WEDNESDAY, Aug. 8 (HealthDay News) -- A new oral medication may be available soon for people with rheumatoid arthritis who have not gained relief from other medicines.
As rheumatoid arthritis progresses, people often struggle with everyday tasks and find walking difficult. To help combat those issues, patients with severe forms of the disease often need drugs that must be injected, typically twice a month.
The new drug, tofacitinib, was approved by an advisory panel of the U.S. Food and Drug Administration in May and could be green-lighted by the FDA this month. However, the drug carries the risk of serious side effects, as do injectable treatments. The risks include blood and lymphatic system disorders, infections, and cancer.
"This is an advance, but it's not a cure-all," said Dr. Roy Fleischmann, study author and clinical professor of medicine at the University of Texas Southwestern Medical Center, in Dallas. "We have not cured rheumatoid arthritis."
Rheumatoid arthritis, which differs from age-related osteoarthritis, is a debilitating autoimmune disorder, meaning the body attacks its own tissues. It is characterized by inflammation of the lining, or synovium, of the joints.
The new drug, called a JAK inhibitor, blocks signals that activate inflammatory immune responses involved in the disease.
The FDA is not required to follow its panel's recommendations, but it usually does. Further evidence supporting the benefits of the drug comes in two studies published Aug. 9 in the New England Journal of Medicine.
Fleishmann explained that while people with the disease have benefitted from the discovery of "biologic" drugs such as Humira (adalimumab), Enbrel (etanercept) and Remicade (infliximab), many patients don't find relief from these medications. Biologic products are large proteins that are available only by injection or intravenous administration. The hope, he said, is that JAK inhibitors will help improve the lives of those not getting enough relief from other medications.
Both studies were phase 3 clinical trials, used to test the effectiveness and safety of potential drug therapies in large groups of people.
In Fleischmann's research, about 700 patients who had been taking methotrexate -- a commonly used drug for rheumatoid arthritis -- with inadequate relief were randomly assigned to take either 5 milligrams (mg) or 10 mg of tofacitinib twice daily, 40 mg of Humira every two weeks, or an inactive placebo.
The rest is here:
New Pill Might Relieve Severe Rheumatoid Arthritis
- CCHR: Psychiatric Drugs Side Effects - March 14th, 2011 [March 14th, 2011]
- Senseless - March 31st, 2011 [March 31st, 2011]
- Acid Reflux Drug Side-Effects - April 3rd, 2011 [April 3rd, 2011]
- Drug Side Effects Up, But Benefits Up More - April 20th, 2011 [April 20th, 2011]
- OCD Drug Commercial Side Effects Spoof - Funny Obsessive-Compulsive Disorder Cartoon - ExoticJess - May 20th, 2011 [May 20th, 2011]
- Bipolar side effects song Dustin Prinz drugs ep - May 22nd, 2011 [May 22nd, 2011]
- Anti-Malaria Drug Side Effects on Military Personnel - Cowardice - May 23rd, 2011 [May 23rd, 2011]
- The A to Z of Drug Side Effects - June 11th, 2011 [June 11th, 2011]
- Neurologic side effects of antipsychotic medication - June 12th, 2011 [June 12th, 2011]
- Side Effects of Drugs - USE a SAFER Alternative - MD / RN - Click link at RIGHT - June 15th, 2011 [June 15th, 2011]
- Yaz | Yasmin Drug Side Effects - June 16th, 2011 [June 16th, 2011]
- Nutrition vs. Conventional Medicine - June 18th, 2011 [June 18th, 2011]
- Side Effects of Cholesterol Drugs (Lipitor) - June 21st, 2011 [June 21st, 2011]
- CCHR: Drugging Our Children—Side Effects - June 25th, 2011 [June 25th, 2011]
- Side effects of Common Arthritis Drugs.wmv - June 30th, 2011 [June 30th, 2011]
- Self Hypnosis Hallucination Video (NO SIDE EFFECTS) - July 11th, 2011 [July 11th, 2011]
- How Medicines Work: Drug Problems 3: Interactions and Substrates - July 25th, 2011 [July 25th, 2011]
- Pharmaceutical Drug Commercial Spoof - July 26th, 2011 [July 26th, 2011]
- Nick Gillespie Talks Ed Schultz, TSA v. Texas on Fox News Red Eye w/ Greg Gutfeld - July 27th, 2011 [July 27th, 2011]
- The Drugging Of Our Children (Full Length) - August 13th, 2011 [August 13th, 2011]
- HIV medicine ATRIPLA/side effects - August 17th, 2011 [August 17th, 2011]
- What are the side-effects of ADHD medications? - August 26th, 2011 [August 26th, 2011]
- Chemotherapy Cancer Treatments - August 31st, 2011 [August 31st, 2011]
- Suzy Cohen Tells You About Side Effects from Drug Muggers - September 11th, 2011 [September 11th, 2011]
- Governor Admits Past Drug Use, Now What? - September 25th, 2011 [September 25th, 2011]
- Adderall - College Student Smart Drug - September 26th, 2011 [September 26th, 2011]
- Children Drugged To Death - Channel 4 - September 26th, 2011 [September 26th, 2011]
- Mom Refuses Ritalin and Heals Her ADHD Autism Kids With Natural Medicine - September 26th, 2011 [September 26th, 2011]
- Taking the Tablets - Side Effects - September 29th, 2011 [September 29th, 2011]
- Side Effects Of HIV Drugs - September 30th, 2011 [September 30th, 2011]
- Narcotics Agent Body Slams Drug Laws - October 4th, 2011 [October 4th, 2011]
- Most Astonishing Health Disaster of the 20th Century - October 4th, 2011 [October 4th, 2011]
- The Drug EFFEXOR will bring you to your knees - October 4th, 2011 [October 4th, 2011]
- Depakote Side Affects Harm Autistic Person - October 4th, 2011 [October 4th, 2011]
- TV Commercial DruG SPOoF ! - October 4th, 2011 [October 4th, 2011]
- Side Effects - Part 2 - October 4th, 2011 [October 4th, 2011]
- Side Effects May Include... : from the Goin' Green album by: Audio Faux Pas - October 5th, 2011 [October 5th, 2011]
- How to Sue Drug Companies for Free - October 5th, 2011 [October 5th, 2011]
- Should You Trust Your Doctor? - October 5th, 2011 [October 5th, 2011]
- Xenical (Orlistat) Side Effects - News Report - October 5th, 2011 [October 5th, 2011]
- Side Effects - Part 1 - October 5th, 2011 [October 5th, 2011]
- Chantix Side Effects: The Carter Albrecht Effect - October 5th, 2011 [October 5th, 2011]
- Can I sue if a pharmaceutical drug I took causes negative side effects? - October 6th, 2011 [October 6th, 2011]
- Powerful Form of Ecstasy Drug Kills Blood Cancer Cells - 8/21/11 - October 6th, 2011 [October 6th, 2011]
- Drug voltaren - October 6th, 2011 [October 6th, 2011]
- The Dark Side Of Psychiatry--Antipsychotic Drugs, Olanzapine, Risperidone, Clozapine - October 6th, 2011 [October 6th, 2011]
- My Review Of Accutane - October 6th, 2011 [October 6th, 2011]
- Evista treatment - October 6th, 2011 [October 6th, 2011]
- Tizanidine medicine - October 6th, 2011 [October 6th, 2011]
- Ponstel 250mg - October 6th, 2011 [October 6th, 2011]
- #14.2 Senior Medication Challenges - October 6th, 2011 [October 6th, 2011]
- Levlen 28 - October 6th, 2011 [October 6th, 2011]
- Diclofenac uses - October 6th, 2011 [October 6th, 2011]
- Happy Juice - Peru - October 6th, 2011 [October 6th, 2011]
- Premarin pill - October 6th, 2011 [October 6th, 2011]
- Revatio cost - October 7th, 2011 [October 7th, 2011]
- Alendronate sodium pills - October 7th, 2011 [October 7th, 2011]
- Provera drug - October 7th, 2011 [October 7th, 2011]
- Tizanidine drug - October 8th, 2011 [October 8th, 2011]
- CCHR Video 8a - Side Effects. Anti-Depressants, Suicidal Thoughts. Psychotropic Drugs. - October 8th, 2011 [October 8th, 2011]
- Drug Duphaston - October 8th, 2011 [October 8th, 2011]
- Dydrogesterone in Usa - October 8th, 2011 [October 8th, 2011]
- Vigora price - October 8th, 2011 [October 8th, 2011]
- Premarin drug - October 8th, 2011 [October 8th, 2011]
- Raloxifene side effects - October 8th, 2011 [October 8th, 2011]
- Tizanidine medication - October 9th, 2011 [October 9th, 2011]
- Zanaflex drug - October 10th, 2011 [October 10th, 2011]
- Zanaflex medicine - October 10th, 2011 [October 10th, 2011]
- Vigora - October 10th, 2011 [October 10th, 2011]
- Side Effects of Alzheimer's Disease Medications - October 10th, 2011 [October 10th, 2011]
- Are You Tired of Your Blood Pressure Medicine? - October 11th, 2011 [October 11th, 2011]
- PCOS- Metformin (Is it worth dealing with the side effects) - October 12th, 2011 [October 12th, 2011]
- 1/5.Prozac, Zoloft, Paxil, Viagra, Lipitor, Cialis, Nexium - October 12th, 2011 [October 12th, 2011]
- Drug Side Effects - Video - October 13th, 2011 [October 13th, 2011]
- Drug Interactions and Side Effects - Video - October 13th, 2011 [October 13th, 2011]
- Do You Understand Your Prescription Blood Pressure Drugs? - Video - October 13th, 2011 [October 13th, 2011]
- What you need to know about statin drugs side effects (animation) - Video - October 14th, 2011 [October 14th, 2011]
- The #1 Most Dangerous Blood Pressure Drug Side Effect - Video - October 14th, 2011 [October 14th, 2011]
- Mental Health Medication Side Effects - October 14th, 2011 [October 14th, 2011]
- Prescription Drug Side Effects - Video - October 15th, 2011 [October 15th, 2011]