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The Crohn’s & Colitis Foundation and RMEI Medical Education’s Clinical Convergence – Business Wire (press release)

Posted: August 9, 2017 at 3:40 pm

NEW YORK–(BUSINESS WIRE)–The Clinical Convergence conference series entitled Patient and Provider Perspectives in IBD, is expanding with three new cities added in 2017. The series, a partnership between the Crohns & Colitis Foundation (the Foundation) and RMEI Medical Education (RMEI) is a continuing education initiative for clinicians who treat patients with inflammatory bowel diseases (IBD) and the patients they care for. This innovative mix of educational courses brings communities of healthcare providers and IBD patients together, for improved care and outcomes. Following the success of the 2016 series, there will be three new metro areas in 2017 and all locations now include a special workshop on shared decision-making for patient attendees.

Gastroenterologists and gastroenterology advanced practice providers (nurse practitioners and physician assistants), will engage in interactive CME sessions, while patients participate in parallel education tracks tailored to their needs. The two groups will then converge into a single session for a structured discussion on best practices for IBD patient care and shared decision-making.

The patient-provider relationship, particularly in chronic conditions like IBD, is critical that patients have a more active and participatory role in the ongoing dialogue with providers, said Laura Wingate, Senior Vice President of Education, Support & Advocacy at the Foundation. We believe this annual series can help meet the Foundations long-term goals of improving the lives of patients with IBD, by empowering them with insights on their condition, and supporting the work of their clinicians at the same time.

The 2017 series kicks off on September 9 in Kansas City, MO, followed by Austin, TX on September 16, and Pittsburgh, PA on November 18. Topics will include:

Registration is available at:

The Clinical Convergence: Patient and Provider Perspectives in IBD is made possible by support from AbbVie Inc., Celgene Corporation, Salix Pharmaceuticals, and Takeda Pharmaceuticals USA.

As the healthcare delivery system in the U.S. evolves from volume-based reimbursement to a value-based model, clinicians are under increasing pressure to meet requirements for patient satisfaction scores and engagement metrics, on top of clinical outcomes, notes Dr. Jacqui Brooks, SVP of Medical Strategy at RMEI. The Clinical Convergence series meets patients and providers where they live, bringing expert faculty from leading institutions to discuss practical approaches to the complex issues in IBD care management.

Known collectively as IBD, Crohns disease and ulcerative colitis affects 1 in 200 people. They are painful, medically incurable diseases that attack the digestive system. Crohn’s disease may attack anywhere along the digestive tract, while ulcerative colitis inflames only the large intestine (colon). Symptoms may include abdominal pain, persistent diarrhea, rectal bleeding, fever and weight loss. Many patients require numerous hospitalizations and surgery. Most people develop the diseases between the ages of 15 and 35; however the incidence is increasing in children.

About the Crohn’s & Colitis Foundation

The Crohn’s & Colitis Foundation (the Foundation) is the largest non-profit, voluntary, health organization dedicated to finding cures for inflammatory bowel diseases (IBD). The Foundations mission is to cure Crohn’s disease and ulcerative colitis, and to improve the quality of life of children and adults who suffer from these diseases. The Foundation works to fulfill its mission by funding research; providing educational resources for patients and their families, medical professionals, and the public; and furnishing supportive services for those afflicted with IBD. For more information visit, call 888-694-8872, or email [email protected].

About RMEI Medical Education

Founded in 1990, RMEI Medical Education (RMEI) is one of the longest operating medical education companies in the U.S. With an emphasis on sophisticated learner analytics for program design, delivery and assessment, RMEI works to elevate the dialogue on what makes for effective education. In designing innovative teaching modalities such as the Clinical Convergence platform for its primary therapeutic areas of focus, RMEI seeks to inspire greater collaboration within the care team and stronger commitment to patient engagement. For more information, visit, call 856-672-3152 or email at [email protected].

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The Crohn’s & Colitis Foundation and RMEI Medical Education’s Clinical Convergence – Business Wire (press release)

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Genetic Alterations May Cause Hemiplegic CP While Fetus Is Developing, Study Reports – Cerebral Palsy News Today

Posted: at 3:40 pm

A Canadian study identified a genetic link that may cause hemiplegic cerebral palsy (CP) in utero while the fetus is developing.

The study was a collaborative effort between many research scientists and clinicians in Ontario, Canada, and it was funded by the CP-NET (Childhood Cerebral Palsy Integrated Neuroscience Discovery Network) Integrated Discovery Program of the Ontario Brain Institute.

Hemiplegic CP affects only one side of the body, and the condition is estimated to affect approximately 1 in 1,300 live births. People generally think cerebral palsyis caused by physical factors such as birth asphyxia, stroke, or infection of the developing fetal brain. Now, this new research suggests that genetics may also play a role in the cause of hemiplegic CP.

The study, De novo and rare inherited copy-number variations in the hemiplegic form of cerebral palsy, wasrecently published in the journalGenetics in Medicine.

Researchers analyzed DNA from nearly 100 children with hemiplegic CP and their biological parents, and compared itto DNA from normal population controls. The team identified specific genetic alterations called copy number variants (CNVs) in several genes important for brain development and function.

Some of these CNVs occur randomly while other CNVs can be inherited although rarely from the parents. Combining both new and inherited CNVs, these genetic alterations were found in over 20 percentof hemiplegic CP cases. Researchers attributed these CNVs to the cause of hemiplegic CP in about 5 percentof the cases.

We are getting closer to understanding the complex biology of CP and the potential brain development genes that impact a childs risk of developing it, Darcy Fehlings, senior clinician scientist at Holland Bloorview Kids Rehabilitation Hospitalin Toronto and principal investigator at CP-NET, saidin a press release.

Findings support a strong genetic link to the cause of hemiplegic CP, which affects 35 percent of kids with CP, Fehlings added. Clinically this supports the use of genomic testing as part of forming the work-up for a child with hemiplegic CP. In the future, understanding the genetic basis of CP may lead to the development of new treatment approaches.

The study shows that genetics can play an important role in the development of cerebral palsy during fetal development, and it raises questions about the role of genetic testing. Genetic testing would offerparents, as well as physicians, more information about the reasons why achild may develop CP. This knowledge could also lead to better treatments.

The discovery of a genetic link to CP not only demonstrates progress in understanding the condition better, but also highlights the benefit and need for increased research collaboration, saidTom Mikkelsen,president and scientific directorat the Ontario Brain Institute.

To find definite answers and effective treatments, we need to come together as a neuroscience community in order to maximize impact and improve the lives of people living with brain disorders, he said.

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Cerebral palsy won’t keep 7-year-old from riding in the rodeo … – Billings Gazette

Posted: at 3:40 pm

Arabelle Laddusaw feels at her most independent when she’sriding her horse and competing in the rodeo. She’s in control and it’s the best thing she does all week.

“It’s exciting and I love doing it,” she said.

Arabelle is 7 and will be a second-grader at Big Sky Elementary when school resumes this month. As a 1-year-old she was diagnosed with cerebral palsy and has spent most of her young life learning to live with it.

Arabelle Laddusaw flashes a smile as she rides her horse, Sister, out of the arena after competing in the pole bending competition during a kid’s rodeo at Miller’s Horse Palace in Laurel last month. Arabelle was born with cerebral palsy and loves riding horses.

And horses and rodeo is how she does it.

Horses have long been a big part of the Laddusaw family.

“My mom has always ridden horses,” said Christine Laddusaw, Arabelle’s mother.

Christine’s parents have owned horses nearly all their lives, and Arabelle’s older sister was a barrel racer all through high school. It wasn’t long after Arabelle learned to talk that she started asking about riding horses.

“She said she wanted to do it and so I told her, ‘We’ll figure it out,'” Christine Laddusaw said.

Ken Laddusaw, left, and Christine Laddusaw, right, walk out with Arabelle Laddusaw on her horse, Sister, to compete in the goat tying competition during a kid’s rodeo at Miller’s Horse Palace in Laurel last month.

Arabelle was born prematurely, and Christine knew at the time that her daughter would likely have cerebral palsy. When the diagnosis was official, Christine knew there would be activities other kids could do that Arabelle likely couldn’t.

Cerebral palsy is a type of damage to specificbrain matter that affects a person’s ability to move. When Arabelle explains it to her friends, she tells them that the signals that fire from her brain giving directions to her legs get lost on the way down.

Specifically, Arabelle has spastic diplegic cerebral palsy. The nerves that tell the muscles in both legs to contract are constantly firing, meaning Arabelle’s legs are rigid and immovable. As a toddler her legs settled in a stiff, scissor position.

That was about the time Arabelle started seeing Susan Apkon, a doctor at Seattle Children’s Hospital in rehabilitation medicine. Apkon specializes in children with disabilities.

To help loosen the rigidity, Apkon had Arabelle undergo a surgery that clips selective sensory nerves in her lower back to reduce the amount of signals telling her legs to flex.

“It’s a really cool surgery and really effective,” Apkon said.

Arabelle Laddusaw, 7, loves to ride in the rodeo. She was diagnosed with cerebral palsy when she was 1.

It’s been a success for Arabelle. Her legs are no longer rigidly scissored and she can use them with the aid of crutches and a walker to get around. But really, nothing would have held her back.

“I’ve had a lot of kids who’ve done horse-based therapy,” Apkon said. “I’ve never had anyone quite like Arabelle.”

Arabelle is bright, funny and headstrong with a shock of curly blonde hair. And being able to participate in the Tomorrow’s Rodeo Champions program she gets to experience complete independence, something she constantly pushes for in her everyday life.

“I say to my aide at school, ‘Just let me do it,'” she said, smiling.

Christine was never really nervous about Arabelle participating in rodeo. Horses and rodeo are a big part of her family culture. But more to the point, for the younger children who participate, the horses are led around the arena by adults and the events are tightly controlled.

Arabelle Laddusaw, who has cerebral palsy, sits atop her horse, Sister, with her mother Christine Laddusaw at her side while waiting to compete in a kid’s rodeo at Miller’s Horse Palace in Laurel last month. A surgery when she was a toddler has helped her be able to ride.

But now that Arabelle is 7, that’s not the case.

“This year has been the scariest,” Christine said.

The horses are no longer guided in competition, and the children control the animals on their own. With the cerebral palsy, Arabelle can’t kick to spur the horse forward, so she uses sounds to control it. She’smore or less strapped onto the horse with a special harness so there’s no danger of her falling out of the saddle. That brings her mother some comfort.

“And it’s great therapy,” Apkon said.”Her participation in that rodeo, it’s just perfect.”

Participating in the rodeo helps Arabelle build core strength and upper body strength. It sharpens her concentration and provides a specific type of mental rigor.

“She constantly has to think ahead,” Christine said.

Most importantly, practicing and competing with the rodeo places Arabelle among peers. It’s a setting in which she can comfortably socialize and create genuine friendships. She’s able to find confidence.

“It’s being part of a group,” Christine said. “She’s not left out.”

Christine Laddusaw lifts daughter Arabelle Laddusaw off her horse, Sister, to compete in the goat tying competition during a kid’s rodeo at Miller’s Horse Palace in Laurel last month.

Apkon sees its value because it allows Arabelle to be a kid and for a few moments not to have to think about cerebral palsy.

For Arabelle, it’s just another way to push a bit on the borders that define her everyday world. She pushes to play unaccompanied on the playground and often tries to talk her mom into letting her try something new. More often than not, Christine will relent just a bit and discover that Arabelle can do some surprising things.

“It’s us that hold her back, not her,” Christine said, smiling.

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Researchers call on province to fund genetic testing for cerebral … – Toronto Star

Posted: at 3:40 pm

Julian Cappelli, 16, who has cerebral palsy, enjoys some time with his mother Donna in their Toronto home. A new study from Holland Bloorview and SickKids has found there’s a stronger genetic link in cases of hemiplegic cerebral palsy, the most common form of CP, than previously thought.(Bernard Weil / Toronto Star) | Order this photo

By Ainslie CruickshankStaff Reporter

Tues., Aug. 8, 2017

Researchers say genetic testing should be standard practice when diagnosing cerebral palsy after a new study found that genetic variations could be a factor in hemiplegic cerebral palsy, the most common form of the motor disability.

Standardizing a genetic workup for children with cerebral palsy, though, would depend on government funding.

There should be genetic testing that happens as soon as possible; thats the take home message in this study, said Stephen Scherer, director of the Centre for Applied Genomics at SickKids and one of the authors of the study, which was done by researchers at Holland Bloorview Kids Rehabilitation Hospital and the Hospital for Sick Children.

For families, genetic testing could help explain why their child developed cerebral palsy. For researchers, it offers new directions for research aimed at preventing and treating the condition, which affects three out of every 1,000 children born in Canada each year.

The impact of this I think is going to be very, very significant, Scherer said.

Sitting in the kitchen of his east-end home, Julian Cappelli, 16, is wearing a red Toronto FC T-shirt. Soccers his favourite sport and TFC is his favourite team.

Julian has quadriplegic cerebral palsy, which affects all four of his limbs. His family received that diagnosis when he was one year old. Julian said if he had the chance to have genetic testing done, hed take it. Even 15 years later, he wants to know why he has a motor condition that, for him, means he wont get the chance to try for a professional soccer career.

His mom, Donna, doesnt spend much time anymore wondering why he has cerebral palsy. Were kind of just moving forward and dealing with what we have, she said.

But that doesnt mean shes not excited about the new research. She is.

She remembers what it was like 15 and 16 years ago, wanting answers.

It was so overwhelming and you do want to know: Why did this happen? Was it something that you did?

Its good to see that theyre still looking into the reasons why this is happening and trying to help prevent it and make these kids lives better, she said.

Cerebral palsy is the most common physical disability in children, said Dr. Darcy Fehlings, a senior clinician scientist at Holland Bloorview specializing in cerebral palsy research and another of the studys authors.

Although it is a permanent disability that affects childrens motor movements, it manifests itself differently in every child. In some cases, children may have difficulty using their hands or walking. In other cases, they may have trouble communicating or might need to use a wheelchair.

Though cerebral palsy is often thought to be caused when a baby doesnt get enough oxygen before, during or after birth, causing damage to their brain or other organs, by stroke or infection in a childs brain, researchers found a significant genetic link in hemiplegic cerebral palsy, which affects only one side of the body.

The study, published in the Genetics in Medicine journal and promoted by, outlines the results of DNA analysis on 97 children with hemiplegic cerebral palsy and their parents compared with more than 10,000 population control samples.

The researchers found that structural variations to the DNA that affect the genes for brain development and function were factors in 20 per cent of hemiplegic cerebral palsy cases and probably the major cause in five per cent of cases.

We didnt even look for this before, Scherer said. In retrospect, we should have.

Diagnosing cerebral palsy can be difficult, especially in children, who arent fully developed. In about 10 per cent of cases, children diagnosed with cerebral palsy may actually have a different disorder, he said. A genetic workup can help confirm the diagnosis and make sure the best treatment plan is developed.

In a statement, a spokesperson for the Ministry of Health and Long-Term Care said the ministry recognizes the importance of genetic testing in providing patient care.

Generally, with new or emerging tests, the test would undergo evidence-based evaluation that would guide decisions whether or not the test is used as part of routine standard of care, and making the best use of public healthcare resources.

Genetic testing is already used to help diagnose and develop treatment for cystic fibrosis and muscular dystrophy. More recently, it is being used to help diagnose and develop treatment for autism spectrum disorder.

Theres way more data here than we had in our early autism studies, Scherer said.

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United Cerebral Palsy’s annual ‘Wing Ding’ coming Thursday –

Posted: at 3:40 pm

In the world of drums and flats, there is no bigger bird show in STL thanUnited Cerebral Palsy Heartland’s annual “Wing-Ding” fundraiser.

This year, the seventh annual meet and treat, will be from 5:30 to 9 p.m. Thursday at the Greensfelder Arena in Queeny Park.

Eleven STL restaurants will compete in three categories: traditional, specialty and dry-rubbed. There also will be a best-of-show award.

Along with yours truly, our fair burg’s top daily newspaper will send Go! Magazine editor Gabe Hartwig and food writerDan Neman.

A flock of radio jocks have signed up for the good cause (and free food):Trish “Vogue” Gazall and Greg Hewitt of KEZK-FM 102.5; John Carney, Jon Grayson and Marc Lillibridge of KTRS-AM 550; Howard Balzer of KXFN-AM 1380; Staci Static of WFUN-FM 95.5; and Scott Rizzuto and Tony Patrico of KPNT-FM 105.7.

But wait, there’s more.Steve Harris of KMOV (Channel 4);St. Louis Magazine dining editor George Mahe; andDee Ryan of Sauce magazine also will be on hand with other celebrity judges.

Contestant are: Barristers; EdgeWild Bistro & Tap; Hot Shots Sports Bar & Grill; Smugalas Pizza Pub; St. Louis Wing Co.; Sugarfire Smokehouse; The Slider House; Three Kings Public House; Truemans Soulard Sports Bar; Walnut Grill; and the Wheelhouse-Downtown.

Tickets are $30 in advance, $35 on the day of the event. A VIP ticket is $50. For tickets or information, call 636-799-2299 or go to thecharity’s website.

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3 Natural Ways To Manage Eczema – Reports Healthcare

Posted: August 8, 2017 at 1:44 pm

Eczema is a prevalent disease caused usually by allergens in food, perfumes, hair and skincare products for most people. A number of cases have had the disorder because of slow and poor digestions as well as gut related problems such as Leaky Gut Syndrome.

While an eczema attacks can occur due to any sudden exposure to a certain type of chemicals or any type of substance, studies have shown that genetics and allergies have been more responsible for most of the incidences.

This is why people are usually diagnosed with eczema at very young ages or as toddlers. People with genetic eczema mostly have it in visible spots such as the cheeks, chin, arms, and legs. For adults and teenagers, it is less likely to happen on the face and is usually observed to be in the back, chest or ankles.

Eczema can be easily spotted because of its reddish, itchy rashes though these marks vary from person to person depending on factors such as the skin type of the particular person. For example, people with dry and sensitive skins have cracked and blister-filled spots while people with oily skin with have a paler tone of red in their spots.

Nevertheless, it is the redness of the eczema rashes that make them easy to be diagnosed as well as the chronic itch that comes with it. Itching induced by this disease can be so chronic that it can make the rashes bleed which further damages the skin.Some researchers have shown that eczema is not a single condition but a combination of various skin problems that have similar symptoms. These different types of eczemas are based on their causes. The most commonly detected ones are:

What are the symptoms of Eczema?Symptoms of Eczema can vary in terms of being chronic or acute. Signs such as redness and cracking tend to occur periodically, usually in response to fluctuating immunity in the specific person or rise in stress levels.

Some of these signs might even go away, leaving behind no spots for several weeks or even years, but they are usually reoccurring and the patients are likely to suffer repeatedly and often in a more severe form if the condition is not treated properly. Though different types of eczema might come with unique symptoms, the most commonly shared ones are:

Conventional Treatments for EczemaA proper cure for eczema really does not exist. Dermatologist instead recommends a routine that can avoid intensification of eczema effects and manage its symptoms which usually consists of avoiding products that can be hard on the skin and daily, mild cleansing.Sometimes these routines can include changes in daily food intake, especially in cases of allergic eczema to lower chances of coming in contact with those allergens in normal meals without knowing.

When professional help and medication becomes a necessity, skin creams can often give to eczema patients to reduce the dryness in the skin and moisturize. An example of this can be steroid creams or Corticosteroid that can control itchiness in the skin and stop a patient from hurting eczema affected parts.

Pimecrolimus and Tacrolimus are used as a substitute for patients whose skin have become too sensitive or is just not suited to handle steroids from Corticosteroid.

The use of skin-sensitive products is recommended by most dermatologists even at the very first symptoms of eczema. Skincare and hair products, in accordance with studies, contribute greatly to eczema as synthetic smells and their chemical-rich formulas can irritate the skin greatly.Companies have therefore developed eczema-special medicated products that do not contribute to the severity of eczema in any other way.

What Can You do to Prevent Eczema?Although most people prefer seeking professional help for eczema, there are a number of ways the severity of eczema can be controlled at home, reducing chances of more harm. Simple changes in habits that can manage this skin disorder include:

Natural home remedies and treatments can always help in managing eczema even if one prefers help from a doctor. In fact, for better health and fast improvement in severe eczema, a combination of both can do wonders if done properly.

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Devaluing human life is no way to thank wounded veterans for their … – The Hill (blog)

Posted: at 1:44 pm

For a veteran facing a lifetime of paralysis after suffering a spinal cord injury, hope is often the last thing to die. Yet, the recently introduced House bill, H.R. 3197, threatens to crush what little hope to which I, and the approximately 60,000 veterans living with spinal cord injury, cling. The act proposes to reduce investment in medical research, and the reason is as simple as it is controversial: animal research.

Introduced by Rep.Dave Brat (R-Va.), the Act follows reports of experimentation on dogs at the McGuire VA Medical Center in the congressmans home state. Purportedly disturbing reports revealed that animals were being given amphetamines and suffering heart attacks, among other research-based details that arent easily digestible by those outside of the scientific community. The mainstream gut reaction that followed these revelations was easy to predict. When contemplated in a vacuum, the thought of animals experiencing induced pain would bother any reasonable person. However, I do not enjoy the luxury of contemplating these thoughts in a vacuum.

When House members voted on July 26, 2017 to ban all VA medical testing that causes pain to animals, specifically targeting VAs canine research program, it was the first step toward a complete devaluation of the lives of catastrophically injured veterans. Brat declared, “From what I read, the type of work that [VA researchers] were doing was on the level of torture.”

I understand how reading a report like that would spur intense emotion and abstract horror. But if the congressman had put down the report and accompanied me to a VA hospital, he would have discovered that the price of military service is not abstract. He would have seen firsthand what it’s like to care for a paralyzed veteran with a failing heart on a VA spinal cord injury unit; or another on the polytrauma unit who needs a new pancreas, among other missing body parts that need to be replaced. After that reality check, Id have asked the congressman, to consider these facts: It was VA’s canine research that spurred the development of the cardiac pacemaker and artificial pancreas the Food and Drug Administration approved just last year, which serves to benefit both veterans and those who have never worn the uniform. Non-VA canine research has also led to the discovery of insulin, new tests and treatments for various types of cancer and has played an important role in ushering in advancements in heart surgery procedures. While that reality may be inconvenient, its like freedom and democracy; it all comes at a price. I’d rather that price involve as little human suffering as possible. It’s apparent, however, not everyone agrees.

I would like to leave the legislative debate to the congressman and his colleagues, but its the ideology behind this bill that troubles me.Those participating in the debate over the VA’s animal research program appear to fall into two camps: those who believe we should doeverythingwe can to improve the lives of seriously injured veterans, and those who refuse to stare the ugly consequences of war in the face. It is not that simple though. The U.S. military faces the ugliness for its citizens, which includes our public servants.Now that those citizens are faced with the aftermath, some are having second thoughts.

The VA has a responsibility to consistently find new and better ways of treat Americas heroes. Animal research helps the department do that. The program has helped save and improve countless lives, and it will continue to do sounless ideology, and in some cases extremism on the issue of animal rights, succeed in forcing the public’s attention away from VA waiting rooms, inpatient wards, and rehabilitation gyms across the country. This is where the price of wars across several eras can be seen almost daily, as well as where medicine and science find their ripest opportunities.

Medical and scientific experts in America, as well as across the globe, agree animal research is essential. Thats because only animal research will provide the answers needed to develop revolutionary new treatments. Whether we like it or not, canine research is especially vital to potential medical breakthroughs because of unique traits shared by humans and dogs. In fact, CNN recently highlighted in a February 2017 story how canine research is leading to better results than traditional cancer research efforts.

Despite the hyperbole used by legislators to invoke disturbing images, VA is conducting research that is vital to seriously disabled veterans.That is what cannot be forgotten or eclipsed by words hyperlinked to extreme ideologies. Canine studies address a host of medical problems afflicting them, and it advances treatments that heal them, or at the very least, mitigate their suffering and give them a better quality of life. Ive seen it for myself, as Paralyzed Veterans of America has collaborative partnerships with Yale University and New Haven VA Medical Center to further the treatment advances that make veterans sacrifices endurable.

The research conducted at these facilities includes exploring cures and treatments for fatal lung infections affecting those with spinal cord injuries, dysfunction in brain circuits that control breathing, and whether service dogs reliably reduce the symptoms of post-traumatic stress disorder. Orthopedics research conducted with animals is especially important to many VA patients, as it has been essential to the design and testing of new prosthetic devices for veterans who have lost limbs.

Much of the animal research VA is doing aims to benefit a small group of veterans with specialized needs those whove sustained serious injuries in the line of duty. As a veteran who represents tens of thousands within this group, veterans who stand to benefit from VAs animal research efforts, I am compelled to challenge those who are fighting to shut this vital program down. I ask them, instead, to take a step back and look at things from our perspective.We are veterans who live with severe disability, many still in the prime of our lives. Our lives after service will never be the same as our lives before service, but advances in research will help us experience lives with less painand more hope.

It is my sincere hope there will come a time when we dont need animals for research. Unfortunately, that time has not arrived, and because of the incredible complexity of human anatomy and our still-limited understanding of how it works, animal research will be needed for the foreseeable future. To those who remain unconvinced, Ill close with two questions:What wouldn’t you do to find a cure for spinal cord injury, cancer, chronic lung infection, orthopedic deterioration, or other serious afflictions associated with military service?Then,what would you do if it wasyourson or daughter who served and returned home profoundly broken by battle, illness or disease?

For many veterans and their families, these questions are not philosophical. Because for them, hope is indeed the last thing to die. It is now up to Congress to decide whether that hope will be put completely out of its misery.

Sherman Gillums Jr. is a retired U.S. Marine officer who suffered a spinal cord injury in 2002 while serving on active duty. His career with Paralyzed Veterans of America started in 2004 after he completed rehabilitation at the San Diego VA Spinal Cord Injury & Disease Center. He is an alum of University of San Diego and Harvard Business School.

The views expressed by this author are their own and are not the views of The Hill.

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Ulcerative Colitis vs. Crohn’s Disease Similarities And Differences … – HuffPost

Posted: at 1:43 pm

Under normal circumstances, our immune system does its job of protecting the body from infection. However, in people who suffer from a condition called inflammatory bowel disease (IBD), the immune system mistakes food, bacteria, and other materials in the intestine for foreign substances by attacking the cells of the intestines.

During the time the immune system is attacking the cells, the body sends white blood cells into the lining of the intestines where they produce chronic inflammation leading to a cascade of various symptoms.

IBDs are complex, multifactorial disorders in which the body loses its tolerance to its gut microorganisms. It is estimated 1.4 million people in the United States have IBD. The peak age of onset is 15 to 30 years, although IBD can occur at any age.

The two most common IBDs are Crohns disease (CD) and ulcerative colitis (UC). Both are conditions characterized by chronic inflammation of the digestive tract. They do share many similarities, yet they also have key differences between them.

Similarities between Crohn disease and Ulcerative Colitis

Both involve a loss of tolerance to intestinal bacteria.

They often develop in teenagers and young adults.

The causes of each are not known, but both have similar types of contributing factors such as environmental, genetic and an inappropriate response by the bodys immune system.

They are diagnosed more frequently in urban areas compared to rural areas.

There is a reduced incidence of IBDs in people living in southern latitudes presumably related to vitamin D status.

Both have signs and symptoms of diarrhea, abdominal pain, weight loss, and decreased bone mineral density. Other symptoms they share are rectal bleeding, urgent need to move bowels, the sensation of incomplete evacuation and constipation.

Both are associated with other conditions like joint pain, eye irritation, kidney stones, and liver disease.

Differences between Crohn disease and Ulcerative Colitis

CD can occur anywhere in the gastrointestinal tract from the mouth to the anus; UC only occurs in the colon.

In CD, there are healthy parts of the intestine mixed in between inflamed areas. UC is a continuous inflammation of the colon.

UC only affects the inner most lining of the colon while Crohns disease can occur in all the layers of the bowel walls.

CD can have additional problems with the skin and gallstones while UC is associated with osteoporosis and possibly colon cancer if the entire colon has been affected over 8 to 10 years.

Over 50 percent of individuals with CD will have nutritional deficiencies of folate and vitamin D while over 50 percent of those with UC will have deficiencies of iron.

Dietary considerations for both Crohns disease and Ulcerative Colitis

Diet is not a cause of either CD or UC, and it will not cure a person but paying special attention to diet can help reduce and control IBD symptoms. Keeping a food journal by writing down food eaten helps to identify foods causing distress is a good method for determining foods to eliminate from the diet. Here are a few suggestions to help control symptoms during flare ups:

Eat frequent, small meals

Reduce the amount of greasy or fried foods

Limit consumption of milk or milk products

Restrict intake of certain high-fiber foods such as nuts, seeds, corn, or popcorn

Both CD and UC have their challenges and complications, yet a person can still lead a full, happy and productive life. Finding a healthcare professional who is experienced treating IBDs will help maintain health, and they can connect the individual with others having the same condition to lend support.

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Ulcerative Colitis vs. Crohn’s Disease Similarities And Differences … – HuffPost

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Ulcerative Colitis Therapeutics – Pipeline Analysis 2017 – Research and Markets – Business Wire (press release)

Posted: at 1:43 pm

DUBLIN–(BUSINESS WIRE)–The “Ulcerative Colitis Therapeutics Pipeline Analysis, 2017” report has been added to Research and Markets’ offering.

Ulcerative colitis is a chronic inflammatory disease, which basically affects colonic mucosa. The main identified symptoms of the disease are bloody diarrhea, abdominal cramps and fatigue. Some of the other symptoms include, fever, vomiting, anorexia, abdominal distension and bloating. The leading cause of ulcerative colitis is the imbalance in regulation of gastrointestinal immune system. According to the International Society for Pharmacoeconomic and Outcomes Research journal named as value in health, the prevalence of ulcerative colitis has increased from 243 to 263 per 100,000 people each year in the U.S. Ulcerative colitis usually affects the upper layer of all parts of intestine mostly in colon and rectum. The main causes of the disease are genetic susceptibility and environmental factors such as, microbiological, smoking, immunological and psychological factors.

The treatment of ulcerative colitis includes tumor necrosis factor inhibitors, such as adalimumab, golimumab and infliximab which were approved for treatment of moderate to severe form of ulcerative colitis in patients who have failed to respond to the other conventional therapies such as, corticosteroids, mesalazine and 5-Aminosalicylic acid. The 5-Aminosalicylic acid is currently used as the first line of therapy for ulcerative colitis and the number of reported cases of relapse of disease or refractory cases are very low.

As of April 2017, the ulcerative colitis pipeline comprised of approximately 89 drug candidates in different stages of development.

Key Topics Covered:

1. Research Background

2. Research Methodology

3. Executive Summary

4. Pipeline Outlook

5. Ulcerative Colitis Therapeutics Pipeline Analysis By Phase (2017)

6. Competitive Landscape

7. Company Profiles

8. Appendix

For more information about this report visit

Ulcerative Colitis Therapeutics – Pipeline Analysis 2017 – Research and Markets – Business Wire (press release)

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Spoiler alert: IBD superheroes prevail as Takeda wraps its Marvel Comics project – FiercePharma

Posted: at 1:43 pm

Takeda has closed the book on its first inflammatory bowel disease awareness graphic novel. In the end, the Unbeatables superhero team prevailednot only over the evil trillionaire trying to take over the world, but also over IBD.

The wrap-up of the first IBD Unmasked comic book, which launchedlast July,incorporated the power of IBD sufferers in theirfinal battle against the enemy. It turns out that the villain Technonaut couldn’t control the Unbeatables because of their awesome willpower. The everyday superheroes who felt weak or embarrassed in real life because of their IBDs were the only ones with the personal strength to combine forces and defeat Technonaut.

The insights in the graphic novel’sfinal chapters include a story line about sibling jealousy over the attention one superhero brother with Crohns disease receives, along with the positive effects of sharing IBD community experiences online. The project featured characters with a variety of IBDs, including Crohns and ulcerative colitis.

Takeda worked with Marvel Comics on the custom series, which was written by Deadpool co-creator Fabian Nicieza. The company created a panel of IBDsufferers to help develop the content, and the final chapters include new patient insights. A spokesman said that while the graphic novel is now completed, the IBD Unmasked campaign will continue.

We worked with a panel of patients from around the globe to provide input and suggestions for the script and design of the complete graphic novel,” said Elissa Johnsen, senior director of global product and pipeline communications at Takeda, in an email interview. “Its important to Takeda that any initiative is based on learnings and insights from the community to make sure any content developed will be beneficial.”

One of the IBD panel members added, via news release, Only a person with IBD can understand what it is truly like. IBD Unmasked has shed light on the patient experience and given me the opportunity to have a positive impact on the IBD community.

While the campaign itselfis unbranded, Takeda markets the biologic therapy Entyvio, a newer IBD market entrant that began a branded campaign in early 2016. The drug faces heavy competition in the crowded IBD space; it’sup against more established Crohn’s and ulcerative colitis brands such as AbbVie’s Humira, Amgen’s Enbrel, and Johnson & Johnson’s Remicade and follow-up Simponi.

In the company’s 2015 year-end financial presentation, Takeda wrote that Entyvio is “on the way to over $2 billion in peak sales. Total Entyvio sales for 2016 were about $775 million (86.2 billion yen), up from about $530 million (59.3 billion yen) in 2015.

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Spoiler alert: IBD superheroes prevail as Takeda wraps its Marvel Comics project – FiercePharma

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