Research in biochemistry and molecular biology | Institute …

Marc Aucoin Process dynamics of virus-based systems for the production of complex biologics such as viral vectors and vaccines, and the development of strategies using multiple viruses to obtain recombinant products in cell culture. Michael Beazely How growth factor receptors and G protein-coupled receptors modulate ion channels involved in excitatory neurotransmission, neuroprotective mechanisms, and neuronal development; intracellular signaling pathways downstream of GPCRs such as the 5-HT7 receptor and growth factor receptors such as the PDGF receptor. Niels C. Bols Animal cell culture, in vitro toxicology, and biotechnology. Differentiated fish cell lines and culture systems. Hormones and polypeptide growth factors. Toxicology of dioxin-like compounds and polycyclic aromatic to cultured cells. Barb Butler Undergraduate teaching in microbiology, the way microorganisms function and interact with surrounding habitat; microbial ecology; biodegradation of organic contaminants, particularly in groundwater and soil environments. Trevor C. Charles Molecular genetic studies of plant-associated bacteria. Rhizobium carbon metabolism. Genetics of polyhydroxyalkanoate metabolism. General environmental microbiology. Jeff Z.Y. Chen Computer simulations of protein folding and protein-protein interaction. Specialization in molecular dynamics and Monte-Carlo simulations. C. Perry Chou Recombinant protein production, biofuel production, and bioprocessing technology. Applied biological sciences and engineering theories to develop novel and effective bioprocesses for the production of recombinant proteins (including industrial enzymes and therapeutic proteins) and metabolites (including biohydrogen, biodiesel, and biobutanol). Such bioprocess development includes upstream technology for biological strain construction, midstream technology for bioreaction (i.e. cultivation), and downstream processing for bioproduct recovery and purification. Thorsten Dieckmann NMR-spectroscopy, RNA and protein structure, RNA-protein interactions, RNA catalysis, viral infections, cellular defense mechanisms. Brian Dixon Characterization of fish immune system at the molecular level. Cytokines and receptors in fish immune systems. Defining fish populations using polymorphism of immune system genes. Cold-blooded vertebrate immunotoxicology. D. George Dixon Effects of toxic chemicals on aquatic organisms. Biotic modifying factors of toxicity. Development of methods for environmental effects monitoring. Physiologically based pharmacokinetic modelling of contaminant levels in fish. Gary I. Dmitrienko Enzyme structure and function. Bernard P. Duncker Genetics and DNA replication. Use of the budding yeast Saccharomyces cerevisiae to investigate protein factors that control the initiation of DNA replication. Heidi Engelhardt The dialogue between the developing fetus and the mother during mammalian pregnancy, and the role of the placenta as the mediator; the ability of the placenta to protect the developing organism from sub-optimal maternal environments through adaptive changes in structure, vasculature or functional exchange capacity. Moira Glerum Mitochondrial myopathies, mitochondrial biogenesis, assembly of cytochrome oxidase in yeast and humans, mitochondrial copper transport, mitochondrial peroxide metabolism, heme A biosynthesis. Bernard R. Glick Isolation and manipulation of microbial genes involved in microbial stimulation of plant growth. Use of bacteria as biocontrol agents. Biochemical consequences of the genetic transformation of plant growth-promoting bacteria. Bruce M. Greenberg Environmental Chemistry and Biology: Photochemistry and photobiology of xenobiotic contamination and ultraviolet radiation. Frank Gu Nanotechnology, Nanomedicine, Cancer Therapy, Drug Delivery, Biomaterials, Bioconjugated Chemisry and Bioinformatics. Guy Guillemette Nitric Oxide Synthase: Function, structure, catalysis, and regulation. Analysis of enzyme activity, mechanism and inhibition. Cytochrome c: Function, structure, stability, redox potential, and protein folding. John J. Heikkila

The use of recombinant DNA methodology to examine the molecular response of amphibian embryos and tissue culture cells to environmental stress. Isolation and expression of heat shock genes.

My laboratorys research interests lie in the areas of enzyme structure, mechanism, inhibition and allostery. In light of these general interests our research currently focuses on the role that conformational plasticity plays in these areas of enzymology and how these dynamic aspects of enzyme structure can be exploited in the regulation of enzyme function.

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Research in biochemistry and molecular biology | Institute ...