What is a stem cell transplant?
A stem cell transplant may be used so that you can have intensive high-dose chemotherapy (and sometimes radiotherapy) to kill cancerous cells. The chemotherapy is higher than conventional chemotherapy and also kills the stem cells in the bone marrow that would normally make blood cells. Therefore, following the chemotherapy, you are given back (transplanted) stem cells which can then make normal blood cells again.
A stem cell transplant is sometimes called a bone marrow transplant. However, stem cells can be obtained from blood as well as from the bone marrow. So, the term stem cell transplant is now used.
I've been concerned about lymphoma for two years.
Blood cells are made in the bone marrow, by stem cells. Bone marrow is the soft sponge-like material in the centre of bones. Large flat bones such as the breastbone (sternum) and pelvis contain the most bone marrow. To make blood cells constantly you need a healthy bone marrow. You also need nutrients from your diet, including iron and some vitamins.
Stem cells are immature (primitive) cells. There are two main types in the bone marrow - myeloid and lymphoid stem cells. These derive from even more primitive cells called common pluripotent stem cells. Stem cells constantly divide and produce new cells. Some new cells remain as stem cells and others go through a series of maturing stages (precursor or blast cells) before forming into fully formed (mature) blood cells.
Mature blood cells are released from the bone marrow into the bloodstream. Mature blood cells are:
Stem cells rapidly multiply to make millions of blood cells each day. Because of this they are more easily killed by chemotherapy than most other cells in the body. This is because chemotherapy medicines work by killing rapidly dividing cells (such as cancer cells).
A stem cell transplant is an option which is considered for various cancer conditions. For example, for types of leukaemia, lymphoma and myeloma. Your specialist will advise when it may be an appropriate option. As a rule, it is not often a first-line treatment. Conventional chemotherapy or other treatments tend to be used first. However, the treatment of cancer and leukaemia is a changing and developing area of medicine. Techniques such as stem cell transplant continue to be refined and improved and may be considered in various different circumstances.
The higher doses of chemotherapy and radiotherapy that can be used in conjunction with a stem cell transplant can improve the chance of a cure for some conditions in certain circumstances.
There is now a great deal of research about using stem cell transplants for many other conditions. For example:
This means that the stem cells used for the transplant come from your own body. They are usually collected when you are free of any sign of disease (when you are in remission) following conventional chemotherapy or other treatments. The stem cells can be used soon after being collected. They can also be frozen, stored and used in the future if needed. An autologous stem cell transplant is also called stem cell support, as the stem cells come from your own body. So, strictly speaking, it is not a transplant from a donor.
This means the stem cells used for the transplant come from someone else - a donor. This is often a close relative such as a brother or sister where there is a good chance of a close match. Unrelated donors are sometimes matched to people needing a transplant.
Stem cells can be collected:
It is very similar to a blood transfusion. Following the intense course of chemotherapy (and sometimes radiotherapy), the solution containing stem cells is given into one of your veins via a drip. The stem cells travel through your bloodstream and end up in your bone marrow. Here they start to make blood cells.
It can take several weeks for your bone marrow to recover, to take up the transplanted stem cells, and to make enough new blood cells. During this time you will need to be in hospital and be closely monitored. You may need several blood transfusions during this time until you are making enough blood cells. Antibiotic medicines are given to minimise the risk of infection. Also, medicines are given to help the stem cells to multiply as quickly as possible.
There is a risk of serious problems with a stem cell transplant. For example:
Your specialist will discuss with you the risks and possible side-effects of a stem cell transplant.
Read more:
Stem Cell Transplant, Bone Marrow Transplant | Patient
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- Stem Cell Transplant Survivors Meet by Dr. Chirag Shah Part 3 - Video - July 11th, 2013 [July 11th, 2013]
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- Neil Mitchell chats to Mauro about his Stem Cell Transplant - Alfred Hospital - Video - September 2nd, 2013 [September 2nd, 2013]
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- Study evaluates early stem cell transplants for non-Hodgkin's lymphoma - October 31st, 2013 [October 31st, 2013]
- Hematopoietic stem cell transplantation - Wikipedia, the free ... - November 3rd, 2013 [November 3rd, 2013]
- Stem cell transplants : Cancer Research UK : CancerHelp UK - November 3rd, 2013 [November 3rd, 2013]
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- Katherine's stem cell transplant - Video - November 3rd, 2013 [November 3rd, 2013]
- Stem Cell Transplant - Dana-Farber Cancer Institute - November 11th, 2013 [November 11th, 2013]
- Peripheral Blood Stem Cell Transplant Donor, Procedure, Benefits ... - November 11th, 2013 [November 11th, 2013]
- A Journey Through A Stem Cell Transplant - Diane M. Sullivan - Video - November 11th, 2013 [November 11th, 2013]
- Bone Marrow - Dr B S Rajput Stem Cell Transplant Surgeon - Video - November 16th, 2013 [November 16th, 2013]
- Stem Cell Transplant Blog - November 18th, 2013 [November 18th, 2013]
- LHC Better Living: Stem Cell Transplant - Video - November 18th, 2013 [November 18th, 2013]
- India stem cell transplant by Dr B S Rajput stem cell transplant Surgeon - Video - November 21st, 2013 [November 21st, 2013]
- Stem Cell Transplants For Incurable and Untreatable Diseases ... - November 23rd, 2013 [November 23rd, 2013]
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- Datri 1st successful unrelated Blood Stem Cell Transplant - Video - November 24th, 2013 [November 24th, 2013]
- India stem cell transplant bone marrow by Dr. B. S. Rajput stem cell transplant surgeon - Video - November 26th, 2013 [November 26th, 2013]
- Stem Cell Transplants - Nemours: Kids Health - November 27th, 2013 [November 27th, 2013]
- Stem Cell Transplantation for Cancer Treatment | CTCA - November 29th, 2013 [November 29th, 2013]
- Bone Marrow/Stem Cell Transplant - Video - November 29th, 2013 [November 29th, 2013]
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- Stem cell transplant: All - MayoClinic.com - December 4th, 2013 [December 4th, 2013]
- The Phases Of Stem Cell Transplant Treatment - Video - December 5th, 2013 [December 5th, 2013]
- Recurrent follicular lymphoma: Novel approaches vs stem cell transplant - Video - December 5th, 2013 [December 5th, 2013]
- Breakthrough in Treating Leukemia, Lymphoma Patients with Umbilical Cord Blood Stem Cells - December 12th, 2013 [December 12th, 2013]
- Advances in stem cell transplantation strategies show promise to improve availability, success - December 12th, 2013 [December 12th, 2013]
- Wilson undergoes transplant on Thursday - December 12th, 2013 [December 12th, 2013]
- Breakthrough in treating leukemia, lymphoma with umbilical cord blood stem cells - December 12th, 2013 [December 12th, 2013]
- HIV Returns in Two Men Thought Cured After Stem Cell Transplant - December 12th, 2013 [December 12th, 2013]
- Wilson resting following stem cell transplant - December 13th, 2013 [December 13th, 2013]
- Boyd: 'I am cancer-free' - December 15th, 2013 [December 15th, 2013]
- Bone Marrow Harvest for Stem Cell Transplant - Video - December 16th, 2013 [December 16th, 2013]
- Bone Marrow Stem Cell Transplant - Video - December 16th, 2013 [December 16th, 2013]
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- Ruxolitinib before Stem Cell Transplant - Video - December 16th, 2013 [December 16th, 2013]
- The Multi Disciplinary Team Involved In A Stem Cell Transplant - Video - December 16th, 2013 [December 16th, 2013]
- Liver cells benefit from mesenchymal stem cell co-culture prior to transplantation - December 19th, 2013 [December 19th, 2013]
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