After careful consideration, the Endocrine Society canceled its annual meeting (ENDO 2020), which was set to take place in San Francisco, California, from March 28 to 31, 2020, because of concerns regarding coronavirus disease 2019 (COVID-19). Research findings that were scheduled to be presented at the meeting have been published in a supplemental issue of the Journal of the Endocrine Society.
The society is hosting ENDO Online, a complimentary virtual event featuring on-demand and live programming, from June 8 to 22, 2020, to provide a platform for continued learning and research exhibition. For more information, visit the Endocrine Societys website.
Switching from daily human growth hormone (hGH; somatropin) therapy to once-weekly TransCon hGH resulted in a similar safety and efficacy profile in children and adolescents, according to study results intended to be presented at the annual meeting of the Endocrine Society (ENDO 2020).
Once-weekly TransCon hGH, an investigational long-acting prodrug consisting of hGH, an inert protective carrier, and a linker that temporarily binds them, was assessed in the phase 3 Flight trial (ClinicalTrials.gov Identifier: NCT03305016).
The study aimed to assess the safety, tolerability, and efficacy of once-weekly hGH over 26 weeks. The main efficacy outcomes were annualized height velocity, height standard deviation score (SDS), and insulinlike growth factor-1 (IGF-1) SDS.
The study cohort included 146 participants aged 1 to 17 years (mean age, 10.6 years) who were treated with open-label once-weekly TransCon hGH at dose of 0.24 mg/kg. Most patients had previously received treatment with daily hGH and only 3 were treatment naive.
Treatment-emergent adverse events were documented in 56.8% patients, but only 4.1% experienced an event that was considered to be related to the study drug. The type and frequency of the treatment-emergent adverse events were in line with the known safety profile of daily hGH and none led to discontinuation of the study drug. Although low-titer anti-hGH binding antibodies were detected in 2.8% of treated patients, no neutralizing antibodies were detected.
At 26 weeks, the least-squares mean annualized height velocity was 8.7 cm/y (95% CI, 8.2-9.2) and the least-squares mean height SDS change from baseline was +0.25 (95% CI, 0.21-0.29). The mean observed annualized height velocity ranged from 8.2 to 16.2 cm/y and mean observed height SDS change ranged from +0.23 to +0.96.
In accordance with previous trials in treatment-naive patients, the linear association between average IGF-1 SDS and TransCon hGH doses was also evident in this cohort of children with prior daily hGH treatment who had dose titrations.
Overall, comparing the daily vs weekly treatment regimens, the researchers concluded that TransCon hGH treatment outcomes, including [annualized height velocity] and height SDS, were as expected across a diversity of ages, disease characteristics, and treatment experiences, reflective of a real-world setting. Dose titrations of TransCon hGH demonstrated a predictable IGF-1 response.
Disclosure: Several study authors declared affiliations with the pharmaceutical industry. Please see the original reference for a full list of authors disclosures.
Reference
Maniatis AK, Nadgir U, Saenger P, et al. Phase 3 FliGHt trial: experience of switching from daily growth hormone therapy to once-weekly TransCon hGH in children with growth hormone deficiency. J Endocr Soc. 2020;4(suppl 1):OR10-05.
Read more from the original source:
How Does the Switch From Daily to Weekly Dosing Affect Growth Hormone Therapy Outcomes? - Endocrinology Advisor
- HGH Infrared Systems Announces Debut of Spynel-S and Product Name Change - April 29th, 2013 [April 29th, 2013]
- Report: Biogenesis documents link A-Rod to HGH - April 29th, 2013 [April 29th, 2013]
- HGH Infrared Systems Announces New Blackbody Products and Updates - April 29th, 2013 [April 29th, 2013]
- "Anti-Aging" Pill SeroVital™-hgh Gets Overwhelming Response in The New York Times Magazine - April 29th, 2013 [April 29th, 2013]
- Radar Online Features Celebrity Makeup Artist's Anti-Aging Secret... SeroVital™-hgh - April 29th, 2013 [April 29th, 2013]
- De Smith says players will not be 'bullied' on HGH testing - April 29th, 2013 [April 29th, 2013]
- Smith says players won't be bullied on HGH test - April 29th, 2013 [April 29th, 2013]
- BraceLand Nutraceuticals - Turn Back Time with HGH - Video - April 29th, 2013 [April 29th, 2013]
- WWE '13 - HGH Clan vs spideysams - Video - April 29th, 2013 [April 29th, 2013]
- 216 Owner - April 29th, 2013 [April 29th, 2013]
- WvW HGH roaming aggressive conditions engineer (100'nades sequel) - Video - April 29th, 2013 [April 29th, 2013]
- WWE"13 WWE"13 xVBIx Pride Owned HGH zBrahmaBullz / My Epic Return - Video - April 29th, 2013 [April 29th, 2013]
- WWE '13 - HGH Clan vs P8909362, MrX206 and Danfort91 - Video - April 29th, 2013 [April 29th, 2013]
- Dr. Ed Park on why TA-65 is better than HGH - iHealthTube 8 - Video - April 29th, 2013 [April 29th, 2013]
- 15 mins HGH (Human Growth Hormone) release with Delta Isochronic - April 29th, 2013 [April 29th, 2013]
- Report: NFL HGH use likely common - May 1st, 2013 [May 1st, 2013]
- Anonymous player: HGH use in NFL 'like clockwork' - May 1st, 2013 [May 1st, 2013]
- HGH in the NFL: A growing menace - May 1st, 2013 [May 1st, 2013]
- HGH use in the NFL, still apparently subject for debate - May 1st, 2013 [May 1st, 2013]
- HGH use 'rampant' in NFL, according to report - May 1st, 2013 [May 1st, 2013]
- Report: HGH Use in NFL Is ‘Rampant,’ ‘Increasing’ With No Blood Test in Place - May 1st, 2013 [May 1st, 2013]
- Report: HGH use increasing - May 1st, 2013 [May 1st, 2013]
- PFT: HGH use reportedly rampant across league - May 3rd, 2013 [May 3rd, 2013]
- WWE '13 - HGH Clan OWNING these T-Rashy ass SPAMMERS - Video - May 3rd, 2013 [May 3rd, 2013]
- League wants HGH testing, needs players to want it, too - May 4th, 2013 [May 4th, 2013]
- WWE '13 - HGH KILLS Vendetta and NK CoLdR - Video - May 6th, 2013 [May 6th, 2013]
- Start Up Suplementos (360°) RENEWAL HGH Workout for Men 30ml Always Young - Video - May 6th, 2013 [May 6th, 2013]
- "Fountain of Youth" Pill SeroVital™-hgh Huge Draw at Annual Gynecology Meeting - May 8th, 2013 [May 8th, 2013]
- hGH Rap (Thrift Shop Parody) - Video - May 8th, 2013 [May 8th, 2013]
- WWE '13 - HGH vs KSA - Video - May 9th, 2013 [May 9th, 2013]
- WWE '13 - HGH Clan vs ObeyCrisz - May 9th, 2013 [May 9th, 2013]
- WWE '13 - HGH Clan vs jaTT253 - May 9th, 2013 [May 9th, 2013]
- WWE '13 - HGH vs The Shield? - Video - May 9th, 2013 [May 9th, 2013]
- WWE '13 - HGH Clan vs The1337Rasengan, Vinodhstanley and Chevyochenta - Video - May 9th, 2013 [May 9th, 2013]
- WWE '13 - HGH Clan OWNS Misfits_Owner, E214Classic and Kieron_Reynolds - Video - May 9th, 2013 [May 9th, 2013]
- WWE '13 - HGH Clan vs bigjoker____, FINAL7ROMANRAT, and VENdeTTA_RIppER - Video - May 11th, 2013 [May 11th, 2013]
- WWE '13 - HGH Clan vs PROOF_WANTED, OcaSs013_NDS and VigilanteWave24 - Video - May 11th, 2013 [May 11th, 2013]
- AhmetKayaGiderim-HGH-vidimob - Video - May 12th, 2013 [May 12th, 2013]
- J-rich94 - May 12th, 2013 [May 12th, 2013]
- WWE '13 - HGH Clan OWNS LordRaiku123 (NK Clan Member) - Video - May 17th, 2013 [May 17th, 2013]
- Footloose - Act One - Scene 4 - A Hgh School Hallway - Video - May 17th, 2013 [May 17th, 2013]
- Genuine HGH Available and AAS - Video - May 18th, 2013 [May 18th, 2013]
- Vlog Diaxu i HGH odc.2 - Video - May 18th, 2013 [May 18th, 2013]
- HGH Hormone Release + 528 Hz Virtual Anti Aging Spa Fatburner Mood Enhancer - Video - May 18th, 2013 [May 18th, 2013]
- WWE '13 - HGH vs 216 - Oh_216_Punk (Owner) and Oh_216_Prophecy - 'Bow Down/I Been On' by Beyonce - Video - May 18th, 2013 [May 18th, 2013]
- HGH Energizer Review By AgeExperts.net - Video - May 20th, 2013 [May 20th, 2013]
- Take me to the king Hgh's flag and banner - Video - May 20th, 2013 [May 20th, 2013]
- Best HGH Supplement - Video - May 21st, 2013 [May 21st, 2013]
- Testosterone - May 22nd, 2013 [May 22nd, 2013]
- Lack of HGH testing leaves hole in drug program - May 23rd, 2013 [May 23rd, 2013]
- Mark Sisson Primal Diet review HGH - May 23rd, 2013 [May 23rd, 2013]
- Humovox HGH Reviews - Supplementing.com - Video - May 23rd, 2013 [May 23rd, 2013]
- Bruce ( Spit ) Kimble - May 24th, 2013 [May 24th, 2013]
- NFL roundup: NFL proposes immediate HGH testing - May 25th, 2013 [May 25th, 2013]
- Report: NFL makes proposal for HGH testing - May 25th, 2013 [May 25th, 2013]
- NFL submitted proposal for immediate HGH testing, according to report - May 25th, 2013 [May 25th, 2013]
- IM A BOSS IN HGH - Video - May 26th, 2013 [May 26th, 2013]
- WWE '13 - HGH vs SMK-Ace_SkillZ (SMK Clan) WEAK BITCHES! - Video - May 28th, 2013 [May 28th, 2013]
- Invigorate HGH Reviews - Supplementing.com - Video - May 28th, 2013 [May 28th, 2013]
- Tarair Returned - 5v5 HGH Elixir Engineer - Video - May 28th, 2013 [May 28th, 2013]
- XxL3GACYxX-_ vs HGH Owner Kavan/BSS Owner Kavan - Video - May 29th, 2013 [May 29th, 2013]
- WWE '13 - HGH vs MOD - Video - May 29th, 2013 [May 29th, 2013]
- Discount Hgh Supplements - Promo Code - Video - May 30th, 2013 [May 30th, 2013]
- WWE '13 - HGH is STILL BETTER THAN NK - Video - May 30th, 2013 [May 30th, 2013]
- HGH Infrared Systems Presents to United 4 Defense, the Growing Cambridge-Based Defense-Technology Networking Group - May 31st, 2013 [May 31st, 2013]
- WWE'13 vs. HGH_LdR_LEVI HGH-Kavan-Owner HGH-Braham_Bullz - Video - May 31st, 2013 [May 31st, 2013]
- Exposing HGH - Video - May 31st, 2013 [May 31st, 2013]
- HGH 800 Hormona del Crecimiento - Video - May 31st, 2013 [May 31st, 2013]
- 2013 NBA Playoffs, Ducks Update, NFL HGH Testing, UFC 160 - May 31st, 2013 [May 31st, 2013]
- Hgh Code - Promo code Code - Video - June 1st, 2013 [June 1st, 2013]
- Hgh Coupon - Coupon Code - Video - June 1st, 2013 [June 1st, 2013]
- Discount Hgh - Coupon code Code - Video - June 3rd, 2013 [June 3rd, 2013]
- Hgh Discount - Discount Code - Video - June 3rd, 2013 [June 3rd, 2013]
- Official HGH Clan™ |Recruiting Videos| - Video - June 3rd, 2013 [June 3rd, 2013]
- Straight Dogged: HGH LDR Gets The Treatment - Video - June 4th, 2013 [June 4th, 2013]
- Increase HGH Naturally - Try RISK FREE - Hype or Real? - Video - June 4th, 2013 [June 4th, 2013]
- Growth Hormone Booster SeroVital®-hgh Causing Frenzy of Excitement at Renowned Sleep Conference - June 6th, 2013 [June 6th, 2013]
- Wwe13 vs HGH CLAN: HGH-Brahma_Bullz - June 6th, 2013 [June 6th, 2013]
- WWE '13 - HGH owns xSinFulxEniGmAx - June 6th, 2013 [June 6th, 2013]
- HGH Energizer Reviews - Video - June 6th, 2013 [June 6th, 2013]