The team at Newcastle University, in collaboration with scientists at Stiefel, a GSK company, have identified how a key skin barrier protein called filaggrin impacts on other proteins and pathways in the skin, which in turn drive the development of eczema.
This has also lead them to identify potential targets for future drug development which could treat the underlying cause rather than treating the symptoms.
Common condition
Atopic eczema is one of the commonest skin conditions in the UK, affecting up to 10% of adults and 20% of children in the UK. Its more common in children, often developing before their first birthday and often persists into adulthood with severe itching that has profound effects on well-being and may lead to sleep disturbance.
The research builds on the important discovery by scientists in Dundee which showed that lack of the protein filaggrin in the skin caused an inherited dry skin condition known as ichthyosis vulgaris that is strongly linked to the development of atopic eczema, as well as other allergic diseases such as hayfever and asthma.
Nick Reynolds, Professor of Dermatology at Newcastle University who also sees patients with skin conditions including eczema at Newcastle's Royal Victoria Infirmary, is the lead investigator of the study. He said: We have shown for the first time that loss of the filaggrin protein alone is sufficient to alter key proteins and pathways involved in triggering eczema. This research reinforces the importance of filaggrin deficiency leading to problems with the barrier function in the skin and predisposing someone to eczema.
New skin model
Publishing in the Journal of Allergy and Clinical Immunology (JACI), researchers at Newcastle University, in collaboration with scientists at Stiefel GSK, report on their development of a human model system. In this, the upper layer of skin (epidermis) was modified, using molecular techniques, to become filaggrin-deficient, directly mimicking the situation observed in the skin of patients with atopic eczema.
This model enabled the team to discover proteins and signalling pathways directly down-stream of filaggrin, and most importantly, identified a number of key regulatory mechanisms. These included regulators of inflammatory signalling, cell structure, barrier function and stress response. These pathways were found to map to those networks observed in the skin of people with active eczema.
This mapping provides researchers with new understanding of the mechanisms involved and suggests targets for future drug development.
Nina Goad of the British Association of Dermatologists said: This latest research from Newcastle is crucial as it expands on our knowledge of how filaggrin impacts on other proteins and pathways in the skin, which in turn trigger the disease. This type of research allows scientists to develop treatments that target the actual root cause of the disease, rather than just managing its symptoms. Given the level of suffering eczema causes, this is a pivotal piece of research.
Reference:
Elias, M., Long, H., Newman, C., Wilson, P., West, A., McGill, P., Wu, K., Donaldson, M. and Reynolds, N. (2017). Proteomic analysis of filaggrin deficiency identifies molecular signatures characteristic of atopic eczema.
This article has been republished frommaterialsprovided byNewcastle University. Note: material may have been edited for length and content. For further information, please contact the cited source.
See more here:
Itch Protein Identified - Technology Networks
- Eczema: Read About Symptoms and Medications - October 15th, 2014 [October 15th, 2014]
- Dermatitis - Wikipedia, the free encyclopedia - October 15th, 2014 [October 15th, 2014]
- Eczema and Your Skin | Eczema Types, Symptoms, Causes, and ... - October 15th, 2014 [October 15th, 2014]
- Kangen Water Testimony - Eczema, Weight Loss, Headaches - Video - October 15th, 2014 [October 15th, 2014]
- Controlling eczema - Video - October 17th, 2014 [October 17th, 2014]
- Eczema update! - When To Seek Medical Attention - Video - October 18th, 2014 [October 18th, 2014]
- My Makeup Routine For Eczema & Psoriasis - Video - October 18th, 2014 [October 18th, 2014]
- Dyson launches humidifier to combat eczema and psoriasis - October 20th, 2014 [October 20th, 2014]
- Sanofi, Regeneron Begin Phase 3 Study For Eczema Drug Dupilumab - October 20th, 2014 [October 20th, 2014]
- Ayurvedic treatment for Atopic Eczema - Video - October 20th, 2014 [October 20th, 2014]
- How To Treating Eczema at Home? EASY! Find it On This Video - Video - October 20th, 2014 [October 20th, 2014]
- Topical BioMedics Announces "Soothe the Skin They're in," a New Program for Children Who Suffer with Eczema - October 21st, 2014 [October 21st, 2014]
- Vitamin D Might Help Kids With Eczema - October 21st, 2014 [October 21st, 2014]
- Edguard tube cream for acne, eczema, scars and pregnancy blemishes - Video - October 21st, 2014 [October 21st, 2014]
- Cara Veldman #1848200 Eczema Cream - Video - October 21st, 2014 [October 21st, 2014]
- Tampa dermatologists clinical trial for sufferers of eczema ongoing - October 23rd, 2014 [October 23rd, 2014]
- Eczema - A recurrent rash everyone complains about - October 23rd, 2014 [October 23rd, 2014]
- My Essentials for Dry Skin & Eczema - Video - October 23rd, 2014 [October 23rd, 2014]
- Taking a 'Selfie' May Help With Dermatology Care, Study Shows - October 24th, 2014 [October 24th, 2014]
- EP.2 Cures Thermales : Business ou Sant ? - EczemaHelp - Video - October 24th, 2014 [October 24th, 2014]
- EP.1 Cures Thermales : Business ou Sant ? - EczemaHelp - Video - October 24th, 2014 [October 24th, 2014]
- Home remedy for eczema - Beat eczema - Video - October 24th, 2014 [October 24th, 2014]
- Trailer - EczemaHelp - Video - October 24th, 2014 [October 24th, 2014]
- Family First: Calming the symptoms of severe eczema - October 25th, 2014 [October 25th, 2014]
- what causes eczema - Eczema Free Providing ... - October 27th, 2014 [October 27th, 2014]
- Atopic eczema - Treatment - NHS Choices - Your health ... - October 27th, 2014 [October 27th, 2014]
- Atopic dermatitis - Wikipedia, the free encyclopedia - October 27th, 2014 [October 27th, 2014]
- Atopic eczema - NHS Choices - October 27th, 2014 [October 27th, 2014]
- Eczema Treatment Options : How To Cure Eczema & Home Remedies For Eczema - Video - October 27th, 2014 [October 27th, 2014]
- Chamomile: A herbal medicine of the past with bright future - October 29th, 2014 [October 29th, 2014]
- How SELFIES can help cure skin conditions - October 30th, 2014 [October 30th, 2014]
- Eczema linked to bone fractures, injuries in new Northwestern study - October 30th, 2014 [October 30th, 2014]
- Adult eczema may be unrecognized risk factor for fracture, other injuries - October 30th, 2014 [October 30th, 2014]
- Mom Tips: Relief for Baby Eczema - Video - October 30th, 2014 [October 30th, 2014]
- BEST BABY ECZEMA PRODUCTS - Video - October 30th, 2014 [October 30th, 2014]
- Eczema Tied to Bone Fracture Risk in Study - October 30th, 2014 [October 30th, 2014]
- Accident prone eczema patients - October 30th, 2014 [October 30th, 2014]
- Eczema girl's agony is over thanks to allergen-busting extra washing machine rinse cycles - November 1st, 2014 [November 1st, 2014]
- Helping Healing Eva's Eczema with Applied Kinesiology - Video - November 1st, 2014 [November 1st, 2014]
- Eczema May Increase Risk of Injury - Video - November 1st, 2014 [November 1st, 2014]
- treatmyeczema - November 2nd, 2014 [November 2nd, 2014]
- My Eczema Care Routine March 2014 | ... ... - November 2nd, 2014 [November 2nd, 2014]
- The Psoriasis Eczema Skin Puzzle #42 - Video - November 3rd, 2014 [November 3rd, 2014]
- Can some patients' bodies become 'addicted' to topical steroids? - November 5th, 2014 [November 5th, 2014]
- How To Treat Eczema Naturally Review DO NATURAL REMEDIES REALLY WORK - Video - November 5th, 2014 [November 5th, 2014]
- I Will Beat Anyone I Find Eczema On His/Her Body - Video - November 5th, 2014 [November 5th, 2014]
- Proper amount of bathing and moisturizing your baby may help prevent skin disease - November 8th, 2014 [November 8th, 2014]
- How to get rid of super dry skin psoriasis, eczema and more! - Video - November 12th, 2014 [November 12th, 2014]
- Easy Homemade Remedy For Eczema - Pulse Daily - Video - November 13th, 2014 [November 13th, 2014]
- Aveeno Eczema Therapy Moisturizing Cream - Video - November 15th, 2014 [November 15th, 2014]
- aveeno eczema moisturizing cream | Sample Promo - Video - November 16th, 2014 [November 16th, 2014]
- Psoriasis & Eczema : Rain soul by Johnny - Video - November 16th, 2014 [November 16th, 2014]
- aveeno baby eczema therapy moisturising cream | Sample Promo - Video - November 17th, 2014 [November 17th, 2014]
- aveeno baby eczema therapy reviews | Sample Promo - Video - November 18th, 2014 [November 18th, 2014]
- Peanut in household dust linked to peanut allergies, especially for children with eczema - November 19th, 2014 [November 19th, 2014]
- Peanut in household dust linked to peanut allergy in children with eczema during infancy - November 19th, 2014 [November 19th, 2014]
- 10 Tips to Manage Psoriasis and Eczema this Winter - November 19th, 2014 [November 19th, 2014]
- Tampa dermatologist excited over eczema clinical trial results - November 20th, 2014 [November 20th, 2014]
- aveeno baby eczema moisturizing cream | Sample Promo - Video - November 20th, 2014 [November 20th, 2014]
- Why I am sharing my eczema journey and what I deal with everyday living with eczema - Video - November 20th, 2014 [November 20th, 2014]
- Cetaphil Restoraderm Restoring Formulated Eczema - Video - November 20th, 2014 [November 20th, 2014]
- Cetaphil Restoraderm Restoring Moisturizer 10 Fluid - Video - November 20th, 2014 [November 20th, 2014]
- Childhood Eczema Cure With Kangen Water - Testimonial - Video - November 22nd, 2014 [November 22nd, 2014]
- Natural Remedies for Eczema - The Best Eczema Treatment - Video - November 23rd, 2014 [November 23rd, 2014]
- Eczema in Kids - Read More About It - Video - November 23rd, 2014 [November 23rd, 2014]
- Hypoallergenic labels may not be accurate - November 23rd, 2014 [November 23rd, 2014]
- Danielle Sheehan's life transformed after Botox eradicates her eczema - November 25th, 2014 [November 25th, 2014]
- Eczema's effects can be bone-deep - November 25th, 2014 [November 25th, 2014]
- New recommendations for treating kids with eczema - November 25th, 2014 [November 25th, 2014]
- Eczema cases rising among U.S. children - November 25th, 2014 [November 25th, 2014]
- Eczema Cases Rising Among U.S. Children: Report - November 25th, 2014 [November 25th, 2014]
- New guidelines released for treating kids with eczema - Video - November 25th, 2014 [November 25th, 2014]
- TCM Recipe Natural Herbal Eczema Cream Review - Video - November 25th, 2014 [November 25th, 2014]
- New product to heal eczema to use topically and progress pictures - Video - November 25th, 2014 [November 25th, 2014]
- 15 Proven Natural Cures for Eczema - Baby dermatitis: how ... - November 26th, 2014 [November 26th, 2014]
- Aveeno Moisturizing Bar - Aveeno Eczema Therapy Moisturizing Cream - Video - November 26th, 2014 [November 26th, 2014]
- How to psychologically & physically confront eczema in you. - Video - November 26th, 2014 [November 26th, 2014]
- Woman, 21, left looking sunburnt by severe eczema finally has the perfect complexion - thanks to a 'magical' cream - November 27th, 2014 [November 27th, 2014]
- Aveeno Baby Sunscreen - Aveeno Baby Coupons - Aveeno Baby Eczema - Video - November 27th, 2014 [November 27th, 2014]
- How I cured my eczema in just over 10 days and you can to. My personal review - Video - November 28th, 2014 [November 28th, 2014]