Can human growth hormones really benefit aging, like the elusive fountain of youth? In 1513, the Spanish explorer Juan Ponce de Len arrived in Florida to search for the fountain of youth. If he got any benefit from his quest, it was due to the exercise involved in the search.
Few men today believe in miraculous waters, but many, it seems, believe in the syringe of youth. Instead of drinking rejuvenating waters, they inject human growth hormone to slow the tick of the clock. Some are motivated by the claims of the "anti-aging" movement, others by the examples of young athletes seeking a competitive edge. Like Ponce de Len, the athletes still get the benefit of exercise, while older men may use growth hormone shots as a substitute for working out. But will growth hormone boost performance or slow aging? And is it safe?
Growth hormone (GH) is a small protein that is made by the pituitary gland and secreted into the bloodstream. GH production is controlled by a complex set of hormones produced in the hypothalamus of the brain and in the intestinal tract and pancreas.
The pituitary puts out GH in bursts; levels rise following exercise, trauma, and sleep. Under normal conditions, more GH is produced at night than during the day. This physiology is complex, but at a minimum, it tells us that sporadic blood tests to measure GH levels are meaningless since high and low levels alternate throughout the day. But scientists who carefully measure overall GH production report that it rises during childhood, peaks during puberty, and declines from middle age onward.
GH acts on many tissues throughout the body. In children and adolescents, it stimulates the growth of bone and cartilage. In people of all ages, GH boosts protein production, promotes the utilization of fat, interferes with the action of insulin, and raises blood sugar levels. GH also raises levels of insulin-like growth factor-1 (IGF-1).
GH is available as a prescription drug that is administered by injection. GH is indicated for children with GH deficiency and others with very short stature. It is also approved to treat adult GH deficiency an uncommon condition that almost always develops in conjunction with major problems afflicting the hypothalamus, pituitary gland, or both. The diagnosis of adult GH deficiency depends on special tests that stimulate GH production; simple blood tests are useless at best, misleading at worst.
Adults with bona fide GH deficiencies benefit from GH injections. They enjoy protection from fractures, increased muscle mass, improved exercise capacity and energy, and a reduced risk of future heart disease. But there is a price to pay. Up to 30% of patients experience side effects that include fluid retention, joint and muscle pain, carpal tunnel syndrome (pressure on the nerve in the wrist causing hand pain and numbness), and high blood sugar levels.
Adults who are GH deficient get larger muscles, more energy, and improved exercise capacity from replacement therapy. Athletes work hard to build their muscles and enhance performance. Some also turn to GH.
It's not an isolated problem. Despite being banned by the International Olympic Committee, Major League Baseball, the National Football League, and the World Anti-Doping Agency, GH abuse has tainted many sports, including baseball, cycling, and track and field. Competitive athletes who abuse GH risk disqualification and disgrace. What do they gain in return? And do they also risk their health?
Because GH use is banned and athletic performance depends on so many physical, psychological, and competitive factors, scientists have been unable to evaluate GH on the field. But they can conduct randomized clinical trials that administer GH or a placebo to healthy young athletes and then measure body composition, strength, and exercise capacity in the lab.
A team of researchers from California conducted a detailed review of 44 high-quality studies of growth hormone in athletes. The subjects were young (average age 27), lean (average body mass index 24), and physically fit; 85% were male. A total of 303 volunteers received GH injections, while 137 received placebo.
After receiving daily injections for an average of 20 days, the subjects who received GH increased their lean body mass (which reflects muscle mass but can also include fluid mass) by an average of 4.6 pounds. That's a big gain but it did not translate into improved performance. In fact, GH did not produce measurable increases in either strength or exercise capacity. And the subjects who got GH were more likely to retain fluid and experience fatigue than were the volunteers who got the placebo.
If you were a jock in high school or college, you're likely to wince at the memory of your coach barking "no pain, no gain" to spur you on. Today, athletes who use illegal performance-enhancing drugs risk the pain of disqualification without proof of gain.
To evaluate the safety and efficacy of GH in healthy older people, a team of researchers reviewed 31 high-quality studies that were completed after 1989. Each of the studies was small, but together they evaluated 220 subjects who received GH and 227 control subjects who did not get the hormone. Two-thirds of the subjects were men; their average age was 69, and the typical volunteer was overweight but not obese.
The dosage of GH varied considerably, and the duration of therapy ranged from two to 52 weeks. Still, the varying doses succeeded in boosting levels of IGF-1, which reflects the level of GH, by 88%.
As compared to the subjects who did not get GH, the treated individuals gained an average of 4.6 pounds of lean body mass, and they shed a similar amount of body fat. There were no significant changes in LDL ("bad") cholesterol, HDL ("good") cholesterol, triglycerides, aerobic capacity, bone density, or fasting blood sugar and insulin levels. But GH recipients experienced a high rate of side effects, including fluid retention, joint pain, breast enlargement, and carpal tunnel syndrome. The studies were too short to detect any change in the risk of cancer, but other research suggests an increased risk of cancer in general and prostate cancer in particular.
"Every man desires to live long," wrote Jonathan Swift, "but no man would be old." He was right, but the fountain of youth has proved illusory. GH does not appear to be either safe or effective for young athletes or healthy older men. But that doesn't mean you have to sit back and let Father Time peck away at you. Instead, use the time-tested combination of diet and exercise. Aim for a moderate protein intake of about .36 grams per pound of body weight; even big men don't need more than 65 grams (about 2 ounces) a day, though athletes and men recovering from illnesses or surgery might do well with about 20% more. Plan a balanced exercise regimen; aim for at least 30 minutes of moderate exercise, such as walking, a day, and be sure to add strength training two to three times a week to build muscle mass and strength. You'll reduce your risk of many chronic illnesses, enhance your vigor and enjoyment of life, and it's true slow the tick of the clock.
Image: porpeller | GettyImages
Link:
Growth hormone, athletic performance, and aging - Harvard Health
- HGH Infrared Systems Announces Debut of Spynel-S and Product Name Change - April 29th, 2013 [April 29th, 2013]
- Report: Biogenesis documents link A-Rod to HGH - April 29th, 2013 [April 29th, 2013]
- HGH Infrared Systems Announces New Blackbody Products and Updates - April 29th, 2013 [April 29th, 2013]
- "Anti-Aging" Pill SeroVital™-hgh Gets Overwhelming Response in The New York Times Magazine - April 29th, 2013 [April 29th, 2013]
- Radar Online Features Celebrity Makeup Artist's Anti-Aging Secret... SeroVital™-hgh - April 29th, 2013 [April 29th, 2013]
- De Smith says players will not be 'bullied' on HGH testing - April 29th, 2013 [April 29th, 2013]
- Smith says players won't be bullied on HGH test - April 29th, 2013 [April 29th, 2013]
- BraceLand Nutraceuticals - Turn Back Time with HGH - Video - April 29th, 2013 [April 29th, 2013]
- WWE '13 - HGH Clan vs spideysams - Video - April 29th, 2013 [April 29th, 2013]
- 216 Owner - April 29th, 2013 [April 29th, 2013]
- WvW HGH roaming aggressive conditions engineer (100'nades sequel) - Video - April 29th, 2013 [April 29th, 2013]
- WWE"13 WWE"13 xVBIx Pride Owned HGH zBrahmaBullz / My Epic Return - Video - April 29th, 2013 [April 29th, 2013]
- WWE '13 - HGH Clan vs P8909362, MrX206 and Danfort91 - Video - April 29th, 2013 [April 29th, 2013]
- Dr. Ed Park on why TA-65 is better than HGH - iHealthTube 8 - Video - April 29th, 2013 [April 29th, 2013]
- 15 mins HGH (Human Growth Hormone) release with Delta Isochronic - April 29th, 2013 [April 29th, 2013]
- Report: NFL HGH use likely common - May 1st, 2013 [May 1st, 2013]
- Anonymous player: HGH use in NFL 'like clockwork' - May 1st, 2013 [May 1st, 2013]
- HGH in the NFL: A growing menace - May 1st, 2013 [May 1st, 2013]
- HGH use in the NFL, still apparently subject for debate - May 1st, 2013 [May 1st, 2013]
- HGH use 'rampant' in NFL, according to report - May 1st, 2013 [May 1st, 2013]
- Report: HGH Use in NFL Is ‘Rampant,’ ‘Increasing’ With No Blood Test in Place - May 1st, 2013 [May 1st, 2013]
- Report: HGH use increasing - May 1st, 2013 [May 1st, 2013]
- PFT: HGH use reportedly rampant across league - May 3rd, 2013 [May 3rd, 2013]
- WWE '13 - HGH Clan OWNING these T-Rashy ass SPAMMERS - Video - May 3rd, 2013 [May 3rd, 2013]
- League wants HGH testing, needs players to want it, too - May 4th, 2013 [May 4th, 2013]
- WWE '13 - HGH KILLS Vendetta and NK CoLdR - Video - May 6th, 2013 [May 6th, 2013]
- Start Up Suplementos (360°) RENEWAL HGH Workout for Men 30ml Always Young - Video - May 6th, 2013 [May 6th, 2013]
- "Fountain of Youth" Pill SeroVital™-hgh Huge Draw at Annual Gynecology Meeting - May 8th, 2013 [May 8th, 2013]
- hGH Rap (Thrift Shop Parody) - Video - May 8th, 2013 [May 8th, 2013]
- WWE '13 - HGH vs KSA - Video - May 9th, 2013 [May 9th, 2013]
- WWE '13 - HGH Clan vs ObeyCrisz - May 9th, 2013 [May 9th, 2013]
- WWE '13 - HGH Clan vs jaTT253 - May 9th, 2013 [May 9th, 2013]
- WWE '13 - HGH vs The Shield? - Video - May 9th, 2013 [May 9th, 2013]
- WWE '13 - HGH Clan vs The1337Rasengan, Vinodhstanley and Chevyochenta - Video - May 9th, 2013 [May 9th, 2013]
- WWE '13 - HGH Clan OWNS Misfits_Owner, E214Classic and Kieron_Reynolds - Video - May 9th, 2013 [May 9th, 2013]
- WWE '13 - HGH Clan vs bigjoker____, FINAL7ROMANRAT, and VENdeTTA_RIppER - Video - May 11th, 2013 [May 11th, 2013]
- WWE '13 - HGH Clan vs PROOF_WANTED, OcaSs013_NDS and VigilanteWave24 - Video - May 11th, 2013 [May 11th, 2013]
- AhmetKayaGiderim-HGH-vidimob - Video - May 12th, 2013 [May 12th, 2013]
- J-rich94 - May 12th, 2013 [May 12th, 2013]
- WWE '13 - HGH Clan OWNS LordRaiku123 (NK Clan Member) - Video - May 17th, 2013 [May 17th, 2013]
- Footloose - Act One - Scene 4 - A Hgh School Hallway - Video - May 17th, 2013 [May 17th, 2013]
- Genuine HGH Available and AAS - Video - May 18th, 2013 [May 18th, 2013]
- Vlog Diaxu i HGH odc.2 - Video - May 18th, 2013 [May 18th, 2013]
- HGH Hormone Release + 528 Hz Virtual Anti Aging Spa Fatburner Mood Enhancer - Video - May 18th, 2013 [May 18th, 2013]
- WWE '13 - HGH vs 216 - Oh_216_Punk (Owner) and Oh_216_Prophecy - 'Bow Down/I Been On' by Beyonce - Video - May 18th, 2013 [May 18th, 2013]
- HGH Energizer Review By AgeExperts.net - Video - May 20th, 2013 [May 20th, 2013]
- Take me to the king Hgh's flag and banner - Video - May 20th, 2013 [May 20th, 2013]
- Best HGH Supplement - Video - May 21st, 2013 [May 21st, 2013]
- Testosterone - May 22nd, 2013 [May 22nd, 2013]
- Lack of HGH testing leaves hole in drug program - May 23rd, 2013 [May 23rd, 2013]
- Mark Sisson Primal Diet review HGH - May 23rd, 2013 [May 23rd, 2013]
- Humovox HGH Reviews - Supplementing.com - Video - May 23rd, 2013 [May 23rd, 2013]
- Bruce ( Spit ) Kimble - May 24th, 2013 [May 24th, 2013]
- NFL roundup: NFL proposes immediate HGH testing - May 25th, 2013 [May 25th, 2013]
- Report: NFL makes proposal for HGH testing - May 25th, 2013 [May 25th, 2013]
- NFL submitted proposal for immediate HGH testing, according to report - May 25th, 2013 [May 25th, 2013]
- IM A BOSS IN HGH - Video - May 26th, 2013 [May 26th, 2013]
- WWE '13 - HGH vs SMK-Ace_SkillZ (SMK Clan) WEAK BITCHES! - Video - May 28th, 2013 [May 28th, 2013]
- Invigorate HGH Reviews - Supplementing.com - Video - May 28th, 2013 [May 28th, 2013]
- Tarair Returned - 5v5 HGH Elixir Engineer - Video - May 28th, 2013 [May 28th, 2013]
- XxL3GACYxX-_ vs HGH Owner Kavan/BSS Owner Kavan - Video - May 29th, 2013 [May 29th, 2013]
- WWE '13 - HGH vs MOD - Video - May 29th, 2013 [May 29th, 2013]
- Discount Hgh Supplements - Promo Code - Video - May 30th, 2013 [May 30th, 2013]
- WWE '13 - HGH is STILL BETTER THAN NK - Video - May 30th, 2013 [May 30th, 2013]
- HGH Infrared Systems Presents to United 4 Defense, the Growing Cambridge-Based Defense-Technology Networking Group - May 31st, 2013 [May 31st, 2013]
- WWE'13 vs. HGH_LdR_LEVI HGH-Kavan-Owner HGH-Braham_Bullz - Video - May 31st, 2013 [May 31st, 2013]
- Exposing HGH - Video - May 31st, 2013 [May 31st, 2013]
- HGH 800 Hormona del Crecimiento - Video - May 31st, 2013 [May 31st, 2013]
- 2013 NBA Playoffs, Ducks Update, NFL HGH Testing, UFC 160 - May 31st, 2013 [May 31st, 2013]
- Hgh Code - Promo code Code - Video - June 1st, 2013 [June 1st, 2013]
- Hgh Coupon - Coupon Code - Video - June 1st, 2013 [June 1st, 2013]
- Discount Hgh - Coupon code Code - Video - June 3rd, 2013 [June 3rd, 2013]
- Hgh Discount - Discount Code - Video - June 3rd, 2013 [June 3rd, 2013]
- Official HGH Clan™ |Recruiting Videos| - Video - June 3rd, 2013 [June 3rd, 2013]
- Straight Dogged: HGH LDR Gets The Treatment - Video - June 4th, 2013 [June 4th, 2013]
- Increase HGH Naturally - Try RISK FREE - Hype or Real? - Video - June 4th, 2013 [June 4th, 2013]
- Growth Hormone Booster SeroVital®-hgh Causing Frenzy of Excitement at Renowned Sleep Conference - June 6th, 2013 [June 6th, 2013]
- Wwe13 vs HGH CLAN: HGH-Brahma_Bullz - June 6th, 2013 [June 6th, 2013]
- WWE '13 - HGH owns xSinFulxEniGmAx - June 6th, 2013 [June 6th, 2013]
- HGH Energizer Reviews - Video - June 6th, 2013 [June 6th, 2013]