th, 2014 [April 25th, 2014]
- Chaput Farms Improves Herd Genetics with CLARIFIDE - Video - April 26th, 2014 [April 26th, 2014]
- Cancer Genetics (NASDAQCM: CGIX) - RedChip Global Online CEO Conference - Video - April 26th, 2014 [April 26th, 2014]
- SkunkHouse Genetics update! - Video - April 26th, 2014 [April 26th, 2014]
- VaderOG Genetics Week 7 HD1080p - Video - April 26th, 2014 [April 26th, 2014]
- 23andMe Research: Understanding Genetics - Video - April 26th, 2014 [April 26th, 2014]
- Cancer and Genetics: Linda's Story - Video - April 26th, 2014 [April 26th, 2014]
- Laser Genetics ND3 Subzero Review - Video - April 26th, 2014 [April 26th, 2014]
- Let's Play The Sims 3 - Perfect Genetics Challenge - Episode 13 - Video - April 26th, 2014 [April 26th, 2014]
- R-Kiem Seeds Indoor Grow for Selecting Genetics - Video - April 27th, 2014 [April 27th, 2014]
- Let's Play The Sims 3 - Perfect Genetics Challenge - Episode 17 - Video - April 29th, 2014 [April 29th, 2014]
- Minecraft Tutorials - Advanced Genetics - The Basics - Video - April 29th, 2014 [April 29th, 2014]
- Dr. Judy Garber on Cancer Genetics - Video - April 29th, 2014 [April 29th, 2014]
- The Sims 3 Perfect Genetics Challenge: Rules - Video - April 30th, 2014 [April 30th, 2014]