SHANGHAI--(BUSINESS WIRE)--Ark Biosciences, a global biotech company developing groundbreaking therapeutics for viral infection and respiratory diseases, today announced its participation in and presentation at the JP Morgan Healthcare Conference on January 15th 2020 at the Westin St. Francis Hotel, San Francisco. Dr. Jim Wu, Founder & CEO, will be presenting at the JP Morgan Healthcare Conference as below:
Date: Wednesday, January 15th, 2020
Time: 8:00AM (PST)
Room: Golden Gate (32nd Floor)
Venue: Westin St. Francis Hotel, 335 Powell Street, San Francisco, CA94102 (USA)
The presentation will include updates on the progress made in the following key Ark programs:
Respiratory Syncytial Virus (RSV) Program
Ark Biosciences anti-RSV program successfully completed a global Phase II study (VICTOR) in 2019, demonstrating, for the first time ever, efficacy and clinical benefit of an antiviral in infants hospitalized with RSV infection. Ziresovir (AK0529), Arks proprietary antiviral against RSV, demonstrated a dose-dependent clinical efficacy, clearly reducing patients' signs and symptoms scores and, concomitantly, their viral loads; Ark was also able to demonstrate a clear correlation between the change in signs and symptoms score, viral load, and Ziresovir concentration. The drug retains its excellent safety profile.
Ark is currently launching a Ziresovir Phase III study in China, with an upcoming global Phase III study to follow. Ark currently also has Ziresovir under clinical study in adults infected with RSV. Commented Dr Jim Wu, "Ark is now the leader in RSV antiviral development, in a therapeutic area with a huge unmet medical need, but littered with failures"; Dr Stephen Toovey, Chief Medical Officer and co-Founder of Ark added, Ark's RSV program is truly ground-breaking, representing a true medical first: the successful antiviral treatment of infant RSV disease."
Idiopathic Pulmonary Fibrosis (IPF) Program
Ark is currently developing its antifibrotic AK3280 for the stand-alone treatment of IPF. The molecule, which is expected to show superior safety, tolerability and efficacy, has successfully completed its first two clinical trials, confirming excellent safety and tolerability in man, without the typical troubling side effects seen with existing standard-of-care. A global Phase II IPF study is on track to commence later this year. Additional indications beyond IPF are being developed in parallel with additional Phase II studies to commence later this year.
Dr Jim Wu added, Our progress reported with AK3280 expands Ark's existing portfolio, reflecting the company's focus on respiratory diseases and viral infections. Ark is a recognized developer of innovative respiratory medicines. We bring a unique focus to the development of AK3280 as the new standard-of-care for IPF, and other fibrotic diseases, both globally and in China.
Commented Dr Stephen Toovey, IPF is a progressive and fatal disease that robs victims of breath and life. Ark is committed to bringing this promising new treatment for IPF to patients, with the goal of offering a better treatment, and a better quality of life to IPF victims.
We are delighted to be presenting again at JPM conference this year, said Dr Jim Wu, CEO of Ark Biosciences. " At Ark, our mission is to become a global leader of innovation in anti-viral, and respiratory diseases.
About Ziresovir
Ziresovir, formerly known as AK0529, was discovered following the optimization of hits obtained screening a very large compound library against respiratory syncytial virus (RSV) replication in cell culture. Thereafter the drug completed rigorous preclinical and toxicological evaluation, including juvenile animal toxicology studies. Ziresovir is a structurally novel compound that binds to the viral 'F' or fusion protein of RSV, preventing entry of the virus into human cells and their infection, and thereby disease; this F-protein inhibition can also exert an anti-pathogenic action, preventing the cell-to-cell fusion (or "syncytium") that is a hallmark of RSV infection. Ziresovirs mechanism of action is thus distinct from that of the common nucleoside class of antiviral drugs, which target and interfere with the production of nucleic acid within infected human cells, and reproduction, and is expected to be free of the nucleoside class safety issues.
About Respiratory Syncytial Virus
RSV is one of the most infectious human viruses, infecting 3-10% of the worlds population each year. It is the most common cause of acute lower respiratory disease in infants and children. It is a leading cause of death in children under 5 years of age, as well as being the leading cause of childhood lower respiratory tract infection (LRTI), bronchiolitis and infant hospitalization.
Globally there are 34 million cases of LRTI and up to two hundred thousand deaths in children under 5 years of age every year from RSV infection. Equally, RSV has been recognized as a cause of severe lung infection and death in older adults. Additional high-risk patient populations for RSV disease include the immunocompromised, as well as those with chronic lung conditions, congenital heart disease, and chronic obstructive pulmonary disease (COPD) e.g. chronic bronchitis and emphysema. There is no vaccine available to protect against RSV infection. Current therapy for those ill with RSV infection comprises solely symptomatic or supportive care.
About AK3280
AK3280 is an orally available, small, synthetic molecule. The molecule is being developed by Ark for the treatment of idiopathic pulmonary fibrosis (IPF) and potentially for other fibrotic diseases.
Preclinical data have demonstrated that AK3280 is a potent fibrosis inhibitor in animal models of pulmonary and hepatic fibrosis. AK3280 is based on the phenyl pyridone chemical scaffold of pirfenidone, a marketed anti-fibrotic and anti-inflammatory agent that has been shown to provide clinically meaningful benefit for patients with IPF. Pharmacokinetic (PK) data with AK3280 in animals and healthy volunteers, suggest that dosing once daily (QD) may be possible in patients with IPF, an improvement on the current standard of care. Also, based on preclinical data, and data generated in healthy volunteers summarized, there appears to be a potential for fewer adverse events (AEs) such as gastrointestinal (GI) effects, liver toxicity, and phototoxicity associated with the current standard of care.
About Idiopathic Pulmonary Fibrosis
Idiopathic Pulmonary Fibrosis is an orphan disease that affects about 5 million people worldwide, including about 100,000 patients in US. It is an invariably fatal disease which progressively destroys lung tissue, replacing healthy lung with fibrotic scar like tissue. The cause is unknown, and the disease is considered incurable. Sufferers experience increasing shortness of breath, chronic cough, and ever decreasing effort tolerance; respiratory failure and death typically supervene within four years of the initial diagnosis.
About Ark Biosciences Inc.
Ark Biosciences is a privately held, clinical stage global biotechnology company with its corporate office located in Zhang Jiang Hi-Tech Park in Shanghai, its R&D Center in Suzhou BioBay, China, and offices in the United States, Australia and Switzerland. Ark Biosciences has its own active R&D programs and programs in collaboration with external partners. Through these efforts, Ark Biosciences aims to be a global biotechnology company, discovering and developing innovative drugs for treatment of viral infections and respiratory diseases. For more information, please visit: http://www.arkbiosciences.com
Follow this link:
Ark Biosciences to Present at JPM Healthcare Conference in San Francisco - Business Wire
- Heart Disease - April 10th, 2018 [April 10th, 2018]
- Heart and Cardiovascular Research - April 10th, 2018 [April 10th, 2018]
- Heart and Cardiovascular Research - iMedPub - May 22nd, 2018 [May 22nd, 2018]
- Heart Disease - A Closer Look at Stem Cell Treatments - May 27th, 2018 [May 27th, 2018]
- Heart Conferences | Heart Congress | Cardiology ... - June 26th, 2018 [June 26th, 2018]
- Heart disease - Symptoms and causes - Mayo Clinic - September 21st, 2018 [September 21st, 2018]
- Diabetes, Heart Disease, and Stroke | NIDDK - September 29th, 2018 [September 29th, 2018]
- Heart Diseases & Disorders - Heart Rhythm Society - October 31st, 2018 [October 31st, 2018]
- Heart Disease - Closer Look at Stem Cells - November 15th, 2018 [November 15th, 2018]
- What is Heart Disease?, HHS, NIH, NHLBI - December 28th, 2018 [December 28th, 2018]
- Types of Heart Disease | Covenant HealthCare - December 30th, 2018 [December 30th, 2018]
- Heart Disease - Lab Tests Online - December 30th, 2018 [December 30th, 2018]
- Heart Diseases | Genetic and Rare Diseases Information Center ... - December 30th, 2018 [December 30th, 2018]
- Heart Healthy Lifestyle - Prevent Heart Diseases - HeartCare - January 26th, 2019 [January 26th, 2019]
- Breast cancer most prevalent in Sabah - The Borneo Post - October 6th, 2019 [October 6th, 2019]
- Menopause and womens heart health - Udaipur Kiran - October 6th, 2019 [October 6th, 2019]
- Low Birth Weight Linked To Heart Problems In Adulthood: Study - News Nation - October 6th, 2019 [October 6th, 2019]
- Consuming Red Meat And Pork Linked To Heart Disease And Cancer - Peoria Observer - October 6th, 2019 [October 6th, 2019]
- Yes, we still need to cut down on red and processed meat - The Conversation AU - October 6th, 2019 [October 6th, 2019]
- On oral contraceptive pills? You could be at risk of heart disease! - Times Now - October 6th, 2019 [October 6th, 2019]
- Rutgers researchers find heart valve infections increasing in hospitals - RU Daily Targum - October 6th, 2019 [October 6th, 2019]
- Most common warning symptoms of heart attack - Elets - October 6th, 2019 [October 6th, 2019]
- Adults Who Lost Teeth More Prone to Heart Attack, Stroke - SciTechDaily - October 6th, 2019 [October 6th, 2019]
- Heart and Stroke Foundation: 80% of heart attacks, strokes can be prevented - Northern Natal Courier - October 6th, 2019 [October 6th, 2019]
- Heart diseases on the rise: experts - newagebd.net - October 6th, 2019 [October 6th, 2019]
- Heart attack: Best diet to protect against the life-threatening condition - Express - October 6th, 2019 [October 6th, 2019]
- Women 'suffering and dying' because of inequalities in heart disease diagnosis and treatment - Holyrood - October 6th, 2019 [October 6th, 2019]
- B'luru's air pollution contributing to heart diseases? Study finds drivers are at risk - The News Minute - October 6th, 2019 [October 6th, 2019]
- Alia Bhatt supports fundraising for kids with heart diseases: They are more positive than adults - India Today - October 6th, 2019 [October 6th, 2019]
- Reduce heart disease at the American Heart Associations Heart Walk - KXAN.com - October 6th, 2019 [October 6th, 2019]
- Losing teeth may not be a good sign, could be indicative of heart disease risk - Economic Times - October 6th, 2019 [October 6th, 2019]
- Tooth Loss Associated with Higher Risk of Heart Disease - Cath Lab Digest - October 6th, 2019 [October 6th, 2019]
- Heart failure is the silent killer you've been ignoring - Times of India - October 10th, 2019 [October 10th, 2019]
- FDA awards 12 grants to fund new clinical trials to advance the development of medical products for the treatment of rare diseases - FDA.gov - October 10th, 2019 [October 10th, 2019]
- Daikon Radish: Types, Nutrition, Benefits, and Uses - Healthline - October 10th, 2019 [October 10th, 2019]
- Air Pollution May Affect Every Organ, Cell in the Body - Voice of America - October 10th, 2019 [October 10th, 2019]
- Less than 6 hours of sleep a night linked to increased risk of early death - NHS Website - October 10th, 2019 [October 10th, 2019]
- Disabled mum left in tears after DWP wrongly stopped all her benefits - Mirror Online - October 10th, 2019 [October 10th, 2019]
- How to live longer: Best diet to boost your life expectancy - what to eat - Express - October 10th, 2019 [October 10th, 2019]
- Men Should Stop Drinking Six Months In Advance If They Plan to Be Fathers - AskMen - October 10th, 2019 [October 10th, 2019]
- Dr. Roach: Assessing the risks of secondhand cigarette smoke - The Detroit News - October 10th, 2019 [October 10th, 2019]
- What is vascular disease? - Midland Daily News - October 10th, 2019 [October 10th, 2019]
- Fauna Bio Receives Grant From the National Institutes of Health to Advance Its Drug Repurposing Platform - BioSpace - October 10th, 2019 [October 10th, 2019]
- Bacon rashers, statistics, and controversy - The BMJ - The BMJ - October 10th, 2019 [October 10th, 2019]
- Why should you have semolina (suji) for weight loss - Times of India - October 10th, 2019 [October 10th, 2019]
- 4 blind spots in the confusing debate about red meat - Inverse - October 10th, 2019 [October 10th, 2019]
- Inflammation Signs That Are Often Overlooked - msnNOW - October 10th, 2019 [October 10th, 2019]
- MKRMS seminar: Experts stress regular exercise, healthy food for heart health - The News International - October 10th, 2019 [October 10th, 2019]
- Exercise, healthy food for heart health stressed - The News International - October 10th, 2019 [October 10th, 2019]
- AstraZeneca HealthCare Foundation Awards $775000 to 11 Innovative Heart Health Programs & Announces Open Call for Applications - Business Wire - October 10th, 2019 [October 10th, 2019]
- How to live longer: The superfood proven to boost brain and heart health - Express - October 10th, 2019 [October 10th, 2019]
- People with mental disorder at high risk of heart diseases - Yahoo India News - October 10th, 2019 [October 10th, 2019]
- Do Women Need To Worry About Heart Disease? - Version Weekly - October 10th, 2019 [October 10th, 2019]
- Stroke rates continue decline in the U.S. - Reuters - October 10th, 2019 [October 10th, 2019]
- 6 Foods That Can Help Protect You Against Life-Threatening Ailments - International Business Times - October 10th, 2019 [October 10th, 2019]
- Prevention of Heart Disease - The Sentinel Assam - October 10th, 2019 [October 10th, 2019]
- Tooth loss linked to higher risk of heart disease - The New Indian Express - October 10th, 2019 [October 10th, 2019]
- Performing HIIT Exercises Can Help Minimize The Risk Of Contracting A Heart Disease - International Business Times - October 10th, 2019 [October 10th, 2019]
- Heart disease: Best exercise to lower the risk of developing the deadly condition - Express - October 10th, 2019 [October 10th, 2019]
- Shropshire people left more than 343000 in wills to British Heart Foundation - shropshirestar.com - October 11th, 2019 [October 11th, 2019]
- Queen's Speech puts air pollution, science and the NHS on the agenda - British Heart Foundation - October 15th, 2019 [October 15th, 2019]
- In a rural Wisconsin village, the doctor makes house calls and sees some of the rarest diseases on Earth - Milwaukee Journal Sentinel - October 15th, 2019 [October 15th, 2019]
- Treatment And Management Of Heart Disease During Pregnancy - Version Weekly - October 15th, 2019 [October 15th, 2019]
- Severe dental diseases persist in S.D. due to chronic poverty and lack of access to dentists - KELO AM-FM - October 15th, 2019 [October 15th, 2019]
- New York Ranks 25th In Nation In First-Ever Childhood Obesity Study - WAER - October 15th, 2019 [October 15th, 2019]
- Saddleridge Fire Leads to Poor Air Quality, Tips on Staying Healthy - NBC Southern California - October 15th, 2019 [October 15th, 2019]
- This country just became the first to ban ads for sugary drinks - WGAL Lancaster - October 15th, 2019 [October 15th, 2019]
- Heart disease: Three dietary tips to keep the risks at bay - Express - October 15th, 2019 [October 15th, 2019]
- Eating habits that can reverse heart disease - Daily Monitor - October 15th, 2019 [October 15th, 2019]
- Hale and hearty: Tips to maintain good heart health - The New Indian Express - October 15th, 2019 [October 15th, 2019]
- Exercise Is Especially Important For Those With Heart Disease - Anti Aging News - October 15th, 2019 [October 15th, 2019]
- Exercise good for people with heart disease, other physical ailments - Al Bawaba - October 15th, 2019 [October 15th, 2019]
- Should you eat red meat or not? A dietitian explains the latest nutrition science on meat, eggs and butter - NBC News - October 15th, 2019 [October 15th, 2019]
- Rheumatic heart disease in Northern Territory 'a bloody health emergency' - The Guardian - October 15th, 2019 [October 15th, 2019]
- PPMD Grants to Promote Gene Therapy for Heart Disease and Patient Outcomes Research - Muscular Dystrophy News - October 15th, 2019 [October 15th, 2019]
- University of Guelph researchers track how cats' weights change over time - Jill Lopez - October 20th, 2019 [October 20th, 2019]
- Study Shows That a 50% Pay Raise Lowers the Risk of Cardiovascular Diseases by 15% - WORLD OF BUZZ - October 20th, 2019 [October 20th, 2019]
- Dog owners less likely to have cardiovascular diseases, and better chances of recovering from strokes or heart - MEAWW - October 20th, 2019 [October 20th, 2019]
- Keep your heart pumping - The New Indian Express - October 20th, 2019 [October 20th, 2019]
- How Can We Curb the Spread of Scientific Racism? - Scientific American - October 20th, 2019 [October 20th, 2019]