Hormone Therapy, The Pros And Cons – An Updated Report

Editor's Choice Academic Journal Main Category: Menopause Also Included In: Women's Health / Gynecology Article Date: 28 May 2012 - 17:00 PDT

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This review, written by researchers from Oregon Health & Science University, and Providence Cancer Center, and published in Annals of Internal Medicine, was conducted to help USPSTF (US Preventive Services Task Force) issue its new recommendations on hormone therapy.

As background information, the researchers explained that menopausal hormone therapy to prevent chronic diseases is not recommended today, because of the high risk of serious adverse events.

The researchers set out to update evidence regarding how effective hormone therapy is in reducing the risk of developing chronic conditions, as well as studying the impact and severity of adverse effects. They also wanted to see what the outcomes might be among females in different subgroups.

They gathered and analyzed data from MEDLINE (Jan 2002 - Nov 2011), the Cochrane Central Register for Controlled Database of Systematic Reviews (up to September 2011), Scopus and some other reference lists. They also looked at randomized, placebo-controlled trials of HRT (hormone replacement therapy) that had been published in the English language since 2002 - the trials were all focused on preventing chronic conditions.

They studied a short-list of 9 trials which met their inclusion criteria - the trials were assessed as being of fair-quality.

Below are some of the findings from this study:

The study did not look into compliance (adherence), some outcome risks, and some other regimens.

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Hormone Therapy, The Pros And Cons - An Updated Report