Public release date: 27-Aug-2012 [ | E-mail | Share ]
Contact: Andrea Teixeira Carvalho atcteixeira@gmail.com Society for Experimental Biology and Medicine
Scientists at the Oswaldo Cruz Foundation and Federal University of Minas Gerais, led by Dr. Andra Teixeira-Carvalho and Dr. Mnica Cristina de Oliveira, have developed and characterized a circulating and pH-sensitive liposome containing cisplatin (SpHL-CDDP) aiming to promote the release of cisplatin near the tumor as well as decreasing toxicity. The development of analog drugs and new formulations are current strategies for increasing the effectiveness and safety of cisplatin as an anti-peritoneal carcinomatosis drug. The results, which appear in the August 2012 issue of Experimental Biology and Medicine demonstrate that the treatment of initial or disseminated Ehrlich ascitic tumor-bearing Swiss mice with SpHL-CDDP improved the antitumor efficacy and decreased renal and bone marrow toxicity of cisplatin-based therapy.
"Peritoneal carcinomatosis is a serious concern in the treatment of abdominal tumors such as hepatic, gastric and gynecological tumors", says Dr. Oliveira. "The strategy of local chemotherapy is interesting due to the possibility to increase the therapeutic efficacy while minimizing systemic side-effects. SpHL-CDDP treatment was able to reduce cancer cell proliferation and increase survival, in the animal model, with no known toxicity clinical signs found in the free CDDP treatment." says Dr. Maroni.
These results open the possibility of future use of SpHL-CDDP in chemotherapy of peritoneal carcinomatosis. "New studies are underway in our research group to investigate the signaling pathways of cell death as well as use of high doses of SpHL-CDDP for the treatment of peritoneal carcinomatosis", says Dr. Teixeira-Carvalho.
Dr. Steven R. Goodman, Editor-in-Chief of Experimental Biology and Medicine, said " This very interesting study has utilized a new pH-sensitive circulating liposome containing cisplatin formulation which decreased cancer proliferation and drug toxicity in a mouse model. This provides the basis for further translational testing of this formulation leading to clinical trials aimed at more effective treatment of abdominal tumors".
###
Experimental Biology and Medicine is a journal dedicated to the publication of multidisciplinary and interdisciplinary research in the biomedical sciences. The journal was first established in 1903.
Experimental Biology and Medicine is the journal of the Society of Experimental Biology and Medicine. To learn about the benefits of society membership visit http://www.sebm.org. If you are interested in publishing in the journal please visit http://ebm.rsmjournals.com .
View original post here:
pH-sensitive liposomal cisplatin improves peritoneal carcinomatosis treatment without side-effects
- CCHR: Psychiatric Drugs Side Effects - March 14th, 2011 [March 14th, 2011]
- Senseless - March 31st, 2011 [March 31st, 2011]
- Acid Reflux Drug Side-Effects - April 3rd, 2011 [April 3rd, 2011]
- Drug Side Effects Up, But Benefits Up More - April 20th, 2011 [April 20th, 2011]
- OCD Drug Commercial Side Effects Spoof - Funny Obsessive-Compulsive Disorder Cartoon - ExoticJess - May 20th, 2011 [May 20th, 2011]
- Bipolar side effects song Dustin Prinz drugs ep - May 22nd, 2011 [May 22nd, 2011]
- Anti-Malaria Drug Side Effects on Military Personnel - Cowardice - May 23rd, 2011 [May 23rd, 2011]
- The A to Z of Drug Side Effects - June 11th, 2011 [June 11th, 2011]
- Neurologic side effects of antipsychotic medication - June 12th, 2011 [June 12th, 2011]
- Side Effects of Drugs - USE a SAFER Alternative - MD / RN - Click link at RIGHT - June 15th, 2011 [June 15th, 2011]
- Yaz | Yasmin Drug Side Effects - June 16th, 2011 [June 16th, 2011]
- Nutrition vs. Conventional Medicine - June 18th, 2011 [June 18th, 2011]
- Side Effects of Cholesterol Drugs (Lipitor) - June 21st, 2011 [June 21st, 2011]
- CCHR: Drugging Our Children—Side Effects - June 25th, 2011 [June 25th, 2011]
- Side effects of Common Arthritis Drugs.wmv - June 30th, 2011 [June 30th, 2011]
- Self Hypnosis Hallucination Video (NO SIDE EFFECTS) - July 11th, 2011 [July 11th, 2011]
- How Medicines Work: Drug Problems 3: Interactions and Substrates - July 25th, 2011 [July 25th, 2011]
- Pharmaceutical Drug Commercial Spoof - July 26th, 2011 [July 26th, 2011]
- Nick Gillespie Talks Ed Schultz, TSA v. Texas on Fox News Red Eye w/ Greg Gutfeld - July 27th, 2011 [July 27th, 2011]
- The Drugging Of Our Children (Full Length) - August 13th, 2011 [August 13th, 2011]
- HIV medicine ATRIPLA/side effects - August 17th, 2011 [August 17th, 2011]
- What are the side-effects of ADHD medications? - August 26th, 2011 [August 26th, 2011]
- Chemotherapy Cancer Treatments - August 31st, 2011 [August 31st, 2011]
- Suzy Cohen Tells You About Side Effects from Drug Muggers - September 11th, 2011 [September 11th, 2011]
- Governor Admits Past Drug Use, Now What? - September 25th, 2011 [September 25th, 2011]
- Adderall - College Student Smart Drug - September 26th, 2011 [September 26th, 2011]
- Children Drugged To Death - Channel 4 - September 26th, 2011 [September 26th, 2011]
- Mom Refuses Ritalin and Heals Her ADHD Autism Kids With Natural Medicine - September 26th, 2011 [September 26th, 2011]
- Taking the Tablets - Side Effects - September 29th, 2011 [September 29th, 2011]
- Side Effects Of HIV Drugs - September 30th, 2011 [September 30th, 2011]
- Narcotics Agent Body Slams Drug Laws - October 4th, 2011 [October 4th, 2011]
- Most Astonishing Health Disaster of the 20th Century - October 4th, 2011 [October 4th, 2011]
- The Drug EFFEXOR will bring you to your knees - October 4th, 2011 [October 4th, 2011]
- Depakote Side Affects Harm Autistic Person - October 4th, 2011 [October 4th, 2011]
- TV Commercial DruG SPOoF ! - October 4th, 2011 [October 4th, 2011]
- Side Effects - Part 2 - October 4th, 2011 [October 4th, 2011]
- Side Effects May Include... : from the Goin' Green album by: Audio Faux Pas - October 5th, 2011 [October 5th, 2011]
- How to Sue Drug Companies for Free - October 5th, 2011 [October 5th, 2011]
- Should You Trust Your Doctor? - October 5th, 2011 [October 5th, 2011]
- Xenical (Orlistat) Side Effects - News Report - October 5th, 2011 [October 5th, 2011]
- Side Effects - Part 1 - October 5th, 2011 [October 5th, 2011]
- Chantix Side Effects: The Carter Albrecht Effect - October 5th, 2011 [October 5th, 2011]
- Can I sue if a pharmaceutical drug I took causes negative side effects? - October 6th, 2011 [October 6th, 2011]
- Powerful Form of Ecstasy Drug Kills Blood Cancer Cells - 8/21/11 - October 6th, 2011 [October 6th, 2011]
- Drug voltaren - October 6th, 2011 [October 6th, 2011]
- The Dark Side Of Psychiatry--Antipsychotic Drugs, Olanzapine, Risperidone, Clozapine - October 6th, 2011 [October 6th, 2011]
- My Review Of Accutane - October 6th, 2011 [October 6th, 2011]
- Evista treatment - October 6th, 2011 [October 6th, 2011]
- Tizanidine medicine - October 6th, 2011 [October 6th, 2011]
- Ponstel 250mg - October 6th, 2011 [October 6th, 2011]
- #14.2 Senior Medication Challenges - October 6th, 2011 [October 6th, 2011]
- Levlen 28 - October 6th, 2011 [October 6th, 2011]
- Diclofenac uses - October 6th, 2011 [October 6th, 2011]
- Happy Juice - Peru - October 6th, 2011 [October 6th, 2011]
- Premarin pill - October 6th, 2011 [October 6th, 2011]
- Revatio cost - October 7th, 2011 [October 7th, 2011]
- Alendronate sodium pills - October 7th, 2011 [October 7th, 2011]
- Provera drug - October 7th, 2011 [October 7th, 2011]
- Tizanidine drug - October 8th, 2011 [October 8th, 2011]
- CCHR Video 8a - Side Effects. Anti-Depressants, Suicidal Thoughts. Psychotropic Drugs. - October 8th, 2011 [October 8th, 2011]
- Drug Duphaston - October 8th, 2011 [October 8th, 2011]
- Dydrogesterone in Usa - October 8th, 2011 [October 8th, 2011]
- Vigora price - October 8th, 2011 [October 8th, 2011]
- Premarin drug - October 8th, 2011 [October 8th, 2011]
- Raloxifene side effects - October 8th, 2011 [October 8th, 2011]
- Tizanidine medication - October 9th, 2011 [October 9th, 2011]
- Zanaflex drug - October 10th, 2011 [October 10th, 2011]
- Zanaflex medicine - October 10th, 2011 [October 10th, 2011]
- Vigora - October 10th, 2011 [October 10th, 2011]
- Side Effects of Alzheimer's Disease Medications - October 10th, 2011 [October 10th, 2011]
- Are You Tired of Your Blood Pressure Medicine? - October 11th, 2011 [October 11th, 2011]
- PCOS- Metformin (Is it worth dealing with the side effects) - October 12th, 2011 [October 12th, 2011]
- 1/5.Prozac, Zoloft, Paxil, Viagra, Lipitor, Cialis, Nexium - October 12th, 2011 [October 12th, 2011]
- Drug Side Effects - Video - October 13th, 2011 [October 13th, 2011]
- Drug Interactions and Side Effects - Video - October 13th, 2011 [October 13th, 2011]
- Do You Understand Your Prescription Blood Pressure Drugs? - Video - October 13th, 2011 [October 13th, 2011]
- What you need to know about statin drugs side effects (animation) - Video - October 14th, 2011 [October 14th, 2011]
- The #1 Most Dangerous Blood Pressure Drug Side Effect - Video - October 14th, 2011 [October 14th, 2011]
- Mental Health Medication Side Effects - October 14th, 2011 [October 14th, 2011]
- Prescription Drug Side Effects - Video - October 15th, 2011 [October 15th, 2011]