When Hossein Tavassoli first told his mother that he was researching heart disease, she responded with But, youre an engineer...
She was right, of course Hosseins undergraduate degree was in material engineering but at the time, he found it difficult to explain the intersections between biology and engineering. Now, not only is he a nanoengineer working in a tissue regeneration lab, but he is also an avid science communicator.
Its very interdisciplinary, says Hossein, who is completing the biology component of his PhD at UNSW Medicine and the engineering component at Swinburne University of Technology.
Hossein began working with the heart several years ago after finding himself interested in the heart-blood development and regeneration research of UNSW biologists Dr Vashe Chandrakanthan and Professor John Pimanda. Fortunately, they were intrigued by the technology Hossein was working on, and a collaboration began.
The heart is the most important organ, with heart disease the number one killer in the world, Hossein says.
My goal is to find a way for mending broken hearts or, in other words, to find a solution for cardiac problems.
During their first seven days of life, baby mice can self-repair broken heart tissue.
They develop this ability while in the embryo, which although impossible for scientists to view under a microscope could hold the clue to repairing heart damage in humans.
We cannot put a mouse embryo under the microscope, but what I do is model what is going on in the embryonic heart in a microchip, at a microscale.
The microchip that Hossein nanoengineered has been embedded with mice heart cells. It was built to mimic the embryonic heart cells natural environment, enabling the researchers to study how the regenerative cells communicate with each other. Knowledge of how this works could be applied to repairing human heart tissue, although Hossein speculates this technology is at least a decade away. In order to expand their research, additional project funding is needed.
Hossein sees many benefits to using nanotechnology in biomedicine.
First of all, its cheap. You dont need to have lots of plastic, petri dishes, culture media all those things we need for the cell culture. Secondly, you dont need too many animals or cells or patients. Instead of 10-100 million cells, what I need in that tiny family is like 100 or 1000 cells.
Or, in a simple way, instead of needing a hundred mice for each series of experiments, I just need one or two.
Hossein observes the cells interacting via a microscope connected to a supercomputer. Visually, it looks like a microchip. It has channels, it has valves it is like a simplified model of a heart.
When the cells interact in just the right way, it starts to pulse just like a heartbeat.
Hossein is lost for words when remembering the first time he saw the cells start beating.
His work, he explains, differs from many other PhD students. Instead of working from 9-5, he needs to visit the lab at all hours sometimes as late as midnight to feed the cells. One particular lab visit stands out to him.
I came to the lab on Friday to add culture media, which is food for the cells. The day after, I was at Coogee Beach with some friends and said, I should go, I need to check on my cells.
His friends were confused, but it was normal routine for Hossein. It was then he realised that the cells were effectively his babies.
Only when he arrived, they werent beating.
I thought, Oh no, something is wrong! He quickly added the culture media, put them in the incubator, and waited.
A few hours later, they started beating again.
It was incredible, Hossein remembers.
For Hossein, when the cells are beating, they are a symbol of hope and life.
"Everything in our world starts with that beating. And everything finishes with that beating. When that line becomes straight I've seen this in my life, with my family you see that everything is gone. As long as there is beating, there is hope."
Everything in our world starts with that beating. And everything finishes with that beating. When that line becomes straight I've seen this in my life, with my family you see that everything is gone.
As long as there is beating, there is hope.
Hossein knew that his family and friends were proud of his achievements but was frustrated at his inability to properly explain his research to them.
He remembers the specific moment when that changed.
Hossein was taking an Uber to university one night (to feed the cells, he recalls) when the driver asked what he studied. Knowing that the answer was convoluted, Hossein kept his response simple: Im an engineer, he said.
An engineer? the driver responded. Then why am I dropping you off at the medicine building?
Hossein then had a realisation: if he could explain his work to an Uber driver, then perhaps he could also explain it to his mum.
From that moment, he tried to articulate his research to any driver who asked. He tested new ways of describing his work and kept the ones that worked best.
Soon, something surprising happened Hossein developed a love for science communication.
I realised that it is important to explain what I'm doing, but in simple words, so that anyone can understand.
The practice paid off. Earlier this year, Hossein was a finalist in FameLab Australia (a live annual science communication competition), a shortlisted speaker at TEDx Melbournes Open Mic, and last year was a finalist in AMP Amplify Ignite (a national PhD pitch competition). He now shares his research via Twitter.
Science communication is an art, he says. For me, informing and educating is more important than doing just research all the time.
And, he adds, I now get five-star ratings on Uber!
Read the rest here:
The nanoengineer working to mend broken hearts - UNSW Newsroom
- Cardiac Regeneration - Center for Regenerative Medicine - Mayo Clinic ... - April 11th, 2018 [April 11th, 2018]
- Cardiac Regeneration - Mayo Clinic - April 22nd, 2018 [April 22nd, 2018]
- Materials - MDPI - May 18th, 2018 [May 18th, 2018]
- Cardiac Stem Cell Research - Cedars-Sinai - May 22nd, 2018 [May 22nd, 2018]
- Cardiac regeneration: current therapiesfuture concepts ... - May 26th, 2018 [May 26th, 2018]
- Cardiac Regeneration - Victor Chang Cardiac Research Institute - May 30th, 2018 [May 30th, 2018]
- Cardiology Conferences | Cardio 2018 Events | Cardiac ... - June 6th, 2018 [June 6th, 2018]
- Laboratory for Cardiac Regeneration | Baylor College of ... - June 18th, 2018 [June 18th, 2018]
- Regeneration of Muscle - July 8th, 2018 [July 8th, 2018]
- Regeneration of Muscle - eLS: Essential for Life Science - July 14th, 2018 [July 14th, 2018]
- Cardiac Repair and Regeneration Research Unit | Heart and ... - July 25th, 2018 [July 25th, 2018]
- Myogenesis - Wikipedia - August 8th, 2018 [August 8th, 2018]
- Regeneration (biology) - Wikipedia - August 21st, 2018 [August 21st, 2018]
- World Cardiology and Cardiologist Meeting - August 21st, 2018 [August 21st, 2018]
- Cardiac (comics) - Wikipedia - August 26th, 2018 [August 26th, 2018]
- Cardiac regeneration and repair - 1st Edition - Elsevier - September 21st, 2018 [September 21st, 2018]
- Post-doc position available cardiac regeneration ... - September 29th, 2018 [September 29th, 2018]
- UW Bioengineering: Building World Leadership in Heart ... - September 29th, 2018 [September 29th, 2018]
- Cardiac Regeneration - What Science Can Do - AstraZeneca - October 2nd, 2018 [October 2nd, 2018]
- Cardiac Regeneration, Stem Cells | Research | Baylor ... - November 30th, 2018 [November 30th, 2018]
- Cardiac Regeneration - Victor Chang Institute - December 6th, 2018 [December 6th, 2018]
- Entering a new era in vascular and cardiac regeneration ... - December 19th, 2018 [December 19th, 2018]
- Cardiac regeneration and repair - 1st Edition - December 19th, 2018 [December 19th, 2018]
- Heart Regeneration Technologies - December 19th, 2018 [December 19th, 2018]
- Cardiac Regeneration - Center for Regenerative Medicine ... - December 19th, 2018 [December 19th, 2018]
- Zebrafish Heart Regeneration | HHMI BioInteractive - December 22nd, 2018 [December 22nd, 2018]
- Rapid cell regeneration - Heroes Wiki - December 22nd, 2018 [December 22nd, 2018]
- Cardiac muscle - Wikipedia - December 23rd, 2018 [December 23rd, 2018]
- Cardiac regeneration in and : discrepancies and problems ... - January 8th, 2019 [January 8th, 2019]
- OHSU Center for Regenerative Medicine Heart Regeneration ... - January 8th, 2019 [January 8th, 2019]
- Dr. Sanjiv Dhingra, Cardiac Regeneration and Tissue ... - January 30th, 2019 [January 30th, 2019]
- Mending a Broken Heart: Stem Cells and Cardiac Repair ... - February 20th, 2019 [February 20th, 2019]
- Cardiac Repair and Regeneration | Division of Cardiology ... - February 20th, 2019 [February 20th, 2019]
- Stem Cell Therapy and Stem Cell Injection Provider Finder ... - March 5th, 2019 [March 5th, 2019]
- KearnsSayre syndrome - Wikipedia - March 8th, 2019 [March 8th, 2019]
- Ruohola-Baker Lab - March 15th, 2019 [March 15th, 2019]
- MTS Science - May 3rd, 2019 [May 3rd, 2019]
- New Insights Into the Healing Capacity of the Heart: The Hippo Pathway - Cath Lab Digest - September 26th, 2019 [September 26th, 2019]
- Conjugated polymers optically regulate the fate of endothelial colony-forming cells - Science Advances - September 29th, 2019 [September 29th, 2019]
- New insights into heart's healing capacity - Baylor College of Medicine News - September 29th, 2019 [September 29th, 2019]
- Tenaya Therapeutics Closes $92 Million Series B Financing - BioSpace - October 5th, 2019 [October 5th, 2019]
- Regenerative medicine today: Are diabetes and vascular disease treatments ready for the clinic? - Science Magazine - October 5th, 2019 [October 5th, 2019]
- Reviewing resTORbio Inc. (TORC)'s and Anika Therapeutics Inc. (NASDAQ:ANIK)'s results - MS Wkly - October 14th, 2019 [October 14th, 2019]
- TAMassociati: the new Church of the Resurrection in Varignano - Floornature.com - October 14th, 2019 [October 14th, 2019]
- What the Hippo pathway in cardiac fibroblasts reveals about heart function - Baylor College of Medicine News - October 19th, 2019 [October 19th, 2019]
- Capricor Therapeutics to Host Key Opinion Leader Call on the Role of CAP-1002 for the Treatment of Duchenne Muscular Dystrophy (DMD) - BioSpace - October 22nd, 2019 [October 22nd, 2019]
- Regenerative Medicine Market Industry Outlook, Growth Prospects and Key Opportunities - Health News Office - October 24th, 2019 [October 24th, 2019]
- Ottawa-based treatment a leap forward in addressing heart failure - Winnipeg Sun - October 27th, 2019 [October 27th, 2019]
- Global Regenerative Medicines Market Demand Analysis & Opportunity Evaluation Report 2019-2027 with Focus on U.S. & Europe -... - November 15th, 2019 [November 15th, 2019]
- The Heart of the Matter: Leveraging Advances in Cardiac Biology to Innovate Gene-Based Therapies for Heart Failure - Physician's Weekly - November 15th, 2019 [November 15th, 2019]
- SANUWAVE Health Reports Third Quarter 2019 Financial Results Other OTC:SNWV - GlobeNewswire - November 16th, 2019 [November 16th, 2019]
- Moderna: Undervalued As The Promising Pipeline Awaits Collaborations - Seeking Alpha - November 23rd, 2019 [November 23rd, 2019]
- Comparative Study of the Therapeutic Potential of Mesenchymal Stem Cells Derived from Adipose Tissue and Bone Marrow on Acute Myocardial Infarction... - November 23rd, 2019 [November 23rd, 2019]
- Stem Cell Therapy May Improve Heart Health In New Ways - TheHealthMania - December 5th, 2019 [December 5th, 2019]
- AgeX Therapeutics Issues Year-End Letter to Shareholders - BioSpace - December 9th, 2019 [December 9th, 2019]
- Polymeric Biomaterials Market Trends Analysis Forecast to 2019-2024 |Evolving Industry Overview by Types, Applications, Size & Share - Sino News... - December 16th, 2019 [December 16th, 2019]
- SMD - Researchers look behind the biological curtain on how fish oil might fight inflammatory disease - QMUL - December 16th, 2019 [December 16th, 2019]
- Suspended animation, you say? The biggest and freakiest scientific breakthroughs of 2019 - SYFY WIRE - December 29th, 2019 [December 29th, 2019]
- 2019: Year in Pictures by Robert Cohen | Metro - STLtoday.com - December 31st, 2019 [December 31st, 2019]
- MicroCures Announces Issuance of New Patent Covering First-of-its-Kind Cell Movement Decelerator Technology with Potential Applications in Oncology... - January 15th, 2020 [January 15th, 2020]
- Cells that regenerate heart in zebrafish discovered - Biology Reporter - February 7th, 2020 [February 7th, 2020]
- SANUWAVE Health Appoints Dr. Tom Price to Its Board of Directors - Yahoo Finance - February 7th, 2020 [February 7th, 2020]
- Capricor Therapeutics Reports Fourth Quarter and Full Year 2019 Financial Results and Provides Corporate Update - Associated Press - March 19th, 2020 [March 19th, 2020]
- Researchers and Doctors alike pursuing the field of stem cell research in treating heart attack survivors - Medical Herald - March 19th, 2020 [March 19th, 2020]
- Artificial Heart Lung Machines Market report reviews opportunities and analysis by size, share, trends, manufacturer, forecast 2020-2026 - WhaTech... - April 29th, 2020 [April 29th, 2020]
- Scientists have figured out how to make the heart to regenerate - The Times Hub - April 29th, 2020 [April 29th, 2020]
- Gene therapy for follistatin mitigates systemic metabolic inflammation and post-traumatic arthritis in high-fat dietinduced obesity - Science Advances - May 9th, 2020 [May 9th, 2020]
- SANUWAVE HEALTH : MANAGEMENT'S DISCUSSION AND ANALYSIS OF FINANCIAL CONDITION AND RESULTS OF OPERATIONS (form 10-Q) - marketscreener.com - May 15th, 2020 [May 15th, 2020]
- SANUWAVE Health to Hold First Quarter Financial Results and Business Update Call on Monday, May 18, 2020 - Yahoo Finance - May 15th, 2020 [May 15th, 2020]
- SANUWAVE Health to Hold Investor Live Webcast on Wednesday, June 10, 2020 - Yahoo Finance - June 10th, 2020 [June 10th, 2020]
- SANUWAVE Health Enters Into Exclusive Letter of Intent to Acquire Celularity's UltraMIST and Exclusive Partnership Rights for Wound Care Biologic... - June 11th, 2020 [June 11th, 2020]
- SANUWAVE Health, Inc. Discusses The Potential of Their Celularity Acquisition with The Stock Day Podcast (SNWV) July 1, 2020 - Stock Day Media - July 1st, 2020 [July 1st, 2020]
- Interim Analysis of Recardio's Phase II Clinical Trial to Be Presented at the 2020 Congress of the European Society of Cardiology - PRNewswire - July 1st, 2020 [July 1st, 2020]
- Growth and demand of Plasma Therapy in the Asia Pacific Region available in the latest report - WhaTech Technology and Markets News - July 4th, 2020 [July 4th, 2020]
- Plasma Therapy Market Size by Top Companies, Regions, Types and Application, End Users and Forecast to 2027 - Bulletin Line - August 14th, 2020 [August 14th, 2020]
- Generex Biotechnology Subsidiary Olaregen Therapeutix Announces Publication on the Use of Excellagen for Vascular Repair - BioSpace - August 14th, 2020 [August 14th, 2020]
- Polymeric Biomaterials Market Insights by Current Trends 2020 Future Demand by Top Key Players, Regions, Industry Size, and Business Strategy... - September 11th, 2020 [September 11th, 2020]
- CORRECTION - SANUWAVE Health Announces Reimbursement Coverage for BIOVANCE From Largest Medicare and Medicaid Administrator in U.S. - Stockhouse - September 11th, 2020 [September 11th, 2020]
- New Research Paper Suggests RegeneRx's Thymosin Beta 4 May be Useful in Treating COVID-19 - PRNewswire - September 11th, 2020 [September 11th, 2020]
- To Repair a Damaged Heart, Three Cells are Better Than One - SDSU Newscenter - September 11th, 2020 [September 11th, 2020]