A new breakthroughin the understanding of the neurological basis of chronic brain dysfunction following stroke
Chronic neurological dysfunction produced by stroke and traumatic brain injury has long been thought to be irreversible. A new scientific discovery by the INR, as documented in the medical literature(article 1; article 2), now promises to change current thinking about the potential for recovery of function, even years after the acute event.
The INR is pleased to make this new therapeutic approach available for selected patients. Individual results vary, not all patients respond. Treatment is an innovative off-label patented invention of the INR. Additional doses may be needed for optimal benefit,please see theTerms of Use. These unprecedented clinical results rely upon the Institutes patented TransBarrier drug delivery technology (multiple issued and pending U.S. and international patents, including U.S. patents 6419944, 6537549, 7214658, 7629311, 8119127, and 8236306, assigned to TACT IP, LLC and Australian patent 758,523), as published in thescientific literatureanddocumented in independentnews stories.
For more scientific information, please see:
Consultation for Stroke at the INR
This treatment is not for acute stroke.Consultation with an INR physician following hospital discharge is encouraged, even if the stroke has occurred years before. Please call the INR (310) 479-0107(California) or, in Florida (561) 353-9707) for further information.
Scientific References(clicking on title willaccess the scientific abstract and full-text of the article)
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13.Tobinick E: Rapid improvement of chronic stroke deficits after perispinal etanercept: three consecutive cases. CNS Drugs 2011, 25:145-155.
14.Tobinick E: Deciphering the physiology underlying the rapid clinical effects of perispinal etanercept in Alzheimers disease. Curr Alzheimer Res 2012, 9:99-109. (Download free full-text PDF).
15.Tobinick E, Kim NM, Reyzin G, Rodriguez-Romanacce H, Depuy V: Selective TNF Inhibition for Chronic Stroke and Traumatic Brain Injury : An Observational Study Involving 629 Consecutive Patients Treated with Perispinal Etanercept. CNS Drugs 2012, 26:1051-1070.
16.King MD, Alleyne CH, Jr., Dhandapani KM: TNF-alpha receptor antagonist, R-7050, improves neurological outcomes following intracerebral hemorrhage in mice. Neurosci Lett 2013, 542:92-96.
17.Lei B, Dawson HN, Roulhac-Wilson B, Wang H, Laskowitz DT, James ML: Tumor necrosis factor alpha antagonism improves neurological recovery in murine intracerebral hemorrhage. J Neuroinflammation 2013, 10:103.
18.Works MG, Koenig JB, Sapolsky RM: Soluble TNF receptor 1-secreting ex vivo-derived dendritic cells reduce injury after stroke. J Cereb Blood Flow Metab 2013.
19.Faingold CL: Chapter 7: Network Control Mechanisms: Cellular Inputs, Neuroactive Substances, and Synaptic Changes. In Neuronal Networks in Brain Function, CNS Disorders, and Therapeutics. Edited by Faingold CL, Blumenfeld H: Elsevier; 2014
20.Siniscalchi A, Gallelli L, Malferrari G, Pirritano D, Serra R, Santangelo E, De Sarro G: Cerebral stroke injury: the role of cytokines and brain inflammation. J Basic Clin Physiol Pharmacol 2014.
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