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HHS takes steps to provide more information about clinical trials to the public

In an effort to make information about clinical trials widely available to the public, the U.S. Department of Health and Human Services (HHS) has issued a final rule specifying the requirements for registering and reporting summary results information to ClinicalTrials.gov. The new rule expands the legal requirements for submitting results. NIH also has issued a complementary policy for submitting summary results information for all NIH-funded clinical trials.

New NIH grants will fund developing computational approaches to finding the differences in DNA that make people susceptible to disease. The awards, totaling around $11.1 million, support research in identifying these differences - or genetic variants - in the less-studied regions of the genome. Understanding these variants should provide clues to understanding how disease develops.

NHGRI has found a new syndrome characterized by intellectual disability, hearing loss, abnormal sexual development and birth defects. It is caused bynew mutations inCHD4, which regulates how DNA is packaged and how RNA copies gene sequences during development. Using "gene-matching" to connect scientists interested in the same gene, researchers found the first three cases. Read about it in the American Journal of Human Genetics.

In this issue of The Genomics Landscape, we feature the history of the Centers of Excellence in Ethical, Legal, and Social Implications Research (CEER) Program dating back to the early days of genomics. We also highlight recent workshops on sharing summary statistics in genomic data and investigative device exceptions, the next stop on the Genome: Unlocking Life's Code traveling exhibition and NHGRI's summer trainees.

A recent study by NHGRI researchers, and collaborators uncovers the attacks and counter-attacks between Yersinia pestis - the bacteria that cause the bubonic plague - and their mammal hosts. The plague bacteria evolved a toxin to paralyze the host's immune system. The host fights the infection through fever and inflammation, which the bacteria then hijack and suppress using another toxin. The research published online August 25 in Cell Host & Microbe.

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