Finding may lead to novel stem cell treatments for chronic wounds (SACRAMENTO, Calif.) - The stress hormone epinephrine - the source of the "fight-or-flight" response - also heightens stresses at the cellular level, inhibiting wound healing and promoting a state of chronic inflammation that prohibits the body's stem cells from migrating to a wound to encourage skin regeneration, UC Davis researchers have found.
The research, published in the April issue of the scientific journal Stem Cells Translational Medicine, is the first to show that epinephrine cross-activates other cellular pathways that feed off each other, generating inflammatory proteins in an exaggerated response that impedes wound healing. The research has important implications for the development of new treatments for chronic nonhealing wounds, conditions that affect more than 5 million Americans.
"We have discovered that the pathways activated by the 'fight-or-flight' hormone epinephrine and those activated by the presence of bacteria in wounds communicate with one another synergistically, greatly promoting inflammation," said Mohan R. Dasu, lead author of the study and an associate researcher in the UC Davis Department of Dermatology. "The combination of stress and infection is a recipe for chronic infection."
Chronic infections are a major global health problem, with annual costs in the United States alone estimated to be more than $23 billion. Nonhealing wounds are particularly common in patients with diabetes, who often develop sores in the foot or leg that become chronic despite intensive antibiotic treatment and sometimes require amputation.
While chronic wounds are traditionally treated primarily with antibiotics, the findings open the way for enhancing therapy with agents that counteract stress hormones. Recent case studies have reported that topical treatment with beta blockers - agents that block adrenergic receptors - have improved chronic skin wounds, although until now, these outcomes have not been well explained.
"Everyone knows that stress is harmful to the body," said Roslyn Isseroff, professor of dermatology at UC Davis and principal investigator of the study. "Our findings provide a framework for systematically developing new therapeutic strategies that could selectively regulate inflammatory responses in nonhealing wounds." Isseroff is also chief of the dermatology service at the UC Davis-affiliated Department of Veterans Affairs Northern California Health Care System where she directs a multi-specialty wound clinic.
Bacterial colonization produces in the body an inflammatory response mediated by "Toll-like receptors" on the cell membrane - receptors that when activated, generate interleukin 6 (IL-6), a protein that plays an important role in fighting infection. Earlier work by lead author Dasu has demonstrated that activation of these receptors can contribute to nonhealing wounds in diabetic patients. In the current work, he provides an important advance to how this pathway works in the face of stress.
At the same time, wounds cause the release of stress hormones such as epinephrine that act on adrenergic receptors to also generate IL-6. Although IL-6 is essential to fighting infection, too much creates a state of chronic inflammation and actually impairs healing. Activation of adrenergic receptors also slows movement of the body's stem cells that naturally migrate to a wound and promote healing and skin regeneration.
By conducting a series of experiments on stem cells and skin cells, the investigators found that separate activation of either the adrenergic receptors or the Toll-like receptor pathways generated a moderate amount of IL-6, but when both stress and bacterial colonization occurred at the same time, the amount of IL-6 was over 40 times more than one would expect. Their experiments showed for the first time that these pathways communicate with and influence one another in a manner known as "cross-talk," causing a highly exaggerated response.
A term borrowed from electronics, cross-talk describes a phenomenon by which a signal transmitted on one circuit creates an effect on another circuit. In the case of the cross-talk between the two pathways in this study, a positive feedback loop is created so that signals from each pathway stimulate the other, resulting in a heightened effect.
Read more:
Recipe For Poor Wound Healing: Bacterial Infection Plus Stress
- Dr. Oz to Oprah and Michael J Fox: "The stem cell debate is dead." - March 13th, 2011 [March 13th, 2011]
- COPD and Stem Cell Treatments - www.StemCellRegenMed.com - April 2nd, 2011 [April 2nd, 2011]
- Stem Cell Treatments - Future Research - April 6th, 2011 [April 6th, 2011]
- Stem Cell Treatment - Current Research - May 11th, 2011 [May 11th, 2011]
- Brain Damage and Stem Cell Treatments - www.stemcellregenmed.com - May 20th, 2011 [May 20th, 2011]
- Stem Cell Treatments and COPD - WWW.STEMCELLREGENMED.COM - May 23rd, 2011 [May 23rd, 2011]
- Adult Stem Cell treatments center - American Stem Cell - May 30th, 2011 [May 30th, 2011]
- Pt. 2--Dr. Darwin Prockop--Adult Stem Cell Treatments - May 31st, 2011 [May 31st, 2011]
- Mother Shares Her Children's Story of Stem Cell Treatments for Autism - June 1st, 2011 [June 1st, 2011]
- Stem cell treatments and rejection reactions - June 1st, 2011 [June 1st, 2011]
- Interview with Dr. Feinerman Stem Cell Treatments and Tay Sachs disease www.stemcellregenmed.com - June 2nd, 2011 [June 2nd, 2011]
- The success rate of stem cell treatments for diabetes - June 12th, 2011 [June 12th, 2011]
- Stem Cell Treatments for Autism: Community Outreach Miami, Florida - Juliana Ubinas - June 13th, 2011 [June 13th, 2011]
- Tay-Sachs Disease and Stem Cell Treatments WWW.STEMCELLREGENMED.COM - June 20th, 2011 [June 20th, 2011]
- Stem Cell Therapy for Spinal Cord Injury - Injured Airline Pilot Flies Again - June 23rd, 2011 [June 23rd, 2011]
- A Dose of Reality on Alternative Stem Cell Treatments: What you don't know can hurt you - July 11th, 2011 [July 11th, 2011]
- Stem Cell City - Lisa Ray - July 15th, 2011 [July 15th, 2011]
- Stem Cell Treatment for Cerebral Palsy at the XCell-Center in Germany - September 10th, 2011 [September 10th, 2011]
- A Touch of Love® - InGeneron - Stem Cell Therapy Interview - September 26th, 2011 [September 26th, 2011]
- A Touch of Love® - Stem Cell Therapy for Thomas a Dogue De Bordeaux - September 27th, 2011 [September 27th, 2011]
- The Spinal Cord Journey - Stem cell therapy stories from three spinal cord injury patients - October 5th, 2011 [October 5th, 2011]
- Cerebral Palsy - October 5th, 2011 [October 5th, 2011]
- Stem Cell Health Alliance - Breakthrough to Independence - October 6th, 2011 [October 6th, 2011]
- ALS Patient Interview, Stem Cell Treatments and ALS www.stemcellregenmed.com - Video - November 13th, 2011 [November 13th, 2011]
- Yankees Pitcher Receives Adult Stem Cell Therapy for Shoulder Injury - Video - November 16th, 2011 [November 16th, 2011]
- Innovative stem cell treatment for Spinal Cord Injuries - Video - January 13th, 2012 [January 13th, 2012]
- Stem Cell Therapy - Medistem Labs Panama Laboratory Tour - Video - January 23rd, 2012 [January 23rd, 2012]
- Adult Stem Cell Treatments for COPD -Real patient results, USA Stem Cells- Shirlen M. Testimonial - Video - January 23rd, 2012 [January 23rd, 2012]
- Adult Stem Cell Treatments for COPD -Real patient results, USA Stem Cells- Leon B. Testimonial - Video - January 23rd, 2012 [January 23rd, 2012]
- Adult Stem Cell Treatments for COPD - Real patient results, USA Stem Cells - Marian H. Testimonial - Video - January 24th, 2012 [January 24th, 2012]
- Stem Cell Treatments - Video - February 7th, 2012 [February 7th, 2012]
- Documenting THE CURE: Seeking Stem Cell Healing Offshore -- MS patient - Video - February 20th, 2012 [February 20th, 2012]
- The Alliance for Regenerative Medicine Statement on Use of Cell Therapies Not Approved by the Federal Drug ... - March 6th, 2012 [March 6th, 2012]
- ETX mom hopes 'Joel's Journey for Sight' leads to China - March 6th, 2012 [March 6th, 2012]
- Nuvilex Forecasts Vast Partnership Opportunities Using Breakthrough Stem Cell Technology - March 6th, 2012 [March 6th, 2012]
- Unveilling stem cells - June 15th, 2012 [June 15th, 2012]
- FDA: Stem cell lab used by Perry has problems - June 26th, 2012 [June 26th, 2012]
- Stem Cells Restore Hearing In Deaf Gerbils - September 14th, 2012 [September 14th, 2012]
- Rylan heads to China soon - September 16th, 2012 [September 16th, 2012]
- Health Link Medical Center Introduces the Regenexx™ Orthopedic Stem Cell Treatments to the San Francisco Area - October 2nd, 2012 [October 2nd, 2012]
- Stem-cell advocacy ‘moved the needle’ - October 2nd, 2012 [October 2nd, 2012]
- Realizing the potential of stem cell therapy - October 16th, 2012 [October 16th, 2012]
- RBCC: Could Stem Cells Be Key to Promising Autism Therapy? - October 17th, 2012 [October 17th, 2012]
- DOH warns public vs stem cell therapies - October 23rd, 2012 [October 23rd, 2012]
- FAQ-8 of 19: Do Stem Cells Have Side Effects In Stem Cell Therapy? - Video - November 1st, 2012 [November 1st, 2012]
- FAQ-8 of 19: With Stem Cell Therapy Are There Any Stem Cell Side Effects? - Video - November 1st, 2012 [November 1st, 2012]
- FAQ-8 of 19: In Stem Cell Therapy Do Stem Cells Cause Side Effects? - Video - November 1st, 2012 [November 1st, 2012]
- FAQ-4 19- What Probability of Stem Cell HELP When I Take Stem Cell Treatments? - Video - November 1st, 2012 [November 1st, 2012]
- HIV and IDS Cure Reality With Stem Cell Treatments - Video - November 1st, 2012 [November 1st, 2012]
- stem cell AIDS cure by Stem Cell Treatments - Video - November 1st, 2012 [November 1st, 2012]
- 'German AIDS Cure' Means Stem Cell Treatments in Thailand, Under License - Video - November 1st, 2012 [November 1st, 2012]
- HIV and AIDS Cure With Stem Cell Treatments - Video - November 1st, 2012 [November 1st, 2012]
- Stem Cell Aids Cure Not Always, But Frequently - Video - November 1st, 2012 [November 1st, 2012]
- Quick Surgeon Profile - Stem Cells Specialist in Mexico - Video - November 1st, 2012 [November 1st, 2012]
- Heart Health - November 1st, 2012 [November 1st, 2012]
- Our adventure - Video - November 1st, 2012 [November 1st, 2012]
- Stem Cell Treatments Hold Hope for HIV-AIDS - Video - November 1st, 2012 [November 1st, 2012]
- Stem Cell Treatments Showing Great Results HIV-AIDS - Video - November 1st, 2012 [November 1st, 2012]
- Skin deep - Catalyst story on fat transfer and stem cell treatments - Video - November 1st, 2012 [November 1st, 2012]
- Disclosure Stem Cell Treatments and Heart Disease Part 2 - Video - November 1st, 2012 [November 1st, 2012]
- Disclosure Stem Cell Treatments and Heart Disease Part 1 - Video - November 1st, 2012 [November 1st, 2012]
- Research and Markets: Commercializing the Stem Cell Sciences - November 3rd, 2012 [November 3rd, 2012]
- FAQ-14 of 19: Do We Provide a Guarantee for Stem Cell Therapy? - Video - November 3rd, 2012 [November 3rd, 2012]
- FAQ-14 of 19: Your Stem Cell Therapy Has a Guarantee for Stem Cell Treatments? - Video - November 5th, 2012 [November 5th, 2012]
- FAQ-14-19: Does Your Stem Cell Clinic Guarantee Stem Cell Therapy? - Video - November 5th, 2012 [November 5th, 2012]
- FAQ-13-19: How Many Stem Cell Treatments Are Right Stem Cell Therapies for Me? - Video - November 5th, 2012 [November 5th, 2012]
- FAQ-14 of 19: Do Your Stem Cell Doctors Offer a Guarantee for Stem Cell Therapy? - Video - November 5th, 2012 [November 5th, 2012]
- FAQ-13 of 19: How Many Stem Cell Treatments Should I Have? - Video - November 5th, 2012 [November 5th, 2012]
- FAQ-11 of 19: For Stem Cell Therapy, Why Thailand's Licensed Stem Cell Treatments? - Video - November 5th, 2012 [November 5th, 2012]
- cord blood | Cord Blood Banking - Your Biological Insurance Policy - Video - November 7th, 2012 [November 7th, 2012]
- jodyMSvideo2012 0001 - Video - November 16th, 2012 [November 16th, 2012]
- Therafit Gym Multiple Sclerosis Jody MS (stem cell trial).wmv - Video - November 20th, 2012 [November 20th, 2012]
- World Renowned Stem Cell Therapist Lectures Around the World - November 24th, 2012 [November 24th, 2012]
- Guillaume Leblanc - Video - November 29th, 2012 [November 29th, 2012]
- Autologous Cell Therapy Market expected to reach $2.2 billion by 2017, growing at a CAGR of 21% : MarketsandMarkets - December 3rd, 2012 [December 3rd, 2012]
- Stem Cell Treatments for Rheumatoid Arthritis and MS at Stem Cell Institute in Panama: Tracey R. - Video - March 15th, 2013 [March 15th, 2013]
- Stem Cell Treatments March 23, 2013 - Video - March 28th, 2013 [March 28th, 2013]
- Rejuv Medical Announces Stem Cell Treatments Now Available - April 9th, 2013 [April 9th, 2013]
- Stem Cell Treatments for Rheumatoid Arthritis - Arminda Bourin - Video - April 13th, 2013 [April 13th, 2013]
- Stem Cell Treatments for Spinal Cord Injury: Theo K. - Stem Cell Institute Panama - Video - May 3rd, 2013 [May 3rd, 2013]