By RTT News, May 05, 2014, 08:34:00 AM EDT
(RTTNews.com) - Regeneron Pharmaceuticals, Inc. ( REGN ) and Avalanche Biotechnologies, Inc. formed a broad collaboration to discover, develop and commercialize novel gene therapy products to treat ophthalmologic diseases. The collaboration includes novel gene therapy vectors and proprietary molecules, discovered jointly by Avalanche and Regeneron, and developed using the Avalanche Ocular BioFactory, an adeno-associated virus (AAV)-based, proprietary, next-generation platform for the discovery and development of gene therapy vectors for ophthalmology.
As part of the agreement, Avalanche would receive an upfront cash payment, contingent payments of up to $640 million upon achievement of certain development and regulatory milestones, plus a royalty on worldwide net sales of collaboration products. The collaboration comprises up to eight distinct therapeutic targets, and Regeneron will have exclusive worldwide rights for each product it moves forward in clinical development. Further, Avalanche has the option to share in development costs and profits for products directed toward two collaboration therapeutic targets selected by Avalanche.
Pursuant to the agreement, Regeneron has a time-limited right of first negotiation for certain rights to AVA-101, Avalanche's gene therapy product targeting vascular endothelial growth factor currently under development for the treatment of wet age-related macular degeneration, upon completion of the ongoing Phase 2a study.
For comments and feedback: contact editorial@rttnews.com
View original post here:
Regeneron, Avalanche To Develop Novel Gene Therapy Products In Ophthalmology
- Gene Therapy: Ethical Issues: Information from Answers.com - February 6th, 2014 [February 6th, 2014]
- Gene, immune therapy help cancer war - April 10th, 2014 [April 10th, 2014]
- Gene Therapy - Genetics Home Reference - Your guide to ... - April 10th, 2014 [April 10th, 2014]
- What is gene therapy? - Genetics Home Reference - April 10th, 2014 [April 10th, 2014]
- Gene therapy - Wikipedia, the free encyclopedia - April 10th, 2014 [April 10th, 2014]
- Gene Therapy PSA Dan Lesser Period 2 - Video - April 15th, 2014 [April 15th, 2014]
- Gene therapy basics - Video - April 15th, 2014 [April 15th, 2014]
- In vivo gene therapy - Video - April 15th, 2014 [April 15th, 2014]
- Ex vivo gene therapy - Video - April 15th, 2014 [April 15th, 2014]
- Broad Institute Gets Patent on Revolutionary Gene-Editing Method - April 17th, 2014 [April 17th, 2014]
- Gene Therapy - Video - April 17th, 2014 [April 17th, 2014]
- Mark Hamalainen: Gene Therapy - Video - April 17th, 2014 [April 17th, 2014]
- JFK - Gene Therapy for Brain Tumors - Video - April 18th, 2014 [April 18th, 2014]
- Fixing the Liver with New Gene Therapy (Brainstorm Ep178) - Video - April 18th, 2014 [April 18th, 2014]
- Gene Therapy | Buzzle.com - April 22nd, 2014 [April 22nd, 2014]
- Gene Therapy I - RCN Corporation - April 22nd, 2014 [April 22nd, 2014]
- Ricky Ashby Microbiology Podcast - Video - April 22nd, 2014 [April 22nd, 2014]
- Regrown nerves boost bionic ears - April 24th, 2014 [April 24th, 2014]
- Cochlear Implant Plus Gene Therapy Could Restore Hearing to the Deaf - April 24th, 2014 [April 24th, 2014]
- Scientists reverse memory loss in mice with Alzheimer's - April 24th, 2014 [April 24th, 2014]
- Bionic Ears Boosted by Gene Therapy and Regrown Nerves - April 24th, 2014 [April 24th, 2014]
- Study: Gene Therapy May Boost Cochlear Implants - April 24th, 2014 [April 24th, 2014]
- Gene therapy may boost hearing, study finds - April 24th, 2014 [April 24th, 2014]
- Pronounce Medical Words Gene Therapy - Video - April 24th, 2014 [April 24th, 2014]
- Gene therapy may boost power of cochlear implants, study says - April 25th, 2014 [April 25th, 2014]
- Gene therapy shows promise to help people regrow auditory nerve cells - April 25th, 2014 [April 25th, 2014]
- Cochlear Implant Also Uses Gene Therapy to Improve Hearing - April 25th, 2014 [April 25th, 2014]
- Gene Therapy May Enhance Cochlear Implants, Animal Study Finds - April 25th, 2014 [April 25th, 2014]
- Uniqure Gene Therapy Info. - Video - April 25th, 2014 [April 25th, 2014]
- Jean Bennett on gene therapy as a treatment for blindness - Video - April 25th, 2014 [April 25th, 2014]
- mice-science-AFPrelax-250414.jpg - April 26th, 2014 [April 26th, 2014]
- Cochlear implant enhances patient experience through gene therapy - April 28th, 2014 [April 28th, 2014]
- Gene therapy may help hearing - April 28th, 2014 [April 28th, 2014]
- Ethics of Gene therapy - Video - April 30th, 2014 [April 30th, 2014]
- Novel Financing For Gene Therapy Company - May 1st, 2014 [May 1st, 2014]
- Gene Therapy To Enhance Hearing - ABC Austrlia News - 2014 - - Video - May 1st, 2014 [May 1st, 2014]
- Biotechnology - GMO's & Gene Therapy - Video - May 1st, 2014 [May 1st, 2014]
- Cochlear Implant Gets an Upgrade with Gene Therapy - Video - May 4th, 2014 [May 4th, 2014]
- Gene therapy for haemophilia - Professor Amit Nathwani - Video - May 4th, 2014 [May 4th, 2014]
- Retrovirus in Gene Therapy - Video - May 4th, 2014 [May 4th, 2014]
- Gene Therapy Used to Preserve Sight in Patients - May 5th, 2014 [May 5th, 2014]
- SCID gene therapy class - Video - May 6th, 2014 [May 6th, 2014]
- Gene Therapy using SMaRT - Video - May 6th, 2014 [May 6th, 2014]
- gene therapy video - Video - May 9th, 2014 [May 9th, 2014]
- Chronic Granulomatous Disease (CGD) - Video - May 12th, 2014 [May 12th, 2014]
- Gene Therapy (Breast Cancer) - Video - May 12th, 2014 [May 12th, 2014]
- Suicide gene therapy - Video - May 12th, 2014 [May 12th, 2014]
- Employment of gene therapy in depression (psychiatric disorder) - Video - May 12th, 2014 [May 12th, 2014]
- Gene therapy for blindness (2012) - Video - May 12th, 2014 [May 12th, 2014]
- AGRC1020 Video Presentation Gene Therapy restores colour vision in monkeys - Video - May 12th, 2014 [May 12th, 2014]
- gene therapy~3 - Video - May 12th, 2014 [May 12th, 2014]
- Gene Delivery System (In-vivo and Ex-vivo) HD - Video - May 12th, 2014 [May 12th, 2014]
- Spark Therapeutics to open headquarters in West Philadelphia - May 14th, 2014 [May 14th, 2014]
- Gene Therapy - Nature - May 14th, 2014 [May 14th, 2014]
- Gene therapy for RTT syndrome benefits and drawbacks - Video - May 16th, 2014 [May 16th, 2014]
- Gene Therapy (Using Biolistic gene gun for gene delivery) - Video - May 16th, 2014 [May 16th, 2014]
- Germline Gene Therapy - Video - May 16th, 2014 [May 16th, 2014]
- Gene Therapy Biology Project for Swavely - Video - May 16th, 2014 [May 16th, 2014]
- Gene therapy extends survival in an animal model of spinal muscular atrophy - May 22nd, 2014 [May 22nd, 2014]
- Novel RNAi therapy silences mutated Huntington's disease gene and reduces symptoms - May 22nd, 2014 [May 22nd, 2014]
- Global Gene Therapy Market: Analysis, Size, Share, Growth, Trends and Forecast 2013 - 2019 - May 22nd, 2014 [May 22nd, 2014]
- Gene therapy hits blood cancers hard - May 22nd, 2014 [May 22nd, 2014]
- Spark Therapeutics late-stage gene therapy for inherited blindness takes a $73M step forward - May 31st, 2014 [May 31st, 2014]
- Genome Editing to Reverse Bubble Boy Syndrome - May 31st, 2014 [May 31st, 2014]
- Genetic Researching: Gene Therapy - Video - May 31st, 2014 [May 31st, 2014]
- BEYOND THE BUBBLE: 10 Years of Gene Therapy - Video - May 31st, 2014 [May 31st, 2014]
- Gene Therapy Combined with IMRT Found to Reduce the Rate of Positive Prostate Biopsy After Treatment for Intermediate ... - June 4th, 2014 [June 4th, 2014]
- Gene therapy combined with IMRT found to reduce recurrence for select prostate cancer patients - June 4th, 2014 [June 4th, 2014]
- Gene therapy combined with IMRT reduces rate of positive prostate biopsy after treatment for intermediate-risk ... - June 4th, 2014 [June 4th, 2014]
- Bluebird, Agios: Preview of Next Week's Important Pipeline Updates - June 12th, 2014 [June 12th, 2014]
- Attack of the B - Team EP8 - Drowning for Science! - Video - June 12th, 2014 [June 12th, 2014]
- 3rd International Conference and Exhibition on Cell & Gene Therapy - Video - June 14th, 2014 [June 14th, 2014]
- Blood Disorder Patients Respond Strongly to Bluebird Bio Gene Therapy - June 15th, 2014 [June 15th, 2014]
- Gene Therapy Partnering Terms and Agreements - Video - June 15th, 2014 [June 15th, 2014]
- Gene Therapy - GMAT Free - GFSC120 - Video - June 18th, 2014 [June 18th, 2014]
- New Gene Therapy Rapidly Helps Patients With Rare Blood Disorder - Video - June 18th, 2014 [June 18th, 2014]
- Isis Could Get a $2 Billion Gain From Heart Attack Trials - June 22nd, 2014 [June 22nd, 2014]
- Gene Therapy for Beta Thalassemia - Video - June 22nd, 2014 [June 22nd, 2014]
- A level. R.7. Cystic fibrosis and gene therapy (Ms Cooper) - Video - June 24th, 2014 [June 24th, 2014]
- Gene therapy for rare seeing impairment disorder shows promise for wider use, doctors say ,mesotheli - Video - June 24th, 2014 [June 24th, 2014]