Stem Cell Research & Therapy is the major forum for translational research into stem cell therapies. An international peer-reviewed journal, it publishes high quality open access research articles with a special emphasis on basic, translational and clinical research into stem cell therapeutics and regenerative therapies, including animal models and clinical trials. The journal also provides reviews, viewpoints, commentaries and reports.
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Paula Lam comments on recent research showing cancer cells may influence mesenchymal stem cells through the effects of soluble factors such as interleukin-1beta and transforming growth factor signalling.
Mechanical hearts
Wolfram Zimmermann reviews heart muscle mechanics, mechanical loading in heart development and physiological loading in myocardial tissue engineering in this final review in thephysical influences on stem cellsseries.
Endogenous primordial germ cells in chicken embryos can recover from the cytotoxic effects of busulfan treatment through promotion of the cell cycle, with implications for germ cell transplantation studies.
The macrophages in ixmyelocel-T may have beneficial effects in atherosclerotic diseases as they influx cholesterol, remain anti-inflammatory in the face of lipid loading and inflammatory challenge, and display enhanced cholesterol efflux capabilities.
Ixmyelocel-T, an expanded, autologous multicellular therapy cultured from bone marrow mononuclear cells, contains M2-like macrophages with clinical potential in tissue repair and regeneration.
The feline amnion is a readily available source of amniotic epithelial cells (AECs) which may be useful for future studies of stem cell biology and cell therapies.
Prostate cells isolated based on ATP binding cassette transporter G2 (ABCG2) activity using the side population assay showed more stem cell potential than those isolated based on high aldehyde dehydrogenase1A1 activity.
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Stem Cell Research & Therapy