June should be national cancer month.
Each year around this time, oncology groups and Wall Street brokerages hold a rash of conferences where researchers reveal the latest, greatest potential cancer cures.
This year has been no exception. Above all, we learned about remarkable advances in two exciting cancer therapies and three great companies that will benefit.
Heres more detail. (Ive kept the technical language to a minimum.)
Tumors are smart. They know how to trick the immune system into missing them. But scientists are wising up to their tricks. In one evasive strategy, tumors release an enzyme that renders them invisible. If you block the enzyme, your immune system can find tumors and destroy them with the help from cancer drugs. This is the key to an early-stage cancer weapon you should invest in, known as IDO inhibitors.
IDO stands for Indoleamine 2,3-dioxygenase, an enzyme released by tumors to blind the bodys immune system. IDO is a strange drug target, because IDO inhibition by itself has no noticeable anti-cancer effect, says Tanguy Seiwert, a cancer-therapy researcher and medical doctor who teaches at the University of Chicago. Suppressing IDO, however, makes tumors vulnerable.
The best pure play in IDO inhibitors is a company whose shares I own, and have suggested since December 2011 in my stock newsletter, Brush Up on Stocks. Were up 750% in this company since 2011 ($14 to $120). But I think this stock is still a hold because there are bigger gains ahead.
Incyte Corp. INCY, +3.58% just released excellent data on its IDO inhibitor, called epacadostat, at the American Society of Clinical Oncology (ASCO) conference. In combination with cancer therapies from Merck & Co. MRK, +1.13% and Bristol-Myers Squibb Co. BMY, +1.40% it showed excellent results against several kinds of cancer.
It looks really good. I think this was a coming-out party for IDO inhibitors, says Seiwert. Besides effectiveness, one of the main positives is that epacadostat is safe. This means it can be readily used to assist many other cancer drugs. You can add it to a ton of things because the cost is low, in terms of toxicity.
Incyte is an ideal biotech company for investors because it is self-funding. It has a very profitable drug called Jakafi, for a rare blood disorder, which supports research on new drugs like the IDO inhibitor. So investors dodge dilutive financings.
So why hasnt Incytes stock shot up? Investors have three main worries. But they look like false fears.
One bit of fake news circulating is that Incyte showed success, in part, only because it omitted patients from some results, which drove up the percentage of success stories. But this is a dubious critique for two reasons. Even if you included the three patients left out, it would only lower the success rate by a few percentage points, notes J.P. Morgan analyst Cory Kasimov. Second, Incyte offered several separate data sets showing success in many types of cancer, but the omission only affected one subgroup, says Seiwert. I think this was way overblown.
The next fear: Competitor NewLink Genetics Corp. NLNK, +3.27% recently announced Roche AG RHHBY, +0.21% handed back development rights to its IDO, following lousy results in a Roche study. Some investors take this as a sign that IDO is malarkey. But William Blair analyst Katherine Xu thinks this is bullish for Incyte, since it signals a competitor may be gone. NewLinks IDO may have fared poorly because it works differently than Incytes IDO, or because Roche used an extremely sick patient population. Neither scenario reflects poorly on Incyte.
The third knock on Incyte is the one to watch. While Seiwert is impressed with Incytes IDO results, he points out the Phase II results are early-stage, and longer-term studies are needed to learn more about patient survival. Those studies are in the works. Incyte has nine Phase III studies planned with Merck and Bristol-Myers Squibb, says Xu. The outcomes here are key, since about $50 worth of the current $120 Incyte stock price is linked to IDO.
In another key advance in cancer therapy in the past two years, doctors have learned how to extract a patients blood and genetically tweak white blood cells so they override evasive tactics used by tumors.
Then the cells are reproduced in a lab to expand the supply, and put back in the patients body so they can move in for the kill. Hopefully, the cells then continue to proliferate and thrive and stay on hand to fight any more cancer that comes along.
Known as chimeric antigen receptor T-cell therapy (CAR-T), this approach has produced remarkable results against blood cancers in patients who otherwise had almost no hope of survival. CAR-T works by unblocking cancer cell receptors normally sought out by the immune system.
This is one of the most exciting therapies in immunotherapy, said Jae Park, a Memorial Sloan Kettering Cancer Center cancer researcher and medical doctor, at the Jefferies 2017 Global Healthcare Conference in early June.
Probably the best pure play here is Kite Pharma Inc. KITE, +1.64% At the Jefferies conference, Kite CEO Arie Belldegrun showed images of a patients body riddled with tumors, which disappeared about a month after treatment began. The patient showed no sign of the disease a year later.
Kite has a product coming on the market by the end of this year, and probably many more on the way, says Brad Loncar, the cancer research expert behind the Loncar Cancer Immunotherapy CNCR, +2.93% exchange traded fund. This is pretty good progress for a therapy that was considered science fiction two years ago.
I suggested Kite in my stock letter at around $71 on May 17, and I think its still a hold even though it has already risen to $87, because this promises to be a blockbuster therapy. At the time, insiders were big buyers as the stock sold off on news of the death of a patient in one of its studies.
That unfortunate death highlights one of the key risks here. CAR-T patients have died because the therapy can cause brain swelling. Doctors are getting better at staving off adverse side effects, says Park. But they still dont fully understand what causes them, which should raise a yellow flag for investors.
Kite also faces competition from other companies developing CAR-T, including power players like Novartis AG NVS, +0.75% Pfizer Inc. PFE, +0.76% Johnson & Johnson JNJ, -0.21% and GlaxoSmithKline PLC GSK, -0.09% as well as Juno Therapeutics Inc. JUNO, +3.91% Cellectis SA CLLS, +0.00% Adaptimmune Therapeutics PLC ADAP, -0.44% and two privately held companies called Poseida Therapeutics and Nanjing Legend Biotech.
Any of these efforts may pan out nicely, but my pick as a third CAR-T play is bluebird bio BLUE, +3.59% which is partnering with Celgene Corp. CELG, +2.29% Bluebird just announced really impressive results for its CAR-T candidate called bb2121. In early studies, just released at ASCO, this therapy produced an overall response rate of 90% to 100% among hospice-type patients whose cancer was so bad that seven different attempts to cure them, on average, had failed.
To generate efficacy data on this level with an overall very tolerable safety profile is highly impressive, says Kasimov, at J.P. Morgan. With more key updates to come in 2017, we would continue to add to positions in bluebird bio.
At the time of publication, Michael Brush held INCY. Brush has suggested INCY and KITE in his stock newsletter Brush Up on Stocks. Brush is a Manhattan-based financial writer who has covered business for the New York Times and The Economist group, and he attended Columbia Business School in the Knight-Bagehot program.
Original post:
Opinion: Three must-own cancer stocks for your biotechnology portfolio - MarketWatch
- Plant biotechnology 3 - Video - January 1st, 2014 [January 1st, 2014]
- Press Release - April 9th, 2014 [April 9th, 2014]
- Biotech Suffers Record Exit at Largest ETF Signaling Turn - April 9th, 2014 [April 9th, 2014]
- Biotechnology World Congress 2014 | Biotechnology ... - April 9th, 2014 [April 9th, 2014]
- What is Biotechnology? - Access Excellence @ the National ... - April 9th, 2014 [April 9th, 2014]
- What is Biotechnology? - BIO | Healing, Fueling and ... - April 9th, 2014 [April 9th, 2014]
- Biotechnology - Wikipedia, the free encyclopedia - April 9th, 2014 [April 9th, 2014]
- IUBP Day5 2 Emerging Opportunities in Biotechnology - Video - April 9th, 2014 [April 9th, 2014]
- B.Tech(Biotechnology), BATCH 2008/09, SVPUAT MEERUT.............. FRIENDS FOREVER...... - Video - April 9th, 2014 [April 9th, 2014]
- Bharat Book Presents : Global Pharmaceutical & Biotechnology Outlook 2014 Mature Biotech - Video - April 9th, 2014 [April 9th, 2014]
- Bharat Book Presents : Global Pharmaceutical & Biotechnology Outlook 2014 Japan Pharma - Video - April 9th, 2014 [April 9th, 2014]
- Bharat Book Presents : Global Pharmaceutical & Biotechnology Outlook 2014 India Pharma - Video - April 9th, 2014 [April 9th, 2014]
- Bharat Book Presents : Global Pharmaceutical & Biotechnology Outlook 2014 Rising Stars - Video - April 10th, 2014 [April 10th, 2014]
- Nasdaq Rout Curbs 2000-Like Boom in Israeli Share Sales - April 15th, 2014 [April 15th, 2014]
- A Glimpse into Biotechnology - Video - April 15th, 2014 [April 15th, 2014]
- Biotechnology: gel electrophoresis, PCR - Video - April 15th, 2014 [April 15th, 2014]
- Plandai Biotechnology, Inc. Qualifies for Grant From South African Department of Trade - Video - April 16th, 2014 [April 16th, 2014]
- Biotechnology Program - University of California, Davis - April 17th, 2014 [April 17th, 2014]
- Biotechnology in Action (Arizona) - Video - April 17th, 2014 [April 17th, 2014]
- France protests new EU approved genetically modified corn ScienceDaily - Video - April 17th, 2014 [April 17th, 2014]
- Drug manufacture and Biotechnology '14 - SCOPS - final phase ( Auditing ) - Video - April 19th, 2014 [April 19th, 2014]
- Mucosis Partners With Chinese Firm Changchun BCHT Biotechnology - April 22nd, 2014 [April 22nd, 2014]
- Biotechnology-2014: Meeting the Needs of a Changing World - April 22nd, 2014 [April 22nd, 2014]
- New patenting guidelines are needed for biotechnology - April 22nd, 2014 [April 22nd, 2014]
- Biotechnology is so cool - Video - April 22nd, 2014 [April 22nd, 2014]
- Bharat Book Presents : Biotechnology Equipment Markets in China - Video - April 22nd, 2014 [April 22nd, 2014]
- New patenting guidelines needed for biotechnology, experts argue - April 24th, 2014 [April 24th, 2014]
- biotechnology videos - Video - April 24th, 2014 [April 24th, 2014]
- Kristi Snell, VP Research and Biotechnology for Metabolix, Inc. - Video - April 24th, 2014 [April 24th, 2014]
- 4th Annual International Conference: Advances in Biotechnology 2014 - Video - April 24th, 2014 [April 24th, 2014]
- Edmonds School District Biotechnology - Video - April 25th, 2014 [April 25th, 2014]
- World congress on Biotechnology - Video - April 25th, 2014 [April 25th, 2014]
- Bahir Dar university biotechnology dr tESFAYE - Video - April 25th, 2014 [April 25th, 2014]
- Algenist Skincare: Biotechnology from San Francisco - Video - April 27th, 2014 [April 27th, 2014]
- nitj biotechnology farewell batch2010-14 - Video - April 28th, 2014 [April 28th, 2014]
- Life Sciences & Biotechnology - Video - April 28th, 2014 [April 28th, 2014]
- Bolder Biotechnology Current Therapeutic Market Developmental Pipeline - Video - April 28th, 2014 [April 28th, 2014]
- Academic and Research Institutions to Play Key Role in 2014 BIO International Convention - April 29th, 2014 [April 29th, 2014]
- 19 Biotechnology - Video - April 29th, 2014 [April 29th, 2014]
- BIOTECHNOLOGY - Video - April 29th, 2014 [April 29th, 2014]
- Program Spotlight: Biotechnology - Video - April 30th, 2014 [April 30th, 2014]
- Biotechnology at Gaston College - Video - April 30th, 2014 [April 30th, 2014]
- Biotechnology - Gene Cloning - Video - April 30th, 2014 [April 30th, 2014]
- Amyris helps launch Brazilian Industrial Biotechnology Association (ABBI) - Video - May 2nd, 2014 [May 2nd, 2014]
- Julius Mugwagwa - Agro-biotechnology and Food Security - Video - May 2nd, 2014 [May 2nd, 2014]
- VIRUN's CEO, Philip Bromley, lecture - Cal Poly Pomona; Biotechnology - Video - May 2nd, 2014 [May 2nd, 2014]
- Biotechnology - gel electrophoresis - Video - May 2nd, 2014 [May 2nd, 2014]
- Plant Biotechnology Information Fair at Penn State 4/18/14 - Video - May 2nd, 2014 [May 2nd, 2014]
- Biotechnology ADHK - Video - May 2nd, 2014 [May 2nd, 2014]
- General Biology 2 - 38 Angiosperm Reproduction and Biotechnology - Flashcards - Video - May 2nd, 2014 [May 2nd, 2014]
- Impact of Biotechnology on Current Life - Video - May 3rd, 2014 [May 3rd, 2014]
- DGAP-Adhoc: Cytos Biotechnology Ltd to wind down Key Operational Activities - May 5th, 2014 [May 5th, 2014]
- Process - Genetic Engineering and Biotechnology - Video - May 6th, 2014 [May 6th, 2014]
- SAT105 Unit 3 Part 2 Biotechnology - Video - May 6th, 2014 [May 6th, 2014]
- highlights of industrial biotechnology - Video - May 6th, 2014 [May 6th, 2014]
- polymer & environmental biotechnology @ acib - Video - May 8th, 2014 [May 8th, 2014]
- SAT105 Unit 3 Part 1 Biotechnology - Video - May 8th, 2014 [May 8th, 2014]
- Talk of the Trade: Biotechnology & Health Sciences - Video - May 9th, 2014 [May 9th, 2014]
- Congratulations to the 2014 Biotechnology Graduates of Athens Technical College! - Video - May 9th, 2014 [May 9th, 2014]
- Plandai Biotechnology (PLPL) - Getting the Most Out of Nature - Video - May 10th, 2014 [May 10th, 2014]
- Stages Of Beans Growth- HU biotechnology - Video - May 11th, 2014 [May 11th, 2014]
- Revisiting the biotechnology stocks - Video - May 11th, 2014 [May 11th, 2014]
- Molecular Biotechnology - Master's Programme - Video - May 11th, 2014 [May 11th, 2014]
- Kevin Ahern's BB 350 (Biotechnology) 2014 - #22 - Video - May 12th, 2014 [May 12th, 2014]
- 5/5, Session 1 - Small biotechnology/Venture capital - Video - May 12th, 2014 [May 12th, 2014]
- Executive Interview - International Biotechnology Trust - Video - May 12th, 2014 [May 12th, 2014]
- Biotechnology Salaries | Salary.com - May 14th, 2014 [May 14th, 2014]
- Biotechnology | University of Wrocaw - Video - May 14th, 2014 [May 14th, 2014]
- JVS Bridges to College - Biotechnology Pathway Program - Video - May 16th, 2014 [May 16th, 2014]
- Biotechnology Paperslide Review by Khalizarek+Brian - Video - May 16th, 2014 [May 16th, 2014]
- Perceptions on the Future of Biotechnology by Robert Paarlberg (USA) - Video - May 16th, 2014 [May 16th, 2014]
- Plant Biotechnology - Video - May 16th, 2014 [May 16th, 2014]
- Playing with Biotechnology at the Age of 20: Kinshuk Mitra at TEDxOhioStateUniversity - Video - May 16th, 2014 [May 16th, 2014]
- biotechnology movie - Video - May 19th, 2014 [May 19th, 2014]
- New report details biotechnology's use in crops - May 20th, 2014 [May 20th, 2014]
- Biotechnology Stock Wins - Video - May 20th, 2014 [May 20th, 2014]
- Plant product of biotechnology - Video - May 21st, 2014 [May 21st, 2014]
- How Biotechnology Cure Diabetes - Video - May 22nd, 2014 [May 22nd, 2014]
- Exploring Laser-Material Interaction for Engineering, Biotechnology, and Medicine #DigInfo - Video - May 22nd, 2014 [May 22nd, 2014]
- Computers, Biotechnology, and Mass Communication - Video - May 22nd, 2014 [May 22nd, 2014]